PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RNF31	3	UBE2D1	0	pull down, pull down	Nakamura M (2006), Kirisako T (2006)	2
PRKN	1	UBE2D1	0	pull down	Kazlauskaite A (2014)	1
TRIM25	5	MAVS	1	affinity chromatography technology	Liu B (2017)	1
PRKN	1	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Imai Y (2003), Sarraf SA (2013), Huttlin EL (2017)	3
AES	2	TRAF1	0	two hybrid	Rolland T (2014)	1
TRAF6	0	BCL10	0	affinity chromatography technology	Bidere N (2006)	1
LIPF	0	SHARPIN	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRAF6	0	UBC	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Muroi M (2011), Park S (2013), Sun L (2004), Kanayama A (2004), Sakamoto H (2015), Yu J (2016), Middleton AJ (2017)	7
TRIM25	5	RABGEF1	1	affinity chromatography technology	Choudhury NR (2017)	1
IKBKG	0	RBCK1	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Fenner BJ (2010), Verhelst K (2012), Zak DE (2011), Niu J (2011), Fu J (2013), Tokunaga F (2011), Xia ZP (2009), Emmerich CH (2013), Abdul-Sater AA (2017), Abdul-Sater AA (2017), Bal E (2017), Bal E (2017)	12
RBCK1	0	ESR1	0	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Gustafsson Sheppard N (2012), Gustafsson Sheppard N (2012), Gustafsson Sheppard N (2012), Gustafsson Sheppard N (2012), Donley C (2013), Donley C (2013)	6
AES	2	SMAD3	1	two hybrid	Rolland T (2014)	1
TNFRSF1A	3	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Won M (2010), Zilberman-Rudenko J (2016), Moquin DM (2013)	3
LTBR	0	RNF31	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TNF	0	TNFAIP3	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Skaug B (2011), Tokunaga F (2012), Verhelst K (2012), Yamaguchi N (2015), Draber P (2015)	5
NTRK1	1	UBC	7	affinity chromatography technology	Emdal KB (2015)	1
PRKCA	7	DDX58	3	enzymatic study, affinity chromatography technology, affinity chromatography technology	Maharaj NP (2011), Maharaj NP (2011), Maharaj NP (2011)	3
RIPK1	2	BIRC2	1	affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Bertrand MJ (2008), Bertrand MJ (2008), Xu M (2009), Dynek JN (2010), Dynek JN (2010), Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011), Puliyappadamba VT (2013), Fu J (2016), Vu NT (2016), Vu NT (2016)	12
TLR3	2	RIPK1	2	affinity chromatography technology, affinity chromatography technology	Cusson-Hermance N (2005), Zinngrebe J (2016)	2
ESR1	0	VCP	6	pull down	Nalvarte I (2010)	1
TNFRSF1A	3	UBC	7	affinity chromatography technology	Nakazawa S (2016)	1
RNF31	3	TRAF2	1	affinity chromatography technology	Schaeffer V (2014)	1
TNF	0	RBCK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Verhelst K (2012), Yamaguchi N (2015), Draber P (2015)	4
BIRC3	1	TRAF1	0	pull down, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology	Roy N (1997), Li X (2002), Goncharov T (2013), Chen TC (2014), Greenfeld H (2015)	5
UBE2D3	1	HDAC6	0	enzymatic study	Hoeller D (2007)	1
MAVS	1	BIRC3	1	affinity chromatography technology	Mao AP (2010)	1
BIRC2	1	RNF31	3	affinity chromatography technology, affinity chromatography technology	Goncharov T (2013), Schaeffer V (2014)	2
TRIM25	5	RNF31	3	affinity chromatography technology, imaging technique, enzymatic study, affinity chromatography technology	Inn KS (2011), Inn KS (2011), Inn KS (2011), Choudhury NR (2017)	4
SPATA2	2	CYLD	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Schlicher L (2016), Schlicher L (2016), Elliott PR (2016), Elliott PR (2016), Elliott PR (2016), Elliott PR (2016)	8
TNFRSF1A	3	CYLD	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Moquin DM (2013), Nakazawa S (2016), Elliott PR (2016)	3
SHARPIN	1	OTULIN	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Keusekotten K (2013), Elliott PR (2014), Draber P (2015), Elliott PR (2016)	4
RIPK1	2	CYLD	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wright A (2007), Nagabhushana A (2011), ODonnell MA (2012), Wu GR (2017)	4
CD40	3	RNF31	3	affinity chromatography technology, affinity chromatography technology	Hostager BS (2010), Hostager BS (2010)	2
IKBKG	0	PRKN	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Henn IH (2007), Henn IH (2007), Sha D (2010)	3
PDLIM7	0	SHARPIN	1	affinity chromatography technology	Wang L (2017)	1
ESR1	0	TRAF6	0	affinity chromatography technology	Robinson LJ (2009)	1
CYLD	2	HDAC6	0	affinity chromatography technology, pull down, affinity chromatography technology	Wickstroem SA (2010), Wickstroem SA (2010), Sun L (2010)	3
RABGEF1	1	SHARPIN	1	affinity chromatography technology	Huttlin EL (2017)	1
BIRC2	1	UBE2D1	0	affinity chromatography technology, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Hu S (2003), Dynek JN (2010), Dynek JN (2010), Xu M (2009), Phu L (2011), Oberoi TK (2012), Bertrand MJ (2011), Guicciardi ME (2014), Takeda AN (2014), Wauer T (2015), Vu NT (2016)	11
TRAF2	1	UBC	7	enzymatic study, enzymatic study	Liu J (2011), Kanayama A (2004)	2
TNFAIP3	3	TRAF1	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Song HY (1996), Song HY (1996), Heyninck K (1999), Greenfeld H (2015), Greenfeld H (2015)	5
NR0B1	2	RNF31	3	two hybrid, two hybrid, affinity chromatography technology	Ehrlund A (2009), Ehrlund A (2009), Ehrlund A (2009)	3
RBCK1	0	UBC	7	affinity chromatography technology, affinity chromatography technology, x-ray crystallography, enzymatic study, pull down, pull down, pull down, pull down, enzymatic study, pull down	Tatematsu K (2008), Yoshimoto N (2009), Sato Y (2011), Kirisako T (2006), Haas TL (2009), Yoshimoto N (2009), Sato Y (2011), Emmerich CH (2013), Emmerich CH (2013), Zhang X (2017)	10
RNF31	3	RBCK1	0	affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, pull down	Haas TL (2009), Yagi H (2012), Yagi H (2012), Yagi H (2012), Nakamura M (2006), Tokunaga F (2012), Kirisako T (2006), Kirisako T (2006), Rivkin E (2013), Schaeffer V (2014), Tokunaga F (2011), Tokunaga F (2011), Chen Y (2015), Draber P (2015), Draber P (2015), Klein T (2015), Klein T (2015), Stieglitz B (2012), Huttlin EL (2017), Liu J (2017), Liu J (2017)	21
TRAF1	0	RBCK1	0	affinity chromatography technology, pull down, affinity chromatography technology, pull down	Li S (2011), Li S (2011), Greenfeld H (2015), Abdul-Sater AA (2017)	4
RIPK2	0	RIPK1	2	affinity chromatography technology	Damgaard RB (2012)	1
UBC	7	VCP	6	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Zhong X (2006), Dai RM (2001), Bish RA (2007), Lim JJ (2016), Zhang X (2017)	6
