PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NFKB1	2	REL	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Huttlin EL (2015), Li X (2015), Huttlin EL (2017)	4
HDAC3	5	HIF1AN	0	pull down, affinity chromatography technology	Mahon PC (2001), Rodriguez J (2016)	2
ASB8	0	HIF1AN	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Andresen CA (2014), Huttlin EL (2015), Huttlin EL (2017), Rodriguez J (2016)	4
NFKBIA	0	NFKB1	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hay DC (2001), Malek S (1998), Fagan-Garcia K (2011), Jeon YJ (2010), Roff M (1996), Keutgens A (2010), Inan MS (2000), Wang J (2011), Arenzana-Seisdedos F (1995), Jaffray E (1995), Wood KM (1998), Bell S (1996), Cockman ME (2006), Cockman ME (2006), Lu Y (2005), Huttlin EL (2015), Hein MY (2015), Li X (2015), Huttlin EL (2017)	19
NFKBIB	2	NFKB1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HIF1A	1	OTUD7B	3	affinity chromatography technology	Bremm A (2014)	1
ANKDD1A	2	HIF1AN	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
REL	5	NFKBIA	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Spiecker M (2000), Chu ZL (1996), Chu ZL (1996), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	6
NFKBIB	2	NFKB2	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NFKBIB	2	HIF1AN	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017), Rodriguez J (2016)	3
NFKB1	2	NFKB2	3	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Bouwmeester T (2004), Bouwmeester T (2004), Wang J (2011), Li X (2015)	4
HIF1AN	0	TNKS	12	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Rodriguez J (2016)	2
HIF1AN	0	ASB13	0	two hybrid, affinity chromatography technology	Rual JF (2005), Rodriguez J (2016)	2
HDAC3	5	HIF1A	1	pull down, affinity chromatography technology, pull down	Mahon PC (2001), Kim SH (2007), Kim SH (2007)	3
OTUD7B	3	HIF1AN	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Huttlin EL (2017), Rodriguez J (2016)	3
REL	5	NFKBIB	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Spiecker M (2000), Chu ZL (1996), Chu ZL (1996), Huttlin EL (2015), Huttlin EL (2017)	5
NFKB2	3	REL	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Scheinman RI (1993), Huttlin EL (2015), Huttlin EL (2017)	4
HIF1AN	0	ANKRD27	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Rodriguez J (2016)	2
NFKBIA	0	ANKRD27	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HIF1AN	0	ANKRD52	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Rodriguez J (2016)	2
UBE3A	4	WDCP	2	affinity chromatography technology	Jung SY (2005)	1
HDAC3	5	NFKBIA	0	affinity chromatography technology	Gao Z (2006)	1
HIF1AN	0	VHL	0	pull down, pull down, pull down	Mahon PC (2001), Mahon PC (2001), Sakamoto T (2009)	3
HIF1AN	0	OSBPL3	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Rodriguez J (2016)	2
ASB6	1	HIF1AN	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Andresen CA (2014), Huttlin EL (2017), Rodriguez J (2016)	3
HIF1AN	0	FBF1	2	two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Huttlin EL (2017), Rodriguez J (2016)	3
HIF1AN	0	ZFP36L2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Rodriguez J (2016)	2
ASB16	2	HIF1AN	0	affinity chromatography technology, affinity chromatography technology	Andresen CA (2014), Huttlin EL (2017)	2
ANKRD44	3	ANKFY1	7	affinity chromatography technology	Huttlin EL (2015)	1
UBE3A	4	HIF1AN	0	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Martinez-Noel G (2012), Martinez-Noel G (2012), Huttlin EL (2017), Rodriguez J (2016)	4
TNKS	12	GMDS	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bisht KK (2012), Bisht KK (2012), Huttlin EL (2017)	3
HIF1AN	0	REL	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Rodriguez J (2016)	2
HIF1AN	0	HIF1AN	0	x-ray crystallography, affinity chromatography technology, affinity chromatography technology	Lee C (2003), Sakamoto T (2009), Rodriguez J (2016)	3
HIF1AN	0	WDCP	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Rodriguez J (2016)	2
NFKBIA	0	NFKB2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	3
ANKRD44	3	HIF1AN	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017), Rodriguez J (2016)	3
HIF1AN	0	HECTD1	16	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Rodriguez J (2016)	2
HIF1AN	0	CASKIN1	8	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Rodriguez J (2016)	2
NFKBIA	0	HIF1AN	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017), Rodriguez J (2016)	3
HIF1AN	0	ASB9	0	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Venkatesan K (2009), Huttlin EL (2015), Huttlin EL (2017)	4
INVS	2	HIF1AN	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Boldt K (2016), Rodriguez J (2016)	3
