PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
XPO1	8	CHMP4C	1	affinity chromatography technology	Kirli K (2015)	1
FGFR1OP	0	SPICE1	2	affinity chromatography technology	Hein MY (2015)	1
CEP135	2	CEP152	2	bioid	Gupta GD (2015)	1
CEP104	4	CEP162	3	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
CNTRL	5	CEP170	4	bioid	Gupta GD (2015)	1
MRAP2	0	CC2D1A	1	affinity chromatography technology	Huttlin EL (2017)	1
CEP162	3	CEP170	4	affinity chromatography technology, affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
CEP128	1	CEP170	4	bioid	Gupta GD (2015)	1
CEP152	2	CC2D1A	1	bioid	Gupta GD (2015)	1
STIL	3	CC2D1A	1	bioid	Gupta GD (2015)	1
TSPAN3	0	CC2D1A	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FGFR1OP	0	CEP170	4	affinity chromatography technology	Hein MY (2015)	1
SPICE1	2	PCM1	5	affinity chromatography technology, bioid, bioid, affinity chromatography technology	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Huttlin EL (2017)	4
CEP152	2	FGFR1OP	0	bioid	Gupta GD (2015)	1
CEP128	1	NINL	1	bioid	Gupta GD (2015)	1
CEP170	4	NIN	4	affinity chromatography technology, bioid, affinity chromatography technology	Huttlin EL (2015), Gupta GD (2015), Huttlin EL (2017)	3
CEP162	3	OFD1	3	affinity chromatography technology, affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
CEP104	4	OFD1	3	bioid	Gupta GD (2015)	1
CC2D1A	1	LRWD1	1	biochemical	Wan C (2015)	1
CEP19	0	CC2D1A	1	bioid	Gupta GD (2015)	1
PCM1	5	CEP170	4	affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
SPICE1	2	CEP44	2	bioid	Gupta GD (2015)	1
CEP128	1	PCM1	5	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
CEP128	1	SPICE1	2	bioid	Gupta GD (2015)	1
CHMP4C	1	CC2D1A	1	two hybrid	Tsang HT (2006)	1
XPO1	8	CC2D1A	1	affinity chromatography technology	Kirli K (2015)	1
FGFR1OP	0	CEP19	0	two hybrid, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology	Rolland T (2014), Huttlin EL (2015), Gupta GD (2015), Gupta GD (2015), Huttlin EL (2017)	5
SPICE1	2	CC2D1A	1	bioid	Gupta GD (2015)	1
NIN	4	PCM1	5	bioid	Gupta GD (2015)	1
CEP89	2	CEP170	4	bioid	Gupta GD (2015)	1
XPO1	8	CEP170	4	affinity chromatography technology	Kirli K (2015)	1
PCM1	5	CC2D1A	1	bioid	Gupta GD (2015)	1
STIL	3	OFD1	3	bioid	Gupta GD (2015)	1
OFD1	3	NIN	4	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
SPICE1	2	CEP135	2	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
CEP128	1	CEP162	3	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
NINL	1	CEP170	4	bioid	Gupta GD (2015)	1
NIN	4	FGFR1OP	0	bioid	Gupta GD (2015)	1
CEP135	2	PCM1	5	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
NIN	4	DCTN1	6	bioid	Gupta GD (2015)	1
NINL	1	CEP162	3	bioid	Gupta GD (2015)	1
CEP89	2	FGFR1OP	0	bioid	Gupta GD (2015)	1
PCM1	5	CEP89	2	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
STIL	3	CDC37	0	bioid	Gupta GD (2015)	1
NINL	1	CC2D1A	1	bioid	Gupta GD (2015)	1
OFD1	3	CDC37	0	bioid	Gupta GD (2015)	1
CEP162	3	CC2D1A	1	bioid	Gupta GD (2015)	1
CEP104	4	CDC37	0	bioid	Gupta GD (2015)	1
CEP128	1	CC2D1A	1	bioid	Gupta GD (2015)	1
CEP152	2	CEP128	1	bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015)	2
CEP128	1	OFD1	3	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
STIL	3	PCM1	5	bioid	Gupta GD (2015)	1
CEP128	1	CEP89	2	bioid	Gupta GD (2015)	1
CEP135	2	CEP44	2	bioid	Gupta GD (2015)	1
CNTRL	5	NIN	4	bioid	Gupta GD (2015)	1
CEP89	2	CC2D1A	1	bioid	Gupta GD (2015)	1
CEP135	2	FGFR1OP	0	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
OFD1	3	PCM1	5	affinity chromatography technology, affinity chromatography technology, bioid, bioid, affinity chromatography technology	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Hein MY (2015)	5
