PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SORT1	1	FBXL19	5	affinity chromatography technology	Hein MY (2015)	1
CUL1	7	FBXL19	5	affinity chromatography technology	Reitsma JM (2017)	1
FBXL19	5	HELZ	6	affinity chromatography technology	Boldt K (2016)	1
FBXL19	5	WDR44	0	affinity chromatography technology	Tan MK (2013)	1
FBXL19	5	RNF20	9	affinity chromatography technology, affinity chromatography technology	Lee BK (2017), Lee BK (2017)	2
TRIM27	2	FBXL19	5	two hybrid	Ravasi T (2010)	1
FBXL19	5	RNF40	11	affinity chromatography technology	Lee BK (2017)	1
PSME3	0	FBXL19	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FBXL19	5	55380	0	affinity chromatography technology	Tan MK (2013)	1
CDK9	3	CUL1	7	affinity chromatography technology, affinity chromatography technology	Kiernan RE (2001), Garriga J (2003)	2
MED21	1	RNF20	9	affinity chromatography technology	Huttlin EL (2017)	1
FBXL19	5	CDK9	3	affinity chromatography technology	Lee BK (2017)	1
SKP1	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Staropoli JF (2003), Min KW (2003), Lisztwan J (1998), Zheng N (2002), Ohta T (1999), Bloom J (2006), Kumar R (2005), Megumi Y (2005), Wang W (2004), Read MA (2000), Wu K (2000), Tan P (1999), Mao X (2011), Lin HK (2009), Yano H (2008), Banerjee S (2010), Gao D (2010), Chua YS (2011), Zhang M (2008), Winston JT (1999), Latres E (1999), Latres E (1999), Arai T (2003), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), Emberley ED (2012), Bennett EJ (2010), Gastaldello S (2012), Michel JJ (1998), Michel JJ (1998), Michel JJ (1998), Lyapina SA (1998), Lyapina SA (1998), Lyapina SA (1998), Lyapina SA (1998), Furukawa M (2000), Furukawa M (2000), Liu J (2002), Liu J (2002), Liu J (2002), Yu ZK (1998), Yu ZK (1998), Postow L (2013), Cordero-Espinoza L (2013), Zhou W (2014), Zhou W (2014), Hao J (2015), Hao J (2015), Han XR (2016), Liu YQ (2015), Gorelik M (2016), Al-Yacoub N (2016), Reiterer V (2017), Hu Y (2017), Hauri S (2016), Reitsma JM (2017), Reitsma JM (2017), Chen F (2017)	59
FGD1	0	FBXL19	5	affinity chromatography technology	Hein MY (2015)	1
SKP1	0	MED21	1	pull down, pull down, protein complementation assay	Ang K (2012), Ang K (2012), Ang K (2012)	3
NSMAF	5	FBXL19	5	affinity chromatography technology	Hein MY (2015)	1
CBFA2T2	3	FBXL19	5	two hybrid	Ravasi T (2010)	1
FBXL19	5	MARF1	8	affinity chromatography technology	Boldt K (2016)	1
RNF20	9	RNF40	11	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Zhang F (2011), Jaeaeskelaeinen T (2011), Jaeaeskelaeinen T (2011), Moyal L (2011), Moyal L (2011), Zhu B (2005), Kim J (2009), Bedi U (2015), Klement K (2014), Duan Y (2016), Duan Y (2016), Foglizzo M (2016)	12
HELZ	6	MARF1	8	affinity chromatography technology	Boldt K (2016)	1
TRIM29	2	TRIM27	2	two hybrid, affinity chromatography technology	Reymond A (2001), Hein MY (2015)	2
SKP1	0	FBXL19	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhao J (2012), Kuchay S (2017), Hauri S (2016)	3
COL11A1	12	FBXL19	5	affinity chromatography technology, affinity chromatography technology	Zhao J (2012), Zhao J (2012)	2
FBXL19	5	STRADA	0	affinity chromatography technology	Tan MK (2013)	1
TRIM27	2	MED21	1	two hybrid	Ravasi T (2010)	1
CTDSPL2	0	FBXL19	5	affinity chromatography technology	Hein MY (2015)	1
TRIM29	2	FBXL19	5	two hybrid	Ravasi T (2010)	1
RNF40	11	CDK9	3	biochemical	Wu L (2014)	1
MED21	1	RNF40	11	affinity chromatography technology	Huttlin EL (2017)	1
CDK9	3	SKP1	0	pull down, affinity chromatography technology	Kiernan RE (2001), Kiernan RE (2001)	2
MED21	1	FBXL19	5	affinity chromatography technology	Huttlin EL (2017)	1
RNF20	9	CDK9	3	biochemical, biochemical	Wu L (2014), Wu L (2014)	2
DENND2D	2	FBXL19	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RAC3	4	FBXL19	5	affinity chromatography technology, affinity chromatography technology	Dong S (2014), Dong S (2014)	2