VHL	0	HIF1A	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, far western blotting, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, pull down, protein complementation assay, pull down, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Corn PG (2003), Li Z (2003), Mahon PC (2001), Tanimoto K (2000), Min JH (2002), Yu F (2001), Yu F (2001), Jung JE (2008), Jung JE (2008), Andre H (2008), Park YK (2008), Kim BY (2008), Park SS (2008), Baek JH (2007), Baek JH (2007), Baek JH (2007), Kondo S (2006), Ietta F (2006), Kwon SJ (2005), Bae MK (2005), Baek JH (2005), Hon WC (2002), Hon WC (2002), Lewis MD (2004), Kasuno K (2004), Metzen E (2003), Metzen E (2003), Zhou J (2003), Yuan Y (2003), Maynard MA (2003), Jeong JW (2002), Yoo YG (2008), Hansen WJ (2002), Masson N (2001), Masson N (2001), Clifford SC (2001), Jaakkola P (2001), Jaakkola P (2001), Kamura T (2000), Kamura T (2000), Kamura T (2000), Ohh M (2000), Ohh M (2000), Cockman ME (2000), Cockman ME (2000), Sufan RI (2006), Chang CC (2011), Sufan RI (2009), Stickle NH (2004), Luo W (2010), Lee HY (2011), Roe JS (2011), Ivan M (2001), Ivan M (2001), Huang LE (2002), Callapina M (2005), Callapina M (2005), Maranchie JK (2002), DAngelo G (2003), DAngelo G (2003), Miller F (2005), Grosfeld A (2007), Grosfeld A (2007), Rajakumar A (2008), Bonicalzi ME (2001), Bemis L (2004), Berra E (2001), Yu F (2001), Bex C (2007), Zhou J (2012), Wiesener MS (2002), Maxwell PH (1999), Maxwell PH (1999), Lee SH (2012), Lee SH (2012), Ivan M (2002), Aprelikova O (2009), Choi CY (2009), Choi CY (2009), Heir P (2013), Russell RC (2008), Russell RC (2008), Park JH (2011), Park JH (2011), Liu Q (2013), Yeh IJ (2013), Choi YK (2010), Yang F (2014), Yang F (2014), Yang F (2014), Parsanejad M (2014), Yang C (2013), Yang C (2013), Chen K (2013), Park MH (2014), Gerez J (2015), Hein MY (2015), Park MH (2015), Fu R (2016), Alahari S (2015), Zhang CS (2015), Song D (2013), Chen K (2016), Hicks KC (2016), Groulx I (2002), Groulx I (2002), Groulx I (2002), Huttlin EL (2017), Guo J (2016), Sun W (2017), Sun W (2017), Guo J (2016), Li YM (2005), Yoo YG (2004), Kimura M (2008), Ferrer CM (2014)	116
HIF1AN	0	OSBPL1A	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Rodriguez J (2016)	2
HIF1AN	0	NOTCH3	9	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Rodriguez J (2016)	2
NFKB1	2	HIF1AN	0	affinity chromatography technology, two hybrid, affinity chromatography technology	Cockman ME (2006), Cockman ME (2006), Rodriguez J (2016)	3
HIF1AN	0	MAP3K21	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Rodriguez J (2016)	2
OTUB1	0	HIF1AN	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Scholz CC (2016), Scholz CC (2016), Huttlin EL (2017), Rodriguez J (2016)	4
HIF1AN	0	RIPK4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Rodriguez J (2016), Rodriguez J (2016), Rodriguez J (2016), Rodriguez J (2016)	5
ASB7	1	ASB4	2	affinity chromatography technology, affinity chromatography technology	Andresen CA (2014), Andresen CA (2014)	2
HIF1AN	0	EIF4ENIF1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Rodriguez J (2016)	2
HIF1AN	0	ANK2	18	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Rodriguez J (2016)	2
ASB7	1	HIF1AN	0	affinity chromatography technology, affinity chromatography technology	Andresen CA (2014), Huttlin EL (2017)	2
HDAC3	5	VHL	0	pull down	Mahon PC (2001)	1
GMDS	3	TNKS2	6	affinity chromatography technology	Huttlin EL (2017)	1
HIF1AN	0	ANKFY1	7	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Rodriguez J (2016)	2
ANKRD55	1	HIF1AN	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FBF1	2	EIF4ENIF1	1	bioid	Gupta GD (2015)	1
HIF1AN	0	GMDS	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Rodriguez J (2016)	2
ANKRD49	0	HIF1AN	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Rodriguez J (2016)	2
HIF1AN	0	ANK3	16	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Rodriguez J (2016)	2
ANKRD44	3	NOTCH3	9	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HIF1AN	0	HIF1A	1	affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, enzymatic study, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology	Mahon PC (2001), Mahon PC (2001), Mahon PC (2001), Luo W (2010), Liu YV (2007), Lee YM (2009), Lee YM (2009), Lee YM (2009), Hewitson KS (2002), Li SH (2008), Sakamoto T (2009), Rodriguez J (2016)	12
NFKBIA	0	NFKBIB	2	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Pringle LM (2011), Pringle LM (2011), Huttlin EL (2015), Huttlin EL (2017)	4
ASB4	2	HIF1AN	0	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Ferguson JE (2007), Ferguson JE (2007), Huttlin EL (2015), Huttlin EL (2017)	4
HIF1AN	0	FEM1B	1	two hybrid, affinity chromatography technology	Cockman ME (2006), Rodriguez J (2016)	2
HIF1AN	0	ANKS1A	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Rodriguez J (2016)	2
NFKBIA	0	OTUB1	0	affinity chromatography technology	Huttlin EL (2015)	1
HIF1AN	0	APBA3	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Huttlin EL (2017), Sakamoto T (2009), Sakamoto T (2009), Sakamoto T (2009), Rodriguez J (2016)	5
HIF1AN	0	RPRD2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Rodriguez J (2016)	2
HDAC3	5	NFKB1	2	affinity chromatography technology, imaging technique	Viatour P (2003), Hoberg JE (2004)	2
HIF1AN	0	NFKB2	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Rodriguez J (2016)	2
HIF1AN	0	RNASEL	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Rodriguez J (2016)	2
CCDC94	0	HIF1AN	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HIF1AN	0	TNKS2	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Rodriguez J (2016)	2
HIF1AN	0	USP24	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Rodriguez J (2016)	2