PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TRIM25	5	PPP2R1B	4	affinity chromatography technology	Choudhury NR (2017)	1
PPP2R1A	8	CCNG1	1	affinity chromatography technology	Yadav L (2017)	1
CHEK2	2	APP	1	pull down	Olah J (2011)	1
EP300	36	BRCA1	7	affinity chromatography technology, pull down, affinity chromatography technology, pull down, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pao GM (2000), Pao GM (2000), Pao GM (2000), Pao GM (2000), Fan S (2002), Fan S (2002), Ma Y (2010), Subbaramaiah K (2011), Subbaramaiah K (2012)	9
PPP2CA	7	PRR14	3	affinity chromatography technology, affinity chromatography technology	Glatter T (2009), Huttlin EL (2017)	2
PPP1CC	2	ATM	9	affinity chromatography technology	Flores-Delgado G (2007)	1
PAXIP1	1	PPP2CA	7	affinity chromatography technology	Woods NT (2012)	1
PPP2R5C	3	PPP2R2A	0	biochemical	Wan C (2015)	1
PPP2R1A	8	PRR14	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Glatter T (2009), Hein MY (2015), Huttlin EL (2017), Yadav L (2017)	4
PPP1CC	2	APP	1	pull down	Olah J (2011)	1
TRIM25	5	PPP2R5E	4	affinity chromatography technology	Choudhury NR (2017)	1
EGFR	5	PPP2R2A	0	affinity chromatography technology	Foerster S (2013)	1
PRR14	3	PPP2R5E	4	affinity chromatography technology	Huttlin EL (2017)	1
CHEK2	2	TP53	0	affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Louria-Hayon I (2003), Shieh SY (2000), Bjorling-Poulsen M (2005), Hirao A (2000), Adams CJ (2008)	5
TRIM25	5	MAPK1	1	affinity chromatography technology	Choudhury NR (2017)	1
PPP1CA	3	PPP1CB	9	biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017), Boldt K (2016)	6
TRIM25	5	APP	1	affinity chromatography technology	Choudhury NR (2017)	1
FAM43A	0	PPP2R5A	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PPP2CA	7	CCNG2	1	affinity chromatography technology, pull down	Bennin DA (2002), Bennin DA (2002)	2
APP	1	PAXIP1	1	two hybrid	Soler-Lopez M (2011)	1
CCNG2	1	PPP2R5C	3	affinity chromatography technology, affinity chromatography technology	Bennin DA (2002), Huttlin EL (2017)	2
TRIM25	5	PPP2CA	7	affinity chromatography technology	Choudhury NR (2017)	1
PPP2CA	7	PPP2R5E	4	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), McCright B (1996), McCright B (1996), Glatter T (2009), Wan C (2015), Hein MY (2015), St-Denis N (2016), Yadav L (2017)	8
PPP2R5C	3	APP	1	pull down	Olah J (2011)	1
TRIM25	5	EP300	36	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
FAF1	1	UGP2	2	biochemical	Kristensen AR (2012)	1
PPP1CB	9	BRCA1	7	affinity chromatography technology, pull down	Winter SL (2007), Winter SL (2007)	2
PPP1CB	9	PPP2R5C	3	two hybrid	Grallert A (2015)	1
PRR14	3	PPP2R5A	2	affinity chromatography technology	Huttlin EL (2017)	1
PPP2R5C	3	LSM6	0	biochemical	Wan C (2015)	1
LSM6	0	APP	1	pull down	Olah J (2011)	1
UGP2	2	PPP2R5C	3	biochemical	Kristensen AR (2012)	1
COL4A3BP	18	PACSIN2	0	biochemical	Kristensen AR (2012)	1
FAF1	1	SWAP70	2	biochemical	Kristensen AR (2012)	1
PPP2CB	1	PPP2R1A	8	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Goudreault M (2009), Zhou J (2003), Zhou J (2003), Glatter T (2009), Glatter T (2009), Fogeron ML (2013), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Hein MY (2015), St-Denis N (2016), Huttlin EL (2017), Boldt K (2016), Yadav L (2017), Yadav L (2017)	15
SOX2	4	PPP2R5C	3	affinity chromatography technology	Cox JL (2013)	1
PPP2R1B	4	PPP2CB	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Zhou J (2003), Zhou J (2003), Glatter T (2009), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	7
PPP2R5A	2	PPP2R1B	4	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical	Goudreault M (2009), Zhou J (2003), Zhou J (2003), McCright B (1996), McCright B (1996)	5
MAPK1	1	IER3	0	enzymatic study, enzymatic study	Garcia J (2002), Letourneux C (2006)	2
