PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
LRSAM1	2	RNF111	2	two hybrid	Woodsmith J (2012)	1
RNF2	1	RNF114	0	affinity chromatography technology	Cao Q (2014)	1
UBE2W	0	UBE2W	0	enzymatic study	David Y (2010)	1
UBE2W	0	TRIM17	5	two hybrid	Markson G (2009)	1
DTX3L	1	RNF111	2	two hybrid	Woodsmith J (2012)	1
UBE2W	0	RNF152	0	two hybrid	van Wijk SJ (2009)	1
BRCA1	7	XIAP	0	affinity chromatography technology, pull down	Martin SA (2005), Martin SA (2005)	2
BIRC2	1	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Silke J (2005), Rajalingam K (2006), Rajalingam K (2006), Oberoi-Khanuja TK (2012), Huttlin EL (2017)	5
UBE2W	0	RNF185	1	two hybrid	Markson G (2009)	1
BRCA1	7	UBE2W	0	two hybrid, x-ray crystallography, pull down, two hybrid, pull down, pull down	Christensen DE (2009), Christensen DE (2009), Christensen DE (2009), Christensen DE (2007), David Y (2011), Vittal V (2015)	6
BARD1	4	UBE2W	0	pull down, pull down	David Y (2011), Vittal V (2015)	2
ELAVL1	0	DTX3L	1	affinity chromatography technology	Abdelmohsen K (2009)	1
DNMT3B	3	POLR2C	0	affinity chromatography technology	Rigbolt KT (2011)	1
UBE2W	0	RNF167	2	two hybrid	van Wijk SJ (2009)	1
UBE2W	0	RNF115	1	two hybrid	van Wijk SJ (2009)	1
UBE2W	0	TRIM31	0	two hybrid	Markson G (2009)	1
AMFR	2	MGRN1	4	affinity chromatography technology, affinity chromatography technology	Mukherjee R (2016), Mukherjee R (2016)	2
RNF2	1	POLR2H	0	affinity chromatography technology	Cao Q (2014)	1
BRCA1	7	POLR2H	0	enzymatic study, enzymatic study	Wu W (2007), Vittal V (2015)	2
EED	1	RNF2	1	affinity chromatography technology, imaging technique, pull down, affinity chromatography technology	Cao Q (2014), Cao Q (2014), Cao Q (2014), Cao Q (2014)	4
UBE2W	0	RNF111	2	two hybrid, two hybrid	van Wijk SJ (2009), Markson G (2009)	2
POLR2C	0	POLR2H	0	pull down, pull down, affinity chromatography technology, biochemical	Acker J (1997), Acker J (1997), Ayguen O (2008), Wan C (2015)	4
AMFR	2	RNF5	0	affinity chromatography technology	Morito D (2008)	1
UBE2W	0	RFWD3	5	two hybrid	Markson G (2009)	1
XIAP	0	STUB1	4	pull down	Dogan T (2008)	1
MAP3K1	4	RNF114	0	enzymatic study	Charlaftis N (2014)	1
ELAVL1	0	MID1	1	affinity chromatography technology	Abdelmohsen K (2009)	1
UBA1	1	UBE2W	0	pull down, enzymatic study, enzymatic study	Jin J (2007), Wauer T (2015), Huguenin-Dezot N (2016)	3
UBE2W	0	RNF138	0	two hybrid	Markson G (2009)	1
RNF2	1	TRIM27	2	affinity chromatography technology	Hein MY (2015)	1
MKRN3	2	TRIM23	3	two hybrid	Woodsmith J (2012)	1
UBE2W	0	MIB1	5	two hybrid	van Wijk SJ (2009)	1
UBE2W	0	DTX3	4	two hybrid	Markson G (2009)	1
ELAVL1	0	CNOT4	4	affinity chromatography technology	Abdelmohsen K (2009)	1
TRIM17	5	LRSAM1	2	two hybrid	Woodsmith J (2012)	1
TRIM8	6	RNF111	2	two hybrid	Woodsmith J (2012)	1
UBE2W	0	AMFR	2	two hybrid, two hybrid	van Wijk SJ (2009), Markson G (2009)	2
UBE2W	0	TRIM27	2	two hybrid	Markson G (2009)	1
DTX3	4	CHFR	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BRCA1	7	UBA1	1	affinity chromatography technology	Ertych N (2016)	1
TRIM23	3	UBE2W	0	pull down	Dawidziak DM (2017)	1
UBE2W	0	MAP3K1	4	two hybrid	van Wijk SJ (2009)	1
