PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HSP90AA1	7	SKP1	0	pull down	Zhang M (2008)	1
FBXL12	1	GSTP1	0	affinity chromatography technology	Nishiyama M (2015)	1
CDC37	0	FBXL12	1	two hybrid	Soler-Lopez M (2011)	1
FBXL12	1	ALDH3A1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Nishiyama M (2015), Nishiyama M (2015), Nishiyama M (2015), Nishiyama M (2015)	4
APOE	1	FBXL12	1	two hybrid	Soler-Lopez M (2011)	1
PSEN2	3	CAPN1	3	two hybrid, affinity chromatography technology	Shinozaki K (1998), Shinozaki K (1998)	2
CDC37	0	SKP1	0	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
MAST1	9	APOE	1	two hybrid	Soler-Lopez M (2011)	1
RBX1	2	UBE2D3	1	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down	Ohta T (2001), Sung CK (2011), DAngiolella V (2010), Kaur M (2012), Amir RE (2004), Tan M (2010), Lan L (2012), Banks D (2006), Saha A (2008), Furukawa M (2000), Gallegos JR (2008), Duan S (2011), He F (2013), Cui Y (2011), Teixeira FR (2013), Vinas-Castells R (2013), Chen Y (2009), Oda H (2010), Pick E (2007), Morimoto M (2003), Kim K (2013), Zhao D (2010), Jiang H (2005), Furukawa M (2005), Thirunavukarasou A (2015), Antonioli M (2014), Li D (2015), Watanabe K (2015), Niikura Y (2015), Zha Z (2015), Walter D (2016), Han XR (2016), Yi J (2015), Kim JH (2015), Moghe S (2012), Xu X (2008), Kuang P (2016), Kuang P (2016), Kuang P (2016), Kuchay S (2017), Xiao J (2015), McGourty CA (2016)	42
PSEN1	11	CDC37	0	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
EGLN3	0	RNH1	8	affinity chromatography technology	Rodriguez J (2016)	1
RNF32	0	APOE	1	two hybrid	Soler-Lopez M (2011)	1
ALDH3A1	1	ALDH3A2	1	affinity chromatography technology	Huttlin EL (2017)	1
A2M	8	RNF32	0	two hybrid	Soler-Lopez M (2011)	1
PRAME	2	RBX1	2	affinity chromatography technology, affinity chromatography technology, pull down	Costessi A (2011), Costessi A (2012), Costessi A (2011)	3
FBXL12	1	CAPN2	1	affinity chromatography technology	Nishiyama M (2015)	1
PSEN2	3	FBXL12	1	two hybrid	Soler-Lopez M (2011)	1
COPS6	0	FBXL12	1	affinity chromatography technology	Bennett EJ (2010)	1
RNF32	0	PSEN1	11	two hybrid	Soler-Lopez M (2011)	1
HSP90AA1	7	FBXL12	1	affinity chromatography technology	Taipale M (2012)	1
PSEN1	11	PSEN2	3	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Gu Y (2003), Soler-Lopez M (2011), Hebert SS (2004), Hebert SS (2004)	4
EGLN3	0	FBXL12	1	affinity chromatography technology	Rodriguez J (2016)	1
COPS6	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Olma MH (2009), Reitsma JM (2017)	7
SKP1	0	RBX1	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Staropoli JF (2003), Kumar R (2005), Wang W (2004), Ohta T (2001), Oshikawa K (2003), Liu J (2002), Li X (2003), Zhou W (2014), Zhou W (2014), Hao J (2015), Hauri S (2016)	11
FBXL12	1	RNH1	8	affinity chromatography technology	Nishiyama M (2015)	1
A2M	8	FBXL12	1	two hybrid	Soler-Lopez M (2011)	1
EGLN3	0	CDC37	0	affinity chromatography technology	Rodriguez J (2016)	1
FBXL12	1	JUN	0	affinity chromatography technology	Koyama-Nasu R (2007)	1
EGLN3	0	SKP1	0	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	HGH1	0	affinity chromatography technology	Rodriguez J (2016)	1
COPS6	0	HSP90AA1	7	affinity chromatography technology	Bennett EJ (2010)	1
MAST1	9	PSEN2	3	two hybrid	Soler-Lopez M (2011)	1