PPP1CC	2	PPP2R5C	3	two hybrid	Grallert A (2015)	1
CCNG1	1	TP53	0	pull down, affinity chromatography technology, affinity chromatography technology	Zhao L (2003), Zhao L (2003), Ohtsuka T (2003)	3
PPP2R5C	3	PSMG3	0	biochemical	Kristensen AR (2012)	1
EP300	36	PPP2R5C	3	pull down, affinity chromatography technology	Chen J (2005), Chen J (2005)	2
EGFR	5	PPP2R1A	8	affinity chromatography technology	Foerster S (2013)	1
TRIM25	5	PPP1CB	9	affinity chromatography technology	Choudhury NR (2017)	1
POLD1	5	PPP2R5C	3	biochemical	Wan C (2015)	1
MDM2	2	TP53	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, protein complementation assay, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, two hybrid, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, pull down, pull down, unspecified method, affinity chromatography technology, two hybrid, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, protein complementation assay, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, x-ray crystallography, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, x-ray crystallography, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, far western blotting, affinity chromatography technology, x-ray crystallography, unspecified method, pull down, pull down, pull down, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, biochemical, unspecified method, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, x-ray crystallography, protein complementation assay, imaging technique, affinity chromatography technology, enzymatic study, affinity chromatography technology, fluorescent resonance energy transfe, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, unspecified method, affinity chromatography technology, imaging technique, enzymatic study, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, enzymatic study, pull down, pull down, unspecified method, fluorescent resonance energy transfe, two hybrid, pull down	Li M (2003), Latonen L (2001), Zhang Y (2003), Zhang Y (2003), Kurki S (2003), Kurki S (2003), Freeman DJ (2003), Ito A (2002), Ito A (2002), Grossman SR (1998), Fang S (2000), Liu G (2000), Zhang Y (1998), Zhang Y (1998), Chen J (1993), Thut CJ (1997), Leung KM (2002), Wawrzynow B (2009), Ochocka AM (2009), Chen D (2009), Hedstroem E (2009), Brenkman AB (2008), Qiu W (2008), Qiu W (2008), Zhang Z (2008), Muller P (2008), Colaluca IN (2008), Colaluca IN (2008), Colaluca IN (2008), Tang Y (2008), Tang Y (2008), Lu X (2007), Lukashchuk N (2007), Lukashchuk N (2007), Lee JH (2007), Carter S (2007), Sasaki M (2007), Brooks CL (2007), Li L (2007), Becker K (2007), Zhao BX (2006), Zhao BX (2006), Abida WM (2007), Yang WH (2006), Ma J (2006), Wallace M (2006), Shimizu H (2006), Andrews P (2006), Yang J (2009), Zhu Z (2009), Wang C (2005), Higashitsuji H (2005), Higashitsuji H (2005), Yan C (2005), Vega FM (2004), Dai MS (2004), Dai MS (2004), Groenroos E (2004), Ohkubo S (2006), Sui G (2004), Di Stefano V (2004), Brignone C (2004), Katayama H (2004), Linares LK (2003), OKeefe K (2003), Wang W (2003), Blattner C (2002), Matt T (2004), Matt T (2004), Eyckerman S (2005), Shimizu H (2002), Shimizu H (2002), Migliorini D (2002), Gu J (2001), Sengupta S (2001), Chernov MV (2001), Cross B (2011), Cross B (2011), Cross B (2011), Buschmann T (2001), Nakamura S (2000), Rodriguez MS (2000), Rodriguez MS (2000), Geyer RK (2000), Zaika A (1999), Maki CG (1999), Chen L (2010), Chen L (2010), Lin RK (2010), Fuchs SY (1998), Xirodimas DP (2001), Fuchs SY (1998), Inoue T (2001), Wu L (2011), Du W (2009), Li DQ (2009), Illuzzi JL (2011), Oliver TG (2011), Kim MM (2007), Marchenko ND (2007), Vaseva AV (2009), Vaseva AV (2009), Lai KP (2010), Naderi EH (2011), Zdzalik M (2010), Singh RK (2007), Meng L (2011), Moore L (2007), Kim S (2010), Inoue Y (2011), Fraser JA (2010), Worrall EG (2009), Wu H (2011), Wang KS (2011), Wang KS (2011), Wang KS (2011), Izumi T (2010), Huang YF (2009), Tang J (2006), Tang J (2006), Fu X (2010), Fu X (2010), Shloush J (2011), Yadavilli S (2009), Stevenson LF (2007), Suzuki T (2010), Cheng Q (2009), Kulikov R (2010), Kulikov R (2010), Li L (2010), Li L (2010), Cheng Q (2011), Li D (2011), Nie J (2010), Demma M (2010), Sun XX (2011), Jung CR (2010), Jung CR (2010), Jung CR (2010), Jung CR (2010), Nishida T (2011), Li M (2011), Li M (2011), Amson R (2011), Amson R (2011), Bhatt P (2011), David Y (2011), Zhang Y (2010), Liu J (2010), Liu J (2010), Song MS (2008), Cummins JM (2004), Kim CK (2010), Kim CK (2010), Yan C (2010), Wang X (2011), Phillips A (2010), Phillips A (2010), Kang HN (2011), Kang HN (2011), Wang X (2004), Sionov RV (2001), Wei S (2012), Camus S (2012), Ding B (2012), Yang Z (2012), Yang Z (2012), Tripathi V (2007), Tripathi V (2007), Dai C (2011), Chen S (2012), Honda R (1997), Kinyamu HK (2003), Zhan C (2012), Zhan C (2012), Lee CW (2010), Zhou X (2012), Bouska A (2008), Wade M (2012), Ferreon JC (2009), Domenici F (2011), Uldrijan S (2007), Uldrijan S (2007), Stad R (2000), Stad R (2000), Banks D (2006), Banks D (2006), Bernal F (2010), Bernal F (2010), Jain AK (2012), Kane SA (2000), Tan Z (2000), Yang Z (2012), Wawrzynow B (2007), Wawrzynow B (2007), Wawrzynow B (2007), Hiramatsu K (2006), Bao-Lei T (2006), Kulikov R (2005), Yang Y (2005), Lindstroem MS (2007), Bech-Otschir D (2001), Li Y (2012), Gillotin S (2010), Burch L (2004), Liu WL (2001), OHagan HM (2004), OHagan HM (2004), Funari G (2009), Candeias MM (2008), Brew CT (2006), Wang J (2011), Calabro V (2002), Burch L (2004), Iyappan S (2010), Poyurovsky MV (2010), Poyurovsky MV (2010), Poyurovsky MV (2010), Kurki S (2004), Tian LF (2006), Wang J (2006), Bae S (2012), Bae S (2012), Frazier DP (2012), Frazier DP (2012), Lew QJ (2012), Lew QJ (2012), Huart AS (2012), Li Z (2004), Balint E (1999), Balint E (1999), Funston G (2012), Dou X (2012), Sadagopan S (2012), Sadagopan S (2012), Dixit D (2012), Roxburgh P (2012), Xu L (2012), Drago-Ferrante R (2008), Li H (2009), Negorev D (2001), Wang X (2012), Wang X (2012), Wang X (2012), Boettger A (1997), Jung H (2008), Oliner JD (1992), Seemann S (2005), Kawai H (2007), Schuster K (2007), Dawson R (2003), DArcy P (2009), Schon O (2004), Schon O (2004), Hogan C (2008), Lottin-Divoux S (2005), Latini P (2011), Latini P (2011), Latini P (2011), McCoy MA (2003), Kussie PH (1996), Shieh SY (1997), Shieh SY (1997), Naski N (2009), Naski N (2009), Schon O (2002), Tamborini E (2001), Wade M (2006), Wade M (2006), Lohrum MA (2003), Garcia JF (2002), Garcia JF (2002), Kallen J (2009), Kulikov R (2006), Kulikov R (2006), Czarna A (2009), Czarna A (2009), Hu B (2007), Chi SW (2005), Yu GW (2006), Yu GW (2006), Saji S (2001), Chen L (1997), Zhang H (1998), Issaeva N (2004), Wade M (2008), Wade M (2008), Chen HF (2007), Chen HF (2007), Li HH (2004), Wang J (2011), Gu L (2009), Gu L (2009), Meng L (2008), Meng L (2008), Okamoto K (2006), Malaguarnera R (2008), Zhou M (2003), Zhou M (2003), Di Conza G (2012), Xirodimas DP (2004), Auger KR (2005), Li J (2011), Li J (2011), Li J (2011), Lee SJ (2007), Chau JF (2012), Lu X (2005), Mazars A (2010), Mazars A (2010), Mazars A (2010), Olson DC (1993), Picksley SM (1994), Issaeva N (2004), Issaeva N (2004), Zhang J (2012), Wen W (2013), Wen W (2013), Bursac S (2012), Yang Y (2013), Yang Y (2013), Landre V (2013), Pettersson S (2012), Thin TH (2007), Thin TH (2007), Piccinin S (2012), Shan B (2012), Caratozzolo MF (2012), Lui K (2013), Kobet E (2000), Lim KH (2010), Ranaweera RS (2013), Cui D (2013), Ebina M (2013), He Y (2013), He Y (2013), Siepe D (2009), Suh HW (2013), Zhan YA (2013), Wang J (2011), Hjerpe R (2010), Murray MF (2007), Jin L (2013), Jin L (2013), Zhang R (2013), Yan S (2013), Sun XX (2011), Heyne K (2014), Heyne K (2014), Bista M (2013), Jin J (2014), Mikawa T (2014), Qi M (2014), Cheng Q (2014), Zhang HH (2014), Perry ME (2000), Nishizaki M (2004), Sanchez-Aguilera A (2006), Chen YC (2013), Bertamino A (2013), Ding G (2013), Kubo N (2013), Kubo N (2013), Hsueh KW (2013), Kofod-Olsen E (2014), Fogeron ML (2013), Chang YS (2013), Gotoh T (2014), Gotoh T (2014), Oi N (2014), Corcoran CA (2009), Corcoran CA (2009), Ayroldi E (2014), Wu G (2014), Rajendra R (2004), Zhang J (2014), Lee MG (2014), Lee MG (2014), Freedman DA (1997), Freedman DA (1997), Saxena A (2006), Shi D (2009), Lohrum MA (2001), Lohrum MA (2001), Grossman SR (2003), Yan S (2013), Xirodimas DP (2004), Yasuhara T (2014), Yasuhara T (2014), Yasuhara T (2014), Yasuhara T (2014), Saville MK (2004), Rodriguez MS (1999), Lui K (2013), Wu PY (2003), Pavithra L (2009), He Y (2013), Tan BX (2014), Huttlin EL (2015), Marcar L (2015), Borcherds W (2014), Borcherds W (2014), Li YC (2014), Ayroldi E (2014), Ling X (2014), Batuello CN (2015), Zhu N (2006), Mo XL (2015), Chen TC (2014), Stindt MH (2015), Caratozzolo MF (2014), Li X (2015), Saxena R (2016), Reed SM (2014), Du C (2016), Du C (2016), Du C (2016), Fraser JA (2015), Fraser JA (2015), Wu B (2015), Qin JJ (2015), Raza S (2015), Raza S (2015), Yamauchi T (2014), Yamauchi T (2014), Yamauchi T (2014), Shi Y (2010), Ahn HJ (2015), Lim KH (2015), Kang JH (2016), Chen J (2015), Liu X (2016), Yang P (2016), Yang P (2016), Liu D (2016), Liu D (2016), Liu D (2016), Datta D (2015), Reddy BA (2014), He X (2016), Shostak K (2014), Liu LJ (2016), Liu LJ (2016), Stegh AH (2010), Liu XH (2005), Medina-Medina I (2016), Medina-Medina I (2016), Kayama K (2017), Singh AK (2016), Liu WT (2016), Yue X (2016), Soares J (2015), Mukhopadhyay R (2016), Mukhopadhyay R (2016), Zhou X (2016), Zhou X (2016), Xie X (2016), Leao M (2015), Luo H (2016), Luo H (2016), Xie N (2016), Maeda R (2017), Maeda R (2017), Maeda R (2017), Sheng W (2017), Sheng W (2017), Liu M (2010), Huttlin EL (2017), Chauhan KM (2016), Goetz C (1999), Zhang J (2017), Unger T (1999), Liu Z (2004), Wu W (2015), Tan G (2017), Nomura K (2017), Lu W (2017), Lu W (2017), Hjerrild M (2001), Landre V (2017), Landre V (2017), Landre V (2017), Landre V (2017), Shangary S (2008), Shangary S (2008), Du WW (2017), Du WW (2017), Bista M (2013), Bista M (2013), Jin M (2017), LaRusch GA (2007), LaRusch GA (2007), Kurokawa M (2013), Ivanov AA (2017), Wong JH (2017), Wong JH (2017)	496
PPP2CB	1	PPP2R5A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), St-Denis N (2016), Huttlin EL (2017)	3
PAXIP1	1	PPP2R5C	3	two hybrid	Woods NT (2012)	1
FAM43A	0	PPP2R1B	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TP53	0	PPP2R5C	3	imaging technique, affinity chromatography technology	Chen TC (2014), Shouse GP (2011)	2
EGFR	5	PPP2R1B	4	affinity chromatography technology	Foerster S (2013)	1
JMJD6	1	SWAP70	2	biochemical	Kristensen AR (2012)	1
PPP2CA	7	PPP2R1B	4	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), Zhou J (2003), Zhou J (2003), Glatter T (2009), Sablina AA (2007), Sablina AA (2007), Havugimana PC (2012), Wan C (2015), Hein MY (2015), Yadav L (2017)	10
PPP2R2A	0	PPP2R1B	4	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, bioid	Kamibayashi C (1992), Zhou J (2003), Glatter T (2009), Sablina AA (2007), Sablina AA (2007), Havugimana PC (2012), Wan C (2015), Hein MY (2015), Yadav L (2017), Yadav L (2017)	10
