PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
UBE2D2	0	LRSAM1	2	two hybrid	Markson G (2009)	1
TRIM21	0	TRIM8	6	two hybrid	Woodsmith J (2012)	1
LRSAM1	2	RNF111	2	two hybrid	Woodsmith J (2012)	1
RNF111	2	SMAD6	9	affinity chromatography technology	Koinuma D (2003)	1
NR4A1	4	RNF111	2	affinity chromatography technology	Zhou F (2014)	1
UBE2E3	0	DTX3L	1	two hybrid	Markson G (2009)	1
SMAD6	9	SMAD7	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Topper JN (1997), Topper JN (1997), Topper JN (1997), Yan X (2016)	4
CSNK2A2	1	CSNK2A1	15	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), So J (2015), Huttlin EL (2015), Wan C (2015), Gao Z (2014), Hein MY (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	9
RNF111	2	TPX2	4	affinity chromatography technology	Huttlin EL (2017)	1
FHL2	0	SMAD3	1	pull down, affinity chromatography technology	Ding L (2009), Ding L (2009)	2
DTX3L	1	RNF111	2	two hybrid	Woodsmith J (2012)	1
TTC9C	2	UBE2V1	0	biochemical	Havugimana PC (2012)	1
HSP90AA1	7	UBE2N	1	pull down	Zhang M (2005)	1
RNF111	2	C21orf59	0	affinity chromatography technology	Huttlin EL (2017)	1
TRIM8	6	TRAF5	1	two hybrid	Woodsmith J (2012)	1
UBE2D4	0	LRSAM1	2	two hybrid	Markson G (2009)	1
CSNK2A1	15	UBE2D3	1	enzymatic study	Gao Z (2014)	1
ANAPC11	0	UBE2D2	0	affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Chang TS (2004), Townsend K (2009), Van Voorhis VA (2014), ODonovan KJ (2010), Tang Z (2001), Tang Z (2001), Vodermaier HC (2003), Shoji S (2014), Brown NG (2014), Brown NG (2015)	10
RNF111	2	SMAD7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Koinuma D (2003), Koinuma D (2003), Erker Y (2013), Elkouris M (2016)	4
RNF111	2	FHL2	0	affinity chromatography technology, affinity chromatography technology	Xia T (2013), Xia T (2013)	2
UBE2D2	0	UBE2V1	0	biochemical	Havugimana PC (2012)	1
TSG101	1	RNF111	2	two hybrid	Markson G (2009)	1
CSNK2A2	1	XPC	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SKIL	3	PML	7	affinity chromatography technology	Pan D (2009)	1
UBE2K	0	DTX3L	1	two hybrid	Markson G (2009)	1
SMAD7	1	SMURF2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Asano Y (2004), Kavsak P (2000), Lee YS (2008), Komuro A (2004), Chong PA (2010), Chong PA (2010), Chong PA (2010), Cai Y (2012), Cai Y (2012), Chong PA (2006), Al-Salihi MA (2012), Ogunjimi AA (2005), Aragon E (2012), Aragon E (2012), Colland F (2004), Zhang L (2013), Chandhoke AS (2015), Iyengar PV (2015), Elkouris M (2016)	19
MARCH7	0	UBE2D2	0	pull down	Flach K (2014)	1
MARCH7	0	UBE2D3	1	two hybrid, pull down	Flach K (2014), Flach K (2014)	2
UBE2E2	1	DTX3L	1	two hybrid	Markson G (2009)	1
UBE2W	0	RNF111	2	two hybrid, two hybrid	van Wijk SJ (2009), Markson G (2009)	2
RNF111	2	ESRP2	2	affinity chromatography technology	Mizutani A (2016)	1
UBE2D1	0	LRSAM1	2	two hybrid, pull down, enzymatic study	Markson G (2009), Chua HH (2016), Hakonen JE (2017)	3
UBE2I	0	SKI	3	pull down, affinity chromatography technology	Ding B (2012), Ding B (2012)	2
UBE2V1	0	UBXN7	3	biochemical	Havugimana PC (2012)	1
SMURF2	3	UBC	7	enzymatic study, affinity chromatography technology, enzymatic study, pull down, pull down	Maspero E (2013), Zhang L (2013), Kristariyanto YA (2015), Mari S (2014), Zhang Y (2017)	5
UBE2E3	0	CSNK2A2	1	affinity chromatography technology	Huttlin EL (2017)	1
