PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PPP5C	2	HSP90AA1	7	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Zeke T (2005), Silverstein AM (1997), Schuelke JP (2010), Gano JJ (2010), Cliff MJ (2006), Skarra DV (2011), Skarra DV (2011), Horibe T (2011), Taipale M (2014), Taipale M (2014), Hein MY (2015), Woo SH (2009), Woo SH (2009), Woodford MR (2016), St-Denis N (2016), Yadav L (2017), Yadav L (2017)	17
HSP90AA1	7	USP19	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology	Gano JJ (2010), Lee JG (2014), Lee JG (2014), Lee JG (2014), He WT (2016), He WT (2016), He WT (2016)	7
RPS17	0	RPS7	0	biochemical	Havugimana PC (2012)	1
CDC37	0	CHORDC1	1	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
CDC37L1	0	XPO1	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014), Kirli K (2015)	3
FKBP6	1	CDC37L1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
STK35	2	HSP90AB1	2	affinity chromatography technology	Huttlin EL (2017)	1
HSP90AA1	7	CHORDC1	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gano JJ (2010), Gano JJ (2010), Gano JJ (2010), Taipale M (2014), Taipale M (2014), Hein MY (2015)	6
CDC37L1	0	TOMM34	0	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
CDC37L1	0	HSPA1A	0	affinity chromatography technology, affinity chromatography technology	Scholz GM (2001), Scholz GM (2001)	2
FKBP4	0	HSP90AB1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014), Taipale M (2014), Taipale M (2014), Huttlin EL (2017)	5
CALM1	0	HSP90AA1	7	pull down	Ning YM (1995)	1
PPP5C	2	XPO1	8	biochemical	Kristensen AR (2012)	1
STK35	2	HSP90AA1	7	affinity chromatography technology	Huttlin EL (2017)	1
HSP90B1	3	USP25	0	biochemical	Kristensen AR (2012)	1
CDC37L1	0	TTC4	1	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
HSP90AA1	7	XPO1	8	affinity chromatography technology	Falsone SF (2005)	1
HSP90AA1	7	TOMM34	0	affinity chromatography technology, affinity chromatography technology	Gano JJ (2010), Skarra DV (2011)	2
HSP90AA1	7	TTC4	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gano JJ (2010), Skarra DV (2011), Taipale M (2014), Taipale M (2014)	4
FKBP6	1	CDC37	0	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
HSP90AB1	2	TTC4	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014), Taipale M (2014), Taipale M (2014)	4
XPO1	8	PTTG1	0	affinity chromatography technology	Kirli K (2015)	1
CDC37	0	GLMN	2	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
CDC37L1	0	USP25	0	biochemical	Kristensen AR (2012)	1
CALM1	0	FKBP4	0	pull down	Ning YM (1995)	1
TTC4	1	CHORDC1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014), Huttlin EL (2017)	3
CDC37	0	USP19	1	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
ELAVL1	0	CALM1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	XPO1	8	affinity chromatography technology	Abdelmohsen K (2009)	1
STK35	2	FKBP5	0	affinity chromatography technology	Huttlin EL (2017)	1
CDC37L1	0	RPS17	0	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
ELAVL1	0	STIP1	1	biochemical	Wan C (2015)	1
XPO1	8	RPS7	0	affinity chromatography technology	Kirli K (2015)	1
ELAVL1	0	STK35	2	affinity chromatography technology	Abdelmohsen K (2009)	1
CDC37L1	0	FKBP5	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014), Taipale M (2014), Taipale M (2014)	4
PPP5C	2	STIP1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Skarra DV (2011), Skarra DV (2011), Yadav L (2017), Yadav L (2017)	4
FKBP4	0	HSP90AA1	7	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology	Li J (2011), Esposito V (2012), Schuelke JP (2010), Gano JJ (2010), Skarra DV (2011), Shimamoto S (2010), Shimamoto S (2010), Kristensen AR (2012), Taipale M (2014), Taipale M (2014), Graumann K (2000), Graumann K (2000), Sun L (2012), Huttlin EL (2017)	14
FKBP5	0	CHORDC1	1	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
UBAP1	2	KIAA1468	5	biochemical	Kristensen AR (2012)	1
FKBP5	0	STIP1	1	pull down	Li J (2011)	1
