PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RBFOX1	1	BBS2	1	affinity chromatography technology	Boldt K (2016)	1
RBFOX2	5	PRRC2A	10	affinity chromatography technology	Huttlin EL (2015)	1
RBPMS	0	C1orf94	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
PLK4	1	LZTS2	4	bioid	Firat-Karalar EN (2014)	1
ATXN1	2	HSFX1	0	two hybrid	Lim J (2006)	1
ATXN1	2	RBPMS	0	two hybrid, affinity chromatography technology, two hybrid	Lim J (2006), Lim J (2006), Rolland T (2014)	3
RBFOX1	1	ECM1	1	affinity chromatography technology	Huttlin EL (2017)	1
LZTS2	4	RHOXF2	0	two hybrid	Rual JF (2005)	1
RIOK1	0	PRMT5	3	affinity chromatography technology	So J (2015)	1
RBFOX1	1	KIFAP3	1	two hybrid	Lim J (2006)	1
MAGED1	0	NUMBL	1	two hybrid	Wang J (2011)	1
RBFOX2	5	DMRTB1	1	two hybrid	Rual JF (2005)	1
RBFOX1	1	PRMT5	3	affinity chromatography technology	Huttlin EL (2017)	1
PHF12	6	RBFOX2	5	affinity chromatography technology	Varier RA (2016)	1
RBFOX1	1	COPRS	0	affinity chromatography technology	Huttlin EL (2017)	1
RBFOX1	1	RIOK1	0	affinity chromatography technology	Huttlin EL (2017)	1
ATN1	2	PRRC2A	10	two hybrid	Lim J (2006)	1
ATXN1	2	RHOXF2	0	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
MAGED1	0	RBPMS	0	two hybrid	Rolland T (2014)	1
DAZAP2	1	PRR20A	0	two hybrid	Rolland T (2014)	1
ATN1	2	NOC2L	5	two hybrid	Lim J (2006)	1
G3BP1	4	PRMT5	3	affinity chromatography technology	Jain S (2016)	1
RBFOX1	1	CAPNS2	0	affinity chromatography technology	Huttlin EL (2017)	1
QKI	1	PSMF1	0	two hybrid	Lim J (2006)	1
RBFOX1	1	TNIP1	1	two hybrid	Lim J (2006)	1
RBFOX1	1	HSFX1	0	two hybrid	Lim J (2006)	1
RBFOX1	1	HSFY1	0	two hybrid	Corominas R (2014)	1
MAGED1	0	DAZAP2	1	two hybrid	Yu H (2011)	1
RBFOX1	1	DAB1	1	two hybrid	Corominas R (2014)	1
DAB1	1	BHLHE40	5	two hybrid	Rolland T (2014)	1
RBFOX1	1	PCBP4	2	two hybrid	Lim J (2006)	1
FAM168A	0	C1orf94	1	two hybrid	Rolland T (2014)	1
ATN1	2	ALG13	9	two hybrid	Lim J (2006)	1
RBFOX1	1	RNF25	1	affinity chromatography technology	Huttlin EL (2017)	1
RBPMS	0	RBFOX2	5	two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Huttlin EL (2015), Huttlin EL (2017)	3
RBFOX1	1	NUMBL	1	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
C1orf94	1	PRR20A	0	two hybrid	Rolland T (2014)	1
RBFOX1	1	CRX	0	two hybrid	Corominas R (2014)	1
RBFOX1	1	FAM168A	0	two hybrid	Corominas R (2014)	1
COPRS	0	PRMT5	3	pull down, two hybrid, pull down, affinity chromatography technology, biochemical	Paul C (2011), Lacroix M (2008), Lacroix M (2008), Lacroix M (2008), Lacroix M (2008)	5
DAB1	1	MAGED1	0	two hybrid	Rolland T (2014)	1
RBFOX2	5	COPRS	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RBPMS	0	FAM168A	0	two hybrid	Rolland T (2014)	1
DAB1	1	RHOXF2	0	two hybrid	Rolland T (2014)	1
FAM168A	0	PRR20A	0	two hybrid	Rolland T (2014)	1
HNRNPF	5	HSFY1	0	two hybrid	Rolland T (2014)	1
DAB1	1	RBFOX2	5	two hybrid	Rolland T (2014)	1
RBFOX1	1	MKRN1	1	affinity chromatography technology	Huttlin EL (2017)	1
RBFOX1	1	ATXN1	2	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