UBE2I	0	EDARADD	0	two hybrid	Rolland T (2014)	1
SMURF2	3	UBE2D3	1	pull down, pull down, pull down, pull down, pull down, pull down, pull down	Kim S (2010), Nie J (2010), Lu K (2011), Maspero E (2013), Kristariyanto YA (2015), Mari S (2014), Emanuelli A (2017)	7
CTBP1	2	UBE2I	0	affinity chromatography technology	Kuppuswamy M (2008)	1
UBE2Q2	4	RNF111	2	two hybrid	Markson G (2009)	1
RNF111	2	SKI	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nagano Y (2007), Le Scolan E (2008), Erker Y (2013)	3
FAM189B	2	UBXN7	3	affinity chromatography technology	Huttlin EL (2017)	1
UBC	7	FHL2	0	affinity chromatography technology	Matsumoto M (2005)	1
UBC	7	SUMO3	0	affinity chromatography technology	Sahin U (2014)	1
SUMO2	0	UBE2I	0	affinity chromatography technology, pull down, two hybrid, two hybrid, pull down, pull down, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, biochemical, affinity chromatography technology, affinity chromatography technology	Li T (2006), Knipscheer P (2007), Boutell C (2011), Hecker CM (2006), Hecker CM (2006), Zilio N (2013), Tatham MH (2001), Knipscheer P (2007), Ullmann R (2012), Matic I (2008), Xu Y (2014), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	14
CSNK2A1	15	RNF111	2	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
UBE2K	0	UBC	7	enzymatic study, x-ray crystallography, x-ray crystallography, pull down, enzymatic study, enzymatic study, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Flierman D (2006), Ko S (2010), Wilson RC (2011), Wilson RC (2011), Wilson RC (2011), Sheng Y (2012), Raasi S (2005), Bishop N (2002), Rajsbaum R (2014), Chong RA (2014), Whitby FG (1998), Singh RK (2012), Cook BW (2015)	13
UBC	7	XPC	1	affinity chromatography technology	Bish RA (2007)	1
UBE2E1	1	LRSAM1	2	two hybrid	Markson G (2009)	1
UBE2E3	0	UBC	7	enzymatic study	Sheng Y (2012)	1
RNF111	2	CGGBP1	1	affinity chromatography technology	Huttlin EL (2017)	1
UBE2D2	0	RNF111	2	two hybrid, two hybrid, pull down, pull down, pull down, pull down	van Wijk SJ (2009), Markson G (2009), Erker Y (2013), Wright JD (2016), Birkou M (2017), Birkou M (2017)	6
HSP90AA1	7	LRSAM1	2	affinity chromatography technology	Taipale M (2012)	1
SMAD2	5	SMAD6	9	affinity chromatography technology	Topper JN (1997)	1
RNF111	2	DCUN1D5	0	affinity chromatography technology	Huttlin EL (2017)	1
KRTAP5-9	0	RNF111	2	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
SKI	3	SKIL	3	pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Cohen SB (1999), Cohen SB (1999), Tan R (2006), He J (2003), Ikeuchi Y (2014)	5
FAM189B	2	RNF111	2	affinity chromatography technology	Huttlin EL (2017)	1
TRIM8	6	RNF111	2	two hybrid	Woodsmith J (2012)	1
UBE2D1	0	UBXN7	3	biochemical	Havugimana PC (2012)	1
RNF111	2	SUGP1	2	affinity chromatography technology	Huttlin EL (2017)	1
SUMO3	0	RNF111	2	pull down	Erker Y (2013)	1
ANAPC11	0	UBE2K	0	pull down, pull down, pull down	Bassermann F (2008), Rodrigo-Brenni MC (2007), Van Voorhis VA (2014)	3
RNF111	2	LCE4A	0	two hybrid	Rolland T (2014)	1
UBE2I	0	UBE2E1	1	biochemical	Wan C (2015)	1
SMAD2	5	SMAD7	1	genetic interference, pull down, affinity chromatography technology	Lebrun JJ (1999), Zhang S (2007), Yan X (2016)	3
