Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
PRKAA1 5562 EHNA CHEMBL50378 NCI 11969266
PRKAA1 5562 STREPTOZOTOCIN CHEMBL1651906 NCI 15616011
PRKAA1 5562 ADENOSINE TRIPHOSPHATE CHEMBL14249 DrugBank 17139284, 17016423
PRKAA1 5562 ADENOSINE PHOSPHATE CHEMBL752 activator DrugBank 17167165
PRKAA1 5562 ASPIRIN CHEMBL25 activator DrugBank 22517326, 22406476
PRKAA1 5562 PENTOSTATIN CHEMBL1580 NCI 11969266
PRKAA1 5562 SIROLIMUS CHEMBL413 NCI 16027121
PRKAA1 5562 METFORMIN HYDROCHLORIDE CHEMBL1703 ClearityFoundationClinicalTrial
PRKAA1 5562 PHENFORMIN CHEMBL170988 activator TdgClinicalTrial, TEND, DrugBank 17603555, 17995453, 17369473
PRKAA1 5562 PHORBOL MYRISTATE ACETATE CHEMBL279115 NCI 15383372
PRKAA1 5562 THYROXINE CHEMBL42115 NCI 12433937

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
PRKAA1 rs249429 T metformin efficacy no Treatment success was defined as 1) achieving HbA1c <7 % and 2) absolute reduction in HbAlc after 6-months of metformin therapy. The relationships between genotypes and outcomes were evaluated using multivariate logistic and linear models. Allele T is not associated with response to metformin in people with Diabetes Mellitus as compared to allele C. 25327507 1296666425