CDC37	0	FKBP4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014), Taipale M (2014), Taipale M (2014)	4
FKBP5	0	GLMN	2	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
CHORDC1	1	TOMM34	0	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
PPP5C	2	HSP90AB1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Skarra DV (2011), Taipale M (2014), Taipale M (2014), Taipale M (2014), Taipale M (2014), Hein MY (2015), St-Denis N (2016), Yadav L (2017), Yadav L (2017)	9
CDC37	0	FKBP5	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014), Taipale M (2014), Taipale M (2014)	4
STUB1	4	HSP90AA1	7	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, enzymatic study, biochemical, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, pull down	Zhang L (2007), Zhang M (2005), Tateishi Y (2004), Tateishi Y (2004), Connell P (2001), Ko HS (2009), Kumar P (2007), Kumar P (2007), Wang L (2011), Stankiewicz M (2010), Graf C (2010), Kundrat L (2010), Kundrat L (2010), Kundrat L (2010), Kundrat L (2010), Morishima Y (2008), Zhou P (2003), Zhang M (2008), Grelle G (2006), Kim SA (2005), Arndt V (2005), Muller P (2012), Burch L (2004), Burch L (2004), Jang KW (2011), Schuelke JP (2010), Wang Q (2012), Shimamoto S (2013), Shimamoto S (2013), Shimamoto S (2013), Gano JJ (2010), Skarra DV (2011), Yang SW (2013), Grelle G (2006), Grelle G (2006), Narayan V (2015)	36
CHORDC1	1	FKBP4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014), Taipale M (2014), Taipale M (2014)	4
HSP90AA1	7	CDC37L1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gano JJ (2010), Taipale M (2014), Taipale M (2014), Hein MY (2015), Scholz GM (2001), Scholz GM (2001)	6
FKBP5	0	TTC4	1	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
PPP5C	2	CDC37	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Skarra DV (2011), Skarra DV (2011), Taipale M (2014), Taipale M (2014), Taipale M (2014), Taipale M (2014), Yadav L (2017)	7
PTTG1	0	CDC37L1	0	genetic interference	Vizeacoumar FJ (2013)	1
CDC37L1	0	RPS7	0	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
CDC37L1	0	TMOD4	0	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
CHORDC1	1	HSP90AB1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014), Hein MY (2015)	3
CDC37L1	0	FAM129A	3	biochemical	Kristensen AR (2012)	1
FKBP5	0	HSP90AB1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014), Taipale M (2014), Taipale M (2014)	4
STK35	2	CDC37L1	0	affinity chromatography technology	Huttlin EL (2017)	1
CDC37L1	0	CHORDC1	1	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
XPO1	8	UBAP1	2	affinity chromatography technology	Kirli K (2015)	1
XPO1	8	RPS17	0	affinity chromatography technology	Kirli K (2015)	1
USP19	1	STUB1	4	affinity chromatography technology	He WT (2016)	1
HSP90AB1	2	TMOD4	0	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
CDC37L1	0	PPP5C	2	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
CDC37L1	0	STUB1	4	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
CDC37	0	TTC4	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014), Taipale M (2014), Taipale M (2014)	4
STK35	2	CDC37	0	affinity chromatography technology	Huttlin EL (2017)	1
FKBP6	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
CDC37L1	0	STIP1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014), Scholz GM (2001)	3
HSP90AB1	2	TOMM34	0	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
CDC37L1	0	UBAP1	2	biochemical	Kristensen AR (2012)	1
CDC37L1	0	KIAA1468	5	biochemical	Kristensen AR (2012)	1
ELAVL1	0	CDC37L1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
HSP90AB1	2	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Cheng MB (2010), Gano JJ (2010), Skarra DV (2011), Kristensen AR (2012), Taipale M (2014), Taipale M (2014), Wan C (2015), Hein MY (2015)	8
FKBP4	0	STIP1	1	pull down	Li J (2011)	1
HSPA1A	0	STIP1	1	biochemical, affinity chromatography technology	Wan C (2015), Scholz GM (2001)	2
CDC37L1	0	FKBP4	0	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