UBE2N	1	MARCH7	0	two hybrid, two hybrid, pull down, two hybrid	Markson G (2009), Flach K (2014), Flach K (2014), Nathan JA (2008)	4
PHF7	5	UBE2D4	0	two hybrid	Rolland T (2014)	1
SMAD7	1	SMAD3	1	genetic interference, genetic interference, affinity chromatography technology, protein complementation assay	Datta PK (2000), Lebrun JJ (1999), Yan X (2016), Yan X (2016)	4
TRIM21	0	UBC	7	enzymatic study	McEwan WA (2013)	1
SMAD2	5	SMURF2	3	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lin X (2000), Lin X (2000), Bonni S (2001), Nakano A (2009), Komuro A (2004), Zhang Y (2001), Zhang Y (2001), Runyan CE (2009), Runyan CE (2009), Chong PA (2010), Brown KA (2008), Colland F (2004), Colland F (2004), Zhang Y (2017), Zhou F (2017), Zhou F (2017)	16
UBE2I	0	DTX3L	1	two hybrid	Markson G (2009)	1
UBE2I	0	ADD3	4	enzymatic study	Gocke CB (2005)	1
RNF111	2	SKIL	3	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Levy L (2007), Levy L (2007), Nagano Y (2007), Erker Y (2013)	4
RNF111	2	MARCH7	0	two hybrid	Woodsmith J (2012)	1
UBC	7	SUMO1	0	affinity chromatography technology	Sahin U (2014)	1
UBE2G2	0	RNF111	2	two hybrid	van Wijk SJ (2009)	1
MARCH7	0	UBC	7	enzymatic study	Flierman D (2006)	1
UBE2I	0	RNF111	2	two hybrid, two hybrid, two hybrid	Markson G (2009), Bandyopadhyay S (2010), Rolland T (2014)	3
UBE2E3	0	RNF111	2	two hybrid, two hybrid	van Wijk SJ (2009), Markson G (2009)	2
UBE2D2	0	UBE2M	0	biochemical	Havugimana PC (2012)	1
UBE2I	0	PML	7	enzymatic study, pull down, enzymatic study, two hybrid, two hybrid, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, pull down	Knipscheer P (2008), Kim YE (2005), Satow R (2012), Duprez E (1999), Wang J (2011), Tatham MH (2003), Duprez E (1999), Gocke CB (2005), Lin DY (2006), Jo S (2016), Schilling EM (2017)	11
RNF111	2	SMAD3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Koinuma D (2003), Yuzawa H (2009), Yuzawa H (2009), Levy L (2007), Erker Y (2013), Le Scolan E (2008)	6
SETD7	2	RNF111	2	affinity chromatography technology	Elkouris M (2016)	1
UBE2M	0	RNF111	2	two hybrid	Markson G (2009)	1
UBE2D1	0	TRIM8	6	two hybrid	Markson G (2009)	1
UBE2D3	1	RNF111	2	two hybrid, two hybrid, pull down, two hybrid	van Wijk SJ (2009), Markson G (2009), Erker Y (2013), Rolland T (2014)	4
UBE2E1	1	RNF111	2	two hybrid, two hybrid	van Wijk SJ (2009), Markson G (2009)	2
RNF111	2	SMAD2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Levy L (2007), Erker Y (2013), Le Scolan E (2008)	3
UBE2D3	1	LRSAM1	2	two hybrid	Markson G (2009)	1
HSP90AA1	7	RNF111	2	affinity chromatography technology	Taipale M (2012)	1
TRIM21	0	UBE2D1	0	pull down, pull down	Mallery DL (2010), Kong HJ (2007)	2
UBE2V1	0	RNF111	2	two hybrid	Markson G (2009)	1
SMAD3	1	SMURF2	3	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lin X (2000), Lin X (2000), Bonni S (2001), Nakano A (2009), Komuro A (2004), Zhang Y (2001), Zhang Y (2001), Tang LY (2011), Brown KA (2008), Zhang L (2013), Li Y (2017), Zhang Y (2017)	12
SUMO1	0	EDARADD	0	two hybrid	Rolland T (2014)	1
UBE2K	0	MARCH7	0	two hybrid, pull down, two hybrid	Markson G (2009), Flierman D (2006), Nathan JA (2008)	3
TRIM21	0	UBE2I	0	two hybrid	Rolland T (2014)	1
UBC	7	UBE2D3	1	affinity chromatography technology, two hybrid, x-ray crystallography, pull down, pull down, pull down	Matsumoto M (2005), Vinayagam A (2011), Pruneda JN (2014), Li Y (2014), Poyurovsky MV (2007), Zhang X (2017)	6
