PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
METTL23	1	UGGT2	5	affinity chromatography technology	Cloutier P (2013)	1
UGGT2	5	BIRC6	15	affinity chromatography technology	Huttlin EL (2017)	1
FBXO6	0	UGGT2	5	affinity chromatography technology	Liu B (2012)	1
BABAM2	2	UGGT2	5	affinity chromatography technology	Sowa ME (2009)	1
FBXO6	0	OS9	4	affinity chromatography technology	Liu B (2012)	1
UGGT2	5	ITIH2	0	affinity chromatography technology	Huttlin EL (2017)	1
APPBP2	3	UGGT2	5	two hybrid	Rolland T (2014)	1
UGGT2	5	APP	1	pull down	Olah J (2011)	1
BABAM1	1	UGGT2	5	affinity chromatography technology	Sowa ME (2009)	1
TCTN1	2	UGGT2	5	bioid	Gupta GD (2015)	1
TCTN1	2	OS9	4	bioid	Gupta GD (2015)	1
APP	1	APPBP2	3	two hybrid, pull down, affinity chromatography technology	Zheng P (1998), Zheng P (1998), Briand S (2011)	3
OS9	4	UGGT2	5	affinity chromatography technology	Tyler RE (2012)	1
SORT1	1	UGGT2	5	affinity chromatography technology	Hein MY (2015)	1
AGMAT	0	UGGT2	5	affinity chromatography technology	Boldt K (2016)	1
BABAM2	2	BABAM1	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Rual JF (2005), Ewing RM (2007), Sowa ME (2009), Sowa ME (2009), Wang B (2009), Wang B (2009), Shao G (2009), Shao G (2009), Hu X (2011), Hu X (2011), Hu X (2011), Patterson-Fortin J (2010), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2009), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	21