RBPMS	0	RHOXF2	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
DAB1	1	PRR20A	0	two hybrid	Rolland T (2014)	1
PLK4	1	RBFOX1	1	affinity chromatography technology	Hein MY (2015)	1
RBFOX1	1	HNRNPF	5	two hybrid	Lim J (2006)	1
ATXN1	2	C1orf94	1	two hybrid, affinity chromatography technology, two hybrid	Lim J (2006), Lim J (2006), Rolland T (2014)	3
SNRPN	0	COPRS	0	affinity chromatography technology	Huttlin EL (2017)	1
PHF12	6	RBFOX1	1	affinity chromatography technology	Varier RA (2016)	1
DAZAP2	1	RHOXF2	0	two hybrid, two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009), Rolland T (2014)	3
GATAD1	0	RBFOX2	5	affinity chromatography technology	Varier RA (2016)	1
RBFOX2	5	ATXN2	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
QKI	1	PCBP4	2	two hybrid	Lim J (2006)	1
RBFOX1	1	MAGED1	0	two hybrid, two hybrid	Lim J (2006), Corominas R (2014)	2
BHLHE40	5	RBPMS	0	two hybrid	Rolland T (2014)	1
ATN1	2	RBPMS	0	two hybrid	Lim J (2006)	1
RBFOX1	1	SERPINA12	0	affinity chromatography technology	Huttlin EL (2017)	1
MAGED1	0	RHOXF2	0	two hybrid	Rolland T (2014)	1
DAZAP2	1	RBPMS	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
ATN1	2	DVL2	5	two hybrid	Lim J (2006)	1
RBFOX1	1	QKI	1	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
RBFOX1	1	PRR20A	0	two hybrid	Corominas R (2014)	1
RBFOX1	1	CELF3	2	two hybrid	Lim J (2006)	1
DAZAP2	1	C1orf94	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
SNRPN	0	PRMT5	3	affinity chromatography technology	Huttlin EL (2017)	1
RBFOX1	1	DMRTB1	1	two hybrid	Lim J (2006)	1
DMRTB1	1	C1orf94	1	two hybrid	Yu H (2011)	1
BHLHE40	5	MAGED1	0	two hybrid	Rolland T (2014)	1
RBFOX1	1	RBFOX2	5	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
RBFOX1	1	DVL2	5	two hybrid	Lim J (2006)	1
DAZAP2	1	RBFOX2	5	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	4
CELF3	2	MKRN1	1	affinity chromatography technology	Huttlin EL (2017)	1
PSMF1	0	RBFOX2	5	two hybrid	Venkatesan K (2009)	1
DAZAP2	1	FAM168A	0	two hybrid	Rolland T (2014)	1
G3BP1	4	RBFOX1	1	affinity chromatography technology	Jain S (2016)	1
RBFOX1	1	RBPMS	0	two hybrid, two hybrid	Corominas R (2014), Rolland T (2014)	2
TSNAX	1	RBFOX1	1	affinity chromatography technology	Hein MY (2015)	1
ATXN1	2	GATAD1	0	two hybrid	Suter B (2013)	1
ATXN1	2	DAZAP2	1	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
RBFOX1	1	C1orf94	1	two hybrid, two hybrid	Corominas R (2014), Rolland T (2014)	2
TSNAX	1	LZTS2	4	two hybrid	Rolland T (2014)	1
DAB1	1	DAZAP2	1	two hybrid	Rolland T (2014)	1
PLK4	1	MAGED1	0	bioid	Firat-Karalar EN (2014)	1
QKI	1	RBPMS	0	two hybrid, affinity chromatography technology, two hybrid	Lim J (2006), Lim J (2006), Rolland T (2014)	3
MAGED1	0	NOC2L	5	affinity chromatography technology	Ewing RM (2007)	1
KLC1	5	RBFOX1	1	affinity chromatography technology	Hein MY (2015)	1
RBFOX1	1	CTSV	0	affinity chromatography technology	Huttlin EL (2017)	1
ATXN1	2	RBFOX2	5	two hybrid, affinity chromatography technology, two hybrid, two hybrid	Lim J (2006), Lim J (2006), Suter B (2013), Rolland T (2014)	4
