PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PAK2	0	SFN	1	biochemical	Kristensen AR (2012)	1
TCEANC2	0	UBE2R2	2	affinity chromatography technology	Huttlin EL (2017)	1
PAK2	0	UBE2R2	2	biochemical	Kristensen AR (2012)	1
CTNNB1	30	EZR	8	affinity chromatography technology	Hiscox S (1999)	1
UBE2R2	2	FBXW5	6	two hybrid	Vinayagam A (2011)	1
C9orf78	0	NUBP2	0	biochemical	Kristensen AR (2012)	1
RBX1	2	UBE2D2	0	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Pick E (2007), Lan L (2012), Tsai WB (2010), Hrecka K (2007), Okuda H (2001), Tai T (2006), Ahn J (2011), Gong B (2010), Lu Y (2012), Ohta A (2013), da Silva Almeida AC (2013), Delucia M (2013), Scott DC (2014), Camp ND (2012), Kim S (2014), Theurillat JP (2014), Kigoshi Y (2011), Pashkova N (2010), Beck J (2013), Pierce WK (2015), Wu K (2016), Parameswaran B (2015), Simo S (2013), Groisman R (2006), Marzahn MR (2016), Courtheoux T (2016), Hasanov E (2017), Ferretti LP (2016), Zhou X (2017), Kroenke J (2014), Mulvaney KM (2016)	31
UBA1	1	UBE2R2	2	pull down, enzymatic study	Jin J (2007), Huguenin-Dezot N (2016)	2
RAD23A	1	UBC	7	pull down, pull down, x-ray crystallography, pull down, x-ray crystallography, affinity chromatography technology, pull down, pull down, unspecified method, pull down, pull down, pull down, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, pull down, pull down, x-ray crystallography, pull down, pull down	Kang Y (2006), Sims JJ (2009), Kang Y (2007), Kang Y (2007), Wang Q (2003), Scanlon TC (2009), Raasi S (2003), Sokratous K (2012), Varadan R (2005), Fenner BJ (2009), Raasi S (2005), Massey LK (2004), Chen L (2006), Nathan JA (2013), Nathan JA (2013), Jung J (2014), Goh AM (2008), Castaneda CA (2013), Nakasone MA (2013), Lai MY (2012), Kristariyanto YA (2015), Zhang X (2017)	22
UBR7	0	NUBP2	0	biochemical	Kristensen AR (2012)	1
UBE2R2	2	ARHGDIA	3	two hybrid	Vinayagam A (2011)	1
UBE2R2	2	RNF113B	1	two hybrid	Markson G (2009)	1
GNPDA1	1	UBE2R2	2	biochemical	Kristensen AR (2012)	1
CBLC	1	UBE2D2	0	pull down, pull down	Ryan PE (2010), Kim M (2004)	2
DRG2	0	UBE2R2	2	biochemical	Kristensen AR (2012)	1
YWHAH	0	PAK2	0	biochemical	Kristensen AR (2012)	1
UBE2R2	2	PNPLA2	2	two hybrid	Vinayagam A (2011)	1
BTRC	1	YWHAG	5	affinity chromatography technology	Coyaud E (2015)	1
EZR	8	UBE2R2	2	biochemical	Kristensen AR (2012)	1
ARHGDIA	3	EZR	8	biochemical, biochemical	Gajate C (2005), Wan C (2015)	2
UBE2R2	2	INF2	5	two hybrid	Vinayagam A (2011)	1
BATF3	0	UBE2R2	2	affinity chromatography technology	Huttlin EL (2017)	1
UBE2R2	2	ARIH2	4	two hybrid	Markson G (2009)	1
UBE2D2	0	MUL1	1	two hybrid, pull down, pull down, pull down	van Wijk SJ (2009), Braschi E (2009), Li W (2008), Ni G (2017)	4
UBC	7	UBA1	1	affinity chromatography technology, unspecified method, x-ray crystallography, biochemical, affinity chromatography technology, pull down	Nicassio F (2007), Zhao B (2012), Schaefer A (2014), Schaefer A (2014), Bish RA (2007), Zhang X (2017)	6
RBX1	2	UBE2R2	2	pull down, pull down	Pierce NW (2013), Hill S (2016)	2
UBE2D2	0	ARIH2	4	two hybrid	Markson G (2009)	1
FBXW11	2	YWHAE	0	affinity chromatography technology, affinity chromatography technology	Kim TY (2014), Coyaud E (2015)	2
YWHAG	5	SFN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Benzinger A (2005), Benzinger A (2005), Huttlin EL (2015), Huttlin EL (2017)	4
PRKN	1	UBE2R2	2	pull down	Kazlauskaite A (2014)	1
UBE2R2	2	DTX3L	1	two hybrid	Markson G (2009)	1
