PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
POLR1E	3	25885	0	far western blotting, affinity chromatography technology, affinity chromatography technology	Yamamoto K (2004), Birch JL (2009), Hein MY (2015)	3
25885	0	TAF1B	0	affinity chromatography technology	Hein MY (2015)	1
TAF1A	0	TAF1B	0	pull down, affinity chromatography technology, affinity chromatography technology	Comai L (1994), Huttlin EL (2015), Huttlin EL (2017)	3
RRN3	3	25885	0	affinity chromatography technology, affinity chromatography technology	Miller G (2001), Hein MY (2015)	2
CDK2	0	RRN3	3	pull down	Mayer C (2004)	1
TAF1B	0	TAF1C	5	pull down, affinity chromatography technology, affinity chromatography technology	Comai L (1994), Huttlin EL (2015), Huttlin EL (2017)	3
RRN3	3	TAF1C	5	pull down	Miller G (2001)	1
TAF1D	0	TBP	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Gorski JJ (2007), Hein MY (2015)	3
CDK2	0	MYO1C	5	affinity chromatography technology	Hein MY (2015)	1
POLR1E	3	UBTF	8	pull down	Yamamoto K (2004)	1
UBTF	8	TBP	0	affinity chromatography technology	Hempel WM (1996)	1
POLR1B	2	RRN3	3	affinity chromatography technology, affinity chromatography technology	Philimonenko VV (2004), Philimonenko VV (2004)	2
EIF3L	4	RRN3	3	pull down	Yuan X (2002)	1
TWISTNB	1	POLR1B	2	affinity chromatography technology, biochemical, affinity chromatography technology	Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	3
RRN3	3	UBTF	8	affinity chromatography technology	Miller G (2001)	1
CCNE1	1	UBTF	8	enzymatic study	Voit R (1999)	1
UBTF	8	TAF1C	5	pull down, pull down	Voit R (2001), Zhai W (2000)	2
25885	0	POLR1C	2	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Birch JL (2009), Havugimana PC (2012), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	5
TAF1A	0	TAF1C	5	pull down	Comai L (1994)	1
TAF1D	0	TWISTNB	1	affinity chromatography technology	Sowa ME (2009)	1
RRN3	3	TAF1A	0	pull down	Miller G (2001)	1
TAF1D	0	TAF1B	0	affinity chromatography technology, affinity chromatography technology, biochemical, far western blotting, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Gorski JJ (2007), Gorski JJ (2007), Gorski JJ (2007), Huttlin EL (2015), Huttlin EL (2017)	6
TAF1D	0	UBTF	8	far western blotting, pull down	Gorski JJ (2007), Gorski JJ (2007)	2
POLR1B	2	ACTA1	1	affinity chromatography technology, affinity chromatography technology	Philimonenko VV (2004), Philimonenko VV (2004)	2
TAF1A	0	TBP	0	pull down, two hybrid, pull down, affinity chromatography technology	Comai L (1994), Xu S (2004), Xu S (2004), Hein MY (2015)	4
RRN3	3	POLR1E	3	affinity chromatography technology	Birch JL (2009)	1
25885	0	POLR1B	2	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Birch JL (2009), Havugimana PC (2012), Wan C (2015), Hein MY (2015), Werner A (2015)	5
TAF1D	0	TAF1A	0	affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Gorski JJ (2007), Gorski JJ (2007), Huttlin EL (2015), Huttlin EL (2017)	5
TAF1D	0	RRN3	3	affinity chromatography technology	Sowa ME (2009)	1
TAF1A	0	UBTF	8	pull down	Zhai W (2000)	1
POLR1C	2	RRN3	3	affinity chromatography technology	Huttlin EL (2017)	1
RRN3	3	TAF1B	0	affinity chromatography technology, pull down	Miller G (2001), Miller G (2001)	2
RRN3	3	MYO1C	5	affinity chromatography technology, affinity chromatography technology	Philimonenko VV (2004), Philimonenko VV (2004)	2
MYO1C	5	ACTA1	1	affinity chromatography technology, affinity chromatography technology	Philimonenko VV (2004), Philimonenko VV (2004)	2
