PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SELENOS	0	VCP	6	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ye Y (2004), Ye Y (2004), Wang Q (2008), Ballar P (2007), Ballar P (2007), Schulze A (2005), Zhong Y (2011), Zhong Y (2011), Christianson JC (2012), Liu Y (2014), Noda C (2014), Lee JH (2014), Mountassif D (2015)	13
DERL2	0	DERL1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lilley BN (2005), Huang CH (2013), Christianson JC (2012)	3
AMFR	2	DERL1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Morito D (2008), Ballar P (2007), Ye Y (2005), Zhong Y (2011)	4
DERL2	0	HERPUD1	2	affinity chromatography technology	Huang CH (2013)	1
DERL2	0	FAF2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Greenblatt EJ (2011), Christianson JC (2012), Christianson JC (2012), Christianson JC (2012), Huttlin EL (2015), Raman M (2015), Huttlin EL (2017)	7
PTGS2	0	DERL1	2	affinity chromatography technology, affinity chromatography technology	Chen SF (2013), Chen SF (2013)	2
HERPUD1	2	SELENOS	0	affinity chromatography technology, affinity chromatography technology	Schulze A (2005), Schulze A (2005)	2
VCP	6	UFD1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Wang Q (2008), Ballar P (2007), Alexandru G (2008), Zhong X (2006), Fernandez-Saiz V (2010), Nagahama M (2009), Noguchi M (2005), Bruderer RM (2004), Bruderer RM (2004), Bruderer RM (2004), Erzurumlu Y (2013), Li JM (2013), Fogeron ML (2013), Haenzelmann P (2016), Haenzelmann P (2016), Haenzelmann P (2016), Raman M (2015), Raman M (2015), Mountassif D (2015), Wang T (2016), Guo X (2017)	21
FAF2	4	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Lee JN (2008), Alexandru G (2008), Alexandru G (2008), Mueller B (2008), Alexandru G (2012), Xu Y (2013), Christianson JC (2012), Besten Wd (2012), Madsen L (2014), Raman M (2015)	10
CAV1	0	UFD1	1	affinity chromatography technology	Chen SF (2013)	1
KPNB1	3	AMFR	2	affinity chromatography technology, affinity chromatography technology, pull down	Zhong Y (2011), Zhong Y (2011), Zhong Y (2011)	3
AMFR	2	HSPA4	3	affinity chromatography technology	Jo Y (2011)	1
TMEM129	2	VCP	6	affinity chromatography technology	van de Weijer ML (2014)	1
AMFR	2	FAF2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lee JN (2008), Lee JN (2008), Alexandru G (2008), Wang Q (2011), Xu Y (2013), Wang Q (2011), Christianson JC (2012), Christianson JC (2012), Zhang T (2015)	9
SELENOS	0	CKAP4	0	affinity chromatography technology, biochemical	Noda C (2014), Noda C (2014)	2
SYVN1	2	DERL1	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Schulze A (2005), Schulze A (2005), Ye Y (2005), Bernardi KM (2010), Huang CH (2013), van de Weijer ML (2014), Hosokawa N (2016)	7
SELENOS	0	SNTG2	2	affinity chromatography technology, affinity chromatography technology	Noda C (2014), Noda C (2014)	2
SVIP	1	AMFR	2	biochemical, affinity chromatography technology	Ballar P (2007), Ballar P (2007)	2
SELENOS	0	SELENOK	0	affinity chromatography technology	Christianson JC (2012)	1
SELENOS	0	UBE4A	2	affinity chromatography technology	Christianson JC (2012)	1
HERPUD1	2	DERL1	2	biochemical, affinity chromatography technology	Schulze A (2005), Schulze A (2005)	2
SELENOS	0	SAA1	0	pull down	Walder K (2002)	1
UBXN8	0	VCP	6	affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Alexandru G (2008), Madsen L (2011), Madsen L (2011), Madsen L (2014), Raman M (2015)	5
SELENOS	0	HSPA4	3	affinity chromatography technology	Ye Y (2004)	1
AMFR	2	VCP	6	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, two hybrid, pull down, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhong X (2004), Zhong X (2004), Lee JN (2008), Cao J (2007), Ballar P (2007), Ballar P (2007), Ye Y (2005), Ye Y (2005), Zhong X (2004), Yang H (2010), Yang H (2010), Ballar P (2010), Jo Y (2011), St-Pierre P (2012), Grelle G (2006), Scheich C (2007), Ballar P (2006), Haenzelmann P (2011), Haenzelmann P (2011), Haenzelmann P (2011), Wang Q (2011), Yu CC (2013), Erzurumlu Y (2013), Liu S (2013), Wang Q (2011), Grelle G (2006), Grelle G (2006), Grelle G (2006), Grelle G (2006), Christianson JC (2012), Zhang T (2015), Khodayari N (2017)	32