UBE2K	0	RNF111	2	two hybrid	Markson G (2009)	1
ANAPC11	0	UBE2D3	1	pull down	Choudhury R (2016)	1
CTBP1	2	RNF111	2	two hybrid	Corominas R (2014)	1
SMAD7	1	NR4A1	4	affinity chromatography technology, affinity chromatography technology	Zhou F (2014), Zhou F (2014)	2
SMAD6	9	CTBP1	2	affinity chromatography technology, affinity chromatography technology	Lin X (2003), Herhaus L (2014)	2
ANAPC11	0	RNF111	2	two hybrid	Woodsmith J (2012)	1
PHF7	5	RNF111	2	two hybrid	Woodsmith J (2012)	1
UBE2K	0	UBE2N	1	biochemical	Wan C (2015)	1
RNF111	2	PML	7	affinity chromatography technology, two hybrid	Erker Y (2013), Woodsmith J (2012)	2
RNF111	2	EDARADD	0	two hybrid	Rolland T (2014)	1
UBE2D4	0	TRIM8	6	two hybrid	Markson G (2009)	1
MARCH7	0	UBE2E1	1	pull down	Flach K (2014)	1
UBE2W	0	LRSAM1	2	two hybrid	Markson G (2009)	1
PML	7	SUMO1	0	two hybrid, imaging technique, fluorescent resonance energy transfe, two hybrid, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down, x-ray crystallography, fluorescent resonance energy transfe, unspecified method, two hybrid, pull down	Lin DY (2002), Cuchet-Lourenco D (2011), Percherancier Y (2009), Cuchet-Lourenco D (2012), Stehmeier P (2009), Duprez E (1999), Shen TH (2006), Shen TH (2006), Saether T (2007), Cappadocia L (2015), Cappadocia L (2015), Cappadocia L (2015), Li C (2017), Li C (2017)	14
SMAD2	5	SKI	3	pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Harada J (2003), Luo K (1999), Tabata T (2009), Prunier C (2003), Prunier C (2003), Akiyoshi S (1999), Akiyoshi S (1999), Takeda M (2004), Inoue Y (2011), Ferrand N (2010), Chen W (2007), Brown KA (2008), He J (2003), Rashidian J (2015), Zhou F (2017)	15
PHF7	5	DTX3L	1	two hybrid	Woodsmith J (2012)	1
RNF111	2	TTC9C	2	affinity chromatography technology	Huttlin EL (2017)	1
UBE2D2	0	TRIM8	6	two hybrid, pull down	Markson G (2009), Li Q (2011)	2
SMURF2	3	RNF111	2	two hybrid	Colland F (2004)	1
SUGP1	2	UBE2I	0	biochemical	Havugimana PC (2012)	1
TRAF5	1	UBC	7	enzymatic study	Middleton AJ (2017)	1
RNF111	2	UBXN7	3	affinity chromatography technology	Huttlin EL (2017)	1
UBE2V1	0	UBC	7	pull down	McKenna S (2003)	1
UBC	7	ANAPC11	0	x-ray crystallography, pull down	Brown NG (2014), Brown NG (2016)	2
KRTAP5-9	0	LCE4A	0	two hybrid	Rolland T (2014)	1
PML	7	SKI	3	affinity chromatography technology, pull down	Khan MM (2001), Khan MM (2001)	2
NR4A1	4	AXIN2	1	affinity chromatography technology	Zhou F (2014)	1
UBE2D1	0	RNF111	2	two hybrid, two hybrid, two hybrid	van Wijk SJ (2009), Markson G (2009), Rolland T (2014)	3
UBE2W	0	TRIM8	6	two hybrid	Markson G (2009)	1
SMURF2	3	SKIL	3	affinity chromatography technology	Bonni S (2001)	1
MVP	1	SKIL	3	two hybrid	Corominas R (2014)	1
UBC	7	MVP	1	pull down	Zhang X (2017)	1
CREB1	1	RNF111	2	two hybrid	Bandyopadhyay S (2010)	1
UBE2D4	0	DTX3L	1	two hybrid	Markson G (2009)	1
UBE2D1	0	UBC	7	x-ray crystallography	Bosanac I (2010)	1
UBE2W	0	DTX3L	1	two hybrid	Markson G (2009)	1
UBXN7	3	SETD7	2	affinity chromatography technology	Raman M (2015)	1
UBC	7	UBE2N	1	affinity chromatography technology, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down	Matsumoto M (2005), Scheper J (2010), Wu PY (2003), McKenna S (2003), Wiener R (2012), Ye Y (2003), Bish RA (2007), Juang YC (2012), Pastushok L (2007), Singh RK (2012), McKenna S (2001), McKenna S (2001)	12
