PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
GTF2IRD1	6	SP1	0	imaging technique	Carmona-Mora P (2015)	1
DCAF6	0	DCAF6	0	affinity chromatography technology	Tsai TC (2005)	1
DDA1	1	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Olma MH (2009), Jin J (2006), Hein MY (2015)	3
NFKBIA	0	COPS2	5	affinity chromatography technology	Schweitzer K (2007)	1
CUL4B	8	DDB1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Guerrero-Santoro J (2008), Guerrero-Santoro J (2008), Angers S (2006), Jin J (2006), Wang H (2006), Higa LA (2006), Higa LA (2006), Kawajiri K (2009), Bennett EJ (2010), Havugimana PC (2012), Ji Q (2014), Wan C (2015), Hein MY (2015), Mo Y (2017), Mo Y (2017), Yang Y (2015), Yang Y (2015), Yang Y (2015), Higa LA (2006), Higa LA (2006), Ohtake F (2007), Ohtake F (2007), Ohtake F (2007)	23
NR2E1	0	DCAF6	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DDB1	6	COPS2	5	affinity chromatography technology, affinity chromatography technology, pull down	Angers S (2006), Jin J (2006), Emberley ED (2012)	3
DCAF6	0	ACACA	5	biochemical	Kristensen AR (2012)	1
HNRNPL	3	GTF2IRD1	6	affinity chromatography technology	Fei T (2017)	1
CBX2	0	CBX4	1	affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Vandamme J (2011)	2
MAGEA1	0	DCAF6	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SP1	0	AR	3	affinity chromatography technology, affinity chromatography technology	Yuan H (2005), Chen PH (2008)	2
HNRNPL	3	DCAF6	0	affinity chromatography technology	Fei T (2017)	1
GTF2IRD1	6	DCAF6	0	two hybrid	Carmona-Mora P (2015)	1
CUL4A	2	DDA1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Angers S (2006), Pick E (2007), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Olma MH (2009), Jin J (2006)	7
C1QTNF2	1	DCAF6	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NXF1	0	DCAF6	0	affinity chromatography technology	Castello A (2012)	1
NXF1	0	SP1	0	affinity chromatography technology	Castello A (2012)	1
TRIM25	5	CUL4A	2	affinity chromatography technology	Choudhury NR (2017)	1
DDB1	6	DDA1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Angers S (2006), Behrends C (2010), Pick E (2007), Pick E (2007), Hrecka K (2007), Hrecka K (2007), Olma MH (2009), Olma MH (2009), Jin J (2006), Wan C (2015)	10
CUL4A	2	COPS2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Angers S (2006), McCall CM (2008), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Rao F (2014), Rao F (2014), Huttlin EL (2015), Cavadini S (2016), Scherer PC (2016), Scherer PC (2016), Scherer PC (2016), Huttlin EL (2017)	13
HNRNPL	3	ACACA	5	affinity chromatography technology	Fei T (2017)	1
DDA1	1	COPS2	5	affinity chromatography technology	Olma MH (2009)	1
MAGEA4	0	DCAF6	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DDB1	6	NXF1	0	biochemical	Havugimana PC (2012)	1
CALN1	0	DCAF6	0	affinity chromatography technology	Huttlin EL (2017)	1
TRIM25	5	DCAF6	0	affinity chromatography technology	Choudhury NR (2017)	1
NXF1	0	ACACA	5	affinity chromatography technology	Castello A (2012)	1
HNRNPL	3	CUL4A	2	affinity chromatography technology	Fei T (2017)	1
COPS2	5	DCAF6	0	affinity chromatography technology	Huttlin EL (2015)	1
DCAF6	0	NR3C1	2	affinity chromatography technology, affinity chromatography technology, pull down	Tsai TC (2005), Tsai TC (2005), Tsai TC (2005)	3
CUL4B	8	NXF1	0	biochemical	Wan C (2015)	1
TRIM25	5	GTF2IRD1	6	affinity chromatography technology	Choudhury NR (2017)	1
NXF1	0	PIH1D1	0	affinity chromatography technology	Castello A (2012)	1
