PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PDPK1	0	CARD11	4	affinity chromatography technology, affinity chromatography technology, two hybrid	Lee KY (2005), Lee KY (2005), Vinayagam A (2011)	3
TRIM41	6	PRKCB	4	affinity chromatography technology, pull down, enzymatic study	Chen D (2007), Chen D (2007), Chen D (2007)	3
PRKCD	2	TIAM1	3	enzymatic study	Fleming IN (1999)	1
HSP90AA1	7	TERF1	1	affinity chromatography technology	Hein MY (2015)	1
AFAP1	3	PRKCB	4	pull down	Qian Y (2002)	1
PRKCA	7	ITGB2	4	enzymatic study	Fagerholm S (2002)	1
HSP90AA1	7	IKBKG	0	affinity chromatography technology, affinity chromatography technology	Gano JJ (2010), Hein MY (2015)	2
FBXO7	1	GSK3B	1	enzymatic study, affinity chromatography technology, pull down	Teixeira FR (2016), Teixeira FR (2016), Teixeira FR (2016)	3
IKBKB	1	PRKCD	2	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Lallena MJ (1999), Lallena MJ (1999), Lallena MJ (1999), Lallena MJ (1999)	4
RGS2	2	IBTK	3	affinity chromatography technology	Ewing RM (2007)	1
EGFR	5	LYN	2	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Wu SL (2006), Wu SL (2006), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	5
IKBKG	0	RBCK1	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Fenner BJ (2010), Verhelst K (2012), Zak DE (2011), Niu J (2011), Fu J (2013), Tokunaga F (2011), Xia ZP (2009), Emmerich CH (2013), Abdul-Sater AA (2017), Abdul-Sater AA (2017), Bal E (2017), Bal E (2017)	12
EP300	36	CDK1	0	affinity chromatography technology, enzymatic study	Wang SA (2014), Wang SA (2014)	2
PRKCB	4	RB1	2	enzymatic study	Suzuma K (2002)	1
TERF1	1	PRKCB	4	two hybrid	Lee OH (2011)	1
HSP90AA1	7	BTK	1	affinity chromatography technology, affinity chromatography technology	Taipale M (2012), Huttlin EL (2017)	2
PRKCA	7	MBP	0	enzymatic study	Rininsland F (2005)	1
PRKCA	7	DDX58	3	enzymatic study, affinity chromatography technology, affinity chromatography technology	Maharaj NP (2011), Maharaj NP (2011), Maharaj NP (2011)	3
PRKCD	2	PDPK1	0	two hybrid, affinity chromatography technology	Hodgkinson CP (2002), Hodgkinson CP (2002)	2
CDK1	0	HSP90AA1	7	affinity chromatography technology	Garcia-Morales P (2007)	1
PRKCB	4	TOP2A	2	enzymatic study	Wells NJ (1995)	1
ARRB2	5	YWHAG	5	affinity chromatography technology	Xiao K (2007)	1
YWHAG	5	SHCBP1	1	affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Jin J (2004)	2
EGFR	5	AKT1	1	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
IKBKB	1	TNFRSF1A	3	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Zhang SQ (2000), Chaudhary PM (2000), Fan YH (2011), Park KJ (2002), Guan YJ (2011), Guan YJ (2011), Guan YJ (2011), Mitsuhashi S (2008), Chen TC (2014)	9
LYN	2	IKBKG	0	affinity chromatography technology	Lee SH (2012)	1
AFAP1	3	PRKCA	7	pull down	Qian Y (2002)	1
PPP1CA	3	IBTK	3	two hybrid	Esteves SL (2012)	1
PRKCA	7	TIAM1	3	enzymatic study	Fleming IN (1999)	1
HSP90AA1	7	TRIM41	6	affinity chromatography technology	Taipale M (2012)	1
PPP1CA	3	AKT1	1	enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li L (2003), Xiao L (2010), Xiao L (2010), Xiao L (2010), Chen CS (2005), Chen CS (2005)	6
GRK2	4	HSP90AA1	7	affinity chromatography technology	Varjosalo M (2013)	1
PRKCB	4	SHCBP1	1	affinity chromatography technology	So J (2015)	1
LYN	2	PRKCB	4	affinity chromatography technology	Zhu J (2013)	1