STUB1	4	UBE2W	0	pull down, pull down, enzymatic study, pull down	Soss SE (2011), Tatham MH (2013), Scaglione KM (2011), Blessing NA (2017)	4
UBE2W	0	BIRC8	0	two hybrid	Markson G (2009)	1
UHRF2	1	CDK6	0	far western blotting	Mori T (2011)	1
RNF8	2	BARD1	4	affinity chromatography technology	Yang Q (2016)	1
DTX3	4	RNF114	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BIRC8	0	XIAP	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2W	0	RNF2	1	two hybrid	Markson G (2009)	1
UBE2W	0	TOPORS	6	two hybrid	van Wijk SJ (2009)	1
TRIM31	0	TRIM27	2	two hybrid	Woodsmith J (2012)	1
ELAVL1	0	RNF115	1	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	MGRN1	4	affinity chromatography technology	Abdelmohsen K (2009)	1
UBE2W	0	RNF4	1	two hybrid, two hybrid, pull down	van Wijk SJ (2009), Markson G (2009), Tatham MH (2013)	3
ELAVL1	0	XIAP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method	Abdelmohsen K (2009), Durie D (2011), Durie D (2011), Durie D (2011)	4
RNF5	0	RNF185	1	two hybrid	Rolland T (2014)	1
UBE2W	0	CHFR	5	two hybrid	Markson G (2009)	1
UBE2W	0	MARCH5	0	two hybrid, two hybrid	Markson G (2009), Rolland T (2014)	2
TRIM27	2	UHRF2	1	two hybrid	Woodsmith J (2012)	1
UBE2W	0	RNF150	2	two hybrid	van Wijk SJ (2009)	1
UBE2W	0	LRSAM1	2	two hybrid	Markson G (2009)	1
UBE2W	0	POLR2H	0	x-ray crystallography	Vittal V (2015)	1
BIRC2	1	UBA1	1	affinity chromatography technology	Goncharov T (2013)	1
TRIM8	6	MKRN3	2	two hybrid	Woodsmith J (2012)	1
UBE2W	0	MID1	1	two hybrid	Markson G (2009)	1
UBE2W	0	RNF26	2	two hybrid, two hybrid	van Wijk SJ (2009), Markson G (2009)	2
RNF2	1	ELAVL1	0	affinity chromatography technology	Cao Q (2014)	1
UBE2W	0	CNOT4	4	two hybrid	van Wijk SJ (2009)	1
UBE2W	0	ZNRF4	1	two hybrid	van Wijk SJ (2009)	1
UBE2W	0	RNF5	0	two hybrid, two hybrid	Markson G (2009), Rolland T (2014)	2
ELAVL1	0	CDK6	0	affinity chromatography technology	Abdelmohsen K (2009)	1
UBE2W	0	TRIM8	6	two hybrid	Markson G (2009)	1
UBE2W	0	EED	1	two hybrid	Vinayagam A (2011)	1
POLR2H	0	BARD1	4	affinity chromatography technology, enzymatic study, enzymatic study	Wu W (2007), Wu W (2007), Vittal V (2015)	3
UBE2W	0	MAPT	1	x-ray crystallography	Vittal V (2015)	1
ELAVL1	0	MKRN1	1	affinity chromatography technology, affinity chromatography technology	Cassar PA (2015), Cassar PA (2015)	2
UBE2W	0	RNF10	0	two hybrid	Markson G (2009)	1
DNMT3B	3	UHRF2	1	affinity chromatography technology	Zhang J (2011)	1
UBE2W	0	RNF123	11	two hybrid	Markson G (2009)	1
UBE2W	0	DTX3L	1	two hybrid	Markson G (2009)	1
BRCA1	7	EED	1	pull down	Wang L (2013)	1
TRIM17	5	TRIM39	0	two hybrid, two hybrid, two hybrid	Rual JF (2005), Woodsmith J (2012), Rolland T (2014)	3
TRIM23	3	UBOX5	4	two hybrid	Woodsmith J (2012)	1
UBE2W	0	RNF125	0	two hybrid	Markson G (2009)	1
UBE2W	0	RNF8	2	two hybrid	Markson G (2009)	1
UHRF2	1	EED	1	affinity chromatography technology	Lai M (2016)	1
RNF2	1	OTUB1	0	affinity chromatography technology	Cao Q (2014)	1
UBE2W	0	TRIM2	1	two hybrid	Markson G (2009)	1
UBE2W	0	RNF114	0	two hybrid	Markson G (2009)	1
ELAVL1	0	TRIM2	1	affinity chromatography technology	Abdelmohsen K (2009)	1
RNF138	0	TRIM8	6	two hybrid	Woodsmith J (2012)	1