CDC37L1	0	CDC37	0	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
HSP90AB1	2	CDC37	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Erazo T (2013), Erazo T (2013), Taipale M (2014), Taipale M (2014), Taipale M (2014), Taipale M (2014), Hein MY (2015), Li J (2013), Karras GI (2017), Synoradzki K (2015)	10
KIAA1468	5	TTC4	1	biochemical	Kristensen AR (2012)	1
CDC37	0	TOMM34	0	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
FKBP6	1	HSP90AB1	2	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
STUB1	4	HSPA1A	0	pull down, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ballinger CA (1999), Ballinger CA (1999), Imai Y (2002), Havugimana PC (2012), Jinwal UK (2012), Yang SW (2013), Choi JR (2016), Schoenbuehler B (2016)	8
USP25	0	KIAA1468	5	biochemical	Kristensen AR (2012)	1
HSP90B1	3	KIAA1468	5	biochemical	Kristensen AR (2012)	1
CDC37	0	STUB1	4	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
HSP90AA1	7	HSPA1A	0	pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Kanelakis KC (2002), Gano JJ (2010), Falsone SF (2005), Brychzy A (2003), Scholz GM (2001), Scholz GM (2001)	6
CDC37L1	0	HSP90AB1	2	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Wang J (2011), Taipale M (2014), Taipale M (2014), Rolland T (2014)	4
HSP90AB1	2	STIP1	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology	Havugimana PC (2012), Taipale M (2014), Taipale M (2014), Taipale M (2014), Taipale M (2014), Wan C (2015), Chadli A (2008), Huttlin EL (2017)	8
STIP1	1	HSP90AA1	7	pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Scheufler C (2000), Johnson BD (1998), Mollapour M (2010), Li J (2011), Kundrat L (2010), Tsutsumi S (2012), Sarkar S (2012), Gano JJ (2010), Skarra DV (2011), Horibe T (2011), Brinker A (2002), Taipale M (2014), Taipale M (2014), Mollapour M (2014), Graumann K (2000), Hein MY (2015), Chadli A (2010), Chadli A (2008), Woodford MR (2016), Scholz GM (2001), Sun L (2012), Woodford MR (2016), Huttlin EL (2017)	23
FKBP4	0	USP19	1	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
CDC37L1	0	GLMN	2	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
FKBP5	0	HSP90AA1	7	affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Nair SC (1997), Nair SC (1997), Li J (2011), Schuelke JP (2010), Gano JJ (2010), Skarra DV (2011), Horibe T (2011), Kristensen AR (2012), Taipale M (2014), Taipale M (2014), Graumann K (2000), Ni L (2010), Luo K (2017)	13
CDC37	0	HSPA1A	0	affinity chromatography technology	Li J (2013)	1
XPO1	8	CHORDC1	1	unspecified method	Xu D (2012)	1
HSP90B1	3	CDC37L1	0	biochemical	Kristensen AR (2012)	1
HSP90AA1	7	CDC37	0	x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Roe SM (2004), Silverstein AM (1998), Mollapour M (2010), Basso AD (2002), Tsutsumi S (2012), De Nardo D (2005), Sarkar S (2012), Gano JJ (2010), Taipale M (2012), Skarra DV (2011), Zhang H (2004), Taipale M (2014), Taipale M (2014), Mollapour M (2014), Hein MY (2015), Hein MY (2015), Li J (2013), Woodford MR (2016), Shao J (2003), Scholz GM (2001), Sun L (2012), Sun L (2012), Woodford MR (2016), Synoradzki K (2015)	24
CALM1	0	CDC37L1	0	pull down	Shen X (2005)	1
TTC4	1	TMOD4	0	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
GLMN	2	FKBP4	0	pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Chambraud B (1996), Chambraud B (1996), Neye H (2001), Krummrei U (2003), Krummrei U (2003), Chambraud B (1999), Taipale M (2014), Taipale M (2014)	8
PPP5C	2	CHORDC1	1	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
HSP90AB1	2	STUB1	4	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
HSP90AB1	2	HSPA1A	0	biochemical, affinity chromatography technology	Havugimana PC (2012), Falsone SF (2005)	2
CDC37L1	0	USP19	1	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
FKBP6	1	USP19	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014), Huttlin EL (2015), Huttlin EL (2017)	4
HSP90AB1	2	XPO1	8	affinity chromatography technology	Falsone SF (2005)	1