RNF31	3	RBCK1	0	affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, pull down	Haas TL (2009), Yagi H (2012), Yagi H (2012), Yagi H (2012), Nakamura M (2006), Tokunaga F (2012), Kirisako T (2006), Kirisako T (2006), Rivkin E (2013), Schaeffer V (2014), Tokunaga F (2011), Tokunaga F (2011), Chen Y (2015), Draber P (2015), Draber P (2015), Klein T (2015), Klein T (2015), Stieglitz B (2012), Huttlin EL (2017), Liu J (2017), Liu J (2017)	21
RIPK4	0	HSP90AA1	7	affinity chromatography technology	Rodriguez J (2016)	1
HIST1H3A	3	PPP1CA	3	affinity chromatography technology, pull down	Zhang H (2013), Zhang H (2013)	2
TOP2A	2	GSK3B	1	affinity chromatography technology	Chen MC (2011)	1
LYN	2	CDK1	0	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Kharbanda S (1994), Kharbanda S (1994), Kharbanda S (1994), Pathan NI (1996)	4
YWHAG	5	GSK3A	1	affinity chromatography technology	Jin J (2004)	1
HSP90AA1	7	LYN	2	affinity chromatography technology	Taipale M (2012)	1
AKT1	1	IBTK	3	affinity chromatography technology	Spatuzza C (2008)	1
RIPK4	0	PRKCB	4	affinity chromatography technology, enzymatic study	Chen L (2001), Chen L (2001)	2
EGFR	5	IKBKG	0	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
PRKCA	7	RACK1	2	affinity chromatography technology	Lee HS (2002)	1
PRKCB	4	EGFR	5	enzymatic study	Khaled Z (1995)	1
LMNB1	1	PRKCA	7	pull down	Tabellini G (2002)	1
IKBKG	0	TRIM41	6	pull down	Fenner BJ (2010)	1
TINF2	1	TERF1	1	affinity chromatography technology, two hybrid, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, far western blotting, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu D (2004), Stelzl U (2005), Kim SH (1999), Kim SH (1999), Giannone RJ (2010), Zhu Q (2009), Zhu Q (2009), Zhu Q (2009), Liu D (2004), Ye JZ (2004), Ye JZ (2004), Lee OH (2011), Lee OH (2011), Ye JZ (2004), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017), Tan R (2017)	18
CHUK	5	PRKCA	7	pull down, affinity chromatography technology, affinity chromatography technology	Lallena MJ (1999), Lallena MJ (1999), Lallena MJ (1999)	3
HSP90AA1	7	GSK3A	1	affinity chromatography technology, affinity chromatography technology	Taipale M (2012), Taipale M (2012)	2
AFAP1	3	PRKCD	2	pull down	Qian Y (2002)	1
YWHAG	5	TERF1	1	two hybrid, two hybrid	Bandyopadhyay S (2010), Lee OH (2011)	2
CDK1	0	MBP	0	enzymatic study	Plun-Favreau H (2007)	1
HSP90AA1	7	KCNA5	2	affinity chromatography technology	Taipale M (2012)	1
ITGB2	4	RACK1	2	two hybrid, pull down, affinity chromatography technology	Liliental J (1998), Liliental J (1998), Liliental J (1998)	3
EGFR	5	HSPA4	3	protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay	Deribe YL (2009), Deribe YL (2009), Citri A (2002), Tong J (2008), Kotlyar M (2015), Petschnigg J (2014)	6
PRKCA	7	SHCBP1	1	affinity chromatography technology	Huttlin EL (2017)	1
IKBKG	0	PRKCB	4	pull down	Fenner BJ (2010)	1
CDK1	0	HIST1H1A	0	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Zhan Q (1999), Horton LE (1997), Pan ZQ (1993), Pan ZQ (1993), Yarden RI (2002), Golsteyn RM (1995), Jiang W (1998), Badea T (2002), Bae Y (2013), Linares JF (2011), Sasaki T (2008), Chen M (2012), Tang J (2008)	13
CHUK	5	CARD11	4	affinity chromatography technology, imaging technique	McCully RR (2008), Sommer K (2005)	2
PRKCD	2	HIST1H1A	0	enzymatic study, enzymatic study	Lee SJ (2006), Fontayne A (2002)	2
CHUK	5	PPP1CA	3	affinity chromatography technology, affinity chromatography technology	Mitsuhashi S (2008), Mitsuhashi S (2008)	2
EP300	36	HIST1H1A	0	enzymatic study, enzymatic study	Loven MA (2004), Sakaguchi K (1998)	2
PRKCD	2	HSPA4	3	pull down	Rex EB (2010)	1
FBXO7	1	RACK1	2	affinity chromatography technology	Teixeira FR (2016)	1