TLR3	2	SHARPIN	1	affinity chromatography technology	Zinngrebe J (2016)	1
VDAC1	2	NDUFA8	1	biochemical	Wan C (2015)	1
LMO2	2	RNF31	3	affinity chromatography technology	Huttlin EL (2017)	1
MAVS	1	RNF31	3	affinity chromatography technology	Khan M (2016)	1
DDX58	3	CYLD	2	affinity chromatography technology	Friedman CS (2008)	1
PRKN	1	VDAC1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Okatsu K (2012), Sun Y (2012), Sun Y (2012), Sarraf SA (2013), Ham SJ (2016), Ham SJ (2016)	6
RIPK2	0	IKBKG	0	affinity chromatography technology, affinity chromatography technology	Inohara N (2000), Hasegawa M (2008)	2
NOD2	1	TNFAIP3	3	affinity chromatography technology	Draber P (2015)	1
OTULIN	0	RBCK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rivkin E (2013), Schaeffer V (2014), Elliott PR (2014), Draber P (2015)	4
PRKN	1	ACTBL2	0	affinity chromatography technology	Zanon A (2013)	1
UBE2L3	1	RBCK1	0	two hybrid, pull down, pull down	Markson G (2009), Tatematsu K (2008), Kirisako T (2006)	3
TRAF2	1	CYLD	2	two hybrid, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kovalenko A (2003), Kovalenko A (2003), Kovalenko A (2003), Kovalenko A (2003), Yang Y (2013), Elliott PR (2016), Wu GR (2017)	7
CYLD	2	UBC	7	enzymatic study, enzymatic study, enzymatic study, pull down	Almeida S (2008), Bremm A (2010), Komander D (2009), Kwasna D (2018)	4
ATN1	2	AES	2	two hybrid	Lim J (2006)	1
BCL10	0	TRAF2	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Yoneda T (2000), Yoneda T (2000), Yoneda T (2000), Yui D (2001), Rolland T (2014)	5
UBE2D2	0	TRIM25	5	two hybrid, pull down, pull down, pull down, affinity chromatography technology	Markson G (2009), Nakajima A (2007), Ronchi VP (2012), Sanchez JG (2016), Choudhury NR (2017)	5
RNF31	3	NDUFA8	1	affinity chromatography technology	Schaeffer V (2014)	1
ESR1	0	FKBPL	1	affinity chromatography technology, affinity chromatography technology	Donley C (2013), Donley C (2013)	2
RNF31	3	VCP	6	affinity chromatography technology, pull down, x-ray crystallography, unspecified method	Schaeffer V (2014), Schaeffer V (2014), Schaeffer V (2014), Elliott PR (2014)	4
RNF31	3	ESR1	0	affinity chromatography technology, affinity chromatography technology	Zhu J (2014), Zhu J (2014)	2
TNF	0	CYLD	2	affinity chromatography technology, affinity chromatography technology	Draber P (2015), Schlicher L (2016)	2
IKBKG	0	PRKCB	4	pull down	Fenner BJ (2010)	1
RNF31	3	PDLIM7	0	affinity chromatography technology, affinity chromatography technology	Wang L (2017), Wang L (2017)	2
RABGEF1	1	BIRC2	1	affinity chromatography technology	Huttlin EL (2017)	1
SHARPIN	1	RNF31	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, biochemical	Verhelst K (2012), Keusekotten K (2013), Schaeffer V (2014), Schaeffer V (2014), Tokunaga F (2011), Tokunaga F (2011), De Franceschi N (2015), De Franceschi N (2015), De Franceschi N (2015), De Franceschi N (2015), Draber P (2015), Draber P (2015), Draber P (2015), Stieglitz B (2012), Huttlin EL (2017), Elliott PR (2016), Liu J (2017), Liu J (2017), Liu J (2017), Liu J (2017), Liu J (2017)	21
TRAF1	0	RNF31	3	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down	Li S (2011), Li S (2011), Greenfeld H (2015), Greenfeld H (2015), Greenfeld H (2015), Abdul-Sater AA (2017)	6
NOD2	1	RBCK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Damgaard RB (2012), Damgaard RB (2013), Draber P (2015)	3
HDAC6	0	UBC	7	affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology	Pai MT (2007), Pozo FM (2011), Sekimoto T (2010), Kovacs JJ (2004), Hao R (2013), Lee JH (2013), Nakashima H (2014), Banerjee I (2014), Hao R (2013), Zhang X (2017), Yu Q (2018)	11
MALT1	1	TNFAIP3	3	affinity chromatography technology	Yang Y (2014)	1
TNF	0	SPATA2	2	affinity chromatography technology	Schlicher L (2016)	1
IKBKG	0	CYLD	2	two hybrid, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Kovalenko A (2003), Kovalenko A (2003), Kovalenko A (2003), Kovalenko A (2003), Brummelkamp TR (2003), Trompouki E (2003), Chu L (2006), Shibata Y (2012), Wang J (2011), Zilberman-Rudenko J (2016), Zilberman-Rudenko J (2016)	11
UBC	7	WRNIP1	3	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down	Nathan JA (2013), Bish RA (2007), Bish RA (2007), Bish RA (2007), Bish RA (2007), Herhaus L (2015), Zhang X (2017)	7
RNF31	3	KRTAP9-2	0	two hybrid	Rolland T (2014)	1
NTRK1	1	AKAP8L	1	affinity chromatography technology	Emdal KB (2015)	1
ATN1	2	RNF31	3	two hybrid	Lim J (2006)	1
DDX58	3	IKBKG	0	affinity chromatography technology	Oshiumi H (2013)	1
IRAK1	1	BCL10	0	pull down	Dong W (2006)	1
TNFAIP3	3	IRF7	2	affinity chromatography technology, affinity chromatography technology	Ning S (2010), Ning S (2010)	2
BIRC2	1	UBE2L3	1	affinity chromatography technology	Hu S (2003)	1
SHARPIN	1	CYLD	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Draber P (2015), Draber P (2015), Elliott PR (2016)	3
NTRK1	1	KIF1A	19	affinity chromatography technology	Emdal KB (2015)	1
RNF31	3	GBP1	4	affinity chromatography technology	Huttlin EL (2017)	1
FKBPL	1	UBC	7	affinity chromatography technology	Donley C (2013)	1
RNF31	3	SMAD3	1	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
TRIM25	5	AKAP8L	1	affinity chromatography technology	Choudhury NR (2017)	1
TNFAIP3	3	TRAF2	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Song HY (1996), Song HY (1996), Fries KL (1999), Yamaguchi N (2013), Rolland T (2014)	5
RNF31	3	HDAC6	0	enzymatic study	Kliza K (2017)	1
OTULIN	0	BCL10	0	enzymatic study	Yang YK (2016)	1
TNFAIP3	3	BIRC3	1	affinity chromatography technology	Yamaguchi N (2013)	1
AZI2	1	RNF31	3	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
TRAF6	0	IRAK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Wesche H (1999), Qian Y (2001), Cao Z (1996), Takatsuna H (2003), Li S (2002), Ling L (2000), Ling L (2000), Takaesu G (2001), Muzio M (1997), Chen F (2008), Li X (2001), Li X (2001), Xiong Y (2011), Xiong Y (2011), Tang H (2010), Muroi M (2011), Liu A (2012), Lee JY (2009), Lee JY (2009), Kollewe C (2004), Jiang Z (2002), Jensen LE (2001), Liu G (2007), Liu G (2007), Jiang Z (2003), Nguyen T (2009), Choi KC (2006), Rao N (2005), Rao N (2005), Lakshmanan U (2007), Lee HJ (2012), Lee HJ (2012), Zhang X (2013), Yao J (2007), Hu MM (2014), Jeon J (2014), Conze DB (2008), Tanishima M (2017)	38
TNF	0	SHARPIN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tokunaga F (2012), Verhelst K (2012), Draber P (2015), Pescatore A (2016), Schlicher L (2016)	5