DAB1	1	C1orf94	1	two hybrid	Rolland T (2014)	1
MAGED1	0	RBFOX2	5	two hybrid	Rolland T (2014)	1
RBFOX1	1	NOC2L	5	two hybrid	Lim J (2006)	1
DVL2	5	RBPMS	0	two hybrid	Rual JF (2005)	1
RBFOX1	1	RHOXF2	0	two hybrid, affinity chromatography technology, two hybrid	Lim J (2006), Lim J (2006), Corominas R (2014)	3
ATN1	2	RHOXF2	0	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
HNRNPF	5	RBFOX2	5	two hybrid, two hybrid, two hybrid	Hegele A (2012), Hegele A (2012), Rolland T (2014)	3
RBFOX1	1	RBFOX1	1	two hybrid	Corominas R (2014)	1
G3BP1	4	MAGED1	0	affinity chromatography technology	Jain S (2016)	1
RBFOX2	5	PRMT5	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BHLHE40	5	NUMBL	1	two hybrid	Wang J (2011)	1
ATXN1	2	ATXN2	3	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
RBFOX2	5	C1orf94	1	two hybrid	Rolland T (2014)	1
TNIP1	1	FAM168A	0	two hybrid	Rolland T (2014)	1
SNRPN	0	RBFOX1	1	two hybrid	Corominas R (2014)	1
PSMF1	0	RHOXF2	0	two hybrid, two hybrid	Rual JF (2005), Xin X (2009)	2
RBFOX1	1	ATXN2	3	two hybrid	Lim J (2006)	1
RBFOX2	5	RIOK1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RBFOX1	1	ATN1	2	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
ATN1	2	RBFOX2	5	two hybrid	Lim J (2006)	1
G3BP1	4	ATXN2	3	affinity chromatography technology	Jain S (2016)	1
RBFOX1	1	BHLHE40	5	two hybrid	Corominas R (2014)	1
MAGED1	0	C1orf94	1	two hybrid	Rolland T (2014)	1
RBFOX1	1	RBM24	0	two hybrid	Lim J (2006)	1
RBFOX2	5	RHOXF2	0	two hybrid	Rual JF (2005)	1
RBPMS	0	PRR20A	0	two hybrid	Rolland T (2014)	1
G3BP1	4	PRRC2A	10	affinity chromatography technology	Jain S (2016)	1
BBS2	1	RBPMS	0	two hybrid	Rolland T (2014)	1
RBFOX1	1	ALG13	9	two hybrid	Corominas R (2014)	1
GATAD1	0	PHF12	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vermeulen M (2010), Hein MY (2015), Hein MY (2015), Varier RA (2016), Varier RA (2016)	5
HNRNPF	5	C1orf94	1	two hybrid	Rolland T (2014)	1
ATN1	2	ECM1	1	two hybrid	Lim J (2006)	1
RBFOX1	1	GCA	0	two hybrid	Lim J (2006)	1
RBFOX1	1	SDR9C7	0	affinity chromatography technology	Huttlin EL (2017)	1
DAB1	1	FAM168A	0	two hybrid	Rolland T (2014)	1
GATAD1	0	RBFOX1	1	affinity chromatography technology	Varier RA (2016)	1
SNRPN	0	RIOK1	0	affinity chromatography technology	Huttlin EL (2017)	1
DVL2	5	RHOXF2	0	two hybrid	Rual JF (2005)	1
ATXN1	2	NUMBL	1	two hybrid	Lim J (2006)	1
ATXN1	2	PRRC2A	10	two hybrid	Lim J (2006)	1
RBFOX1	1	PRRC2A	10	two hybrid	Lim J (2006)	1
RBFOX1	1	DAZAP2	1	two hybrid	Corominas R (2014)	1
RBPMS	0	LZTS2	4	two hybrid	Rual JF (2005)	1
ATXN1	2	QKI	1	two hybrid	Suter B (2013)	1
RBFOX1	1	PSMF1	0	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
ATXN1	2	PRR20A	0	two hybrid	Rolland T (2014)	1
RBFOX1	1	IMPA2	0	affinity chromatography technology	Huttlin EL (2017)	1
QKI	1	RBFOX2	5	two hybrid, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Lim J (2006), Lim J (2006), Hegele A (2012), Hegele A (2012), Huttlin EL (2015), Huttlin EL (2017)	6
RBFOX1	1	LZTS2	4	two hybrid	Lim J (2006)	1
ATXN1	2	GCA	0	two hybrid	Lim J (2006)	1