Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications
CACNA2D3	55799	IMAGABALIN	CHEMBL2103836	modulator	ChemblInteractions
CACNA2D3	55799	PREGABALIN	CHEMBL1059	modulator	ChemblInteractions
CACNA2D3	55799	ATAGABALIN	CHEMBL593430	modulator	ChemblInteractions
CACNA2D3	55799	BEPRIDIL HYDROCHLORIDE	CHEMBL1200382	blocker	ChemblInteractions
CACNA2D3	55799	GABAPENTIN ENACARBIL	CHEMBL1628502	modulator	ChemblInteractions
CACNA2D3	55799	CELECOXIB	CHEMBL118		PharmGKB
CACNA2D3	55799	NILVADIPINE	CHEMBL517427	inhibitor	DrugBank	11426839, 19634509, 20097194, 10525060, 10374627, 9249249
CACNA2D3	55799	GABAPENTIN	CHEMBL940	modulator	ChemblInteractions

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
CACNA2D3	rs4505744	AA	antipsychotics	efficacy	yes	Patients with the AA genotype had a greater decrease in Positive and Negative Syndrome Scale (PANSS)-negative scores over a period of 12 months as compared to those with the GG genotype. No significant association was seen when comparing the AG vs GG genotype. Significance was set at p<3.45E-6. Please note that alleles have been complemented to the plus chromosomal strand.	Genotype AA is associated with increased response to antipsychotics in people with Schizophrenia as compared to genotype GG.	30032160	1449753292
CACNA2D3	rs7427395	CC	antipsychotics	efficacy	yes	Patients with the CC genotype had a greater decrease in Positive and Negative Syndrome Scale (PANSS)-general scores over a period of 12 months as compared to those with the TT genotype. No significant association was seen when comparing the CT vs CC genotype. Significance was set at p<3.45E-6.	Genotype CC is associated with increased response to antipsychotics in people with Schizophrenia as compared to genotype TT.	30032160	1449753400