BIRC3	1	RIPK2	0	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Thome M (1998), Bertrand MJ (2009), Bertrand MJ (2009), Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011)	6
TNF	0	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Yamaguchi N (2015)	2
CYLD	2	TRAF6	0	enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology	Kovalenko A (2003), Bremm A (2010), Wu J (2015), Wu J (2015)	4
LDLRAD4	1	SMAD3	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AES	2	RNF31	3	two hybrid	Rolland T (2014)	1
PPARD	4	NR0B2	1	two hybrid	Albers M (2005)	1
LMO2	2	RBCK1	0	affinity chromatography technology	Huttlin EL (2017)	1
TNFRSF1A	3	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Hsu H (1996), Hsu H (1996), Shu HB (1996), Vince JE (2009), Mahul-Mellier AL (2011), Won M (2010), Kolliputi N (2009), Park KJ (2002), Lee IT (2010), Kim WJ (2005), Zheng L (2006), Vince JE (2007), Jeon J (2014), Chen TC (2014), Lee CK (2015), Jeong M (2017)	16
TNFAIP3	3	UBC	7	x-ray crystallography, enzymatic study, pull down, pull down, x-ray crystallography, pull down, enzymatic study, enzymatic study, enzymatic study, pull down, pull down, enzymatic study, x-ray crystallography, pull down	Bosanac I (2010), Bremm A (2010), Fenner BJ (2009), Tokunaga F (2012), Tokunaga F (2012), Verhelst K (2012), Mevissen TE (2013), Komander D (2009), Evans PC (2004), Skaug B (2011), Bohgaki M (2008), Boone DL (2004), Mevissen TE (2016), Mevissen TE (2016)	14
MALT1	1	RNF31	3	affinity chromatography technology	Yang Y (2014)	1
SMAD3	1	IRF7	2	pull down, affinity chromatography technology, imaging technique	Qing J (2004), Qing J (2004), Qing J (2004)	3
IKBKG	0	BCL10	0	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Wu CJ (2008), Wu CJ (2008), Bhattacharyya S (2010), Stilo R (2004), Poyet JL (2001), Poyet JL (2001), Park Y (2013), Zhou H (2004), Yang YK (2016)	9
MAVS	1	TRAF1	0	affinity chromatography technology	Minassian A (2015)	1
UBE2D1	0	TRAF6	0	two hybrid, pull down	Markson G (2009), Markson G (2009)	2
RIPK1	2	BIRC3	1	affinity chromatography technology, enzymatic study, enzymatic study, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study	Bertrand MJ (2008), Bertrand MJ (2008), Dynek JN (2010), Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011), Puliyappadamba VT (2013), Wu CJ (2006)	8
TNF	0	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Ea CK (2006), Tokunaga F (2012), Verhelst K (2012), Draber P (2015), Pescatore A (2016)	6
GFI1B	1	NDUFA8	1	genetic interference	Horlbeck MA (2018)	1
TRAF2	1	TRAF6	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Li S (2011), Davies CC (2005), Relaix F (1998), Rolland T (2014), Yu H (2011), Huttlin EL (2017)	7
ESR1	0	GBP1	4	affinity chromatography technology	Huttlin EL (2017)	1
RNF31	3	CCDC14	2	affinity chromatography technology	Schaeffer V (2014)	1
UBE2D1	0	TRIM25	5	two hybrid, pull down, pull down, pull down, pull down	Markson G (2009), Gack MU (2007), Wang Y (2014), Ronchi VP (2012), Wang S (2016)	5
TNFRSF1A	3	TNF	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Bouwmeester T (2004), Micheau O (2003), Legler DF (2003), Kuai J (2004), Skaug B (2011), Tokunaga F (2012), Klingseisen L (2012), Thoma B (1990), Keusekotten K (2013), Crowe PD (1994), Liu LS (1998), Higuchi M (1992), Chaturvedi MM (1994), Schaeffer V (2014), Fritsch J (2014), Chainy GB (1996), Huttlin EL (2015), Chen TC (2014), Yamaguchi N (2015), Draber P (2015), Pescatore A (2016), Huttlin EL (2017), Nielsen FS (2004), Ameloot P (2001)	24
UBE2D3	1	DDX58	3	enzymatic study	Arimoto K (2008)	1
TRAF6	0	BIRC3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mao AP (2010), Goncharov T (2013), Harikumar KB (2014), Harikumar KB (2014)	4
IKBKG	0	CARD11	4	pull down, affinity chromatography technology, affinity chromatography technology	Stilo R (2004), McCully RR (2008), Shambharkar PB (2007)	3
LTBR	0	RBCK1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LDLRAD4	1	RBCK1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SHARPIN	1	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology	Verhelst K (2012), Verhelst K (2012)	2
TRAF6	0	NOD2	1	affinity chromatography technology	Park S (2013)	1
PRKN	1	UBE2L3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down, pull down, pull down, pull down, pull down	Shimura H (2001), Imai Y (2000), Ramsey CP (2010), Sato S (2006), Chaugule VK (2011), Um JW (2012), Choi P (2003), Uchiki T (2009), Joch M (2007), Li Y (2011), Shin JH (2011), Chung KK (2001), Sato S (2006), Hampe C (2006), Um JW (2006), Chaugule VK (2011), Wang H (2011), Imam SZ (2011), Duda DM (2013), Wauer T (2013), Rankin CA (2014), Shimura H (2000), Durcan TM (2011), Wenzel DM (2011), Romani-Aumedes J (2014), Caulfield TR (2014), Koyano F (2014), Kurup PK (2015), Wauer T (2015), Song P (2016), Kumar A (2015), Lee SB (2015), Lee SB (2015), Song P (2016), Kazlauskaite A (2015), Veeriah S (2010), Park S (2017), Park S (2017), Kumar A (2017), Klosowiak JL (2016), Gersch M (2017), Tang MY (2017), Kazlauskaite A (2014), Sul JW (2013)	44
UBC	7	UBE2D3	1	affinity chromatography technology, two hybrid, x-ray crystallography, pull down, pull down, pull down	Matsumoto M (2005), Vinayagam A (2011), Pruneda JN (2014), Li Y (2014), Poyurovsky MV (2007), Zhang X (2017)	6
TNFRSF1A	3	BIRC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shu HB (1996), Vince JE (2009), Vince JE (2007), Wang YB (2015)	4
BIRC3	1	UBE2D2	0	x-ray crystallography, pull down, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down	Mace PD (2008), Mace PD (2008), Dynek JN (2010), Feltham R (2011), Dou H (2012), Li X (2002), Schumacher FR (2013), Choi JS (2014), Wu CJ (2006), Fang S (2001), Hu S (2003), Suzuki S (2017)	12
MAVS	1	BIRC2	1	affinity chromatography technology	Mao AP (2010)	1
TNF	0	OTULIN	0	affinity chromatography technology	Schaeffer V (2014)	1
NOD2	1	SHARPIN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Damgaard RB (2012), Damgaard RB (2013), Draber P (2015)	3
NOD2	1	RNF31	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Damgaard RB (2012), Damgaard RB (2013), Draber P (2015)	3
RNF31	3	PRKCA	7	enzymatic study	Queisser MA (2014)	1
RNF31	3	UBE2D3	1	pull down, pull down, pull down	Inn KS (2011), Tokunaga F (2011), Kirisako T (2006)	3
RNF31	3	PRIM1	1	affinity chromatography technology	Huttlin EL (2017)	1
OTULIN	0	VCP	6	unspecified method, biochemical	Elliott PR (2014), Elliott PR (2014)	2