PRKCD	2	MBP	0	enzymatic study	Ren J (2002)	1
DDX58	3	IKBKG	0	affinity chromatography technology	Oshiumi H (2013)	1
RIPK4	0	SDC2	0	affinity chromatography technology	Rodriguez J (2016)	1
PRKCB	4	H1F0	3	enzymatic study	Goss VL (1994)	1
FBXO7	1	HSP90AA1	7	affinity chromatography technology	Teixeira FR (2016)	1
AKT1	1	GSK3B	1	pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Thimmaiah KN (2005), Drendall CI (2010), Connor MK (2005), Hunter MG (2004), Zhu QS (2011), Li L (2003), Nam SY (2010), Yang WL (2009), Zeng L (2013), Yang H (2005), Boehme KA (2008), Cross DA (1995), Hinton CV (2007), Kapoor GS (2004), Pitre A (2012), Guo J (2016)	16
PRKCD	2	PRKCB	4	affinity chromatography technology	Varjosalo M (2013)	1
PRKCA	7	GSK3A	1	enzymatic study	Fang X (2002)	1
LYN	2	CSF2RB	6	unspecified method, affinity chromatography technology	Adachi T (1999), Li Y (1995)	2
GNA12	2	HSP90AA1	7	affinity chromatography technology, two hybrid	Vaiskunaite R (2001), Vaiskunaite R (2001)	2
FBXO7	1	PRKCB	4	enzymatic study	Teixeira FR (2016)	1
IKBKG	0	AKT1	1	pull down, affinity chromatography technology	Fenner BJ (2010), Hou Y (2010)	2
HSP90AA1	7	HSPA4	3	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical	Kim TS (2006), Hidalgo-de-Quintana J (2008), Skarra DV (2011), Wan C (2015)	4
AKT1	1	GSK3A	1	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Drendall CI (2010), Nakamura H (2001), Ma Y (2007), Li L (2003), Sundaresan NR (2011), Dragoi AM (2005), Dixon DA (2006), Sun L (2012), Kapoor GS (2004), Hellyer NJ (2001)	10
PPP1CA	3	CDK1	0	affinity chromatography technology	Flores-Delgado G (2007)	1
PRKCB	4	IKBKB	1	imaging technique	Chen TC (2014)	1
EGFR	5	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay	Citri A (2002), Yang S (2006), Shimamura T (2005), Lavictoire SJ (2003), Lavictoire SJ (2003), Foerster S (2013), Kotlyar M (2015), Petschnigg J (2014)	8
MBP	0	DDX58	3	affinity chromatography technology, affinity chromatography technology	Feng M (2012), Feng M (2012)	2
PRKCB	4	HIST1H1B	4	enzymatic study	Thompson LJ (1996)	1
SDC2	0	PDPK1	0	affinity chromatography technology	Huttlin EL (2017)	1
PRKCB	4	IBTK	3	enzymatic study, affinity chromatography technology	Janda E (2011), Janda E (2011)	2
TINF2	1	PRKCB	4	two hybrid	Lee OH (2011)	1
ARRB2	5	HIST1H1A	0	affinity chromatography technology	Xiao K (2007)	1
PRKCA	7	CASR	2	enzymatic study	Bai M (1998)	1
PRKCB	4	RGS2	2	enzymatic study	Cunningham ML (2001)	1
EGFR	5	TNFRSF1A	3	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
PPP1CA	3	RB1	2	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Flores-Delgado G (2007), Dunaief JL (2002), Durfee T (1993), Durfee T (1993), Durfee T (1993), Guo C (2007)	6
IKBKG	0	CHUK	5	pull down, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, pull down, pull down, pull down, pull down, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology	Agou F (2002), Chen G (2002), Deng L (2000), Shifera AS (2008), Fenner BJ (2010), Rothwarf DM (1998), Rothwarf DM (1998), Hasegawa M (2008), Liu J (2009), Li S (2011), Li S (2011), Xia X (2011), Kensche T (2012), May MJ (2002), Wu ZH (2006), Wu ZH (2006), Palkowitsch L (2008), Le Page C (2001), Le Page C (2001), Huang TT (2002), Sebban-Benin H (2007), Tegethoff S (2003), Hai T (2006), Ammirante M (2010), McKenzie FR (2000), Solt LA (2007), Li XH (2001), Rottenberg S (2002), Poyet JL (2000), Poyet JL (2000), Stilo R (2004), Marienfeld RB (2006), Marienfeld RB (2006), Strnad J (2006), Strnad J (2006), Funakoshi-Tago M (2005), Shibata Y (2012), Wu X (2007), Stehlik C (2002), Ryzhakov G (2007), Chen RA (2008), Marinis JM (2012), Mitsuhashi S (2008), Mitsuhashi S (2008), Fujita H (2014), Lee SH (2012), Jackson SS (2014), Tokunaga F (2011), Criollo A (2010), Emmerich CH (2013), Liu D (2014), Hein MY (2015), Medunjanin S (2016), Huttlin EL (2017), Nowicka AM (2016), Rushe M (2008), Bal E (2017)	57