PACSIN2	0	SWAP70	2	biochemical	Kristensen AR (2012)	1
PPP2R5A	2	PPP2R5C	3	affinity chromatography technology	Strack S (2002)	1
PPP2R5C	3	PPP2R1B	4	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical	McCright B (1996), McCright B (1996), Sablina AA (2007), Wan C (2015)	4
PPP2CA	7	PPP2R5A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), Goudreault M (2009), McCright B (1996), McCright B (1996), Widau RC (2010), Wan C (2015), Hein MY (2015), Craney A (2016), St-Denis N (2016), Yadav L (2017)	10
EP300	36	PPP2CA	7	affinity chromatography technology	Chen J (2005)	1
PPP2CA	7	TP53	0	affinity chromatography technology	Shouse GP (2011)	1
PAXIP1	1	PPP1CC	2	affinity chromatography technology	Woods NT (2012)	1
MAPK1	1	MBP	0	enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Plun-Favreau H (2007), Momose H (2003), Cavigelli M (1995), Tresini M (2001), Blaukat A (2000), Blaukat A (2000), Blaukat A (1999), Blaukat A (2001), Sang N (2003), Raskin A (2012), Egan JE (2002), Chen G (2000), Lammering G (2003), Larsson H (1999), Camps M (1998)	15
CHEK2	2	MDM2	2	enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study	Pereg Y (2006), Kass EM (2009), Kass EM (2009), Bjorling-Poulsen M (2005), Bjorling-Poulsen M (2005), Bjorling-Poulsen M (2005), Bjorling-Poulsen M (2005)	7
PPP2R1A	8	PPP2R2A	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, bioid	Goudreault M (2009), Zhou J (2003), Zhou J (2003), Glatter T (2009), Glatter T (2009), Sablina AA (2007), Havugimana PC (2012), Junttila MR (2007), Fogeron ML (2013), Wan C (2015), Hein MY (2015), Hein MY (2015), Boldt K (2016), Yadav L (2017), Yadav L (2017), Yadav L (2017), Yadav L (2017)	17
TRIM25	5	PPP1CA	3	affinity chromatography technology	Choudhury NR (2017)	1
CCNG2	1	PPP2R5E	4	affinity chromatography technology	Huttlin EL (2017)	1
CHEK2	2	PPP2R5E	4	two hybrid, pull down	Dozier C (2004), Dozier C (2004)	2
TP53	0	EP300	36	pull down, genetic interference, pull down, enzymatic study, pull down, pull down, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, imaging technique, affinity chromatography technology, enzymatic study, affinity chromatography technology, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, unspecified method, affinity chromatography technology, enzymatic study, unspecified method, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, unspecified method	An W (2004), Pastorcic M (2000), Livengood JA (2002), Livengood JA (2002), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Tang Y (2008), Wang H (2008), Valbuena A (2008), Shi D (2009), Vega FM (2004), Finlan L (2004), Groenroos E (2004), Zhao Y (2006), Roe JS (2006), Pedeux R (2005), Sekaric P (2007), Pan X (2009), Tang Y (2006), Sen GS (2011), Li Y (2012), Li Y (2012), Gillotin S (2010), Grossman SR (2003), Issaeva N (2004), Kitagawa M (2008), Sabbatini P (2002), Burge S (2009), Zilfou JT (2001), Issaeva N (2004), Issaeva N (2004), Feng H (2009), Feng H (2009), Lill NL (1997), Dornan D (2004), Dornan D (2004), Di Agostino S (2006), Wells M (2008), Fath DM (2006), Kobet E (2000), Costanzo A (2002), Kumazawa T (2011), Borger DR (2006), Cui D (2013), Borger DR (2006), Lee SJ (2013), Tang HY (2006), Lin C (2011), Choi WI (2014), Ding G (2013), Kim MK (2013), Ali A (2013), Wu G (2014), Mizuguchi Y (2012), Sinha S (2012), Sinha S (2012), Her YR (2013), Her YR (2013), Wu SY (2009), Wu SY (2009), Liu L (1999), Sakaguchi K (1998), Harrod R (2003), Gu W (1997), Teufel DP (2007), Mantovani F (2007), Mantovani F (2007), Dornan D (2003), Dornan D (2003), Dornan D (2003), Dornan D (2003), Dornan D (2003), MacPartlin M (2005), Mujtaba S (2004), Wang YH (2003), Chen H (1999), Tang Z (2013), Graczyk A (2013), Graczyk A (2013), Chan HM (2001), Thomas MC (2005), Miller Jenkins LM (2015), Miller Jenkins LM (2015), Koh DI (2014), Koh DI (2014), Koh DI (2014), Li H (2015), Chen LF (2005), Shi D (2016), Wright DG (2016), Zhang X (2016), Procopio MG (2015), Tong Q (2015)	95
