PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
AVPR2	0	STUB1	4	affinity chromatography technology	Apaja PM (2010)	1
ARRB2	5	VCP	6	affinity chromatography technology	Xiao K (2007)	1
ARRB2	5	HGS	5	affinity chromatography technology, affinity chromatography technology	Han SO (2012), Malik R (2010)	2
AVPR2	0	GNB1	4	fluorescent resonance energy transfe	Gales C (2005)	1
GNB1	4	GNAS	9	fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Gales C (2005), Huttlin EL (2015), Huttlin EL (2017)	3
CLTC	12	HGS	5	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Raiborg C (2001), Raiborg C (2001), Nakamura M (2006), Zlatic SA (2011)	4
AVPR2	0	ARRB2	5	affinity chromatography technology	Tohgo A (2003)	1
AVPR2	0	C1QTNF1	1	two hybrid, pull down	Innamorati G (2002), Innamorati G (2002)	2
AVPR2	0	AVPR2	0	affinity chromatography technology, pull down	Schulz A (2000), Schulz A (2000)	2
ARRB2	5	STUB1	4	affinity chromatography technology	Zhang Z (2009)	1
ARRDC4	1	ARRB2	5	affinity chromatography technology	Shea FF (2012)	1
ARRB2	5	MAPK3	4	affinity chromatography technology, imaging technique	Tohgo A (2003), Chen TC (2014)	2
GNG2	0	GNB1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, fluorescent resonance energy transfe	Snow BE (1999), Poon LS (2009), Snow BE (1998), Howlett AC (2009), Lukov GL (2005), Howlett AC (2009), Gales C (2005), Rosskopf D (2003), Zhou JY (2003)	9
AVPR2	0	HGS	5	affinity chromatography technology	Shea FF (2012)	1
AVPR2	0	GNAS	9	fluorescent resonance energy transfe	Gales C (2005)	1
STUB1	4	VCP	6	affinity chromatography technology, pull down	Vij N (2006), Liu S (2013)	2
GRK5	7	AVPR2	0	affinity chromatography technology	Berrada K (2000)	1
AVPR2	0	VCP	6	affinity chromatography technology	Schwieger I (2008)	1
AVPR2	0	CLTC	12	affinity chromatography technology	Shea FF (2012)	1
AVPR2	0	DERL1	2	affinity chromatography technology	Schwieger I (2008)	1
VCP	6	MAPK3	4	affinity chromatography technology	Yu CC (2013)	1
AVPR2	0	MAPK3	4	affinity chromatography technology	Tohgo A (2003)	1
AVPR2	0	ARRDC4	1	affinity chromatography technology, affinity chromatography technology	Shea FF (2012), Shea FF (2012)	2
VCP	6	DERL1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography	Wang Q (2008), Ballar P (2007), Schulze A (2005), Schulze A (2005), Ye Y (2005), Lilley BN (2005), Greenblatt EJ (2011), Younger JM (2006), Christianson JC (2012), You H (2017), Lim JJ (2016), Lim JJ (2016)	12
AVPR2	0	GNG2	0	fluorescent resonance energy transfe	Gales C (2005)	1
AVPR2	0	AVP	0	pull down	Schulz A (2000)	1
GNG2	0	GNAS	9	affinity chromatography technology	Nagai Y (2010)	1
CLTC	12	ARRB2	5	pull down	Goodman OB (1997)	1