Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
CFAP44 rs13064411 G hmg coa reductase inhibitors efficacy yes Carriers of the minor G allele of the rs13064411 polymorphism, associated with statin-induced PCSK9-levels, showed an association with a decreased LDL-lowering and total cholesterol-lowering response to statins compared with AA carriers measured as delta total and LDL cholesterol [total: delta=0.551 mmol/l (AG+GG) vs. delta=0.732 mmol/l (AA), Pinteraction: 5.2×10E-7; LDL: delta=0.566 mmol/l (AG+GG) vs. delta=0.720 mmol/l (AA), Pinteraction: 1.8×10E-5]. Allele G is associated with decreased response to hmg coa reductase inhibitors as compared to genotype AA. 25602530 1444672903