UBE2W	0	FANCL	0	protein complementation assay, protein complementation assay, pull down, two hybrid	Zhang Y (2011), Zhang Y (2011), Zhang Y (2011), Alpi AF (2008)	4
ELAVL1	0	UBE2W	0	affinity chromatography technology	Abdelmohsen K (2009)	1
UBE2W	0	BFAR	0	two hybrid	Markson G (2009)	1
UBE2W	0	PJA2	4	two hybrid	van Wijk SJ (2009)	1
TRIM27	2	TRIM23	3	two hybrid, two hybrid	Reymond A (2001), Woodsmith J (2012)	2
RNF166	0	RNF114	0	affinity chromatography technology	Huttlin EL (2017)	1
UBE2W	0	MARCH3	0	two hybrid	Markson G (2009)	1
UBE2W	0	UBOX5	4	two hybrid	Markson G (2009)	1
TRIM8	6	UHRF2	1	two hybrid	Woodsmith J (2012)	1
ELAVL1	0	BARD1	4	affinity chromatography technology	Abdelmohsen K (2009)	1
TRIM31	0	TRIM23	3	two hybrid, two hybrid	Reymond A (2001), Reymond A (2001)	2
UBE2W	0	ZNRF1	1	two hybrid	Markson G (2009)	1
UBE2W	0	MGRN1	4	two hybrid	Markson G (2009)	1
BRCA1	7	POLR2C	0	affinity chromatography technology	Woods NT (2012)	1
UBE2W	0	XIAP	0	two hybrid, two hybrid	Markson G (2009), Dynek JN (2010)	2
AKR1C3	1	UBE2W	0	two hybrid	Stelzl U (2005)	1
ELAVL1	0	AMFR	2	affinity chromatography technology	Abdelmohsen K (2009)	1
OTUB1	0	UBE2W	0	affinity chromatography technology	Scholz CC (2016)	1
POLR2C	0	UBE2W	0	two hybrid	Stelzl U (2005)	1
UBE2W	0	RNF103	1	two hybrid	van Wijk SJ (2009)	1
UBE2W	0	MUL1	1	two hybrid	van Wijk SJ (2009)	1
XIAP	0	DTX3	4	two hybrid	Woodsmith J (2012)	1
UBE2W	0	UFM1	0	two hybrid	van Wijk SJ (2009)	1
OTUB1	0	STUB1	4	affinity chromatography technology	Scholz CC (2016)	1
ELAVL1	0	TRIM8	6	affinity chromatography technology	Abdelmohsen K (2009)	1
UBE2W	0	MKRN3	2	two hybrid	Markson G (2009)	1
ELAVL1	0	PJA2	4	affinity chromatography technology	Abdelmohsen K (2009)	1
ROPN1	0	UBE2W	0	two hybrid	Rolland T (2014)	1
UBE2W	0	RNF165	0	two hybrid	van Wijk SJ (2009)	1
MAPT	1	STUB1	4	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method	Dickey CA (2008), Hatakeyama S (2004), Hatakeyama S (2004), Hatakeyama S (2004), Petrucelli L (2004), Dolan PJ (2010), Dolan PJ (2010), Shimura H (2004), Shimura H (2004), Shimura H (2004), Dickey CA (2007), Sakagami Y (2013), Ozdemir AY (2013), Grelle G (2006), Grelle G (2006)	15
UBE2W	0	RNF14	2	two hybrid	Markson G (2009)	1
TRIM8	6	TRIM2	1	two hybrid	Woodsmith J (2012)	1
XIAP	0	TRIM8	6	two hybrid	Woodsmith J (2012)	1
UBE2W	0	MKRN1	1	two hybrid	Vinayagam A (2011)	1
RNF125	0	CHFR	5	two hybrid	Woodsmith J (2012)	1
EED	1	DNMT3B	3	affinity chromatography technology, imaging technique, affinity chromatography technology	Vire E (2006), Vire E (2006), OHagan HM (2011)	3
ELAVL1	0	UFM1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	RFWD3	5	affinity chromatography technology	Abdelmohsen K (2009)	1
RNF166	0	MKRN3	2	two hybrid	Woodsmith J (2012)	1
BIRC2	1	DZIP3	6	two hybrid	Woodsmith J (2012)	1
UBE2W	0	DNMT3B	3	two hybrid	Vinayagam A (2011)	1
TRIM31	0	MKRN3	2	two hybrid	Woodsmith J (2012)	1
UBE2W	0	DZIP3	6	two hybrid	Markson G (2009)	1
RNF166	0	TRIM39	0	two hybrid	Woodsmith J (2012)	1
TRIM8	6	TRIM39	0	two hybrid	Woodsmith J (2012)	1
DNMT3B	3	POLR2H	0	affinity chromatography technology	Rigbolt KT (2011)	1
UBE2W	0	CADPS2	0	two hybrid	van Wijk SJ (2009)	1
LRSAM1	2	MKRN3	2	two hybrid	Woodsmith J (2012)	1
UBE2W	0	BIRC2	1	two hybrid	van Wijk SJ (2009)	1
