PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ADAP2	3	APP	1	pull down	Olah J (2011)	1
TRIM25	5	ADAP2	3	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	EEF1G	0	affinity chromatography technology	Choudhury NR (2017)	1
IKBKG	0	ADAP2	3	pull down	Fenner BJ (2010)	1
TRIM25	5	APP	1	affinity chromatography technology	Choudhury NR (2017)	1
NEDD4L	3	SNCA	0	enzymatic study	Sugeno N (2014)	1
TRIM25	5	NEDD4L	3	affinity chromatography technology	Choudhury NR (2017)	1
NCL	1	TRIM25	5	affinity chromatography technology	Salvetti A (2016)	1
ADAP2	3	NCL	1	pull down	Haase A (2008)	1
APP	1	SNCA	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique	Jensen PH (1997), Yoshimoto M (1995), Tsigelny IF (2008), Tsigelny IF (2008), Tsigelny IF (2008), Olah J (2011), Chen TC (2014)	7
ADAP2	3	RANBP9	5	pull down	Haase A (2008)	1
NEDD4L	3	ADAP2	3	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
PRNP	4	ADAP2	3	pull down	Satoh J (2009)	1
ADAP2	3	KCTD10	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ADAP2	3	EEF1G	0	two hybrid	Stelzl U (2005)	1
TRIM25	5	MICA	0	affinity chromatography technology	Choudhury NR (2017)	1
SNCA	0	ADAP2	3	pull down	Schnack C (2008)	1
MICA	0	ADAP2	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RANBP9	5	APP	1	affinity chromatography technology	Lakshmana MK (2009)	1