CUL4A	2	DDB1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Guerrero-Santoro J (2008), Guerrero-Santoro J (2008), Angers S (2006), Angers S (2006), Jin J (2006), Wang H (2006), Kapetanaki MG (2006), Matsuda N (2005), Hu J (2004), Hu J (2004), Hu J (2004), Ahn J (2010), Maddika S (2009), Fischer ES (2011), Tan L (2007), He YJ (2006), He YJ (2006), He YJ (2006), McCall CM (2008), McCall CM (2008), Shiyanov P (1999), Bennett EJ (2010), Gastaldello S (2012), Kanei-Ishii C (2012), Hodgson AJ (2012), Kulaksiz G (2005), Wu Z (2012), Wu Z (2012), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Rao F (2014), Wan C (2015), Liu Y (2015), Zha Z (2015), Mouysset J (2015), Gao J (2015), Yang Y (2016), Yang Y (2016), Scherer PC (2016), Eichner R (2016), Mo Y (2017), Mo Y (2017), Peng Z (2016), Higa LA (2006), Ohtake F (2007)	46
TRIM25	5	HNRNPL	3	affinity chromatography technology	Choudhury NR (2017)	1
DCAF6	0	USP9X	15	biochemical	Kristensen AR (2012)	1
GTF2IRD1	6	KPNA1	5	two hybrid	Carmona-Mora P (2015)	1
SP1	0	NR2E1	0	affinity chromatography technology, affinity chromatography technology	Elmi M (2010), Elmi M (2010)	2
CBX2	0	DCAF6	0	affinity chromatography technology	Vandamme J (2011)	1
YAF2	1	DCAF6	0	affinity chromatography technology	Huttlin EL (2017)	1
CUL4A	2	DCAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Angers S (2006), Bennett EJ (2010), Olma MH (2009), Jin J (2006), Chen HH (2017)	5
CBX4	1	DCAF6	0	affinity chromatography technology	Vandamme J (2011)	1
FAM46A	2	CBX4	1	affinity chromatography technology	Hein MY (2015)	1
NR3C1	2	KPNA1	5	bioid	Lempiaeinen JK (2017)	1
VPS28	2	DCAF6	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
C10orf88	1	DCAF6	0	affinity chromatography technology	Huttlin EL (2017)	1
NFKBIA	0	DCAF6	0	affinity chromatography technology	Huttlin EL (2015)	1
SP1	0	DCAF6	0	affinity chromatography technology	Chen PH (2008)	1
CUL4B	8	COPS2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017), Higa LA (2006)	5
TRIM25	5	ACACA	5	affinity chromatography technology	Choudhury NR (2017)	1
TRIM63	0	TRIM55	2	two hybrid, two hybrid	Centner T (2001), Witt CC (2008)	2
TRIM63	0	DCAF6	0	two hybrid	Witt CC (2008)	1
BMP15	1	DCAF6	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DDB1	6	DCAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Angers S (2006), Jin J (2006), Jin J (2006), Chen HH (2017), Chen HH (2017), Chen HH (2017)	6
TRIM25	5	COPS2	5	affinity chromatography technology	Choudhury NR (2017)	1
DCAF6	0	CUL4B	8	affinity chromatography technology	Jin J (2006)	1
DCAF6	0	KPNA1	5	biochemical	Kristensen AR (2012)	1
CUL4A	2	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Guerrero-Santoro J (2008), Angers S (2006), Bennett EJ (2010), Bennett EJ (2010), Sertic S (2013)	5
DNAJB1	1	DCAF6	0	affinity chromatography technology	Huttlin EL (2017)	1
HNRNPL	3	AR	3	affinity chromatography technology	Fei T (2017)	1
AR	3	DCAF6	0	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Tsai TC (2005), Tsai TC (2005), Tsai TC (2005), Tsai TC (2005), Chen HH (2017), Chen HH (2017)	6
KPNA1	5	CUL4B	8	pull down, affinity chromatography technology	Zou Y (2009), Bennett EJ (2010)	2
PIH1D1	0	DCAF6	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRIM25	5	USP9X	15	affinity chromatography technology	Choudhury NR (2017)	1
HNRNPL	3	KPNA1	5	affinity chromatography technology	Fei T (2017)	1
DDA1	1	DCAF6	0	affinity chromatography technology	Olma MH (2009)	1
WDFY3	17	DCAF6	0	affinity chromatography technology	Huttlin EL (2017)	1
MOV10	6	WDFY3	17	affinity chromatography technology	Castello A (2012)	1
TRIM25	5	DDB1	6	affinity chromatography technology	Choudhury NR (2017)	1
AR	3	COPS2	5	two hybrid, pull down, affinity chromatography technology	Moehren U (2007), Moehren U (2007), Moehren U (2007)	3
FAM46A	2	DCAF6	0	affinity chromatography technology	Huttlin EL (2017)	1
TRIM55	2	DCAF6	0	two hybrid	Witt CC (2008)	1
MOV10	6	ACACA	5	affinity chromatography technology	Castello A (2012)	1
NXF1	0	WDFY3	17	affinity chromatography technology	Castello A (2012)	1
MOV10	6	DCAF6	0	affinity chromatography technology	Castello A (2012)	1