PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
APPL2	4	MLST8	1	two hybrid	Grossmann A (2015)	1
NTRK1	1	APPL2	4	affinity chromatography technology	Emdal KB (2015)	1
RAB5C	2	LDHAL6B	0	biochemical	Wan C (2015)	1
APPL1	1	MTA2	1	affinity chromatography technology, pull down	Banach-Orlowska M (2009), Miaczynska M (2004)	2
TINF2	1	APPL2	4	two hybrid	Lee OH (2011)	1
NTRK1	1	ABI2	4	affinity chromatography technology	Emdal KB (2015)	1
APPL1	1	APPL2	4	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Rual JF (2005), Nechamen CA (2007), Nechamen CA (2007), Rolland T (2014), Huttlin EL (2017)	5
RAB5C	2	APPL2	4	two hybrid	Rolland T (2014)	1
CRBN	2	RUVBL2	4	affinity chromatography technology	Nguyen TV (2016)	1
POT1	2	TINF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ye JZ (2004), Ye JZ (2004), Liu D (2004), Loayza D (2003), Loayza D (2003), Giannone RJ (2010), Liu D (2004), Liu D (2004), Ye JZ (2004), Lee OH (2011), Lee OH (2011), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	14
APPL2	4	LIX1	1	two hybrid	Grossmann A (2015)	1
ABI2	4	APPL2	4	biochemical	Kristensen AR (2012)	1
RUVBL2	4	APPL1	1	affinity chromatography technology, affinity chromatography technology, pull down	Rashid S (2009), Rashid S (2009), Rashid S (2009)	3
APPL2	4	RBBP7	1	pull down	Miaczynska M (2004)	1
APPL2	4	CNMD	2	two hybrid	Grossmann A (2015)	1
APPL2	4	ATF3	0	two hybrid	Grossmann A (2015)	1
APPL2	4	RAB22A	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
APPL2	4	CRBN	2	two hybrid	Grossmann A (2015)	1
RAB22A	0	RAB5A	0	affinity chromatography technology	Zhu H (2009)	1
APPL2	4	MAPRE3	0	two hybrid, affinity chromatography technology	Grossmann A (2015), Grossmann A (2015)	2
APPL2	4	CRLF3	2	two hybrid	Grossmann A (2015)	1
APPL1	1	DOK3	5	two hybrid	Grossmann A (2015)	1
APPL2	4	TSC1	4	two hybrid	Grossmann A (2015)	1
NTRK1	1	RUVBL2	4	affinity chromatography technology	Emdal KB (2015)	1
APPL2	4	RBP7	3	two hybrid	Grossmann A (2015)	1
NTRK1	1	APPL1	1	affinity chromatography technology	Emdal KB (2015)	1
TPM1	0	APPL2	4	biochemical	Kristensen AR (2012)	1
RAB5A	0	RAB5C	2	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
APPL2	4	RAI2	0	two hybrid	Grossmann A (2015)	1
RAB5A	0	APPL2	4	pull down	Miaczynska M (2004)	1
TPM1	0	ABI2	4	biochemical	Kristensen AR (2012)	1
POT1	2	APPL2	4	two hybrid	Lee OH (2011)	1
APPL1	1	RBBP7	1	affinity chromatography technology, pull down	Banach-Orlowska M (2009), Miaczynska M (2004)	2
RAB5A	0	APPL1	1	affinity chromatography technology, pull down, affinity chromatography technology, pull down	Miaczynska M (2004), Miaczynska M (2004), Mao X (2006), Zhu G (2007)	4
APPL2	4	MTA2	1	pull down	Miaczynska M (2004)	1
NTRK1	1	RAB5C	2	affinity chromatography technology	Emdal KB (2015)	1
TSC1	4	RUVBL2	4	affinity chromatography technology	Cloutier P (2017)	1
FSHR	2	APPL2	4	affinity chromatography technology	Nechamen CA (2007)	1
APPL2	4	KMT2C	28	two hybrid	Grossmann A (2015)	1
APPL2	4	388407	0	two hybrid	Grossmann A (2015)	1
MTA2	1	RBBP7	1	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Yao YL (2003), Zhang Y (1999), Feng Q (2001), Wang Y (2009), Fu J (2011), Havugimana PC (2012), Huttlin EL (2015), Huttlin EL (2017), Brasen C (2017), Brasen C (2017), Hauri S (2016)	11
NTRK1	1	MTA2	1	affinity chromatography technology	Emdal KB (2015)	1
RUVBL2	4	APPL2	4	affinity chromatography technology, affinity chromatography technology, pull down	Rashid S (2009), Rashid S (2009), Rashid S (2009)	3
APPL2	4	PINK1	2	two hybrid	Grossmann A (2015)	1
FSHR	2	APPL1	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Cohen BD (2004), Nechamen CA (2004), Nechamen CA (2004), Nechamen CA (2004)	4
APPL2	4	SUV39H2	3	two hybrid, two hybrid	Weimann M (2013), Rolland T (2014)	2
RIPOR1	8	APPL2	4	biochemical	Kristensen AR (2012)	1
CRADD	0	APPL2	4	two hybrid	Rolland T (2014)	1
APPL2	4	DOK3	5	two hybrid	Grossmann A (2015)	1
APPL2	4	LGALS9C	0	two hybrid	Grossmann A (2015)	1
APPL2	4	LDHAL6B	0	two hybrid	Grossmann A (2015)	1