PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SLX1A	0	HMMR	1	affinity chromatography technology	Huttlin EL (2017)	1
ERCC1	1	MUS81	1	affinity chromatography technology, affinity chromatography technology	Perez-Oliva AB (2015), Huttlin EL (2017)	2
GRB2	2	UQCC2	0	two hybrid	Grossmann A (2015)	1
SLX1A	0	UBR4	15	affinity chromatography technology	Huttlin EL (2017)	1
SLX1A	0	GPBP1	2	affinity chromatography technology	Huttlin EL (2017)	1
SLX4	6	SLX1B	0	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique	Svendsen JM (2009), Svendsen JM (2009), Wan B (2013), Wan B (2013), Wan B (2013)	5
SLX1B	0	ERCC4	2	affinity chromatography technology	Svendsen JM (2009)	1
SLX4	6	ERCC4	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, biochemical, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique, two hybrid, affinity chromatography technology, affinity chromatography technology	Svendsen JM (2009), Svendsen JM (2009), Svendsen JM (2009), Ghosal G (2012), Kim Y (2011), Andersen SL (2009), Munoz IM (2009), Munoz IM (2009), Munoz IM (2009), Munoz IM (2009), Fekairi S (2009), Kim Y (2013), Wilson JS (2013), Wilson JS (2013), Wan B (2013), Wan B (2013), Wan B (2013), Perez-Oliva AB (2015), Schuster B (2013), Bogliolo M (2013)	20
ARNT	1	NCOA1	6	affinity chromatography technology, two hybrid, pull down	Beischlag TV (2002), Beischlag TV (2002), Beischlag TV (2002)	3
SLX1A	0	CDKN2C	0	affinity chromatography technology	Huttlin EL (2017)	1
ARNT	1	CDKN2C	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MUS81	1	EME1	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down	Ciccia A (2003), Fekairi S (2009), Matos J (2011), Zeng S (2009), Nair N (2014), Huttlin EL (2017), Gwon GH (2014), Zhou X (2016), Phung HTT (2018)	9
BACH1	3	HMMR	1	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dohi Y (2008), Yamasaki C (2005), Yamasaki C (2005), Hein MY (2015), Huttlin EL (2017)	5
SLX1A	0	FLYWCH2	0	affinity chromatography technology	Huttlin EL (2017)	1
SLX1A	0	ERCC4	2	pull down, pull down	Munoz IM (2009), Fekairi S (2009)	2
SLX1A	0	HDAC6	0	affinity chromatography technology	Huttlin EL (2017)	1
SLX1A	0	EAPP	1	affinity chromatography technology	Huttlin EL (2017)	1
SLX4	6	ERCC1	1	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Svendsen JM (2009), Svendsen JM (2009), Ghosal G (2012), Kim Y (2011), Munoz IM (2009), Munoz IM (2009), Kim Y (2013), Huttlin EL (2015), Perez-Oliva AB (2015), Huttlin EL (2017), Schuster B (2013), Bogliolo M (2013)	12
SLX1A	0	ERCC1	1	pull down	Munoz IM (2009)	1
SLX1A	0	PSME4	9	affinity chromatography technology	Huttlin EL (2017)	1
SLX1A	0	MAP3K21	4	affinity chromatography technology	Huttlin EL (2017)	1
SLX1A	0	UQCC1	2	affinity chromatography technology	Huttlin EL (2017)	1
SLX1A	0	BACH1	3	affinity chromatography technology	Huttlin EL (2017)	1
SLX1A	0	UQCC2	0	affinity chromatography technology	Huttlin EL (2017)	1
SLX1A	0	MUS81	1	pull down, pull down	Munoz IM (2009), Fekairi S (2009)	2
SLX4	6	MUS81	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Svendsen JM (2009), Svendsen JM (2009), Ghosal G (2012), Kim Y (2011), Munoz IM (2009), Munoz IM (2009), Fekairi S (2009), Kim Y (2013), Wilson JS (2013), Wan B (2013), Wan B (2013), Wan B (2013), Rolland T (2014), Yu H (2011), Nair N (2014), Nair N (2014), Nair N (2014), Ouyang J (2015), Huttlin EL (2017), Schuster B (2013), Bogliolo M (2013)	21
SLX4	6	SLX1A	0	two hybrid, pull down, pull down, biochemical, two hybrid, two hybrid, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique	Munoz IM (2009), Munoz IM (2009), Munoz IM (2009), Munoz IM (2009), Fekairi S (2009), Fekairi S (2009), Fekairi S (2009), Kim Y (2013), Wan B (2013), Wan B (2013), Wan B (2013)	11
SLX1A	0	EME1	3	pull down	Munoz IM (2009)	1
SLX1A	0	TOP3A	0	affinity chromatography technology	Huttlin EL (2017)	1
SLX1B	0	EME1	3	affinity chromatography technology	Svendsen JM (2009)	1
SLX1A	0	UBR7	0	affinity chromatography technology	Huttlin EL (2017)	1
SLX1A	0	GRB2	2	two hybrid	Wang J (2011)	1
SLX1A	0	NCOA1	6	affinity chromatography technology	Huttlin EL (2017)	1
SLX1A	0	ARNT	1	affinity chromatography technology	Huttlin EL (2017)	1
ERCC1	1	ERCC4	2	pull down, pull down, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	de Laat WL (1998), Park CH (1994), Ciccia A (2007), Havugimana PC (2012), Lan L (2004), Lan L (2004), Lan L (2004), Huttlin EL (2015), Wan C (2015), Perez-Oliva AB (2015), Perez-Oliva AB (2015), Liccardi G (2014), Huttlin EL (2017), Friboulet L (2013)	14
SLX1A	0	USP4	3	affinity chromatography technology	Huttlin EL (2017)	1
SLX1B	0	MUS81	1	affinity chromatography technology	Svendsen JM (2009)	1
SLX1B	0	ERCC1	1	affinity chromatography technology, affinity chromatography technology	Svendsen JM (2009), Huttlin EL (2017)	2
MUS81	1	ERCC4	2	affinity chromatography technology	Huttlin EL (2017)	1
SLX1A	0	SLX1B	0	affinity chromatography technology	Huttlin EL (2017)	1
GRB2	2	UBR4	15	affinity chromatography technology	Brehme M (2009)	1
UQCC1	2	UQCC2	0	biochemical, biochemical, affinity chromatography technology	Tucker EJ (2013), Tucker EJ (2013), Huttlin EL (2017)	3
SLX4	6	EME1	3	affinity chromatography technology, pull down, biochemical, affinity chromatography technology, pull down	Svendsen JM (2009), Munoz IM (2009), Munoz IM (2009), Fekairi S (2009), Fekairi S (2009)	5