HSP90AA1	7	AKT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Haendeler J (2003), Kawauchi K (2005), Sato S (2000), Basso AD (2002), Su CH (2011), Klein JB (2005), Sun L (2012)	7
IKBKB	1	PRKCA	7	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Lallena MJ (1999), Lallena MJ (1999), Lallena MJ (1999), Lallena MJ (1999)	4
FN1	17	HSP90AA1	7	affinity chromatography technology	Humphries JD (2009)	1
PRKCA	7	TOP2A	2	enzymatic study	Wells NJ (1995)	1
IKBKG	0	CARD11	4	pull down, affinity chromatography technology, affinity chromatography technology	Stilo R (2004), McCully RR (2008), Shambharkar PB (2007)	3
PRKCB	4	PDLIM5	0	two hybrid, affinity chromatography technology	Kuroda S (1996), Kuroda S (1996)	2
CDK1	0	ITGB3	6	enzymatic study	Kirk RI (2000)	1
PPP1CA	3	HSPA4	3	affinity chromatography technology	Flores-Delgado G (2007)	1
TNFRSF1A	3	PPP1CA	3	affinity chromatography technology	Mitsuhashi S (2008)	1
ARRB2	5	CHUK	5	affinity chromatography technology, imaging technique	Xiao K (2007), Chen TC (2014)	2
PPP1CA	3	GSK3B	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tanji C (2002), Varjosalo M (2013), St-Denis N (2016)	3
PRKCB	4	EP300	36	enzymatic study	Yuan LW (2000)	1
FN1	17	PRKCB	4	affinity chromatography technology	Humphries JD (2009)	1
EGFR	5	ARRB2	5	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
PRKCD	2	GNA13	0	enzymatic study	Offermanns S (1996)	1
PRKCA	7	GSK3B	1	enzymatic study	Goode N (1992)	1
FBXO7	1	PRKCA	7	enzymatic study	Teixeira FR (2016)	1
FN1	17	HIST1H1B	4	affinity chromatography technology	Humphries JD (2009)	1
RNF31	3	PRKCA	7	enzymatic study	Queisser MA (2014)	1
AKT1	1	ARRB2	5	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Beaulieu JM (2008), Beaulieu JM (2008), Lodeiro M (2009), Luan B (2009)	4
FN1	17	DAB2	1	affinity chromatography technology	Humphries JD (2009)	1
BTK	1	IBTK	3	pull down, affinity chromatography technology, pull down, affinity chromatography technology	Liu W (2001), Liu W (2001), Janda E (2011), Spatuzza C (2008)	4
PRKCD	2	GNA12	2	enzymatic study	Offermanns S (1996)	1
CDK1	0	H1F0	3	enzymatic study, enzymatic study, enzymatic study	Kim KS (2002), Toji S (2004), Goss VL (1994)	3
RNF31	3	DDX58	3	affinity chromatography technology, affinity chromatography technology	Inn KS (2011), Inn KS (2011)	2
RACK1	2	HIST1H3A	3	affinity chromatography technology	He DY (2010)	1
TOP2A	2	RB1	2	affinity chromatography technology, affinity chromatography technology	Bhat UG (1999), Bhat UG (1999)	2
PTPA	0	AKT1	1	enzymatic study, enzymatic study	Ma Y (2007), Li L (2003)	2
PRKCB	4	GSK3B	1	imaging technique	Chen TC (2014)	1
CARD11	4	RNF31	3	affinity chromatography technology, affinity chromatography technology	Yang YK (2016), Yang YK (2016)	2
PDPK1	0	AKT1	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Barry FA (2002), Persad S (2001), Lin K (2012), Guo J (2016), Guo J (2016)	5
GSK3B	1	HSP90AA1	7	enzymatic study	Muller P (2012)	1
CDK1	0	LMNB1	1	enzymatic study	Goss VL (1994)	1
KCNA5	2	PRKCB	4	affinity chromatography technology	David M (2012)	1
PRKCD	2	NCF1	2	enzymatic study	Fontayne A (2002)	1
EGFR	5	ITGB2	4	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