SKP1	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Staropoli JF (2003), Min KW (2003), Lisztwan J (1998), Zheng N (2002), Ohta T (1999), Bloom J (2006), Kumar R (2005), Megumi Y (2005), Wang W (2004), Read MA (2000), Wu K (2000), Tan P (1999), Mao X (2011), Lin HK (2009), Yano H (2008), Banerjee S (2010), Gao D (2010), Chua YS (2011), Zhang M (2008), Winston JT (1999), Latres E (1999), Latres E (1999), Arai T (2003), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), Emberley ED (2012), Bennett EJ (2010), Gastaldello S (2012), Michel JJ (1998), Michel JJ (1998), Michel JJ (1998), Lyapina SA (1998), Lyapina SA (1998), Lyapina SA (1998), Lyapina SA (1998), Furukawa M (2000), Furukawa M (2000), Liu J (2002), Liu J (2002), Liu J (2002), Yu ZK (1998), Yu ZK (1998), Postow L (2013), Cordero-Espinoza L (2013), Zhou W (2014), Zhou W (2014), Hao J (2015), Hao J (2015), Han XR (2016), Liu YQ (2015), Gorelik M (2016), Al-Yacoub N (2016), Reiterer V (2017), Hu Y (2017), Hauri S (2016), Reitsma JM (2017), Reitsma JM (2017), Chen F (2017)	59
FBXL12	1	CDKN1C	0	affinity chromatography technology	Kim M (2008)	1
COPS6	0	RBX1	2	affinity chromatography technology	Olma MH (2009)	1
CUL1	7	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, enzymatic study, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, pull down, x-ray crystallography, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Dias DC (2002), Kim J (2002), Zheng N (2002), Kim AY (2008), Ohta T (1999), Ohta T (1999), Ohta T (1999), Bloom J (2006), Block K (2005), Hu J (2004), Hwang JW (2003), Furukawa M (2002), Kawakami T (2001), Ohta T (2001), Chen A (2000), Read MA (2000), Wu K (2000), Tan P (1999), Banerjee S (2010), Gao D (2010), Tron AE (2012), Tron AE (2012), Shteingart S (2012), Tan M (2010), Arai T (2003), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), Huang DT (2004), Emberley ED (2012), Gastaldello S (2012), Furukawa M (2000), Furukawa M (2000), Liu J (2002), Liu J (2002), Liu J (2002), Li X (2003), Calabrese MF (2011), Scott DC (2014), Scott DC (2014), Siergiejuk E (2009), Zhou W (2014), Zhou W (2014), Huang DT (2009), Pick E (2007), Morimoto M (2003), Morimoto M (2003), Ohki Y (2009), Duda DM (2008), Duda DM (2008), Wan C (2015), Hao J (2015), Hao J (2015), Han XR (2016), Kuang P (2016), Zhou W (2017), Hu Y (2017), Reitsma JM (2017)	59
STYX	1	SKP1	0	affinity chromatography technology, affinity chromatography technology	St-Denis N (2016), Li X (2016)	2
CUL1	7	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Taipale M (2012)	2
FBXL12	1	CAPN1	3	affinity chromatography technology	Nishiyama M (2015)	1
ECSIT	3	PSEN2	3	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
FBXL12	1	TTC27	3	affinity chromatography technology	Nishiyama M (2015)	1
RNF32	0	FBXL12	1	two hybrid, pull down	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
JUN	0	HSP90AA1	7	two hybrid, pull down	Bandyopadhyay S (2010), Miyamoto-Sato E (2010)	2
ECSIT	3	FBXL12	1	two hybrid, pull down	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
HSP90AA1	7	LNX1	7	affinity chromatography technology	Taipale M (2012)	1
FBXL12	1	RCN1	0	affinity chromatography technology	Nishiyama M (2015)	1
CUL1	7	FBXL12	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Kim M (2008), Postow L (2013), Nishiyama M (2015), Reitsma JM (2017)	5
