PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
POLB	0	APTX	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
APTX	3	BAD	1	affinity chromatography technology	Huttlin EL (2017)	1
CRBN	2	POLB	0	affinity chromatography technology	Kroenke J (2014)	1
CNTROB	6	TRIM37	7	bioid	Gupta GD (2015)	1
SORT1	1	APTX	3	affinity chromatography technology	Hein MY (2015)	1
PNMA1	0	APTX	3	two hybrid	Rolland T (2014)	1
APTX	3	HSPA4	3	affinity chromatography technology	Luo H (2004)	1
POLB	0	LIG3	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CRBN	2	APTX	3	affinity chromatography technology	Kroenke J (2014)	1
CRBN	2	7515	0	affinity chromatography technology	Kroenke J (2014)	1
PARP1	3	7515	0	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gueven N (2004), Gueven N (2004), Masson M (1998), Masson M (1998), Cazzalini O (2010), Lee CH (2010), Leppard JB (2003)	7
APTX	3	TSPYL2	4	two hybrid	Lim J (2006)	1
APTX	3	CALCOCO1	2	two hybrid	Lim J (2006)	1
7515	0	TP53	0	affinity chromatography technology	Gueven N (2004)	1
SORT1	1	SYNCRIP	6	affinity chromatography technology	Hein MY (2015)	1
SYNCRIP	6	DDX21	0	affinity chromatography technology	Huttlin EL (2017)	1
APTX	3	XRCC4	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Lim J (2006), Huttlin EL (2015), Huttlin EL (2017)	3
APTX	3	MAPKBP1	8	two hybrid	Lim J (2006)	1
APTX	3	TP53	0	affinity chromatography technology, pull down	Gueven N (2004), Gueven N (2004)	2
APTX	3	PICK1	2	two hybrid	Lim J (2006)	1
APTX	3	LIG3	6	affinity chromatography technology	Luo H (2004)	1
APTX	3	DDX21	0	affinity chromatography technology	Luo H (2004)	1
TP53	0	HSPA4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Muller P (2008), Fraser JA (2010), Sun Y (2007), Wang J (2011), Horikawa I (2014), Horikawa I (2014), Kishor A (2013)	7
APTX	3	ZNF639	3	two hybrid	Lim J (2006)	1
LIG3	6	PARP1	3	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology	Leppard JB (2003), Leppard JB (2003), Leppard JB (2003), Leppard JB (2003)	4
PARP1	3	TP53	0	affinity chromatography technology, far western blotting, pull down, affinity chromatography technology, pull down, pull down	Gueven N (2004), Malanga M (1998), Vaziri H (1997), Vaziri H (1997), Wesierska-Gadek J (2003), Simbulan-Rosenthal CM (2003)	6
CNTROB	6	BANF1	0	bioid	Gupta GD (2015)	1
APTX	3	7515	0	affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Date H (2004), Date H (2004), Date H (2004), Date H (2004), Gueven N (2004), Gueven N (2004), Gueven N (2004), Lim J (2006), Luo H (2004), Luo H (2004), Luo H (2004), Luo H (2004), Hein MY (2015)	13
CRBN	2	LIG3	6	affinity chromatography technology	Kroenke J (2014)	1
APTX	3	CNTROB	6	two hybrid	Lim J (2006)	1
7515	0	LIG3	6	two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Whitehouse CJ (2001), Ewing RM (2007), Caldecott KW (1994), Nash RA (1997), Dulic A (2001), Taylor RM (1998), Ogi T (2010), Hein MY (2015)	8
APTX	3	MBP	0	two hybrid	Lim J (2006)	1
PARP1	3	POLB	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cazzalini O (2010), Cazzalini O (2010), Lee CH (2010), Huttlin EL (2015), Huttlin EL (2017)	5
BANF1	0	APTX	3	affinity chromatography technology	Montes de Oca R (2009)	1
POLB	0	7515	0	two hybrid, pull down, pull down, far western blotting, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang L (2004), Fan J (2004), Kubota Y (1996), Kubota Y (1996), Bhattacharyya N (2001), Bhattacharyya N (2001), Luo H (2004), Huttlin EL (2015), Hein MY (2015), Fang Q (2014), Fang Q (2014), Huttlin EL (2017)	12
DDX21	0	PARP1	3	biochemical	Havugimana PC (2012)	1
APTX	3	PARP1	3	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Date H (2004), Date H (2004), Gueven N (2004), Gueven N (2004), Gueven N (2004)	5
XRCC4	0	KIF3A	4	affinity chromatography technology	Boldt K (2016)	1
APTX	3	TRIM37	7	two hybrid	Lim J (2006)	1
SORT1	1	BAD	1	affinity chromatography technology	Hein MY (2015)	1
APTX	3	KIF3A	4	affinity chromatography technology	Huttlin EL (2017)	1
BANF1	0	PARP1	3	affinity chromatography technology, affinity chromatography technology	Montes de Oca R (2009), Montes de Oca R (2009)	2
APTX	3	SYT17	0	two hybrid	Lim J (2006)	1
RBM8A	2	APTX	3	affinity chromatography technology	Hein MY (2015)	1
APTX	3	CEP350	4	two hybrid	Lim J (2006)	1
SYNCRIP	6	APTX	3	affinity chromatography technology	Hein MY (2015)	1
SYNCRIP	6	BAD	1	affinity chromatography technology	Hein MY (2015)	1
APTX	3	HIVEP1	13	two hybrid	Lim J (2006)	1