AXIN2	1	RNF111	2	affinity chromatography technology	Zhou F (2014)	1
RB1CC1	9	SKIL	3	affinity chromatography technology	Koinuma D (2011)	1
HSP90AA1	7	TTC9C	2	affinity chromatography technology	Gano JJ (2010)	1
CREB1	1	FHL2	0	two hybrid, affinity chromatography technology	Fimia GM (2000), Fimia GM (2000)	2
CREB1	1	UBE2I	0	two hybrid	Bandyopadhyay S (2010)	1
UBE2I	0	UBE2K	0	enzymatic study, enzymatic study, enzymatic study, enzymatic study, biochemical	Knipscheer P (2008), Gruenwald M (2011), Pichler A (2005), Galisson F (2011), Wan C (2015)	5
RNF111	2	UBC	7	enzymatic study	Wright JD (2016)	1
DTX3L	1	UBE2D3	1	affinity chromatography technology, two hybrid	Takeyama K (2003), Markson G (2009)	2
SKI	3	SMURF2	3	affinity chromatography technology	Zhou F (2017)	1
UBE2E2	1	RNF111	2	two hybrid	Markson G (2009)	1
RNF111	2	RBM27	5	affinity chromatography technology	Huttlin EL (2017)	1
UBE2D4	0	RNF111	2	two hybrid, two hybrid	van Wijk SJ (2009), Markson G (2009)	2
NR4A1	4	SMAD3	1	two hybrid	Wang J (2011)	1
UBE2I	0	UBE2D2	0	biochemical	Wan C (2015)	1
UBE2K	0	LRSAM1	2	two hybrid	Markson G (2009)	1
SMAD3	1	SMAD2	5	affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Nakao A (1997), Lebrun JJ (1999), Dumont E (2003), Brown KA (2008), Brown KA (2008), Wu RY (1997), Wu RY (1997), Tang Y (2003), Tang Y (2003), Wang J (2011), Huttlin EL (2015), Huttlin EL (2017)	12
RB1CC1	9	RNF111	2	affinity chromatography technology	Koinuma D (2011)	1
DTX3L	1	UBE2D1	0	affinity chromatography technology, two hybrid, pull down	Takeyama K (2003), Markson G (2009), Yan Q (2009)	3
UBE2V1	0	UBE2K	0	biochemical	Wan C (2015)	1
SUMO3	0	PML	7	imaging technique	Cuchet-Lourenco D (2011)	1
AXIN2	1	SMAD7	1	affinity chromatography technology, pull down	Zhou F (2014), Elkouris M (2016)	2
RNF111	2	TRAF5	1	two hybrid	Woodsmith J (2012)	1
FAM189B	2	SETD7	2	affinity chromatography technology	Huttlin EL (2015)	1
RNF111	2	SPAST	8	affinity chromatography technology	Huttlin EL (2017)	1
RB1CC1	9	SKI	3	affinity chromatography technology, affinity chromatography technology	Koinuma D (2011), Koinuma D (2011)	2
SMURF2	3	UBE2D2	0	pull down	Kristariyanto YA (2015)	1
UBE2N	1	UBE2V1	0	biochemical, pull down, pull down, pull down, two hybrid, two hybrid, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, two hybrid, biochemical, pull down, pull down, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Deng L (2000), Deng L (2000), Zhang M (2005), Andersen PL (2005), Andersen PL (2005), Scheper J (2010), Scheper J (2010), Scheper J (2010), Wooff J (2004), Plans V (2006), Huen MS (2008), Huen MS (2008), Havugimana PC (2012), Bohgaki M (2008), Petroski MD (2007), Sawasaki T (2008), Wan C (2015), Chen J (2015), Boldt K (2016), Zhang Y (2018)	20
DTX3L	1	UBE2D2	0	affinity chromatography technology, two hybrid, pull down	Takeyama K (2003), Markson G (2009), Yan Q (2009)	3
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
RNF111	2	RNF111	2	enzymatic study, two hybrid, two hybrid, enzymatic study	Xia T (2013), Woodsmith J (2012), Rolland T (2014), Poulsen SL (2013)	4
TRIM21	0	RNF111	2	two hybrid	Woodsmith J (2012)	1