CDK1	0	HSPA4	3	affinity chromatography technology	Garcia-Morales P (2007)	1
KCNA5	2	RACK1	2	affinity chromatography technology, affinity chromatography technology	David M (2012), David M (2012)	2
PRKCA	7	NCF1	2	enzymatic study	Fontayne A (2002)	1
TRIM41	6	PRKCD	2	affinity chromatography technology	Chen D (2007)	1
PRKCB	4	HIST1H3A	3	enzymatic study	Metzger E (2010)	1
CDK1	0	MARCKS	0	enzymatic study	Manenti S (1999)	1
PRKCD	2	IBTK	3	affinity chromatography technology	Janda E (2011)	1
FBXO7	1	H1F0	3	enzymatic study	Teixeira FR (2016)	1
TNFRSF1A	3	IKBKG	0	affinity chromatography technology, affinity chromatography technology	Zhang SQ (2000), Nakazawa S (2016)	2
EGFR	5	FN1	17	protein complementation assay	Deribe YL (2009)	1
PRKCB	4	GNA12	2	enzymatic study	Offermanns S (1996)	1
CSF2RB	6	PRKCB	4	affinity chromatography technology	Geijsen N (1999)	1
PRKCA	7	IBTK	3	affinity chromatography technology	Janda E (2011)	1
PRKCB	4	SYT6	1	enzymatic study	Roggero CM (2005)	1
PRKCB	4	RASGRP3	3	enzymatic study, enzymatic study	Brodie C (2004), Teixeira C (2003)	2
PRKCA	7	PRKCB	4	affinity chromatography technology	Huttlin EL (2017)	1
AKT1	1	EP300	36	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Lin WN (2008), Lee IT (2010), Sundaresan NR (2011), Howie HL (2011), Chen J (2004), Chen J (2004)	6
FN1	17	CDK1	0	affinity chromatography technology	Humphries JD (2009)	1
PRKCB	4	GSK3A	1	enzymatic study	Fang X (2002)	1
PRKCB	4	LSP1	3	affinity chromatography technology	Harrison RE (2004)	1
HSP90AA1	7	CHUK	5	affinity chromatography technology, affinity chromatography technology	Qu X (2012), Gano JJ (2010)	2
PRKCA	7	NUMB	1	enzymatic study	Smith CA (2007)	1
IKBKB	1	PPP1CA	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li HY (2008), Mitsuhashi S (2008), Mitsuhashi S (2008)	3
BLVRA	0	PRKCB	4	enzymatic study, pull down	Lerner-Marmarosh N (2007), Lerner-Marmarosh N (2007)	2
SDC2	0	FN1	17	pull down	Kusano Y (2000)	1
PRKCB	4	RACK1	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Ron D (1999), Ron D (1999), Chen S (2008), Sato T (2014), Sato T (2014), Sato T (2014)	6
DDX58	3	RBCK1	0	affinity chromatography technology	Inn KS (2011)	1
PRKCB	4	DDX58	3	enzymatic study, affinity chromatography technology, affinity chromatography technology	Maharaj NP (2011), Maharaj NP (2011), Maharaj NP (2011)	3
RB1	2	EP300	36	affinity chromatography technology, affinity chromatography technology, enzymatic study	Iyer NG (2007), Iyer NG (2007), Chan HM (2001)	3
PRKCB	4	CARD11	4	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Sommer K (2005), Sommer K (2005), Sommer K (2005), Sommer K (2005)	4
TRIM41	6	PRKCA	7	affinity chromatography technology, pull down	Chen D (2007), Chen D (2007)	2
TINF2	1	YWHAG	5	two hybrid	Lee OH (2011)	1
AKT1	1	YWHAG	5	affinity chromatography technology	Klein JB (2005)	1
PPP1CA	3	GSK3A	1	affinity chromatography technology	St-Denis N (2016)	1
RACK1	2	RB1	2	affinity chromatography technology	Ozaki T (2003)	1
PRKCD	2	DAB2	1	enzymatic study	Tseng CP (1999)	1
EP300	36	HIST1H3A	3	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study	Liu B (2009), Brackertz M (2006), Faiola F (2005), Daujat S (2002), Kalkhoven E (2002), Seo SB (2002), Kim JH (2005), Bordoli L (2001), Kim MY (2001), Kutney SN (2004), Wang F (2010), Loven MA (2004), Kiernan RE (1999), Wong K (2005), Ogryzko VV (1996), Yamaguchi Y (2004), Furumatsu T (2005), An W (2002), Delvecchio M (2013), Delvecchio M (2013), Tropberger P (2013), Das C (2009), Shimura M (2011), Ji A (2003), Fu M (2005), Suganuma T (2002), Tang Z (2013), Kim JH (2006), Lopes da Rosa J (2013), Li X (2014), Wang YL (2008), Du C (2017), Yi P (2017), Wan W (2017)	34