FBXL12	1	HGH1	0	affinity chromatography technology	Nishiyama M (2015)	1
FBXL12	1	FXYD3	0	two hybrid	Stelzl U (2005)	1
ECSIT	3	PSEN1	11	two hybrid, affinity chromatography technology, pull down	Soler-Lopez M (2011), Soler-Lopez M (2011), Soler-Lopez M (2011)	3
MAST1	9	A2M	8	two hybrid	Soler-Lopez M (2011)	1
FBXL12	1	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim M (2008), Postow L (2013), Postow L (2013), Nishiyama M (2015), Hauri S (2016)	5
A2M	8	ECSIT	3	two hybrid	Soler-Lopez M (2011)	1
A2M	8	CDC37	0	two hybrid	Soler-Lopez M (2011)	1
FBXL12	1	STYX	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tan MK (2013), St-Denis N (2016), Li X (2016)	3
FBXL12	1	CBWD3	0	affinity chromatography technology	Nishiyama M (2015)	1
MAST1	9	ECSIT	3	two hybrid	Soler-Lopez M (2011)	1
EGLN3	0	TTC27	3	affinity chromatography technology	Rodriguez J (2016)	1
A2M	8	APOE	1	affinity chromatography technology, pull down, two hybrid	Krimbou L (1998), Krimbou L (1998), Soler-Lopez M (2011)	3
FBXL12	1	RBX1	2	affinity chromatography technology	Kim M (2008)	1
FBXL12	1	FBXL12	1	affinity chromatography technology	Tsuruta F (2015)	1
FBXL12	1	ANXA2	0	affinity chromatography technology	Nishiyama M (2015)	1
MAST1	9	FBXL12	1	two hybrid	Soler-Lopez M (2011)	1
CDC37	0	RNF32	0	two hybrid	Soler-Lopez M (2011)	1
PSEN1	11	APOE	1	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	APOE	1	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
FBXL12	1	ALDH3B1	0	affinity chromatography technology	Nishiyama M (2015)	1
EGLN3	0	JUN	0	affinity chromatography technology	Rodriguez J (2016)	1
CDC37	0	ECSIT	3	two hybrid	Soler-Lopez M (2011)	1
FBXL12	1	ASTN2	5	affinity chromatography technology	Nishiyama M (2015)	1
RNF32	0	ECSIT	3	two hybrid	Soler-Lopez M (2011)	1
FBXL12	1	DOCK8	10	two hybrid	Rolland T (2014)	1
PSEN2	3	RNF32	0	two hybrid	Soler-Lopez M (2011)	1
FBXL12	1	SLA	2	affinity chromatography technology	Nishiyama M (2015)	1
STYX	1	CUL1	7	affinity chromatography technology	Li X (2016)	1
EGLN3	0	CAPN2	1	affinity chromatography technology	Rodriguez J (2016)	1
FBXL12	1	ALDH3A2	1	affinity chromatography technology, affinity chromatography technology	Nishiyama M (2015), Nishiyama M (2015)	2
FBXL12	1	UBE2D3	1	pull down	Nishiyama M (2015)	1
HSP90AA1	7	CDC37	0	x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Roe SM (2004), Silverstein AM (1998), Mollapour M (2010), Basso AD (2002), Tsutsumi S (2012), De Nardo D (2005), Sarkar S (2012), Gano JJ (2010), Taipale M (2012), Skarra DV (2011), Zhang H (2004), Taipale M (2014), Taipale M (2014), Mollapour M (2014), Hein MY (2015), Hein MY (2015), Li J (2013), Woodford MR (2016), Shao J (2003), Scholz GM (2001), Sun L (2012), Sun L (2012), Woodford MR (2016), Synoradzki K (2015)	24
CAPN1	3	CAPN2	1	affinity chromatography technology	Huttlin EL (2017)	1
CDC37	0	APOE	1	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
RNF32	0	MAST1	9	two hybrid	Soler-Lopez M (2011)	1
FBXL12	1	LNX1	7	two hybrid	Rolland T (2014)	1
COPS6	0	SKP1	0	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009)	2
FBXL12	1	PRAME	2	affinity chromatography technology, affinity chromatography technology	Tan MK (2013), Tan MK (2013)	2
PSEN1	11	FBXL12	1	two hybrid	Soler-Lopez M (2011)	1