UBC	7	CSNK2A2	1	affinity chromatography technology	Matsumoto M (2005)	1
SETD7	2	SMURF2	3	affinity chromatography technology	Elkouris M (2016)	1
MVP	1	RNF111	2	two hybrid	Corominas R (2014)	1
UBE2N	1	RNF111	2	affinity chromatography technology, pull down	Poulsen SL (2013), Wright JD (2016)	2
CSNK2A2	1	RNF111	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	3
RNF111	2	GNAQ	1	affinity chromatography technology	Huttlin EL (2017)	1
UBE2D3	1	TRIM8	6	two hybrid	Markson G (2009)	1
UBC	7	SUMO2	0	affinity chromatography technology	Sahin U (2014)	1
FHL2	0	SMAD2	5	pull down, affinity chromatography technology	Ding L (2009), Ding L (2009)	2
RNF111	2	SUMO1	0	pull down, affinity chromatography technology, pull down	Sun H (2012), Sun H (2012), Erker Y (2013)	3
TSG101	1	UBC	7	affinity chromatography technology, x-ray crystallography, affinity chromatography technology, pull down, x-ray crystallography, pull down, pull down	Schlundt A (2009), Sundquist WI (2004), Bishop N (2002), Bishop N (2002), Pornillos O (2002), Kharitidi D (2015), Zhang X (2017)	7
SMAD3	1	PML	7	affinity chromatography technology	Lin HK (2004)	1
MARCH7	0	UBE2D1	0	two hybrid	Flach K (2014)	1
PML	7	SMAD2	5	affinity chromatography technology	Lin HK (2004)	1
SETD7	2	SMAD7	1	enzymatic study	Elkouris M (2016)	1
ANAPC11	0	UBE2D1	0	pull down, pull down, pull down, pull down	Wu T (2010), Townsend K (2009), Summers MK (2009), Cao J (2015)	4
UBE2I	0	SMURF2	3	affinity chromatography technology	Chandhoke AS (2015)	1
UBC	7	UBXN7	3	pull down, affinity chromatography technology, pull down, affinity chromatography technology	Kelsall IR (2013), Alexandru G (2008), Besten Wd (2012), Besten Wd (2012)	4
UBE2E1	1	DTX3L	1	two hybrid	Markson G (2009)	1
UBE2K	0	UBE2D2	0	biochemical	Wan C (2015)	1
UBE2M	0	DCUN1D5	0	pull down, affinity chromatography technology, pull down, pull down	Monda JK (2013), Bommelje CC (2013), Monda JK (2013), Keuss MJ (2016)	4
SKIL	3	SMAD2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Stroschein SL (2001), Stroschein SL (1999), Tan R (2006), Mizuide M (2003), Brown KA (2008), Colland F (2004), Colland F (2004), He J (2003), Ikeuchi Y (2014)	9
RNF111	2	XPC	1	affinity chromatography technology	Poulsen SL (2013)	1
UBC	7	CSNK2A1	15	affinity chromatography technology	Matsumoto M (2005)	1
UBE2V1	0	TRIM8	6	two hybrid	Markson G (2009)	1
PML	7	NR4A1	4	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Wu WS (2002), Wu WS (2002), Wu WS (2002), Wu WS (2002)	4
RNF111	2	ADD3	4	affinity chromatography technology	Huttlin EL (2017)	1
TSG101	1	LRSAM1	2	two hybrid, two hybrid, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, enzymatic study, two hybrid, imaging technique, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Rual JF (2005), Amit I (2004), Amit I (2004), Amit I (2004), Markson G (2009), McDonald B (2008), Schlundt A (2009), Amit I (2004), Rolland T (2014), Amit I (2004), Chua HH (2016), Chua HH (2016), Chua HH (2016), Hakonen JE (2017)	14
UBE2D2	0	UBXN7	3	biochemical	Havugimana PC (2012)	1
SMAD3	1	SKIL	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Stroschein SL (2001), Stroschein SL (2001), Stroschein SL (1999), Liberati NT (2001), Tan R (2006), Mizuide M (2003), Colland F (2004), He J (2003), Jinnin M (2007), Jinnin M (2007)	10