PRKCA	7	HIST1H3A	3	enzymatic study	Metzger E (2010)	1
ITGB3	6	PRKCB	4	affinity chromatography technology	Prevost N (2009)	1
PRKCA	7	HIST1H1A	0	enzymatic study, enzymatic study, enzymatic study	Rininsland F (2005), Lee SJ (2006), Fontayne A (2002)	3
PRKCB	4	RBCK1	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tatematsu K (2008), Vallentin A (2007), Vallentin A (2007), Nakamura M (2006), Gustafsson Sheppard N (2012)	5
IKBKG	0	HSPA4	3	affinity chromatography technology	Ammirante M (2010)	1
FN1	17	PDLIM5	0	affinity chromatography technology	Humphries JD (2009)	1
AKT1	1	ITGB3	6	enzymatic study	Kirk RI (2000)	1
PRKCB	4	YWHAG	5	affinity chromatography technology	Autieri MV (1999)	1
CSF2RB	6	RACK1	2	two hybrid, affinity chromatography technology, pull down	Geijsen N (1999), Geijsen N (1999), Geijsen N (1999)	3
EGFR	5	RGS2	2	enzymatic study	Derrien A (2001)	1
PRKCA	7	SDC2	0	enzymatic study	Oh ES (1997)	1
CHUK	5	PRKCD	2	pull down, affinity chromatography technology, affinity chromatography technology	Lallena MJ (1999), Lallena MJ (1999), Lallena MJ (1999)	3
PRKCB	4	CHUK	5	imaging technique	Chen TC (2014)	1
PRKCD	2	HSP90AA1	7	pull down	Rex EB (2010)	1
EGFR	5	CDK1	0	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay	Tong J (2008), Foerster S (2013), Kotlyar M (2015), Petschnigg J (2014)	4
TNFRSF1A	3	PRKCD	2	affinity chromatography technology, enzymatic study	Kilpatrick LE (2000), Kilpatrick LE (2000)	2
CHUK	5	TNFRSF1A	3	enzymatic study, affinity chromatography technology, affinity chromatography technology	Guan YJ (2011), Guan YJ (2011), Mitsuhashi S (2008)	3
FN1	17	RACK1	2	affinity chromatography technology	Humphries JD (2009)	1
TNFRSF1A	3	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
PRKCA	7	RBCK1	0	affinity chromatography technology, enzymatic study	Queisser MA (2014), Queisser MA (2014)	2
PPP1CA	3	PRKCB	4	enzymatic study	Keranen LM (1995)	1
YWHAG	5	TIAM1	3	affinity chromatography technology	Jin J (2004)	1
PRKCB	4	DAB2	1	enzymatic study	Tseng CP (1999)	1
AKT1	1	IKBKB	1	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Vandermoere F (2005), Vandermoere F (2005), Chen TC (2014), Busch F (2012)	4
TNFRSF1A	3	RBCK1	0	affinity chromatography technology	Nakazawa S (2016)	1
CDK1	0	DAB2	1	affinity chromatography technology, enzymatic study	He J (2003), He J (2003)	2
NCAM1	1	PRKCB	4	affinity chromatography technology	Leshchynska I (2003)	1
PRKCD	2	HIST1H1B	4	enzymatic study, enzymatic study	Kaul S (2005), Uddin S (2002)	2
NCF1	2	PRKCB	4	affinity chromatography technology, enzymatic study	Korchak HM (2001), Fontayne A (2002)	2
AKT1	1	HSPA4	3	affinity chromatography technology	Doong H (2003)	1
HIST1H3A	3	HIST1H1B	4	imaging technique	Soldi M (2013)	1
HSPA4	3	PRKCB	4	affinity chromatography technology, pull down	Gao T (2006), Gao T (2006)	2
HSP90AA1	7	MARCKS	0	biochemical	Havugimana PC (2012)	1
FN1	17	PPP1CA	3	affinity chromatography technology	Humphries JD (2009)	1
CSF2RB	6	IKBKB	1	two hybrid	Ebner K (2003)	1
AKT1	1	CHUK	5	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Ozes ON (1999), Ozes ON (1999), Romashkova JA (1999), Lu Y (2005), Chen TC (2014), Takada Y (2005), Koul D (2001)	7
PRKCB	4	TIAM1	3	enzymatic study	Fleming IN (1999)	1
EGFR	5	NCAM1	1	pull down	Povlsen GK (2008)	1
IKBKB	1	HSP90AA1	7	affinity chromatography technology	Xue J (2010)	1
HSP90AA1	7	PRKCA	7	affinity chromatography technology	Taipale M (2012)	1
