PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PRKCA	7	ITGB2	4	enzymatic study	Fagerholm S (2002)	1
RGS2	2	IBTK	3	affinity chromatography technology	Ewing RM (2007)	1
PRKCG	3	DDX58	3	enzymatic study	Maharaj NP (2011)	1
PRKCA	7	DDX58	3	enzymatic study, affinity chromatography technology, affinity chromatography technology	Maharaj NP (2011), Maharaj NP (2011), Maharaj NP (2011)	3
PRKCG	3	APP	1	pull down	Olah J (2011)	1
AFAP1	3	PRKCA	7	pull down	Qian Y (2002)	1
GFAP	0	APP	1	pull down	Olah J (2011)	1
PRKCA	7	PICK1	2	affinity chromatography technology	Dev KK (2000)	1
PRKCA	7	NOXA1	0	enzymatic study	Kroviarski Y (2010)	1
PRKCA	7	TIAM1	3	enzymatic study	Fleming IN (1999)	1
PRKCG	3	GABRA4	0	affinity chromatography technology	Kumar S (2002)	1
YWHAG	5	GSK3A	1	affinity chromatography technology	Jin J (2004)	1
PRKCG	3	EPHB1	9	pull down	Rex EB (2010)	1
HSP90AA1	7	APP	1	affinity chromatography technology	Kumar P (2007)	1
HSP90AA1	7	GSK3A	1	affinity chromatography technology, affinity chromatography technology	Taipale M (2012), Taipale M (2012)	2
PRKCG	3	PICK1	2	two hybrid	Lim J (2006)	1
RANBP9	5	RANBP10	0	affinity chromatography technology	Boldt K (2016)	1
HSP90AA1	7	EPHB1	9	affinity chromatography technology	Taipale M (2012)	1
PRKCG	3	IBTK	3	affinity chromatography technology	Janda E (2011)	1
FBXO7	1	HSP90AA1	7	affinity chromatography technology	Teixeira FR (2016)	1
PRKCA	7	GSK3A	1	enzymatic study	Fang X (2002)	1
HSP90AA1	7	HSPA4	3	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical	Kim TS (2006), Hidalgo-de-Quintana J (2008), Skarra DV (2011), Wan C (2015)	4
GSK3A	1	CTNNB1	30	enzymatic study, affinity chromatography technology	Koo J (2015), Hein MY (2015)	2
PRKCG	3	YWHAG	5	affinity chromatography technology	Autieri MV (1999)	1
PRKCG	3	NOXA1	0	two hybrid	Lim J (2006)	1
PRKCA	7	CASR	2	enzymatic study	Bai M (1998)	1
PRKCA	7	PRKCG	3	affinity chromatography technology	Huttlin EL (2017)	1
CTNNB1	30	SMURF1	4	affinity chromatography technology, pull down	Boonanantanasarn K (2015), Boonanantanasarn K (2015)	2
PRKCA	7	TOP2A	2	enzymatic study	Wells NJ (1995)	1
SMURF1	4	PRKCG	3	enzymatic study	Andrews PS (2010)	1
FBXO7	1	PRKCA	7	enzymatic study	Teixeira FR (2016)	1
PRKCG	3	GRIA4	4	affinity chromatography technology, pull down	Correia SS (2003), Correia SS (2003)	2
PRKCG	3	PRKCG	3	enzymatic study	Niture SK (2009)	1
PRKCG	3	SDC2	0	enzymatic study	Oh ES (1997)	1
CTNNB1	30	TOP2A	2	affinity chromatography technology, affinity chromatography technology	Sato S (2005), Sato S (2005)	2
PRKCG	3	CCHCR1	2	two hybrid	Lim J (2006)	1
PRKCA	7	NFE2L2	1	enzymatic study, enzymatic study	Niture SK (2009), Bloom DA (2003)	2
PRKCA	7	CTNNB1	30	affinity chromatography technology	Mertz JA (2011)	1
PRKCA	7	IBTK	3	affinity chromatography technology	Janda E (2011)	1
PRKCG	3	DAB2	1	enzymatic study	Tseng CP (1999)	1
PRKCG	3	GFAP	0	pull down	Rex EB (2010)	1
PRKCG	3	RGS2	2	enzymatic study	Cunningham ML (2001)	1
FBXO7	1	PRKCG	3	enzymatic study	Teixeira FR (2016)	1
PRKCG	3	SCN3A	7	pull down	Rex EB (2010)	1
PRKCG	3	ARHGEF25	0	pull down	Rex EB (2010)	1
PRKCA	7	SDC2	0	enzymatic study	Oh ES (1997)	1
HSPA4	3	APP	1	affinity chromatography technology	Kumar P (2007)	1
PRKCG	3	CASR	2	enzymatic study	Bai M (1998)	1
YWHAG	5	TIAM1	3	affinity chromatography technology	Jin J (2004)	1
SMURF1	4	APP	1	pull down	Olah J (2011)	1
GABRA4	0	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
PRKCG	3	RANBP10	0	pull down, affinity chromatography technology	Rex EB (2010), Rex EB (2010)	2
PRKCG	3	HSPA4	3	pull down	Rex EB (2010)	1
ITGB2	4	RANBP9	5	two hybrid, pull down, affinity chromatography technology	Denti S (2004), Denti S (2004), Denti S (2004)	3
APP	1	YWHAG	5	two hybrid, affinity chromatography technology, unspecified method	Sumioka A (2005), Sumioka A (2005), Sumioka A (2005)	3
PRKCG	3	GSK3A	1	enzymatic study	Fang X (2002)	1
PRKCG	3	ITGB2	4	enzymatic study	Fagerholm S (2002)	1
PRKCG	3	TOP2A	2	enzymatic study	Wells NJ (1995)	1
HSP90AA1	7	PRKCA	7	affinity chromatography technology	Taipale M (2012)	1
SMURF1	4	PRKCA	7	enzymatic study	Andrews PS (2010)	1
PICK1	2	GRIA4	4	two hybrid, pull down	Hirbec H (2002), Hirbec H (2002)	2
CTNNB1	30	APP	1	pull down	Olah J (2011)	1
PRKCG	3	NFE2L2	1	enzymatic study	Niture SK (2009)	1
HSP90AA1	7	PRKCG	3	affinity chromatography technology	Taipale M (2012)	1
GABRA1	6	PRKCG	3	affinity chromatography technology	Kumar S (2002)	1
PRKCG	3	TIAM1	3	enzymatic study	Fleming IN (1999)	1
PRKCG	3	RANBP9	5	affinity chromatography technology	Rex EB (2010)	1
PRKCA	7	RGS2	2	enzymatic study	Cunningham ML (2001)	1
AFAP1	3	PRKCG	3	pull down	Qian Y (2002)	1
PRKCA	7	YWHAG	5	affinity chromatography technology	Autieri MV (1999)	1
PRKCG	3	UBE2T	0	enzymatic study	Lv Z (2017)	1
PRKCG	3	CTNNB1	30	enzymatic study	Xue J (2015)	1
PRKCG	3	EXOC5	2	two hybrid	Lim J (2006)	1
DAB2	1	APP	1	pull down	Morris SM (2001)	1
RANBP9	5	APP	1	affinity chromatography technology	Lakshmana MK (2009)	1
PRKCG	3	TRIM5	4	pull down	Rex EB (2010)	1