PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SIRT7	1	SMARCC1	5	affinity chromatography technology	Tsai YC (2012)	1
SIRT7	1	ARID1A	16	affinity chromatography technology	Tsai YC (2012)	1
POU5F1	0	SALL3	3	affinity chromatography technology	Oliviero G (2015)	1
CHD7	22	PBRM1	5	affinity chromatography technology, affinity chromatography technology	Bajpai R (2010), Bajpai R (2010)	2
TERF2	2	CHD8	44	affinity chromatography technology	Giannone RJ (2010)	1
TERF2	2	WDR5	2	affinity chromatography technology	Giannone RJ (2010)	1
CHD7	22	MTA1	3	affinity chromatography technology	Engelen E (2011)	1
SMARCA4	19	SMARCC1	5	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical	Sif S (2001), Wang W (1996), Otsuki T (2001), Zhao K (1998), Kaeser MD (2008), Kaeser MD (2008), Kaeser MD (2008), Kaeser MD (2008), Inayoshi Y (2006), Inayoshi Y (2006), Pal S (2003), Pal S (2003), Bultman SJ (2005), Nagl NG (2005), Mahajan MC (2005), Trotter KW (2008), Dallas PB (1998), Tando T (2010), Tando T (2010), Bartlett C (2011), Bartlett C (2011), Oh J (2008), Oh J (2008), Havugimana PC (2012), Wan C (2015)	25
CHD7	22	VARS	5	affinity chromatography technology	Engelen E (2011)	1
SNW1	0	CHD8	44	affinity chromatography technology	Lleres D (2010)	1
SMARCC1	5	PBRM1	5	affinity chromatography technology, affinity chromatography technology	Ryme J (2009), Yan Z (2005)	2
CHD7	22	SMARCE1	1	affinity chromatography technology, affinity chromatography technology	Bajpai R (2010), Engelen E (2011)	2
SIRT7	1	PBRM1	5	affinity chromatography technology	Tsai YC (2012)	1
CHD7	22	ARID1A	16	affinity chromatography technology	Engelen E (2011)	1
SMARCC2	9	BRD7	2	affinity chromatography technology, affinity chromatography technology	Mak AB (2010), Huttlin EL (2017)	2
ARID1A	16	SMARCC1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Ryme J (2009), Ryme J (2009), Nagl NG (2005), Wang X (2004), Havugimana PC (2012), Wan C (2015), Dallas PB (1998)	7
SIRT7	1	CTCF	15	affinity chromatography technology	Tsai YC (2012)	1
ARID2	5	SMARCC1	5	affinity chromatography technology	Yan Z (2005)	1
SIRT7	1	CHD8	44	affinity chromatography technology	Tsai YC (2012)	1
AR	3	ASH2L	2	affinity chromatography technology, affinity chromatography technology	Grasso CS (2012), Grasso CS (2012)	2
SNW1	0	CHD7	22	affinity chromatography technology	Lleres D (2010)	1
BRD7	2	PBRM1	5	biochemical	Wan C (2015)	1
CHD7	22	CTCF	15	unspecified method	Allen MD (2007)	1
SOX2	4	MTA1	3	affinity chromatography technology, affinity chromatography technology	Engelen E (2011), Cox JL (2013)	2
PBRM1	5	ARID2	5	affinity chromatography technology, affinity chromatography technology, biochemical	Yan Z (2005), Yan Z (2005), Wan C (2015)	3
SMARCE1	1	ARID1A	16	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Hu K (2006), Ryme J (2009), Kaeser MD (2008), Kaeser MD (2008), Mak AB (2010), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	9
SMARCC2	9	SMARCC1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Ryme J (2009), Ryme J (2009), Kaeser MD (2008), Kaeser MD (2008), Nagl NG (2005), Mak AB (2010), Havugimana PC (2012), Wan C (2015), Dallas PB (1998), Huttlin EL (2017)	10
CHD7	22	SMARCA4	19	affinity chromatography technology, affinity chromatography technology	Bajpai R (2010), Engelen E (2011)	2