PDLIM7	0	TRAF2	1	protein complementation assay, protein complementation assay	Talaty P (2011), Talaty P (2011)	2
PPARD	4	RNF31	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TNF	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Micheau O (2003), Kuai J (2004), Kuai J (2004), Haas TL (2009), Ea CK (2006), Fritsch J (2014), Yamaguchi N (2015)	7
TRAF1	0	SHARPIN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Greenfeld H (2015), Greenfeld H (2015), Abdul-Sater AA (2017), Abdul-Sater AA (2017)	4
SHARPIN	1	ESR1	0	affinity chromatography technology	Zhuang T (2017)	1
NOD2	1	UBC	7	x-ray crystallography	Ver Heul AM (2013)	1
SNTG2	2	RNF31	3	affinity chromatography technology	Huttlin EL (2017)	1
RNF31	3	RIPK1	2	affinity chromatography technology	Draber P (2015)	1
RNF31	3	DDX58	3	affinity chromatography technology, affinity chromatography technology	Inn KS (2011), Inn KS (2011)	2
DDX58	3	UBC	7	pull down, pull down	Feng M (2012), Zeng W (2010)	2
UBC	7	RABGEF1	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, two hybrid, pull down, pull down, pull down	Mattera R (2004), La Rosa P (2011), Kalesnikoff J (2007), Penengo L (2006), Sokratous K (2012), Rolland T (2014), Mattera R (2006), Zhang X (2017), Kristariyanto YA (2017)	9
CD40	3	TRAF1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pullen SS (1998), Hostager BS (2010), Hostager BS (2010)	3
UBE2D3	1	TRIM25	5	two hybrid, pull down, pull down, affinity chromatography technology	Markson G (2009), Ronchi VP (2012), Choudhury NR (2017), Choudhury NR (2017)	4
NTRK1	1	RNF31	3	affinity chromatography technology	Emdal KB (2015)	1
BIRC3	1	UBE2D3	1	affinity chromatography technology, two hybrid, pull down, pull down	Hu S (2003), Dynek JN (2010), Darding M (2011), Hu S (2003)	4
NOD2	1	BIRC3	1	affinity chromatography technology	Damgaard RB (2012)	1
TRAF6	0	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, two hybrid, enzymatic study, affinity chromatography technology, enzymatic study, two hybrid, two hybrid	Heyninck K (1999), Evans PC (2001), Lin SC (2008), Xiong Y (2011), Bremm A (2010), Kelly C (2012), Hayes SD (2012), Lin SC (2008), Garg AV (2013), Boone DL (2004), Schimmack G (2017), Schimmack G (2017)	12
BIRC2	1	UBE2D2	0	two hybrid, pull down, pull down, pull down	Dynek JN (2010), Li X (2002), Feltham R (2011), Choi YE (2009)	4
CARD11	4	RNF31	3	affinity chromatography technology, affinity chromatography technology	Yang YK (2016), Yang YK (2016)	2
GFI1B	1	TRAF1	0	two hybrid	Lim J (2006)	1
MAVS	1	IKBKG	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tang ED (2010), Li S (2011), Li S (2011), Wang L (2012), Wang L (2012), Zhou Z (2014)	6
RNF31	3	UBC	7	pull down, pull down, affinity chromatography technology, enzymatic study, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, pull down, enzymatic study, enzymatic study	Wauer T (2013), Fujita H (2014), Schaeffer V (2014), Tokunaga F (2011), Kirisako T (2006), Haas TL (2009), Emmerich CH (2013), Sakamoto H (2015), Lechtenberg BC (2016), Lechtenberg BC (2016), Stieglitz B (2012), Zhang X (2017), Kliza K (2017), Liu J (2017)	14
RNF31	3	CCDC24	1	two hybrid	Rolland T (2014)	1
HDAC6	0	DDX58	3	affinity chromatography technology, affinity chromatography technology	Choi SJ (2016), Choi SJ (2016)	2
BIRC2	1	UBC	7	pull down, pull down, pull down, pull down, enzymatic study	Dynek JN (2010), Gyrd-Hansen M (2008), Gyrd-Hansen M (2008), Komander D (2009), Sakamoto H (2015)	5
TRIM25	5	TNFRSF1A	3	affinity chromatography technology	Choudhury NR (2017)	1
TNF	0	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Legler DF (2003), Haas TL (2009), Ea CK (2006), Ramakrishnan P (2011), Skaug B (2011), Darding M (2011), Tokunaga F (2012), Klingseisen L (2012), Schaeffer V (2014), Fritsch J (2014), Yamaguchi N (2015), Draber P (2015), Pescatore A (2016), Schlicher L (2016)	14
TLR3	2	BIRC2	1	affinity chromatography technology	Zinngrebe J (2016)	1
IKBKG	0	TRAF1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Greenfeld H (2015), Greenfeld H (2015), Abdul-Sater AA (2017)	3
UBE2D2	0	UBE2L3	1	biochemical	Havugimana PC (2012)	1
AES	2	LMO2	2	two hybrid	Rolland T (2014)	1
VCP	6	TRIM25	5	affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Choudhury NR (2017)	2
TRIM25	5	UBE2L3	1	affinity chromatography technology	Choudhury NR (2017)	1
SHARPIN	1	RBCK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Verhelst K (2012), Schaeffer V (2014), Tokunaga F (2011), Tokunaga F (2011), Draber P (2015), Liu J (2017)	6
ESR1	0	KIF1A	19	two hybrid	Albers M (2005)	1
RNF31	3	UBE2L3	1	pull down, pull down, pull down	Kirisako T (2006), Greenfeld H (2015), Liu J (2017)	3
RNF31	3	TNFAIP3	3	affinity chromatography technology, affinity chromatography technology	Tokunaga F (2012), Verhelst K (2012)	2
BIRC3	1	TRAF2	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology	Uren AG (1996), Roy N (1997), Yoneda T (2000), Yoneda T (2000), Li X (2002), Behrends C (2010), Samuel T (2006), Vince JE (2009), Darding M (2011), Zheng C (2010), Zheng C (2010), Zheng C (2010), Zheng C (2010), Zheng C (2010), Rothe M (1995), Varfolomeev E (2006), Choudhary S (2013), Goncharov T (2013), Wang J (2011), Harikumar KB (2014), Shen RR (2012), Chen TC (2014), Akhtar N (2016)	23
TRIM25	5	SMAD3	1	affinity chromatography technology	Choudhury NR (2017)	1
VCP	6	ATXN1	2	affinity chromatography technology, pull down	Fujita K (2013), Fujita K (2013)	2
ATXN1	2	RNF31	3	two hybrid	Lim J (2006)	1
TNFRSF1A	3	BCL10	0	two hybrid	Costanzo A (1999)	1
NTRK1	1	RABGEF1	1	affinity chromatography technology	Emdal KB (2015)	1
PRKN	1	RBCK1	0	two hybrid	Corominas R (2014)	1
ESR1	0	SEPT2	4	pull down	Nalvarte I (2010)	1
TNFRSF1A	3	IKBKG	0	affinity chromatography technology, affinity chromatography technology	Zhang SQ (2000), Nakazawa S (2016)	2
TLR3	2	BIRC3	1	affinity chromatography technology	Zinngrebe J (2016)	1
PRKCA	7	PRKCB	4	affinity chromatography technology	Huttlin EL (2017)	1
BIRC2	1	TRAF1	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Roy N (1997), Shu HB (1996), Li X (2002), Li S (2011), Mace PD (2010), Rothe M (1995), Varfolomeev E (2006), Goncharov T (2013), Wang J (2011), Greenfeld H (2015), Huttlin EL (2017)	11