FN1	17	YWHAG	5	affinity chromatography technology	Humphries JD (2009)	1
AKT1	1	PRKCB	4	two hybrid, enzymatic study	Arroyo R (2015), Wu D (2009)	2
BTK	1	LYN	2	pull down	Cheng G (1994)	1
PRKCB	4	ITGB2	4	enzymatic study	Fagerholm S (2002)	1
TERF1	1	EP300	36	affinity chromatography technology	Her YR (2013)	1
PRKCB	4	MARCKS	0	enzymatic study	Palmer RH (1996)	1
PRKCB	4	ARRB2	5	affinity chromatography technology, affinity chromatography technology	Zheng M (2015), Zheng M (2015)	2
EP300	36	CHUK	5	imaging technique	Hao L (2010)	1
HIST1H3A	3	YWHAG	5	affinity chromatography technology, pull down	Macdonald N (2005), Macdonald N (2005)	2
HSP90AA1	7	PRKCB	4	affinity chromatography technology	Taipale M (2012)	1
PRKCB	4	NUMB	1	enzymatic study	Smith CA (2007)	1
PRKCB	4	CDK1	0	affinity chromatography technology	Chiarini A (2002)	1
PRKCB	4	RNF31	3	affinity chromatography technology, enzymatic study, affinity chromatography technology	Nakamura M (2006), Nakamura M (2006), Nakamura M (2006)	3
GSK3B	1	HSPA4	3	enzymatic study, pull down	Muller P (2012), Kawakami F (2011)	2
PRKCD	2	EP300	36	enzymatic study	Yuan LW (2000)	1
PRKCD	2	RASGRP3	3	enzymatic study, affinity chromatography technology, affinity chromatography technology	Brodie C (2004), Brodie C (2004), Brodie C (2004)	3
ITGB3	6	FN1	17	pull down	Kauf AC (2001)	1
NCAM1	1	PPP1CA	3	pull down	Wobst H (2012)	1
CDK1	0	HIST1H1B	4	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Deep G (2006), Olsen BB (2008), Porter LA (2002), Kabuta T (2013), Ling YH (1998), Thompson LJ (1996), Vincent I (2001)	7
FN1	17	TOP2A	2	affinity chromatography technology	Humphries JD (2009)	1
FN1	17	LMNB1	1	affinity chromatography technology	Humphries JD (2009)	1
PRKCA	7	EGFR	5	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Gauthier ML (2003), Gauthier ML (2003), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	5
RIPK4	0	IKBKG	0	affinity chromatography technology	Rodriguez J (2016)	1
PRKCD	2	RIPK4	0	affinity chromatography technology, affinity chromatography technology	Bhr C (2000), Rodriguez J (2016)	2
PRKCB	4	PRKCB	4	enzymatic study, enzymatic study, enzymatic study, enzymatic study	Niture SK (2009), Goss VL (1994), Keranen LM (1995), Roggero CM (2005)	4
PDPK1	0	PRKCB	4	pull down	Gao T (2001)	1
GRK2	4	PRKCB	4	pull down, affinity chromatography technology	Yang XL (2003), Yang XL (2003)	2
PRKCD	2	GSK3A	1	enzymatic study	Fang X (2002)	1
CDK1	0	RB1	2	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Horton LE (1997), Lees JA (1991), Knudsen ES (1996), Jiang W (1998), De Luca A (1997), Chen Z (2002), Knudsen ES (1997), Pan W (2001)	8
RNF31	3	TNFRSF1A	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Draber P (2015), Nakazawa S (2016), Elliott PR (2016)	3
PRKCB	4	HIST1H1A	0	enzymatic study	Fontayne A (2002)	1
CARD11	4	PRKCD	2	affinity chromatography technology	Liu Y (2012)	1
PRKCA	7	RGS2	2	enzymatic study	Cunningham ML (2001)	1
HSP90AA1	7	RB1	2	genetic interference	Srivas R (2016)	1
PRKCD	2	YWHAG	5	affinity chromatography technology	Autieri MV (1999)	1
IKBKB	1	CHUK	5	affinity chromatography technology, biochemical, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Zandi E (1997), Chen G (2002), Otsuki T (2002), May MJ (2000), May MJ (2000), Woronicz JD (1997), Woronicz JD (1997), Deng L (2000), Yeung KC (2001), Mercurio F (1997), Mercurio F (1997), Rothwarf DM (1998), Wu ZH (2010), Li S (2011), Li S (2011), May MJ (2002), Heilker R (1999), Leotoing L (2011), McKenzie FR (2000), Zandi E (1998), Lee DF (2007), Li XH (2001), Yeh PY (2011), Yeh PY (2011), Stehlik C (2002), Li Q (2006), So J (2015), Chen TC (2014), Karim ZA (2015), Huttlin EL (2017)	30