TSG101	1	UBE2I	0	biochemical	Wan C (2015)	1
SMURF2	3	UBE2D1	0	pull down, pull down, enzymatic study, affinity chromatography technology, pull down	Kim S (2010), Shukla S (2014), Shukla S (2014), Shukla S (2014), Kristariyanto YA (2015)	5
UBE2N	1	LRSAM1	2	two hybrid, two hybrid, two hybrid	van Wijk SJ (2009), Markson G (2009), Hakonen JE (2017)	3
UBE2D2	0	UBC	7	x-ray crystallography, x-ray crystallography, enzymatic study, pull down, pull down	Juang YC (2012), Dou H (2012), Sheng Y (2012), Buetow L (2015), Zhang X (2017)	5
SKI	3	MVP	1	affinity chromatography technology	Rashidian J (2015)	1
ACTN3	2	RNF111	2	two hybrid	Rolland T (2014)	1
UBE2G2	0	UBC	7	x-ray crystallography, pull down, pull down	Bocik WE (2011), Bocik WE (2011), Reyes LF (2006)	3
SMAD6	9	SMURF2	3	affinity chromatography technology, two hybrid, affinity chromatography technology	Komuro A (2004), Colland F (2004), Herhaus L (2014)	3
RB1CC1	9	UBC	7	pull down	Choi JD (2012)	1
TRIM21	0	UBE2D2	0	pull down, pull down, pull down, pull down	Wada K (2006), Wada K (2006), Wada K (2009), Wada K (2006)	4
HSP90AA1	7	CSNK2A1	15	pull down, enzymatic study, enzymatic study, affinity chromatography technology	Miyata Y (1995), Muller P (2012), Zhang M (2011), Woo SH (2009)	4
SMAD3	1	SKI	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Harada J (2003), Ueki N (2003), Ueki N (2003), Tabata T (2009), Prunier C (2003), Liberati NT (2001), Akiyoshi S (1999), Akiyoshi S (1999), Takeda M (2004), Mizuide M (2003), Wu K (2003), Chen W (2007), Band AM (2009), Qin BY (2002), He J (2003), He J (2003), Jinnin M (2007), Jinnin M (2007), Rashidian J (2015)	19
SKIL	3	UBE2I	0	two hybrid	Colland F (2004)	1
RNF111	2	SUMO2	0	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Sun H (2012), Sun H (2012), Erker Y (2013), Poulsen SL (2013), Poulsen SL (2013)	5
SUMO2	0	PML	7	imaging technique, two hybrid, pull down	Cuchet-Lourenco D (2011), Li C (2017), Li C (2017)	3
MARCH7	0	UBE2M	0	two hybrid	Flach K (2014)	1
UBE2I	0	SUMO1	0	affinity chromatography technology, pull down, two hybrid, two hybrid, fluorescent resonance energy transfe, pull down, two hybrid, two hybrid, pull down, pull down, two hybrid, pull down, fluorescent resonance energy transfe, pull down, two hybrid, pull down, pull down, enzymatic study, enzymatic study, biochemical, affinity chromatography technology	Ewing RM (2007), Tatham MH (2003), Minty A (2000), Shen Z (1996), Song Y (2011), Knipscheer P (2007), Boutell C (2011), Gong L (1997), Gong L (1997), Hemelaar J (2004), Hecker CM (2006), Hecker CM (2006), Martin SF (2008), Everett RD (2014), Rolland T (2014), Zilio N (2013), Carbia-Nagashima A (2007), Knipscheer P (2007), Matic I (2008), Wan C (2015), Hein MY (2015)	21
UBE2I	0	SUMO3	0	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, enzymatic study, biochemical, affinity chromatography technology	Ewing RM (2007), Li T (2006), Boutell C (2011), Hecker CM (2006), Tatham MH (2001), Wan C (2015), Huttlin EL (2017)	7
RNF111	2	ESRP1	1	affinity chromatography technology	Mizutani A (2016)	1
PML	7	CSNK2A1	15	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study	Rabellino A (2012), Stehmeier P (2009), Hung MS (2010), Hung MS (2010), Scaglioni PP (2006)	5
HSP90AA1	7	CSNK2A2	1	pull down	Miyata Y (1995)	1