IKBKG	0	TRAF6	0	pull down, pull down, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Lamothe B (2008), Windheim M (2008), Lamothe B (2007), Gautheron J (2010), Gautheron J (2010), Hinz M (2010), Sebban-Benin H (2007), Zotti T (2014), Sun L (2004), Emmerich CH (2013), Zhou L (2014), Chen J (2015), Kim EK (2017), Medunjanin S (2016), Xing J (2016), Bal E (2017), Bal E (2017)	17
LIPF	0	RNF31	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BIRC2	1	BCL10	0	affinity chromatography technology, affinity chromatography technology	Yoneda T (2000), Hu S (2006)	2
RNF31	3	VDAC1	2	enzymatic study	Kliza K (2017)	1
NOD2	1	BIRC2	1	affinity chromatography technology	Damgaard RB (2012)	1
RNF31	3	UBE2D2	0	pull down, x-ray crystallography, pull down	Kirisako T (2006), Lechtenberg BC (2016), Lechtenberg BC (2016)	3
RNF31	3	SPATA2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Goto E (2017), Schlicher L (2016), Schlicher L (2016), Elliott PR (2016), Elliott PR (2016), Elliott PR (2016)	6
TRIM25	5	BIRC2	1	affinity chromatography technology	Choudhury NR (2017)	1
IKBKG	0	SHARPIN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique	Verhelst K (2012), Zak DE (2011), Tokunaga F (2011), Tokunaga F (2011), Emmerich CH (2013), Abdul-Sater AA (2017), Abdul-Sater AA (2017), Bal E (2017), Bal E (2017), Bal E (2017)	10
UBE2D1	0	UBC	7	x-ray crystallography	Bosanac I (2010)	1
RNF31	3	CYLD	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Draber P (2015), Draber P (2015), Draber P (2015), Goto E (2017), Schlicher L (2016), Elliott PR (2016), Elliott PR (2016), Elliott PR (2016)	8
TRAF1	0	TSSC4	2	two hybrid	Rolland T (2014)	1
PRKCA	7	HDAC6	0	affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology	Zhu J (2011), Zhu J (2011), Mertz JA (2011), Mertz JA (2011), Mertz JA (2011)	5
RNF31	3	OTULIN	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, affinity chromatography technology, pull down, unspecified method, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid	Rivkin E (2013), Rivkin E (2013), Schaeffer V (2014), Schaeffer V (2014), Schaeffer V (2014), Schaeffer V (2014), Schaeffer V (2014), Elliott PR (2014), Elliott PR (2014), Elliott PR (2014), Elliott PR (2014), Elliott PR (2014), Elliott PR (2014), Draber P (2015), Draber P (2015), Draber P (2015), Goto E (2017), Schlicher L (2016), Elliott PR (2016), Schimmack G (2017)	20
PRKN	1	MAVS	1	affinity chromatography technology, affinity chromatography technology	Khan M (2016), Khan M (2016)	2
DDX58	3	RBCK1	0	affinity chromatography technology	Inn KS (2011)	1
RIPK2	0	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	McCarthy JV (1998), LeBlanc PM (2008), Marinis JM (2011)	3
LTBR	0	TRAF1	0	pull down, affinity chromatography technology, affinity chromatography technology	Marsters SA (1997), Huttlin EL (2015), Huttlin EL (2017)	3
PRKCB	4	DDX58	3	enzymatic study, affinity chromatography technology, affinity chromatography technology	Maharaj NP (2011), Maharaj NP (2011), Maharaj NP (2011)	3
SHARPIN	1	SPATA2	2	affinity chromatography technology	Elliott PR (2016)	1
PRKCB	4	CARD11	4	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Sommer K (2005), Sommer K (2005), Sommer K (2005), Sommer K (2005)	4
NOD2	1	RIPK2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ogura Y (2001), Tao M (2009), Abbott DW (2004), Abbott DW (2004), Tigno-Aranjuez JT (2010), Tigno-Aranjuez JT (2010), Damgaard RB (2012), Marinis JM (2011), Draber P (2015)	9
RNF31	3	SOCS3	0	two hybrid	Wang J (2011)	1
RIPK2	0	RNF31	3	affinity chromatography technology	Damgaard RB (2012)	1
TRAF6	0	VDAC1	2	affinity chromatography technology	Ewing RM (2007)	1
VCP	6	WRNIP1	3	affinity chromatography technology	Yu CC (2013)	1
PRKCB	4	RBCK1	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tatematsu K (2008), Vallentin A (2007), Vallentin A (2007), Nakamura M (2006), Gustafsson Sheppard N (2012)	5
TRAF6	0	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Mao AP (2010), Hinz M (2010)	2
CARD11	4	MALT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang S (2013), Karim ZA (2015), Liu Y (2012)	3
ATXN7	0	RNF31	3	two hybrid	Kahle JJ (2011)	1
RIPK2	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology	Thome M (1998), Li S (2011)	2
TRIM25	5	ESR1	0	affinity chromatography technology, pull down, enzymatic study	Nakajima A (2007), Nakajima A (2007), Nakajima A (2007)	3
RABGEF1	1	TRAF2	1	affinity chromatography technology	Huttlin EL (2017)	1
TRAF1	0	RIPK2	0	affinity chromatography technology	Thome M (1998)	1
CYLD	2	VCP	6	affinity chromatography technology	Elliott PR (2016)	1
TRAF2	1	TSSC4	2	two hybrid	Rolland T (2014)	1
RNF31	3	IRF7	2	affinity chromatography technology	Wang L (2017)	1
TRIM25	5	DDX58	3	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Gack MU (2007), Gack MU (2007), Gack MU (2007), Gack MU (2010), Nistal-Villan E (2010), Nistal-Villan E (2010), Inn KS (2011), Inn KS (2011), Maharaj NP (2011), Oshiumi H (2013), Weng L (2014), Xia ZP (2009), Feng M (2012), Gao D (2009), Gao D (2009), Jiang J (2016), Hu Y (2017), Hu Y (2017)	18
TRAF1	0	UBC	7	affinity chromatography technology	Greenfeld H (2015)	1
TNFAIP3	3	UBE2D1	0	pull down, pull down	Wertz IE (2004), Lee JH (2017)	2
RNF31	3	ACTBL2	0	affinity chromatography technology	Huttlin EL (2017)	1
TRAF2	1	PRKN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Henn IH (2007), Henn IH (2007), Um JW (2012), Im E (2015)	4
RBCK1	0	UBE2D3	1	pull down, pull down, pull down, pull down	Zenke-Kawasaki Y (2007), Yamanaka K (2003), Inn KS (2011), Kirisako T (2006)	4
RBCK1	0	TRAF6	0	affinity chromatography technology	Tian Y (2007)	1
BIRC3	1	IKBKG	0	pull down, affinity chromatography technology	Gyrd-Hansen M (2008), Goncharov T (2013)	2
RABGEF1	1	UBE2D1	0	pull down	Kalesnikoff J (2007)	1
PRKCA	7	RBCK1	0	affinity chromatography technology, enzymatic study	Queisser MA (2014), Queisser MA (2014)	2
PDLIM7	0	RBCK1	0	affinity chromatography technology	Wang L (2017)	1
SHARPIN	1	TNFRSF1A	3	affinity chromatography technology, affinity chromatography technology	Keusekotten K (2013), Nakazawa S (2016)	2
FKBPL	1	RNF31	3	affinity chromatography technology	Huttlin EL (2017)	1
TRAF2	1	SPATA2	2	two hybrid	Rual JF (2005)	1
MAVS	1	TRAF2	1	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li S (2011), Xu LG (2005), Yu H (2011), Minassian A (2015), Khan M (2016), Fang R (2017), Fang R (2017)	7
BIRC2	1	BIRC3	1	affinity chromatography technology, affinity chromatography technology	Rajalingam K (2006), Rajalingam K (2006)	2
UBE2D2	0	DDX58	3	enzymatic study	Arimoto K (2008)	1