BRCA1	7	BARD1	4	two hybrid, two hybrid, pull down, pull down, pull down, pull down, imaging technique, imaging technique, affinity chromatography technology, pull down, biochemical, pull down, biochemical, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, two hybrid, pull down, pull down, fluorescent resonance energy transfe, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid, x-ray crystallography, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, two hybrid, x-ray crystallography, imaging technique, imaging technique, two hybrid, affinity chromatography technology, protein complementation assay, protein complementation assay, pull down, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology	Wu LC (1996), Wang Q (2001), Wang Q (2001), Mallery DL (2002), Wu-Baer F (2003), Hashizume R (2001), Fabbro M (2002), Rodriguez JA (2004), Brzovic PS (2003), Nishikawa H (2004), Dong Y (2003), Dong Y (2003), Chiba N (2001), Kleiman FE (2001), Kleiman FE (2001), Kleiman FE (2001), Wu LC (1996), Morris JR (2002), Brzovic PS (2001), Xia Y (2003), Meza JE (1999), Kentsis A (2002), Hashizume R (2001), Fabbro M (2004), Brzovic PS (2001), Yu X (1998), Jin Y (1997), Scully R (1999), Fabbro M (2004), Kleiman FE (1999), Kleiman FE (1999), Tascou S (2003), Brzovic PS (2003), Benezra M (2003), Meza JE (1999), Cantor SB (2001), Wang Q (1998), Ryser S (2009), Ryser S (2009), Nishikawa H (2009), Nishikawa H (2009), Sobhian B (2007), Harte MT (2010), Simons AM (2006), Wei L (2008), Kumaraswamy E (2007), Kumaraswamy E (2007), Dizin E (2010), Dizin E (2010), Greenberg RA (2006), Greenberg RA (2006), Greenberg RA (2006), Zhu Q (2011), Chen A (2002), Chen A (2002), Sy SM (2009), Sy SM (2009), Nelson AC (2010), Nelson AC (2010), Morris JR (2006), Brzovic PS (2001), Mok MT (2010), Au WW (2005), Ayi TC (1998), Choudhury AD (2005), Sarkar M (2008), Sarkar M (2008), Thakar A (2010), Lu Y (2012), Kentsis A (2002), Christou CM (2014), Christou CM (2014), Sevcik J (2013), Johnson N (2013), Matsuzawa A (2014), Matsuzawa A (2014), Hill SJ (2014), Hill SJ (2014), Hill SJ (2014), Starita LM (2015), Hu Y (2014), Wu W (2015), Loke J (2015), Densham RM (2016), Boukerroucha M (2015), Huttlin EL (2017), Liang Y (2017), Liang Y (2017), Liang Y (2017), Ertych N (2016), Ertych N (2016)	91
ELAVL1	0	RNF150	2	affinity chromatography technology	Abdelmohsen K (2009)	1
UBE2W	0	USHBP1	1	two hybrid	Rolland T (2014)	1
ZNRF4	1	AMFR	2	affinity chromatography technology	Huttlin EL (2017)	1
UBE2W	0	TRIM39	0	two hybrid	Markson G (2009)	1
BIRC2	1	OTUB1	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Goncharov T (2013), Goncharov T (2013), Goncharov T (2013)	3
PSTPIP1	3	UBE2W	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
UBE2W	0	TRIM35	1	two hybrid	Markson G (2009)	1
CDK6	0	UBE2W	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2W	0	UHRF2	1	two hybrid	van Wijk SJ (2009)	1
ELAVL1	0	RNF138	0	affinity chromatography technology	Abdelmohsen K (2009)	1
UBE2W	0	RMND5B	0	two hybrid	van Wijk SJ (2009)	1
EED	1	ELAVL1	0	affinity chromatography technology	Cao Q (2014)	1
BRCA1	7	MAP3K1	4	two hybrid	Woods NT (2012)	1
UBE2W	0	RNF166	0	two hybrid	Markson G (2009)	1