FBXW11	2	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Suzuki H (2000), Suzuki H (2000), Sowa ME (2009), Sowa ME (2009), Coyaud E (2015), Coyaud E (2015), Coyaud E (2015), Huttlin EL (2017), Liu X (2017)	9
CTNNB1	30	PRKN	1	affinity chromatography technology, affinity chromatography technology	Lin DC (2015), Lin DC (2015)	2
UBE2R2	2	WDR4	4	biochemical	Kristensen AR (2012)	1
FBXW11	2	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Watanabe N (2005), Fuchs SY (1999), Gao D (2011), DAnnibale S (2014), Kim TY (2014), Coyaud E (2015), Low TY (2014), Low TY (2014)	8
APPBP2	3	MUL1	1	two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009)	2
UBE2R2	2	SFN	1	biochemical	Kristensen AR (2012)	1
UBE2R2	2	DZIP3	6	two hybrid	Markson G (2009)	1
GNPDA1	1	EZR	8	biochemical	Kristensen AR (2012)	1
SFN	1	CTNNB1	30	affinity chromatography technology	Mancini M (2015)	1
UBE2R2	2	CBLC	1	two hybrid	Markson G (2009)	1
UBA1	1	UBE2D2	0	enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Tokgoez Z (2012), Jin J (2007), Choi JS (2014), Huang DT (2009), Kang D (2002), Kumar B (2010), Liu X (2017), Huguenin-Dezot N (2016)	8
CBLC	1	UBC	7	enzymatic study	Kim M (2004)	1
UBE2R2	2	RAD23A	1	biochemical	Kristensen AR (2012)	1
KRAS	1	UBE2R2	2	genetic interference	Luo J (2009)	1
RAD23A	1	PRKN	1	enzymatic study, affinity chromatography technology	Scanlon TC (2009), Sarraf SA (2013)	2
MEOX1	0	UBE2R2	2	two hybrid	Rolland T (2014)	1
UBE2R2	2	YWHAH	0	biochemical	Kristensen AR (2012)	1
UBE2D2	0	BTRC	1	enzymatic study	Cenciarelli C (1999)	1
UBE2R2	2	UBE2R2	2	enzymatic study, pull down	David Y (2010), David Y (2010)	2
FBXW11	2	UBE2R2	2	affinity chromatography technology, affinity chromatography technology	Coyaud E (2015), Low TY (2014)	2
RBX1	2	BTRC	1	affinity chromatography technology, affinity chromatography technology, bioid	Tan M (2010), Oshikawa K (2003), Coyaud E (2015)	3
UBE2R2	2	UBE2D2	0	biochemical	Wan C (2015)	1
UBE2R2	2	BTRC	1	pull down, affinity chromatography technology, bioid	Semplici F (2002), Coyaud E (2015), Coyaud E (2015)	3
FBXW11	2	RBX1	2	affinity chromatography technology	Tan P (1999)	1
PRKN	1	YWHAH	0	affinity chromatography technology, affinity chromatography technology	Sato S (2006), Sato S (2006)	2
CTNNB1	30	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, protein complementation assay, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, enzymatic study, protein complementation assay, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yang J (2006), Yang J (2006), Cong F (2003), Kitagawa M (1999), Kitagawa M (1999), Kitagawa M (1999), Hart M (1999), Hart M (1999), Hart M (1999), Su Y (2008), Winston JT (1999), Peschiaroli A (2010), Latres E (1999), Liu J (2004), Dorrello NV (2006), Godin JD (2010), Guardavaccaro D (2008), Evrard-Todeschi N (2008), Saha A (2008), Saha A (2008), Chen CH (2012), Wei S (2008), Dehan E (2009), Wang D (2011), Gao D (2011), Li VS (2012), Sahasrabuddhe AA (2014), Mbom BC (2014), Mbom BC (2014), Kovacev J (2014), Gao C (2014), Kluge SF (2013), Chong RA (2014), Herrero-Ruiz J (2014), Zhang L (2012), Coyaud E (2015), Loveless TB (2015), Low TY (2014), Coyaud E (2015), Tseng RC (2015), Wu K (2016), Villalobos V (2010), Pierce NW (2009), Shrestha H (2016), Gu JJ (2016), Vaid M (2011)	46
KRAS	1	UBA1	1	genetic interference	Luo J (2009)	1
FBXW11	2	UBA1	1	affinity chromatography technology	Low TY (2014)	1
MUL1	1	UBC	7	enzymatic study	Braschi E (2009)	1
UBE2R2	2	UBR7	0	biochemical	Kristensen AR (2012)	1
UBC	7	MAEA	3	affinity chromatography technology	Matsumoto M (2005)	1