TLR3	2	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yang M (2011), Jiang Z (2003), Jiang Z (2003), Cusson-Hermance N (2005), Zinngrebe J (2016)	5
RNF31	3	PRIM2	1	affinity chromatography technology	Huttlin EL (2017)	1
UBC	7	UBE2L3	1	affinity chromatography technology	Bish RA (2007)	1
NTRK1	1	TRAF6	0	affinity chromatography technology, enzymatic study, affinity chromatography technology	Jadhav T (2008), Geetha T (2005), Zheng C (2015)	3
BIRC3	1	UBE2L3	1	affinity chromatography technology	Hu S (2003)	1
RABGEF1	1	ESR1	0	affinity chromatography technology	La Rosa P (2011)	1
NOS3	7	RNF31	3	two hybrid	Soler-Lopez M (2011)	1
DDX58	3	MAVS	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gack MU (2010), Gack MU (2009), Nistal-Villan E (2010), Kawai T (2005), Li S (2011), Li S (2011), Inn KS (2011), Arnaud N (2011), Maharaj NP (2011), Meylan E (2005), Xu LG (2005), Cui J (2010), Wei C (2010), Zhang H (2015), Tan P (2017)	15
VCP	6	ATXN7	0	affinity chromatography technology, pull down	Fujita K (2013), Fujita K (2013)	2
BCL10	0	CARD11	4	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bertin J (2001), Bertin J (2001), Bertin J (2001), Kojo S (2009), Welteke V (2009), Oruganti SR (2011), Langel FD (2008), McCully RR (2008), Sommer K (2005), Park Y (2013), Chen J (2015), Qiao Q (2013), Qiao Q (2013), Eitelhuber AC (2011), Yang YK (2016), Liu Y (2012), Bidere N (2009)	17
NTRK1	1	PRKCA	7	affinity chromatography technology	Emdal KB (2015)	1
TNFRSF1A	3	RBCK1	0	affinity chromatography technology	Nakazawa S (2016)	1
TRAF6	0	UBE2L3	1	pull down, pull down	Geetha T (2005), Babu JR (2005)	2
TRIM25	5	ATN1	2	affinity chromatography technology	Choudhury NR (2017)	1
RNF31	3	NR0B2	1	two hybrid	Ehrlund A (2009)	1
NOD2	1	IKBKG	0	affinity chromatography technology	Damgaard RB (2012)	1
IKBKG	0	TNFAIP3	3	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Zhang SQ (2000), Zhang SQ (2000), Skaug B (2011), Skaug B (2011), Klinkenberg M (2001), Verhelst K (2012), Verhelst K (2012), Wang J (2011), Zilberman-Rudenko J (2016)	9
CD40	3	RIPK2	0	affinity chromatography technology	McCarthy JV (1998)	1
MAVS	1	RIPK2	0	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
TNFRSF1A	3	RABGEF1	1	affinity chromatography technology	Huttlin EL (2017)	1
SOCS3	0	TRAF6	0	affinity chromatography technology, affinity chromatography technology	Frobose H (2006), Zhou X (2015)	2
TRIM25	5	RBCK1	0	affinity chromatography technology, imaging technique, pull down, enzymatic study	Inn KS (2011), Inn KS (2011), Inn KS (2011), Inn KS (2011)	4
RNF31	3	SEPT2	4	enzymatic study	Kliza K (2017)	1
LTBR	0	BIRC2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RIPK2	0	UBC	7	affinity chromatography technology	Park S (2013)	1
NTRK1	1	HDAC6	0	affinity chromatography technology	Emdal KB (2015)	1
LMO2	2	SHARPIN	1	affinity chromatography technology	Huttlin EL (2017)	1
PDLIM7	0	TRAF6	0	affinity chromatography technology, affinity chromatography technology	Uemura N (2006), Uemura N (2006)	2
BIRC3	1	RBCK1	0	affinity chromatography technology	Goncharov T (2013)	1
RNF31	3	PRKN	1	affinity chromatography technology	Khan M (2016)	1
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
NTRK1	1	VDAC1	2	affinity chromatography technology	Emdal KB (2015)	1
PITX1	2	RNF31	3	two hybrid	Corominas R (2014)	1
NOD2	1	RIPK1	2	affinity chromatography technology	Damgaard RB (2012)	1
NR0B2	1	TRAF6	0	affinity chromatography technology	Yuk JM (2011)	1
TRAF1	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Takeuchi M (1996), Li S (2011), Li S (2011), Fries KL (1999), He L (2004), Zheng C (2010), Zheng C (2010), Relaix F (1998), Relaix F (1998), Jang HD (2001), Fotin-Mleczek M (2004), Pullen SS (1998), Wicovsky A (2009), Rothe M (1994), Rothe M (1994), Chen TC (2014), Greenfeld H (2015), Huttlin EL (2017)	19
TRAF6	0	VCP	6	affinity chromatography technology	Ewing RM (2007)	1
IRAK1	1	RNF31	3	affinity chromatography technology	Yang Y (2014)	1
SMAD3	1	PITX1	2	affinity chromatography technology	Lamba P (2008)	1
NTRK1	1	PRIM2	1	affinity chromatography technology	Emdal KB (2015)	1
SEPT2	4	VASN	2	biochemical	Havugimana PC (2012)	1
TLR3	2	IKBKG	0	affinity chromatography technology	Zinngrebe J (2016)	1
PRIM1	1	PRIM2	1	biochemical, affinity chromatography technology	Havugimana PC (2012), Huttlin EL (2017)	2
BIRC3	1	RNF31	3	affinity chromatography technology	Goncharov T (2013)	1
RBCK1	0	UBE2D1	0	pull down	Kirisako T (2006)	1
TNFRSF1A	3	TRAF6	0	affinity chromatography technology	Chang YL (2014)	1
IRF7	2	MAVS	1	affinity chromatography technology	Xu LG (2005)	1
CD40	3	TRAF6	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Tsukamoto N (1999), Roy N (1997), Davies CC (2005), Pullen SS (1998), Peters AL (2010), Ye H (2002), Deregibus MC (2003), Basaki Y (2002), Zhang W (2010), Zhang W (2010), He B (2010), Hostager BS (2010), Hostager BS (2010), Verstak B (2014)	14
IKBKG	0	MALT1	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Duewel M (2009), Gyrd-Hansen M (2008), Oeckinghaus A (2007), Karim ZA (2015)	4
CD40	3	BIRC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Werneburg BG (2001), Peters AL (2010), Hostager BS (2010), Hostager BS (2010)	4
BIRC2	1	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Tang ED (2003), Hinz M (2010), Hinz M (2010), Shibata Y (2012), Goncharov T (2013), Fu J (2013)	6
ARHGEF10	4	RNF31	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRAF6	0	IRF7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kawai T (2004), Young JA (2011), Hu Y (2011), Ning S (2008), Ning S (2008), Naiki Y (2015), Naiki Y (2015)	7
ENDOV	3	RNF31	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ZNF785	0	RNF31	3	affinity chromatography technology	Huttlin EL (2017)	1
IRAK1	1	TNFAIP3	3	affinity chromatography technology	Xiong Y (2011)	1
BIRC3	1	UBE2D1	0	affinity chromatography technology, two hybrid, pull down, pull down, pull down, pull down	Hu S (2003), Dynek JN (2010), Dynek JN (2010), Bertrand MJ (2011), Hu S (2006), Guicciardi ME (2014)	6
TNFRSF1A	3	TRAF1	0	affinity chromatography technology, pull down, affinity chromatography technology	Hsu H (1996), Mosialos G (1995), Wicovsky A (2009)	3
TRAF2	1	UBE2D1	0	pull down	Alvarez SE (2010)	1
NTRK1	1	VCP	6	affinity chromatography technology	Emdal KB (2015)	1
TLR3	2	RNF31	3	affinity chromatography technology	Zinngrebe J (2016)	1
ATXN7	0	TRAF2	1	two hybrid	Kahle JJ (2011)	1