SELENOS	0	SYVN1	2	affinity chromatography technology, affinity chromatography technology	Ballar P (2007), Schulze A (2005)	2
HSPA4	3	VCP	6	affinity chromatography technology, affinity chromatography technology	Vij N (2006), Yu CC (2013)	2
CAV1	0	DERL1	2	affinity chromatography technology	Chen SF (2013)	1
SELENOS	0	UFD1	1	affinity chromatography technology	Ye Y (2004)	1
CAV1	0	SELENOS	0	affinity chromatography technology	Chen SF (2013)	1
PTGS2	0	SELENOS	0	affinity chromatography technology	Chen SF (2013)	1
TMEM129	2	DERL2	0	affinity chromatography technology	van de Weijer ML (2014)	1
UFD1	1	NPLOC4	4	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, x-ray crystallography, biochemical, affinity chromatography technology, affinity chromatography technology	Botta A (2001), Lass A (2008), Vong QP (2005), Bruderer RM (2004), Havugimana PC (2012), Li JM (2013), Pye VE (2007), Wan C (2015), Raman M (2015), Raman M (2015)	10
FAF2	4	CAV1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SVIP	1	SELENOS	0	affinity chromatography technology, affinity chromatography technology	Ballar P (2007), Ballar P (2007)	2
HERPUD1	2	VCP	6	biochemical, affinity chromatography technology, affinity chromatography technology, pull down	Schulze A (2005), Schulze A (2005), Schulze A (2005), Schulze A (2005)	4
HERPUD1	2	SYVN1	2	biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Schulze A (2005), Schulze A (2005), Schulze A (2005), Schulze A (2005), Kny M (2011), Kny M (2011), Kny M (2011), Huang CH (2013), Zhang T (2015), Hosokawa N (2016), Schulz J (2017)	11
TMEM129	2	SYVN1	2	affinity chromatography technology	van de Weijer ML (2014)	1
CAV1	0	VCP	6	affinity chromatography technology, imaging technique, affinity chromatography technology, pull down	Kirchner P (2013), Kirchner P (2013), Chen SF (2013), Chen SF (2013)	4
SELENOS	0	UBXN8	0	affinity chromatography technology	Christianson JC (2012)	1
UBXN8	0	NPLOC4	4	affinity chromatography technology	Alexandru G (2008)	1
VCP	6	SYVN1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, unspecified method, affinity chromatography technology, biochemical	Ballar P (2007), Schulze A (2005), Schulze A (2005), Schulze A (2005), Ye Y (2005), Ye Y (2005), Zhong X (2006), Fernandez-Saiz V (2010), Liu S (2013), Liu S (2013), Liu S (2013), Liu S (2013), Zhang T (2015), Hosokawa N (2016)	14
SELENOS	0	NPLOC4	4	affinity chromatography technology	Ballar P (2007)	1
PTGS2	0	CAV1	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Liou JY (2001), Liou JY (2001), Liou JY (2001), Chen SF (2010), Liou JY (2001), Liou JY (2001), Chen SF (2013), Chen SF (2013), Chen SF (2013)	9
APOB	8	SELENOS	0	affinity chromatography technology	Rutledge AC (2009)	1
HSPA4	3	PTGS2	0	affinity chromatography technology	Kishor A (2013)	1
SELENOS	0	AMFR	2	affinity chromatography technology, affinity chromatography technology	Ballar P (2007), Zhong Y (2011)	2
GTF2IRD1	6	SELENOS	0	two hybrid	Carmona-Mora P (2015)	1
FAF2	4	NPLOC4	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Raman M (2015), Raman M (2015)	4
APOB	8	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fisher EA (2008), Rutledge AC (2009), Zhang J (2017)	3
SRPK2	1	SELENOS	0	enzymatic study	Varjosalo M (2013)	1
SELENOS	0	FAF2	4	affinity chromatography technology, affinity chromatography technology	Christianson JC (2012), Christianson JC (2012)	2
NPLOC4	4	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Lass A (2008), Ballar P (2007), Alexandru G (2008), Alexandru G (2008), Fernandez-Saiz V (2010), Noguchi M (2005), Bruderer RM (2004), Bruderer RM (2004), Lee JJ (2013), Erzurumlu Y (2013), Raman M (2015), Raman M (2015), Mountassif D (2015), Wang T (2016), Guo X (2017)	15
