PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
WDR5B	1	RNF220	2	affinity chromatography technology	Huttlin EL (2017)	1
RNF220	2	GSK3B	1	affinity chromatography technology	Ma P (2014)	1
TRIM25	5	CTNNB1	30	affinity chromatography technology	Choudhury NR (2017)	1
SIN3B	5	RNF220	2	affinity chromatography technology, pull down, enzymatic study	Kong Q (2010), Kong Q (2010), Kong Q (2010)	3
CTNNB1	30	GSK3B	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Davies G (2001), Kishida S (1999), Fischer L (2002), Kitagawa M (1999), Hart M (1999), Su Y (2008), Huang X (2009), Ding Q (2005), Piao S (2008), Varjosalo M (2013), Gao C (2014), Koo J (2015), Chen TC (2014), Lu D (2012), Kuslansky Y (2016), Novellasdemunt L (2017), Lu WJ (2015)	17
RNF220	2	UBE2D3	1	pull down	Kong Q (2010)	1
UBE2D3	1	TRIM25	5	two hybrid, pull down, pull down, affinity chromatography technology	Markson G (2009), Ronchi VP (2012), Choudhury NR (2017), Choudhury NR (2017)	4
USP7	14	UBE2D3	1	enzymatic study	Zhang ZM (2015)	1
TRIM25	5	RNF220	2	affinity chromatography technology	Choudhury NR (2017)	1
ZC4H2	3	RNF220	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CLEC3A	2	RNF220	2	affinity chromatography technology	Huttlin EL (2017)	1
USP7	14	RNF220	2	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Lim J (2006), Ma P (2014), Ma P (2014)	4
TRIM25	5	USP7	14	affinity chromatography technology	Choudhury NR (2017)	1
UBE2E3	0	RNF220	2	affinity chromatography technology	Huttlin EL (2017)	1
CTNNB1	30	USP7	14	affinity chromatography technology, affinity chromatography technology, enzymatic study, unspecified method	Novellasdemunt L (2017), Novellasdemunt L (2017), Novellasdemunt L (2017), Novellasdemunt L (2017)	4
UBE2E3	0	USP7	14	affinity chromatography technology	Huttlin EL (2017)	1
CTNNB1	30	RNF220	2	affinity chromatography technology, affinity chromatography technology	Ma P (2014), Ma P (2014)	2
RNF220	2	GOPC	5	two hybrid	Rolland T (2014)	1