PRKCB	4	RNF31	3	affinity chromatography technology, enzymatic study, affinity chromatography technology	Nakamura M (2006), Nakamura M (2006), Nakamura M (2006)	3
NTRK1	1	WRNIP1	3	affinity chromatography technology	Emdal KB (2015)	1
BCL10	0	RNF31	3	affinity chromatography technology, affinity chromatography technology	Yang YK (2016), Yang YK (2016)	2
PRKN	1	UBC	7	enzymatic study, imaging technique, enzymatic study, fluorescent resonance energy transfe, pull down, pull down, pull down, pull down, x-ray crystallography, imaging technique, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, enzymatic study, enzymatic study, pull down, x-ray crystallography, enzymatic study	Kondapalli C (2012), Kane LA (2014), Kane LA (2014), Koyano F (2014), Zheng X (2013), Shiba-Fukushima K (2014), Shiba-Fukushima K (2014), Kumar A (2015), Kumar A (2015), Okatsu K (2015), Okatsu K (2015), Okatsu K (2015), Yamano K (2015), Fiesel FC (2015), Ordureau A (2015), Kazlauskaite A (2015), Kazlauskaite A (2015), Kumar A (2017), Kliza K (2017)	19
TRIM25	5	LTBR	0	affinity chromatography technology	Choudhury NR (2017)	1
KIF1A	19	TRAF1	0	two hybrid	Corominas R (2014)	1
NR0B2	1	HDAC6	0	pull down	Gobinet J (2005)	1
LTBR	0	TRAF2	1	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marsters SA (1997), Sanjo H (2010), Sanjo H (2010), Li C (2003), Liu HP (2011), Huttlin EL (2015), Huttlin EL (2017)	7
MAVS	1	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li S (2011), Wang Y (2012), Xu LG (2005), Wang P (2013), Wang P (2013), Shi Z (2015), Shi Z (2015), Minassian A (2015), Khan M (2016), Fang R (2017), Fang R (2017)	11
RIPK1	2	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Inohara N (2000), Li H (2006), Ea CK (2006), Dynek JN (2010), Skaug B (2011), Wagner S (2008), Wu CJ (2006), Legarda-Addison D (2009), Yang Y (2011), Bohgaki M (2008), Lucas PC (2001), Biton S (2011), Zhu G (2007), Zhu G (2007), Keusekotten K (2013), Jeon J (2014), Wu CJ (2006), Vincendeau M (2016), Baratchian M (2016), Zilberman-Rudenko J (2016), Medunjanin S (2016), Bal E (2017), Bal E (2017)	23
DDX58	3	WRNIP1	3	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology	Li S (2011), Li S (2011), Tan P (2017), Tan P (2017), Tan P (2017)	5
RABGEF1	1	RNF31	3	affinity chromatography technology	Huttlin EL (2017)	1
LTBR	0	SHARPIN	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FKBPL	1	RBCK1	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Donley C (2013), Donley C (2013), Donley C (2013), Huttlin EL (2017)	4
RIPK1	2	TNFRSF1A	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim JW (2000), Duan H (1997), Hsu H (1996), Blankenship JW (2009), Newton K (2008), Varfolomeev E (2008), Fearns C (2006), Vince JE (2009), Dynek JN (2010), Kim S (2010), Cheung HH (2009), Tenev T (2011), Mahul-Mellier AL (2011), Won M (2010), Glowacka WK (2012), Fan YH (2011), Cusson-Hermance N (2005), ODonnell MA (2012), Zheng L (2006), Vince JE (2007), Mitsuhashi S (2008), Kim TW (2013), Wertz IE (2004), Liao W (2008), Wang YB (2015), Chang YL (2014), Zilberman-Rudenko J (2016), Zemirli N (2014), Moquin DM (2013), Nakazawa S (2016), Jeong M (2017), Huttlin EL (2017), Elliott PR (2016)	33
RNF31	3	RNF31	3	affinity chromatography technology	Elliott PR (2014)	1
IKBKG	0	IRAK1	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Conze DB (2008), Conze DB (2008), Windheim M (2008), Windheim M (2008), Ordureau A (2008), Xiong Y (2011), Jeon J (2014), Emmerich CH (2013)	8
RIPK2	0	TNFRSF1A	3	affinity chromatography technology	McCarthy JV (1998)	1
RBCK1	0	UBE2D2	0	pull down	Kirisako T (2006)	1
TNFRSF1A	3	BIRC3	1	affinity chromatography technology, affinity chromatography technology	Blankenship JW (2009), Vince JE (2009)	2
UBC	7	IKBKG	0	pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, x-ray crystallography, pull down, unspecified method, x-ray crystallography, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Dynek JN (2010), Dynek JN (2010), Chiaravalli J (2011), Laplantine E (2009), Hubeau M (2011), Lo YC (2009), Ikeda F (2010), Cordier F (2009), Cordier F (2009), Cordier F (2009), Renner F (2011), Fenner BJ (2009), Fenner BJ (2009), Ivins FJ (2009), Rahighi S (2009), Rahighi S (2009), Zhu G (2007), Zhu G (2007), Niu J (2011), Keusekotten K (2013), van Wijk SJ (2013), Hooper C (2014), Wagner S (2008), Saul VV (2014), Gleason CE (2011), Komander D (2009), Kensche T (2012), Skaug B (2011), Ea CK (2006), Ea CK (2006), Lo YC (2009), Laplantine E (2009), Laplantine E (2009), Emmerich CH (2013), Dubosclard V (2015), Vincendeau M (2015), Vincendeau M (2016), Zhang X (2017), Fang R (2017), Kliza K (2017), Joo D (2016), Fang R (2017), Hauenstein AV (2017)	43
ATXN1	2	TRAF2	1	two hybrid, affinity chromatography technology, two hybrid	Lim J (2006), Lim J (2006), Rolland T (2014)	3
RNF31	3	TNFRSF1A	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Draber P (2015), Nakazawa S (2016), Elliott PR (2016)	3
UBE2D2	0	UBC	7	x-ray crystallography, x-ray crystallography, enzymatic study, pull down, pull down	Juang YC (2012), Dou H (2012), Sheng Y (2012), Buetow L (2015), Zhang X (2017)	5
RIPK2	0	BIRC2	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	McCarthy JV (1998), Thome M (1998), Bertrand MJ (2009), Bertrand MJ (2009), Bertrand MJ (2009), Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011)	8
BIRC2	1	TRAF2	1	two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique, enzymatic study, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Uren AG (1996), Roy N (1997), Shu HB (1996), Yoneda T (2000), Yoneda T (2000), Li X (2002), Li X (2002), Li X (2002), Behrends C (2010), Samuel T (2006), Samuel T (2006), Samuel T (2006), Silke J (2005), Wu CJ (2005), Vince JE (2009), Csomos RA (2009), Li S (2011), Darding M (2011), Sanjo H (2010), Mace PD (2010), Choi JW (2009), Kanno Y (2010), Jang HD (2001), Rothe M (1995), Rothe M (1995), Cartier J (2011), Varfolomeev E (2006), Varfolomeev E (2006), Shen RR (2012), Shen RR (2012), Goncharov T (2013), Wang J (2011), Marivin A (2013), Shen RR (2012), Park ES (2015), Wang YB (2015), Chen TC (2014), Petersen SL (2015), Huttlin EL (2017), Akhtar N (2016)	41
MALT1	1	TRAF2	1	pull down, affinity chromatography technology	Sun L (2004), Garrison JB (2009)	2
IRF7	2	IRAK1	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, enzymatic study	Li S (2011), Li S (2011), Uematsu S (2005), Uematsu S (2005), Uematsu S (2005), Uematsu S (2005)	6
MALT1	1	RBCK1	0	enzymatic study	Klein T (2015)	1