ARID2	5	SMARCA4	19	affinity chromatography technology, affinity chromatography technology	Yan Z (2005), Yan Z (2005)	2
SOX2	4	CHD8	44	affinity chromatography technology	Cox JL (2013)	1
TRIM25	5	ARID1A	16	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	GATAD2A	3	affinity chromatography technology	Choudhury NR (2017)	1
AR	3	SMARCE1	1	pull down, pull down, bioid	Link KA (2008), Link KA (2005), Lempiaeinen JK (2017)	3
POU5F1	0	SMARCC2	9	affinity chromatography technology	Oliviero G (2015)	1
TRIM25	5	SMARCC1	5	affinity chromatography technology	Choudhury NR (2017)	1
CHD7	22	CHD8	44	two hybrid, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, two hybrid, two hybrid	Batsukh T (2010), Batsukh T (2010), Batsukh T (2010), Schulz Y (2014), Schulz Y (2014), Schulz Y (2014), Schulz Y (2014)	7
CHD7	22	ASH2L	2	imaging technique, affinity chromatography technology, affinity chromatography technology	Schulz Y (2014), Schulz Y (2014), Schulz Y (2014)	3
CHD7	22	MTA2	1	affinity chromatography technology	Engelen E (2011)	1
ASH2L	2	CHD8	44	imaging technique, pull down, affinity chromatography technology, two hybrid	Yates JA (2010), Yates JA (2010), Schulz Y (2014), Schulz Y (2014)	4
AR	3	SMARCA4	19	affinity chromatography technology, two hybrid, affinity chromatography technology, bioid	Wang Q (2004), van de Wijngaart DJ (2009), Dai Y (2008), Lempiaeinen JK (2017)	4
TRIM25	5	MTA1	3	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Zang HL (2017)	2
SMARCC2	9	PBRM1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ryme J (2009), Yan Z (2005), Mak AB (2010), Huttlin EL (2017)	4
CHD7	22	RBBP5	3	imaging technique, affinity chromatography technology, affinity chromatography technology	Schulz Y (2014), Schulz Y (2014), Schulz Y (2014)	3
TRIM25	5	CHD7	22	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	CTCF	15	affinity chromatography technology	Choudhury NR (2017)	1
CHD7	22	OLIG1	0	affinity chromatography technology	Engelen E (2011)	1
SOX2	4	CHD7	22	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Engelen E (2011), Engelen E (2011), Engelen E (2011), Cox JL (2013)	4
SIRT7	1	MTA2	1	affinity chromatography technology	Tsai YC (2012)	1
BRD7	2	SMARCC1	5	affinity chromatography technology	Kaeser MD (2008)	1
SIRT7	1	SNW1	0	affinity chromatography technology	Tsai YC (2012)	1
CHD7	22	ZBTB20	9	affinity chromatography technology	Engelen E (2011)	1
SNW1	0	VARS	5	biochemical	Wan C (2015)	1
SOX2	4	SMARCC2	9	affinity chromatography technology	Engelen E (2011)	1
SIRT7	1	CHD7	22	affinity chromatography technology	Tsai YC (2012)	1
AR	3	SMARCC2	9	bioid	Lempiaeinen JK (2017)	1
PBRM1	5	SMARCA4	19	affinity chromatography technology	Yan Z (2005)	1
MTA2	1	MTA1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Yao YL (2003), Yao YL (2003), Cui S (2011), Wan C (2015)	4
SMARCA4	19	ARID1A	16	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Wang W (1996), Zhao K (1998), Pal S (2003), Bultman SJ (2005), Wang X (2004), Trotter KW (2008), Tando T (2010), Havugimana PC (2012), Wan C (2015), Dallas PB (1998)	10
SIRT7	1	SMARCA4	19	affinity chromatography technology	Tsai YC (2012)	1