BTK	1	PRKCB	4	pull down	Yang XL (2003)	1
PRKCB	4	SDC2	0	enzymatic study	Oh ES (1997)	1
PRKCB	4	GNA13	0	enzymatic study	Offermanns S (1996)	1
PPP1CA	3	PTPA	0	affinity chromatography technology	Flores-Delgado G (2007)	1
FBXO7	1	NUMB	1	enzymatic study	Teixeira FR (2016)	1
PRKCA	7	HIST1H1B	4	enzymatic study, enzymatic study	Rininsland F (2005), Thompson LJ (1996)	2
PRKCA	7	YWHAG	5	affinity chromatography technology	Autieri MV (1999)	1
IKBKG	0	H1F0	3	pull down	Fenner BJ (2010)	1
IKBKB	1	IKBKG	0	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, biochemical, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography, pull down, affinity chromatography technology	Chen G (2002), Chen G (2002), Chariot A (2002), Wu RC (2002), Deng L (2000), Shifera AS (2008), Fenner BJ (2010), Fenner BJ (2010), Fenner BJ (2010), Lee KY (2005), Rothwarf DM (1998), Ea CK (2006), Thurston TL (2009), Orel L (2010), Wu ZH (2010), Napolitano G (2009), Liu J (2009), Skaug B (2011), Li S (2011), Li S (2011), Kensche T (2012), Chiaravalli J (2011), Wu CJ (2006), Wu ZH (2006), Ahmad R (2007), Ahmad R (2007), Palkowitsch L (2008), Palkowitsch L (2008), Lo YC (2008), Mabb AM (2006), Baima ET (2010), Tegethoff S (2003), Tegethoff S (2003), Hai T (2006), Ammirante M (2010), Lee DF (2007), Rottenberg S (2002), Poyet JL (2000), Stilo R (2004), Marienfeld RB (2006), Marienfeld RB (2006), Strnad J (2006), Funakoshi-Tago M (2005), Ivins FJ (2009), Shibata Y (2012), Shibata Y (2012), Wu X (2007), Stehlik C (2002), Ryzhakov G (2007), Chen RA (2008), Wu ZH (2008), Mitsuhashi S (2008), Fujita H (2014), Golden MS (2013), Lee SH (2012), Cote SM (2013), Kim HJ (2014), Jackson SS (2014), Liao W (2008), Tokunaga F (2011), Criollo A (2010), Emmerich CH (2013), So J (2015), Liu D (2014), Guo B (2014), Guo B (2014), Guo B (2014), Zhou L (2014), Zhou L (2014), Hein MY (2015), Bagneris C (2015), Medunjanin S (2016), Huttlin EL (2017), Nowicka AM (2016), Rushe M (2008), Rushe M (2008), Hauenstein AV (2017), Bal E (2017)	78
PRKCB	4	LMNB1	1	affinity chromatography technology, enzymatic study	Chiarini A (2002), Goss VL (1994)	2
RNF31	3	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Tokunaga F (2012), Verhelst K (2012), Niu J (2011), Fujita H (2014), Tokunaga F (2011), Tokunaga F (2011), Xia ZP (2009), Fu J (2013), Emmerich CH (2013), Chen Y (2015), Bal E (2017)	11
PRKCB	4	CASR	2	enzymatic study	Bai M (1998)	1
TERF1	1	HIST1H1A	0	two hybrid	Lee OH (2011)	1
EGFR	5	NUMB	1	unspecified method	Jones RB (2006)	1
PRKCD	2	ITGB2	4	enzymatic study	Fagerholm S (2002)	1
PRKCA	7	EP300	36	enzymatic study, affinity chromatography technology	Yuan LW (2000), Rath S (2016)	2
TERF1	1	HSPA4	3	affinity chromatography technology	Giannone RJ (2010)	1
RIPK4	0	HSPA4	3	affinity chromatography technology	Rodriguez J (2016)	1
ARRB2	5	PTPA	0	affinity chromatography technology	Kendall RT (2011)	1
TNFRSF1A	3	PRKCB	4	affinity chromatography technology	Kilpatrick LE (2000)	1
RBCK1	0	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Donley C (2013), Donley C (2013)	2
PTPA	0	PRKCB	4	enzymatic study	Keranen LM (1995)	1
PRKCB	4	MBP	0	enzymatic study	Sato T (2014)	1
GSK3B	1	IKBKG	0	imaging technique, enzymatic study, affinity chromatography technology, affinity chromatography technology	Chen TC (2014), Medunjanin S (2016), Medunjanin S (2016), Medunjanin S (2016)	4