SVIP	1	DERL1	2	biochemical, affinity chromatography technology	Ballar P (2007), Ballar P (2007)	2
APOB	8	FAF2	4	affinity chromatography technology, affinity chromatography technology	Suzuki M (2012), Huttlin EL (2015)	2
AMFR	2	HERPUD1	2	enzymatic study, enzymatic study, enzymatic study, pull down, affinity chromatography technology, enzymatic study, enzymatic study, pull down, enzymatic study, affinity chromatography technology	Li W (2007), David Y (2011), Yan L (2014), Yan L (2014), Wang Q (2011), Liu W (2014), Li W (2009), Li W (2009), Liu W (2014), Zhang T (2015)	10
PTGS2	0	VCP	6	affinity chromatography technology	Chen SF (2013)	1
SVIP	1	SYVN1	2	biochemical, affinity chromatography technology	Ballar P (2007), Ballar P (2007)	2
AMFR	2	UFD1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Cao J (2007), Cao J (2007), Cao J (2007), Cao J (2007)	4
FAF2	4	UFD1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Raman M (2015), Raman M (2015)	4
SELENOS	0	DERL2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lilley BN (2005), Huang CH (2013), Christianson JC (2012), Christianson JC (2012)	4
UBXN8	0	UFD1	1	affinity chromatography technology	Alexandru G (2008)	1
SYVN1	2	FAF2	4	affinity chromatography technology	Zhang T (2015)	1
DERL1	2	FAF2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Greenblatt EJ (2011), Suzuki M (2012), Suzuki M (2012), Xu Y (2013), Christianson JC (2012), Christianson JC (2012)	6
AMFR	2	DERL2	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Morito D (2008), Zhong Y (2011), Huang CH (2013), Christianson JC (2012), Zhang T (2015)	5
SVIP	1	VCP	6	biochemical, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, x-ray crystallography, pull down, unspecified method	Ballar P (2007), Ballar P (2007), Ballar P (2007), Wang Y (2011), Haenzelmann P (2011), Liu S (2013), Liu S (2013), Liu S (2013)	8
SELENOS	0	KPNB1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Zhong Y (2011), Zhong Y (2011), Zhong Y (2011), Zhong Y (2011)	4
DERL2	0	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lilley BN (2005), Greenblatt EJ (2011), Huang CH (2013), Christianson JC (2012)	4
AMFR	2	SYVN1	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference	Zhong Y (2011), Ballar P (2010), Zhang T (2015), Zhang T (2015), Zhang T (2015)	5
TMEM129	2	SELENOS	0	affinity chromatography technology	van de Weijer ML (2014)	1
KPNB1	3	DERL1	2	affinity chromatography technology	Zhong Y (2011)	1
SYVN1	2	UBXN8	0	affinity chromatography technology	Madsen L (2011)	1
VCP	6	DERL1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography	Wang Q (2008), Ballar P (2007), Schulze A (2005), Schulze A (2005), Ye Y (2005), Lilley BN (2005), Greenblatt EJ (2011), Younger JM (2006), Christianson JC (2012), You H (2017), Lim JJ (2016), Lim JJ (2016)	12
FAF2	4	PTGS2	0	affinity chromatography technology	Raman M (2015)	1
APOB	8	SYVN1	2	affinity chromatography technology	Rutledge AC (2009)	1
AMFR	2	NPLOC4	4	affinity chromatography technology, affinity chromatography technology	Wang Q (2011), Wang Q (2011)	2
SVIP	1	UFD1	1	biochemical	Ballar P (2007)	1
SELENOS	0	DERL1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ye Y (2004), Ballar P (2007), Schulze A (2005), Ye Y (2005), Lilley BN (2005), Zhong Y (2011), Christianson JC (2012)	7
TMEM129	2	DERL1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	van de Weijer ML (2014), van den Boomen DJ (2014), van den Boomen DJ (2014)	3
SELENOS	0	KLHDC2	1	affinity chromatography technology, affinity chromatography technology	Christianson JC (2012), Huttlin EL (2017)	2
SVIP	1	NPLOC4	4	biochemical, affinity chromatography technology	Ballar P (2007), Ballar P (2007)	2
DERL2	0	SYVN1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lilley BN (2005), Bernardi KM (2010), Huang CH (2013), Huang CH (2013), Huang CH (2013), Zhang T (2015)	6
APOB	8	DERL1	2	affinity chromatography technology, affinity chromatography technology	Rutledge AC (2009), Suzuki M (2012)	2