RAD23A	1	UBA1	1	affinity chromatography technology, affinity chromatography technology	Chen L (2006), Chen L (2006)	2
YWHAG	5	UBC	7	affinity chromatography technology	Jin J (2004)	1
SIRT7	1	ARHGDIA	3	affinity chromatography technology	Tsai YC (2012)	1
UBE2R2	2	C9orf78	0	biochemical	Kristensen AR (2012)	1
FBXW11	2	YWHAG	5	affinity chromatography technology	Coyaud E (2015)	1
UBE2R2	2	UBC	7	two hybrid, enzymatic study	Vinayagam A (2011), Hill S (2016)	2
DTX3L	1	UBE2D2	0	affinity chromatography technology, two hybrid, pull down	Takeyama K (2003), Markson G (2009), Yan Q (2009)	3
IRF9	0	UBE2R2	2	affinity chromatography technology	Huttlin EL (2017)	1
UBE2R2	2	YWHAG	5	biochemical	Kristensen AR (2012)	1
GNPDA1	1	RAD23A	1	biochemical	Kristensen AR (2012)	1
SIRT7	1	UBE2R2	2	affinity chromatography technology	Mo Y (2017)	1
UBE2R2	2	CTNNB1	30	enzymatic study	Hill S (2016)	1
GNPDA1	1	NUBP2	0	biochemical	Kristensen AR (2012)	1
APPBP2	3	UBE2R2	2	two hybrid	Rolland T (2014)	1
PAK2	0	YWHAE	0	biochemical	Kristensen AR (2012)	1
PRKN	1	YWHAE	0	affinity chromatography technology	Zanon A (2013)	1
UBE2R2	2	MAEA	3	enzymatic study	Lampert F (2018)	1
PRKN	1	UBC	7	enzymatic study, imaging technique, enzymatic study, fluorescent resonance energy transfe, pull down, pull down, pull down, pull down, x-ray crystallography, imaging technique, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, enzymatic study, enzymatic study, pull down, x-ray crystallography, enzymatic study	Kondapalli C (2012), Kane LA (2014), Kane LA (2014), Koyano F (2014), Zheng X (2013), Shiba-Fukushima K (2014), Shiba-Fukushima K (2014), Kumar A (2015), Kumar A (2015), Okatsu K (2015), Okatsu K (2015), Okatsu K (2015), Yamano K (2015), Fiesel FC (2015), Ordureau A (2015), Kazlauskaite A (2015), Kazlauskaite A (2015), Kumar A (2017), Kliza K (2017)	19
YWHAE	0	YWHAH	0	two hybrid, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Bandyopadhyay S (2010), Gloeckner CJ (2007), Kristensen AR (2012), Wan C (2015), Hein MY (2015)	5
UBC	7	BTRC	1	affinity chromatography technology, enzymatic study	Matsumoto M (2005), Kumar KG (2007)	2
UBE2D2	0	DZIP3	6	two hybrid, pull down	Markson G (2009), Zhou W (2008)	2
ARIH2	4	UBC	7	enzymatic study	Marteijn JA (2009)	1
UBC	7	APPBP2	3	affinity chromatography technology	Matsumoto M (2005)	1
UBE2D2	0	UBC	7	x-ray crystallography, x-ray crystallography, enzymatic study, pull down, pull down	Juang YC (2012), Dou H (2012), Sheng Y (2012), Buetow L (2015), Zhang X (2017)	5
UBE2R2	2	YWHAE	0	biochemical	Kristensen AR (2012)	1
BTRC	1	YWHAE	0	affinity chromatography technology	Coyaud E (2015)	1
MUL1	1	UBE2R2	2	pull down	Ni G (2017)	1
KRAS	1	BTRC	1	affinity chromatography technology	Shukla S (2014)	1
PRKN	1	MEOX1	0	two hybrid	Corominas R (2014)	1
YWHAG	5	YWHAE	0	two hybrid, affinity chromatography technology, two hybrid, biochemical	Bandyopadhyay S (2010), Gloeckner CJ (2007), Wang J (2011), Wan C (2015)	4
PAK2	0	YWHAG	5	biochemical	Kristensen AR (2012)	1
C9orf78	0	UBR7	0	biochemical	Kristensen AR (2012)	1
UBE2R2	2	NUBP2	0	biochemical	Kristensen AR (2012)	1
PRKN	1	UBE2D2	0	pull down, pull down, pull down, pull down, pull down, pull down	Joch M (2007), Imai Y (2002), Chaugule VK (2011), Durcan TM (2011), Caulfield TR (2014), Kazlauskaite A (2014)	6
YWHAG	5	YWHAH	0	biochemical, biochemical, affinity chromatography technology	Kristensen AR (2012), Wan C (2015), Hein MY (2015)	3
UBA1	1	EZR	8	biochemical	Kristensen AR (2012)	1