POU5F1	0	WDR5	2	affinity chromatography technology, biochemical, affinity chromatography technology, pull down	Ang YS (2011), Ang YS (2011), Ang YS (2011), Ang YS (2011)	4
AR	3	ARID1A	16	bioid	Lempiaeinen JK (2017)	1
SOX2	4	SALL3	3	affinity chromatography technology	Engelen E (2011)	1
CHD8	44	AR	3	affinity chromatography technology, pull down	Menon T (2010), Menon T (2010)	2
RBBP5	3	SMARCC1	5	biochemical	Havugimana PC (2012)	1
RBBP5	3	WDR5	2	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yokoyama A (2004), Lee JH (2005), Higa LA (2006), Wysocka J (2005), Wysocka J (2005), Patel SR (2007), Cho YW (2007), Avdic V (2011), Avdic V (2011), Avdic V (2011), Mo R (2006), Gan Q (2011), Mak AB (2010), Mak AB (2010), Wu MZ (2011), Huttlin EL (2015), Bailey JK (2015), Huttlin EL (2017), Carugo A (2016), Hauri S (2016)	20
SMARCE1	1	BRD7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kaeser MD (2008), Mak AB (2010), Huttlin EL (2015), Huttlin EL (2017)	4
ARID1A	16	SMARCC2	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Ryme J (2009), Ryme J (2009), Mak AB (2010), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	6
CHD8	44	RBBP5	3	pull down, affinity chromatography technology, two hybrid	Yates JA (2010), Schulz Y (2014), Schulz Y (2014)	3
ASH2L	2	RBBP5	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, pull down	Yokoyama A (2004), Lee JH (2005), Lee JH (2005), Garapaty S (2009), Wysocka J (2005), Patel SR (2007), Patel SR (2007), Cho YW (2007), Cho YW (2007), Butler JS (2011), Avdic V (2011), Mo R (2006), Mo R (2006), Cao F (2010), Cao F (2010), Mak AB (2010), Mak AB (2010), Rolland T (2014), Tang Z (2013), Yu H (2011), Li Y (2016)	21
SMARCE1	1	SMARCC2	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Zhao K (1998), Hu K (2006), Lai D (2009), Ryme J (2009), Kaeser MD (2008), Kaeser MD (2008), Chen J (2005), Mak AB (2010), Mak AB (2010), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	13
CHD7	22	BRD7	2	affinity chromatography technology	Bajpai R (2010)	1
SOX2	4	ARID1A	16	affinity chromatography technology, affinity chromatography technology	Engelen E (2011), Cox JL (2013)	2
WDR5	2	CHD8	44	pull down, affinity chromatography technology, pull down, two hybrid	Thompson BA (2008), Thompson BA (2008), Yates JA (2010), Schulz Y (2014)	4
ASH2L	2	WDR5	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yokoyama A (2004), Lee JH (2005), Wysocka J (2005), McKinnell IW (2008), McKinnell IW (2008), Patel SR (2007), Butler JS (2011), Mo R (2006), Gan Q (2011), Gan Q (2011), Mak AB (2010), Mak AB (2010), Wu MZ (2011), Havugimana PC (2012), Tang Z (2013), Huttlin EL (2015), Bailey JK (2015), Huttlin EL (2017), Hauri S (2016)	19
POU5F1	0	CHD7	22	affinity chromatography technology	Oliviero G (2015)	1
TERF2	2	CHD7	22	affinity chromatography technology	Giannone RJ (2010)	1
ARID2	5	SMARCC2	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yan Z (2005), Mak AB (2010), Huttlin EL (2017)	3
SIRT7	1	NES	2	affinity chromatography technology	Tsai YC (2012)	1
SOX2	4	MTA2	1	affinity chromatography technology, affinity chromatography technology	Engelen E (2011), Engelen E (2011)	2
GATAD2A	3	MTA1	3	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
RBBP5	3	SMARCE1	1	biochemical	Havugimana PC (2012)	1
CHD7	22	SALL3	3	affinity chromatography technology	Engelen E (2011)	1
