PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HCFC1	4	OGT	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, biochemical, affinity chromatography technology	Wysocka J (2003), Wysocka J (2003), Mazars R (2010), Daou S (2011), Capotosti F (2011), Capotosti F (2011), Capotosti F (2011), Havugimana PC (2012), Hauri S (2016)	9
TRAF6	0	UBC	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Muroi M (2011), Park S (2013), Sun L (2004), Kanayama A (2004), Sakamoto H (2015), Yu J (2016), Middleton AJ (2017)	7
BAP1	4	FOXK2	9	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Sowa ME (2009), Machida YJ (2009), Yu H (2010), Okino Y (2015), Okino Y (2015), Okino Y (2015), Li X (2015), Ji Z (2014), Ji Z (2014), Ji Z (2014), Ji Z (2014), Shan L (2016), Shan L (2016), Shan L (2016), Hauri S (2016)	15
TRIM25	5	OGT	4	affinity chromatography technology	Choudhury NR (2017)	1
ASXL2	6	KDM1B	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017), Hauri S (2016)	4
KRBOX4	0	ASXL2	6	affinity chromatography technology	Hein MY (2015)	1
ASXL2	6	OGT	4	affinity chromatography technology, affinity chromatography technology	Daou S (2015), Hauri S (2016)	2
TRIM25	5	APP	1	affinity chromatography technology	Choudhury NR (2017)	1
UBC	7	BAP1	4	pull down, pull down, pull down, pull down	Duerksen-Hughes PJ (1989), Daou S (2015), Kwasna D (2018), Hanpude P (2017)	4
BAP1	4	TUBA1C	1	affinity chromatography technology	Hauri S (2016)	1
ASXL2	6	SLURP1	0	affinity chromatography technology	Hauri S (2016)	1
FOXK2	9	KDM1B	4	affinity chromatography technology	Li X (2015)	1
UBC	7	OGT	4	pull down	Zhang X (2017)	1
ASXL2	6	HCFC1	4	affinity chromatography technology, affinity chromatography technology	Daou S (2015), Hauri S (2016)	2
ASXL2	6	TUBA1C	1	affinity chromatography technology	Hauri S (2016)	1
HECW2	13	TRIM25	5	affinity chromatography technology	Lu L (2013)	1
PRPF40A	5	ASXL2	6	two hybrid	Colland F (2004)	1
TRIM25	5	ASXL2	6	affinity chromatography technology	Choudhury NR (2017)	1
FOXK1	5	FOXK2	9	affinity chromatography technology	Li X (2015)	1
TRIM25	5	FOXK2	9	affinity chromatography technology	Choudhury NR (2017)	1
UBC	7	EXOSC2	2	affinity chromatography technology	Matsumoto M (2005)	1
ASXL2	6	FOXK1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Daou S (2015), Huttlin EL (2017), Hauri S (2016)	4
TRAF6	0	APP	1	pull down	Olah J (2011)	1
KDM1B	4	OGT	4	enzymatic study, affinity chromatography technology, affinity chromatography technology	Yang Y (2015), Yang Y (2015), Yang Y (2015)	3
BAP1	4	FOXK1	5	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Machida YJ (2009), Yu H (2010), Okino Y (2015), Okino Y (2015), Okino Y (2015), Li X (2015), Hauri S (2016)	8
BAP1	4	ASXL2	6	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Machida YJ (2009), Yu H (2010), Huttlin EL (2015), Daou S (2015), Daou S (2015), Daou S (2015), Daou S (2015), Daou S (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	12
EXOSC2	2	ASXL2	6	affinity chromatography technology	Hein MY (2015)	1
ASXL2	6	APP	1	pull down	Olah J (2011)	1
TRAF6	0	ASXL2	6	affinity chromatography technology	Ewing RM (2007)	1
BAP1	4	HCFC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, biochemical, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Machida YJ (2009), Machida YJ (2009), Machida YJ (2009), Machida YJ (2009), Yu H (2010), Yu H (2010), Yu H (2010), Yu H (2010), Pena-Llopis S (2012), Pena-Llopis S (2012), Bott M (2011), Bott M (2011), Misaghi S (2009), Mashtalir N (2014), Eletr ZM (2013), Eletr ZM (2013), Daou S (2015), Hauri S (2016)	19
BAP1	4	OGT	4	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Yu H (2010), Mashtalir N (2014), Daou S (2015), Hauri S (2016), Hauri S (2016)	6
ASXL2	6	MBD6	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016)	3
HECW2	13	ASXL2	6	affinity chromatography technology	Lu L (2013)	1
FOXK1	5	HCFC1	4	affinity chromatography technology	Okino Y (2015)	1
UBC	7	ASXL2	6	pull down	Daou S (2015)	1
BAP1	4	MBD6	5	affinity chromatography technology	Hauri S (2016)	1
TRAF6	0	TRIM25	5	two hybrid	Woodsmith J (2012)	1
FOXK2	9	HCFC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down	Okino Y (2015), Li X (2015), Ji Z (2014), Ji Z (2014), Ji Z (2014)	5
ASXL2	6	MBD5	14	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRIM25	5	UBC	7	enzymatic study	Sanchez JG (2016)	1
OGT	4	TUBA1C	1	affinity chromatography technology	Hauri S (2016)	1
FOXK2	9	ASXL2	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li X (2015), Daou S (2015), Ji Z (2014), Hauri S (2016)	4
HECW2	13	FOXK2	9	affinity chromatography technology	Lu L (2013)	1
BAP1	4	KDM1B	4	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Machida YJ (2009), Yu H (2010), Hein MY (2015), Hauri S (2016)	5