PPP2R5E	4	APP	1	pull down	Olah J (2011)	1
TRIM25	5	MDM2	2	affinity chromatography technology	Choudhury NR (2017)	1
ATM	9	BRCA1	7	affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, pull down, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Gatei M (2000), Gatei M (2000), Kim ST (1999), Cortez D (1999), Cortez D (1999), Tibbetts RS (2000), Wang Y (2000), Mu JJ (2007), Tsai WB (2008), Gatei M (2000), Gatei M (2000), Gatei M (2000)	12
JMJD6	1	PPP2R5C	3	biochemical	Kristensen AR (2012)	1
TP53	0	PPP2R1A	8	imaging technique, affinity chromatography technology	Chen TC (2014), Kikuchi J (2003)	2
MAPK1	1	TP53	0	affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, imaging technique	Persons DL (2000), How PC (2011), Srivastav RK (2011), Fogeron ML (2013), Chen TC (2014)	5
SOX2	4	LSM6	0	affinity chromatography technology	Cox JL (2013)	1
ATM	9	PPP2R5C	3	enzymatic study	Shouse GP (2011)	1
PRR14	3	PPP2R5C	3	affinity chromatography technology	Huttlin EL (2017)	1
COL4A3BP	18	PPP2R5C	3	biochemical	Kristensen AR (2012)	1
CCNG1	1	APP	1	pull down	Olah J (2011)	1
PPP1CA	3	MDM2	2	affinity chromatography technology	Liu X (2016)	1
BRCA1	7	MAPK1	1	affinity chromatography technology, affinity chromatography technology	Yan Y (2008), Yan Y (2008)	2
CHEK2	2	PPP2R1A	8	affinity chromatography technology	Dozier C (2004)	1
PPP1CA	3	BRCA1	7	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Winter SL (2007), Liu Y (2002), Liu Y (2002), Liu Y (2002), Liu Y (2002), Woods NT (2012), Chen BY (2014)	7
CCNG1	1	PPP2R5E	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CNOT9	1	EGFR	5	affinity chromatography technology, pull down	Ajiro M (2010), Ajiro M (2010)	2
PPP1CC	2	TP53	0	affinity chromatography technology	Flores-Delgado G (2007)	1
TRIM25	5	PACSIN2	0	affinity chromatography technology	Choudhury NR (2017)	1
PAXIP1	1	EP300	36	pull down	Hoffmeister A (2002)	1
PPP2R5C	3	SWAP70	2	biochemical	Kristensen AR (2012)	1
EGFR	5	APP	1	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
PPP2R1A	8	PPP2R5C	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Goudreault M (2009), Glatter T (2009), Dozier C (2004), Fogeron ML (2013), Wan C (2015), Hein MY (2015), Boldt K (2016), Shouse GP (2011), Yadav L (2017), Yadav L (2017)	10
TRIM25	5	CCNG1	1	affinity chromatography technology	Choudhury NR (2017)	1
PRR14	3	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
CHEK2	2	PPP2R5C	3	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study	Dozier C (2004), Dozier C (2004), Dozier C (2004), Dozier C (2004), Dozier C (2004), Dozier C (2004)	6
PRR14	3	PPP2R1B	4	affinity chromatography technology	Huttlin EL (2017)	1
PPP2CA	7	PPP2R5C	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ito A (2000), Goudreault M (2009), McCright B (1996), McCright B (1996), Glatter T (2009), Dozier C (2004), Letourneux C (2006), Wan C (2015), St-Denis N (2016), Shouse GP (2011), Shouse GP (2011), Yadav L (2017)	12
TRIM25	5	PSMG3	0	affinity chromatography technology	Choudhury NR (2017)	1
PPP2CB	1	PPP2R5C	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Glatter T (2009), Huttlin EL (2015), St-Denis N (2016), Huttlin EL (2017)	4
PPP2R5C	3	MBP	0	enzymatic study	Dozier C (2004)	1
CHEK2	2	BRCA1	7	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, imaging technique	Lee JS (2000), Lee JS (2000), Chabalier-Taste C (2008), Chabalier-Taste C (2008), Liu Y (2002), Inoue Y (2007), Dutta D (2015), Dutta D (2015)	8
TRIM25	5	PPP1CC	2	affinity chromatography technology	Choudhury NR (2017)	1