SMARCE1	1	PBRM1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ryme J (2009), Yan Z (2005), Huttlin EL (2015), Huttlin EL (2017)	4
SMARCA4	19	SMARCE1	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Wang W (1996), Zhao K (1998), Zhao K (1998), Hu K (2006), Kaeser MD (2008), Kaeser MD (2008), Kaeser MD (2008), Kaeser MD (2008), Pal S (2003), Bultman SJ (2005), Battaglioli E (2002), ONeill DW (2000), Tando T (2010), Mak AB (2010), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	18
BRD7	2	SMARCA4	19	affinity chromatography technology	Kaeser MD (2008)	1
CTCF	15	CHD8	44	pull down, affinity chromatography technology, two hybrid	Ishihara K (2006), Ishihara K (2006), Ishihara K (2006)	3
SNW1	0	WDR5	2	affinity chromatography technology	Lleres D (2010)	1
ARID1A	16	PBRM1	5	affinity chromatography technology	Ryme J (2009)	1
TRIM25	5	SMARCA4	19	affinity chromatography technology	Choudhury NR (2017)	1
SNW1	0	RBBP5	3	affinity chromatography technology	Lleres D (2010)	1
CHD7	22	ARID2	5	affinity chromatography technology	Bajpai R (2010)	1
SOX2	4	GATAD2A	3	affinity chromatography technology, affinity chromatography technology	Engelen E (2011), Cox JL (2013)	2
AR	3	CHD7	22	bioid	Lempiaeinen JK (2017)	1
SMARCE1	1	SMARCC1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Zhao K (1998), Hu K (2006), Ryme J (2009), Kaeser MD (2008), Kaeser MD (2008), Kaeser MD (2008), Kaeser MD (2008), Chen J (2005), Chen J (2005), Keppler BR (2010), Mak AB (2010), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	15
POU5F1	0	PBRM1	5	affinity chromatography technology	Oliviero G (2015)	1
CHD7	22	SMARCC2	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bajpai R (2010), Bajpai R (2010), Engelen E (2011)	3
MTA2	1	GATAD2A	3	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	3
BRD7	2	ARID2	5	affinity chromatography technology, biochemical	Kaeser MD (2008), Wan C (2015)	2
CHD7	22	GATAD2A	3	affinity chromatography technology	Engelen E (2011)	1
NES	2	CHD7	22	affinity chromatography technology	Hein MY (2015)	1
TRIM25	5	ARID2	5	affinity chromatography technology	Choudhury NR (2017)	1
CHD7	22	WDR5	2	imaging technique	Schulz Y (2014)	1
SMARCA4	19	SMARCC2	9	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Wang W (1996), Otsuki T (2001), Zhao K (1998), Kaeser MD (2008), Kaeser MD (2008), Pal S (2003), Trotter KW (2008), Tando T (2010), Mak AB (2010), Nishimoto N (2012), Nishimoto N (2012), Havugimana PC (2012), Wan C (2015), Dallas PB (1998), Huttlin EL (2017)	15
SNW1	0	ARID1A	16	affinity chromatography technology	Lleres D (2010)	1
CHD7	22	SMARCC1	5	affinity chromatography technology	Bajpai R (2010)	1
SOX2	4	SMARCC1	5	affinity chromatography technology	Engelen E (2011)	1
SMARCE1	1	ARID2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kaeser MD (2008), Kaeser MD (2008), Yan Z (2005), Yan Z (2005), Mak AB (2010), Huttlin EL (2015), Huttlin EL (2017)	7
SIRT7	1	SMARCC2	9	affinity chromatography technology	Tsai YC (2012)	1
POU5F1	0	SOX2	4	pull down, affinity chromatography technology, affinity chromatography technology	Remenyi A (2003), Xu C (2013), Oliviero G (2015)	3
AR	3	SMARCC1	5	affinity chromatography technology, bioid	Wang Q (2004), Lempiaeinen JK (2017)	2