CDK2	0	UBTF	8	enzymatic study	Voit R (1999)	1
MYO1C	5	POLR1B	2	affinity chromatography technology	Philimonenko VV (2004)	1
UBTF	8	25885	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tsai YC (2012), Tsai YC (2012), Tsai YC (2012), Lee D (2017)	4
25885	0	TAF1C	5	affinity chromatography technology	Hein MY (2015)	1
ELAVL1	0	PPP2R2A	0	affinity chromatography technology	Abdelmohsen K (2009)	1
POLR1E	3	POLR1C	2	affinity chromatography technology, far western blotting, biochemical, affinity chromatography technology	Ewing RM (2007), Yamamoto K (2004), Seither P (1997), Huttlin EL (2017)	4
TWISTNB	1	25885	0	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	4
POLR1C	2	TWISTNB	1	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
CCNE1	1	RRN3	3	pull down	Mayer C (2004)	1
TAF1D	0	POLR1E	3	affinity chromatography technology	Sowa ME (2009)	1
TWISTNB	1	RRN3	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TAF1D	0	POLR1C	2	affinity chromatography technology	Sowa ME (2009)	1
TAF1C	5	TBP	0	pull down, affinity chromatography technology, affinity chromatography technology	Comai L (1994), Denissov S (2007), Hein MY (2015)	3
ELAVL1	0	TWISTNB	1	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	TBP	0	affinity chromatography technology	Abdelmohsen K (2009)	1
TMEM108	1	RRN3	3	affinity chromatography technology	Huttlin EL (2017)	1
ELAVL1	0	RBM15	7	affinity chromatography technology	Abdelmohsen K (2009)	1
TAF1B	0	TBP	0	pull down, affinity chromatography technology	Comai L (1994), Hein MY (2015)	2
TAF1D	0	TAF1C	5	affinity chromatography technology, affinity chromatography technology, biochemical, far western blotting, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Gorski JJ (2007), Gorski JJ (2007), Gorski JJ (2007), Huttlin EL (2015), Huttlin EL (2017)	6
ELAVL1	0	RRN3	3	affinity chromatography technology	Abdelmohsen K (2009)	1
TAF1D	0	POLR1B	2	affinity chromatography technology	Sowa ME (2009)	1
POLR1B	2	POLR1C	2	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	3
PPP2R2A	0	RRN3	3	pull down	Mayer C (2004)	1
RBM15	7	RRN3	3	biochemical	Havugimana PC (2012)	1
UNK	3	RRN3	3	affinity chromatography technology	Murn J (2015)	1
RRN3	3	TBP	0	affinity chromatography technology	Miller G (2001)	1
TAF1D	0	25885	0	affinity chromatography technology	Sowa ME (2009)	1
CDK2	0	ACTA1	1	affinity chromatography technology	Neganova I (2011)	1
TAF1B	0	UBTF	8	pull down	Zhai W (2000)	1
RRN3	3	ACTA1	1	affinity chromatography technology	Philimonenko VV (2004)	1
CCNE1	1	CDK2	0	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	McKenzie PP (2003), Shanahan F (1999), Koff A (1992), Koff A (1992), Mayer C (2004), Connor MK (2003), Boudrez A (2000), Varshochi R (2005), Jeong JH (2010), Bustany S (2011), Yeh ES (2006), Hui S (2011), Kim J (2007), Kiviharju-af Haellstroem TM (2007), Abbas T (2007), Nishimura T (2005), Matsumoto Y (2004), Harwell RM (2004), Harwell RM (2004), Peiretti A (2003), Peiretti A (2003), Kim YB (2000), Manenti S (1999), Datta NS (1998), Sheaff RJ (1997), Higashi H (1996), Higashi H (1996), Musgrove EA (1996), Vlach J (1996), Grim JE (2008), Liu S (2009), Ciarallo S (2002), Desai D (1995), Baydoun HH (2010), Baydoun HH (2010), Chu I (2007), Chu I (2007), Levkau B (1998), Poon RY (1996), Zhao J (1998), Zhao J (1998), Larrea MD (2009), Varjosalo M (2013), Varjosalo M (2013), Chan HM (2001), So J (2015), Ungermannova D (2005), Song MS (2011), Huttlin EL (2015), Hein MY (2015), Lin CH (2015), Lin CH (2015), Davis RJ (2017), Huttlin EL (2017)	54