BRCA1	7	TRIM25	5	affinity chromatography technology	Ertych N (2016)	1
TRIM25	5	PPP2R5C	3	affinity chromatography technology	Choudhury NR (2017)	1
PPP2CB	1	PPP2R5E	4	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Glatter T (2009), Huttlin EL (2015), Wan C (2015), Hein MY (2015), St-Denis N (2016), Huttlin EL (2017)	6
IER3	0	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
TRIM25	5	API5	0	affinity chromatography technology	Choudhury NR (2017)	1
EGFR	5	PRR14	3	affinity chromatography technology	Yao Z (2017)	1
TRIM25	5	PPP2R5A	2	affinity chromatography technology	Choudhury NR (2017)	1
PPP1CC	2	PPP1CA	3	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017), Boldt K (2016), Yadav L (2017), Yadav L (2017), Yadav L (2017)	8
BRCA1	7	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, biochemical, pull down, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Abramovitch S (2004), Ouchi T (1998), Dong Y (2003), Dong Y (2003), Chai YL (1999), Chai YL (1999), Zhang H (1998), Dong Y (2003), Chen Y (2006), Quaresima B (2006), Zhang H (1998), Zhang H (1998), Mark WY (2005), Jin S (2009), Jiang J (2011), Rasti M (2015), Rasti M (2015)	17
PPP2CB	1	PRR14	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Glatter T (2009), Huttlin EL (2015), Huttlin EL (2017)	3
MAPK1	1	CHEK2	2	biochemical	Wan C (2015)	1
FAM43A	0	PPP2R5C	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PPP2R5E	4	API5	0	biochemical	Wan C (2015)	1
TRIM25	5	PPP2CB	1	affinity chromatography technology	Choudhury NR (2017)	1
FAM43A	0	PPP2R5E	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PPP1CA	3	PPP2R5C	3	two hybrid, affinity chromatography technology	Grallert A (2015), Grallert A (2015)	2
ATM	9	MDM2	2	enzymatic study, enzymatic study	Wang Z (2012), Luo H (2016)	2
PPP2R5E	4	PPP2R1B	4	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, two hybrid, biochemical	McCright B (1996), McCright B (1996), Sablina AA (2007), Sablina AA (2007), Wallach T (2013), Wan C (2015)	6
TRIM25	5	PPP2R1A	8	affinity chromatography technology	Choudhury NR (2017)	1
PPP2R5C	3	API5	0	biochemical	Wan C (2015)	1
CNOT9	1	PPP2R5C	3	biochemical	Wan C (2015)	1
LSM6	0	LSM7	0	biochemical, two hybrid, two hybrid, two hybrid, two hybrid, biochemical, affinity chromatography technology	Havugimana PC (2012), Hegele A (2012), Hegele A (2012), Lehner B (2004), Lehner B (2004), Wan C (2015), Huttlin EL (2017)	7
PPP2R1A	8	PPP2R5E	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Goudreault M (2009), Glatter T (2009), Fogeron ML (2013), Wallach T (2013), Wan C (2015), Hein MY (2015), Boldt K (2016), Yadav L (2017), Yadav L (2017)	9
UGP2	2	PACSIN2	0	biochemical	Kristensen AR (2012)	1
PPP1CA	3	ATM	9	affinity chromatography technology	Flores-Delgado G (2007)	1
MAPK1	1	PPP1CC	2	affinity chromatography technology	Quevedo C (2003)	1
PACSIN2	0	PPP2R5C	3	biochemical	Kristensen AR (2012)	1
TRIM25	5	FAF1	1	affinity chromatography technology	Choudhury NR (2017)	1
ATM	9	TP53	0	pull down, pull down, pull down, genetic interference, unspecified method, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, imaging technique	Kang J (2005), Fabbro M (2004), Khanna KK (1998), Westphal CH (1997), Kim ST (1999), Khanna KK (1998), Lee JH (2004), Lee JH (2004), Hunt CR (2007), Lin WC (2001), Ling S (2011), Taira N (2010), Lee JH (2005), Zhou BB (2000), Chan DW (2000), Yoshiyama KO (2013), Kim ST (1999), Zhang P (2014), Wang L (2014), Golding SE (2004), Ochodnicka-Mackovicova K (2016)	21
EP300	36	MAPK1	1	affinity chromatography technology, enzymatic study, enzymatic study	Chen YJ (2007), Chen YJ (2007), Sang N (2003)	3
PPP2CB	1	PPP2CA	7	biochemical, affinity chromatography technology	Wan C (2015), St-Denis N (2016)	2
PPP1CA	3	TP53	0	two hybrid	Colland F (2004)	1