MALT1	1	TRAF6	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sun L (2004), Sun L (2004), Garrison JB (2009), Li Y (2013), Oeckinghaus A (2007), Oeckinghaus A (2007), Nie Z (2015), Liu Y (2012), Liu Y (2012)	9
TRAF2	1	RIPK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Takeuchi M (1996), Tada K (2001), Hsu H (1996), Hsu H (1996), Malinin NL (1997), Knox PG (2011), Ea CK (2006), Chang EJ (2011), Vince JE (2009), Alvarez SE (2010), Jang HD (2001), Shen RR (2012), Shen RR (2012), Puliyappadamba VT (2013), Hu MM (2014), Jeon J (2014), Rolland T (2014), Park ES (2015), Petersen SL (2015), Lin B (2016), Lin B (2016)	21
RBCK1	0	RIPK1	2	affinity chromatography technology	Tian Y (2007)	1
UBE2D1	0	DDX58	3	enzymatic study	Arimoto K (2008)	1
TRAF2	1	IKBKG	0	affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tang ED (2003), Poyet JL (2000), Shen RR (2012), Shen RR (2012), Bal E (2017), Bal E (2017)	6
TRAF6	0	TRIM25	5	two hybrid	Woodsmith J (2012)	1
CYLD	2	BIRC2	1	affinity chromatography technology	Elliott PR (2016)	1
AES	2	SNRPC	0	two hybrid	Rolland T (2014)	1
MALT1	1	BCL10	0	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Uren AG (2000), Uren AG (2000), Uren AG (2000), Noels H (2009), Carvalho G (2010), Welteke V (2009), Oruganti SR (2011), Lucas PC (2001), Langel FD (2008), Langel FD (2008), Blonska M (2007), Oeckinghaus A (2007), Park Y (2013), Park Y (2013), Borthakur A (2013), Zhou H (2004), Zhou H (2004), Chen J (2015), Karim ZA (2015), Nie Z (2015), Eitelhuber AC (2011), Paul S (2012), Yang YK (2016), Liu Y (2012), Bidere N (2009), Bidere N (2009), Afonina IS (2016), Howes A (2016)	28
BIRC3	1	UBC	7	pull down, pull down, enzymatic study	Gyrd-Hansen M (2008), Nakatani Y (2012), Sakamoto H (2015)	3
RABGEF1	1	UBE2D3	1	pull down	Xu L (2010)	1
TRAF6	0	CARD11	4	affinity chromatography technology	McCully RR (2008)	1
RNF31	3	VASN	2	two hybrid	Rolland T (2014)	1
IQCN	0	RNF31	3	affinity chromatography technology	Huttlin EL (2017)	1
NOD2	1	CYLD	2	affinity chromatography technology	Draber P (2015)	1
BIRC2	1	UBE2D3	1	affinity chromatography technology, two hybrid, pull down	Hu S (2003), Dynek JN (2010), Hu S (2003)	3
RNF31	3	AKAP8L	1	affinity chromatography technology	Schaeffer V (2014)	1
UBE2D3	1	TRAF6	0	two hybrid, enzymatic study, pull down, pull down, pull down	Markson G (2009), Petroski MD (2007), Xia ZP (2009), Markson G (2009), Wauer T (2015)	5
BIRC3	1	BCL10	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Yoneda T (2000), Hu S (2006), Yui D (2001), Hu S (2006), Hu S (2006), Hu S (2006), Hu S (2006)	7
LTBR	0	IKBKG	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2D1	0	HDAC6	0	enzymatic study	Hoeller D (2007)	1
TRAF1	0	RIPK1	2	affinity chromatography technology, affinity chromatography technology, two hybrid	Hsu H (1996), Wicovsky A (2009), Rolland T (2014)	3
RNF31	3	WRNIP1	3	affinity chromatography technology	Schaeffer V (2014)	1
TRIM25	5	UBC	7	enzymatic study	Sanchez JG (2016)	1
NR0B2	1	ESR1	0	two hybrid, pull down, pull down	Seol W (1998), Seol W (1998), Klinge CM (2002)	3
PRKN	1	UBE2D3	1	pull down, pull down, pull down	Shin JH (2011), Wenzel DM (2011), Kazlauskaite A (2014)	3
MAVS	1	WRNIP1	3	affinity chromatography technology, imaging technique	Tan P (2017), Tan P (2017)	2
TRAF2	1	CD40	3	x-ray crystallography, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	McWhirter SM (1999), Tsukamoto N (1999), Malinin NL (1997), Knox PG (2011), Davies CC (2005), Pullen SS (1998), Werneburg BG (2001), Peters AL (2010), Boucher LM (1997), Graham JP (2009), Deregibus MC (2003), Yacoub D (2010), Hostager BS (1999), Basaki Y (2002), Zhang W (2010), Zhang W (2010), He B (2010), Rolland T (2014), Hostager BS (2010), Hostager BS (2010), Yao X (2016)	21
TSSC4	2	RNF31	3	two hybrid	Rolland T (2014)	1
TNF	0	RNF31	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Tokunaga F (2012), Verhelst K (2012), Keusekotten K (2013), Fu J (2013), Schaeffer V (2014), Draber P (2015)	7
UBE2D2	0	TRAF6	0	two hybrid, pull down	Markson G (2009), Markson G (2009)	2
NTRK1	1	SEPT2	4	affinity chromatography technology	Emdal KB (2015)	1
RNF31	3	TRAF6	0	enzymatic study	Kliza K (2017)	1
UBC	7	SHARPIN	1	pull down	Zhang X (2017)	1
SNRPC	0	RNF31	3	two hybrid	Rolland T (2014)	1
OTULIN	0	UBC	7	enzymatic study, x-ray crystallography, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down	Keusekotten K (2013), Keusekotten K (2013), Rivkin E (2013), Schaeffer V (2014), Mevissen TE (2013), Wauer T (2015), Kliza K (2017), Kwasna D (2018)	8
TRIM25	5	PPARD	4	affinity chromatography technology	Choudhury NR (2017)	1
RIPK1	2	UBC	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao L (2015), Ding Z (2015), Varfolomeev E (2015)	3
KIF1A	19	RNF31	3	two hybrid	Corominas R (2014)	1
RNF31	3	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Tokunaga F (2012), Verhelst K (2012), Niu J (2011), Fujita H (2014), Tokunaga F (2011), Tokunaga F (2011), Xia ZP (2009), Fu J (2013), Emmerich CH (2013), Chen Y (2015), Bal E (2017)	11
TNFAIP3	3	RBCK1	0	affinity chromatography technology, two hybrid	Verhelst K (2012), Hayes SD (2012)	2
TRAF1	0	TRAF6	0	two hybrid, two hybrid, two hybrid, affinity chromatography technology	Wang J (2011), Rolland T (2014), Yu H (2011), Huttlin EL (2017)	4
RABGEF1	1	RBCK1	0	affinity chromatography technology	Huttlin EL (2017)	1
GFI1B	1	AES	2	two hybrid	Lim J (2006)	1
UBC	7	VDAC1	2	affinity chromatography technology	Matsumoto M (2005)	1
SMAD3	1	ESR1	0	affinity chromatography technology	Ito I (2010)	1
TLR3	2	RBCK1	0	affinity chromatography technology	Zinngrebe J (2016)	1
BIRC2	1	TNFAIP3	3	affinity chromatography technology	Yamaguchi N (2013)	1
TNFRSF1A	3	PRKCB	4	affinity chromatography technology	Kilpatrick LE (2000)	1
PRKN	1	UBE2D2	0	pull down, pull down, pull down, pull down, pull down, pull down	Joch M (2007), Imai Y (2002), Chaugule VK (2011), Durcan TM (2011), Caulfield TR (2014), Kazlauskaite A (2014)	6
RIPK1	2	TNFAIP3	3	affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study	Shembade N (2009), Wertz IE (2004), Wertz IE (2004), Wertz IE (2004), Shembade N (2008), Bellail AC (2012)	6
LDLRAD4	1	RNF31	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TNF	0	UBC	7	affinity chromatography technology, affinity chromatography technology	Haas TL (2009), Fritsch J (2014)	2
GFI1B	1	RNF31	3	two hybrid	Lim J (2006)	1
AES	2	TRAF2	1	two hybrid	Rolland T (2014)	1