NCOA2	2	CC2D1A	1	affinity chromatography technology	Jung SY (2005)	1
NINL	1	PCM1	5	bioid	Gupta GD (2015)	1
NINL	1	FGFR1OP	0	bioid	Gupta GD (2015)	1
CNTRL	5	PCM1	5	bioid	Gupta GD (2015)	1
NINL	1	DCTN1	6	affinity chromatography technology	Boldt K (2016)	1
SPICE1	2	OFD1	3	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
DCTN1	6	CC2D1A	1	bioid	Gupta GD (2015)	1
CDH1	4	CC2D1A	1	bioid	Guo Z (2014)	1
CRYAB	0	CC2D1A	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FBF1	2	PCM1	5	bioid	Gupta GD (2015)	1
CNTRL	5	CEP152	2	bioid	Gupta GD (2015)	1
CEP170	4	DCTN1	6	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
CHMP4B	2	CHMP4A	1	two hybrid	Tsang HT (2006)	1
CNTRL	5	CC2D1A	1	bioid	Gupta GD (2015)	1
OFD1	3	CEP170	4	bioid	Gupta GD (2015)	1
CRYAB	0	CDH1	4	affinity chromatography technology	Huang Z (2012)	1
CEP162	3	SPICE1	2	affinity chromatography technology, affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	4
CEP128	1	CEP135	2	affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
NINL	1	OFD1	3	bioid	Gupta GD (2015)	1
CEP128	1	CEP44	2	bioid	Gupta GD (2015)	1
FBF1	2	CC2D1A	1	bioid	Gupta GD (2015)	1
CHMP4C	1	CHMP4A	1	two hybrid	von Schwedler UK (2003)	1
CDC37	0	DCTN1	6	two hybrid	Vinayagam A (2011)	1
NINL	1	CEP89	2	bioid	Gupta GD (2015)	1
CEP162	3	CEP89	2	bioid	Gupta GD (2015)	1
CHMP4A	1	CC2D1A	1	two hybrid	Tsang HT (2006)	1
CEP104	4	CEP170	4	bioid	Gupta GD (2015)	1
CEP152	2	PCM1	5	bioid	Gupta GD (2015)	1
CHMP4C	1	CHMP4B	2	two hybrid, two hybrid	von Schwedler UK (2003), Tsang HT (2006)	2
FBF1	2	CEP170	4	bioid	Gupta GD (2015)	1
OFD1	3	FGFR1OP	0	bioid, affinity chromatography technology, affinity chromatography technology	Gupta GD (2015), Hein MY (2015), Hein MY (2015)	3
CEP89	2	OFD1	3	bioid	Gupta GD (2015)	1
CDH1	4	CHMP4B	2	bioid	Guo Z (2014)	1
CHMP4B	2	CC2D1A	1	affinity chromatography technology	Hein MY (2015)	1
CEP44	2	OFD1	3	bioid	Gupta GD (2015)	1
CEP128	1	CNTRL	5	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
XPO1	8	FGFR1OP	0	affinity chromatography technology	Kirli K (2015)	1
FBF1	2	OFD1	3	bioid	Gupta GD (2015)	1
PCM1	5	FGFR1OP	0	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
CNTRL	5	OFD1	3	bioid	Gupta GD (2015)	1
CEP44	2	CEP170	4	bioid	Gupta GD (2015)	1
CEP44	2	FGFR1OP	0	bioid	Gupta GD (2015)	1
CEP128	1	FBF1	2	bioid	Gupta GD (2015)	1
CEP128	1	FGFR1OP	0	bioid	Gupta GD (2015)	1
FGFR1OP	0	CC2D1A	1	bioid	Gupta GD (2015)	1
CEP135	2	CC2D1A	1	bioid	Gupta GD (2015)	1
CEP44	2	CC2D1A	1	bioid	Gupta GD (2015)	1
OFD1	3	CC2D1A	1	bioid	Gupta GD (2015)	1
XPO1	8	MKS1	3	affinity chromatography technology	Kirli K (2015)	1
CDC37	0	CC2D1A	1	two hybrid	Vinayagam A (2011)	1
DCTN1	6	CEP44	2	bioid	Gupta GD (2015)	1
CEP135	2	OFD1	3	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
CEP135	2	CEP170	4	bioid	Gupta GD (2015)	1
CEP104	4	CC2D1A	1	bioid	Gupta GD (2015)	1
XPO1	8	SPICE1	2	affinity chromatography technology	Kirli K (2015)	1
CEP135	2	CEP162	3	affinity chromatography technology, affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
CNTRL	5	CEP89	2	bioid	Gupta GD (2015)	1
LRP1	25	CC2D1A	1	two hybrid	Kajiwara Y (2010)	1
CEP170	4	CC2D1A	1	bioid	Gupta GD (2015)	1
CEP128	1	NIN	4	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
PCM1	5	CEP162	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	5
MKS1	3	CC2D1A	1	bioid	Gupta GD (2015)	1
NIN	4	CC2D1A	1	bioid	Gupta GD (2015)	1
CNTRL	5	CEP162	3	bioid	Gupta GD (2015)	1
SLC1A1	1	CC2D1A	1	affinity chromatography technology	Huttlin EL (2017)	1
CEP104	4	PCM1	5	bioid	Gupta GD (2015)	1
CEP152	2	OFD1	3	bioid	Gupta GD (2015)	1