PPP2R5C	3	MDM2	2	affinity chromatography technology	Shouse GP (2011)	1
IER3	0	PPP2R5C	3	affinity chromatography technology, affinity chromatography technology	Letourneux C (2006), Letourneux C (2006)	2
EGFR	5	API5	0	affinity chromatography technology	Yao Z (2017)	1
MAPK1	1	PPP2R5C	3	enzymatic study	Letourneux C (2006)	1
BRCA1	7	PPP2R5C	3	two hybrid, affinity chromatography technology	Woods NT (2012), Woods NT (2012)	2
PPP2CB	1	PPP2R2A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Goudreault M (2009), Glatter T (2009), Glatter T (2009), Huttlin EL (2015), Wan C (2015), Hein MY (2015), St-Denis N (2016), Huttlin EL (2017), Yadav L (2017), Yadav L (2017)	10
CHEK2	2	PPP2R5A	2	two hybrid, pull down	Dozier C (2004), Dozier C (2004)	2
MDM2	2	APP	1	pull down	Miyamoto-Sato E (2010)	1
PPP2R1A	8	PPP2R1B	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Goudreault M (2009), Sablina AA (2007), Fogeron ML (2013), Wan C (2015), Hein MY (2015)	5
PPP2R1A	8	PPP2R5A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, bioid	Goudreault M (2009), Goudreault M (2009), Zhou J (2003), Zhou J (2003), Widau RC (2010), Wan C (2015), Hein MY (2015), Yadav L (2017), Yadav L (2017)	9
BRCA1	7	PPP2CA	7	affinity chromatography technology	Woods NT (2012)	1
ATM	9	CHEK2	2	enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Lee JH (2004), Lee JH (2004), Matsuoka S (2000), Lee JH (2005), Zhou BB (2000), Chan DW (2000)	6
PPP1CB	9	PPP1CC	2	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
PPP2R5C	3	729873	0	affinity chromatography technology, affinity chromatography technology	Wainszelbaum MJ (2012), Wainszelbaum MJ (2012)	2
EGFR	5	PPP2R5C	3	affinity chromatography technology	Tong J (2014)	1
IER3	0	MDM2	2	affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Jin H (2016), Jin H (2016), Jin H (2016), Jin H (2016)	4
EGFR	5	PPP2R5E	4	affinity chromatography technology	Foerster S (2013)	1
CCNG1	1	MDM2	2	pull down, affinity chromatography technology	Zhao L (2003), Zhao L (2003)	2
PPP2R2A	0	PPP2CA	7	pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, bioid	Kamibayashi C (1992), Kamibayashi C (1992), Goudreault M (2009), Glatter T (2009), Glatter T (2009), Havugimana PC (2012), Wan C (2015), Hein MY (2015), St-Denis N (2016), Bryant JC (1999), Yadav L (2017), Yadav L (2017), Yadav L (2017), Yadav L (2017)	14
CHEK2	2	PPP2CA	7	affinity chromatography technology, enzymatic study	Dozier C (2004), Liang X (2006)	2
TP53	0	EGFR	5	genetic interference, genetic interference	Xie L (2013), Ye H (2016)	2
CCNG1	1	PPP2R5C	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017), Shouse GP (2011)	3
PPP2R5E	4	PPP2R5C	3	biochemical	Wan C (2015)	1
PPP2CA	7	PPP2R1A	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, bioid	Goudreault M (2009), Goudreault M (2009), Zhou J (2003), Zhou J (2003), Glatter T (2009), Glatter T (2009), Sablina AA (2007), Sablina AA (2007), Kong M (2009), Kong M (2009), Shamay M (2012), Havugimana PC (2012), Junttila MR (2007), Junttila MR (2007), Nazarenko I (2007), Kristensen AR (2012), Fogeron ML (2013), Sablina AA (2010), Lee CW (2014), Wan C (2015), Hein MY (2015), Hein MY (2015), Cianfanelli V (2015), St-Denis N (2016), Bryant JC (1999), Shouse GP (2011), Yadav L (2017), Yadav L (2017), Yadav L (2017), Yadav L (2017)	30
EP300	36	MDM2	2	pull down, affinity chromatography technology, biochemical, pull down, pull down, enzymatic study, affinity chromatography technology, biochemical, enzymatic study	Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Matt T (2004), Wang X (2004), Gillotin S (2010), Kobet E (2000), Nihira NT (2017)	9
PPP2R5C	3	LSM7	0	biochemical	Wan C (2015)	1
FAF1	1	PPP2R5C	3	biochemical	Kristensen AR (2012)	1
PPP1CA	3	PPP2R5E	4	two hybrid	Wallach T (2013)	1