PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
USHBP1	1	KANSL1	11	two hybrid	Rual JF (2005)	1
EIF4E2	2	CARD9	3	two hybrid	Rolland T (2014)	1
INPP1	0	USHBP1	1	two hybrid	Corominas R (2014)	1
ISCU	0	NECAB2	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
TTR	0	NECAB2	1	two hybrid	Rolland T (2014)	1
BYSL	3	AIMP2	0	two hybrid	Rolland T (2014)	1
POLR2C	0	NECAB2	1	two hybrid	Yu H (2011)	1
SDCBP	0	RIC8A	4	two hybrid	Rolland T (2014)	1
CAPN3	1	NECAB2	1	two hybrid	Rual JF (2005)	1
KLC4	2	KPNA2	0	two hybrid	Wang J (2011)	1
RUNX1T1	1	NECAB2	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
CARD9	3	LENG1	2	two hybrid	Rolland T (2014)	1
NECAB2	1	KLC4	2	two hybrid	Rolland T (2014)	1
CCDC33	3	USHBP1	1	two hybrid	Rual JF (2005)	1
NECAB2	1	NECAB3	2	affinity chromatography technology	Huttlin EL (2017)	1
FXR2	2	CCDC33	3	two hybrid	Rual JF (2005)	1
KIFC3	3	CCDC33	3	two hybrid	Rolland T (2014)	1
KLC3	3	KLC4	2	affinity chromatography technology	Hein MY (2015)	1
MED14	0	NECAB2	1	two hybrid	Albers M (2005)	1
NECAB2	1	CARD9	3	two hybrid	Rolland T (2014)	1
CAPN3	1	WDYHV1	0	two hybrid	Rolland T (2014)	1
ISCU	0	LNX1	7	two hybrid	Rolland T (2014)	1
DAXX	5	USP7	14	pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tang J (2006), Tang J (2006), Tang J (2006), Tang J (2006), Song MS (2008), Giovinazzi S (2013), Giovinazzi S (2013), Giovinazzi S (2013), Kumar N (2013)	9
NOC4L	3	USHBP1	1	two hybrid, affinity chromatography technology	Rual JF (2005), Rual JF (2005)	2
USP7	14	NECAB2	1	two hybrid	Lim J (2006)	1
NECAB2	1	KDM1A	2	two hybrid	Weimann M (2013)	1
PRKAA2	1	AIMP2	0	two hybrid	Rolland T (2014)	1
AIMP2	0	BEX3	0	two hybrid	Wang J (2011)	1
FXR2	2	NECAB2	1	two hybrid	Rual JF (2005)	1
DAXX	5	NECAB2	1	two hybrid	Rolland T (2014)	1
KPNA2	0	USHBP1	1	two hybrid	Rolland T (2014)	1
EIF4E2	2	USHBP1	1	two hybrid	Rolland T (2014)	1
SDCBP	0	NECAB2	1	two hybrid	Rolland T (2014)	1
CCDC146	3	USHBP1	1	two hybrid	Rolland T (2014)	1
PRKAA2	1	NECAB2	1	two hybrid	Rolland T (2014)	1
NECAB2	1	NECAB2	1	two hybrid, affinity chromatography technology, two hybrid	Rual JF (2005), Rual JF (2005), Rolland T (2014)	3
NECAB2	1	HAUS1	0	two hybrid	Rolland T (2014)	1
NECAB2	1	RIC8A	4	two hybrid	Rolland T (2014)	1
NECAB2	1	DCAF10	2	affinity chromatography technology	Huttlin EL (2017)	1
KIFC3	3	NECAB2	1	two hybrid	Rolland T (2014)	1
MRPS27	2	NECAB2	1	two hybrid	Rolland T (2014)	1
KIFC3	3	KDM1A	2	two hybrid	Weimann M (2013)	1
HAUS1	0	KDM1A	2	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
NECAB2	1	GOLGA4	6	affinity chromatography technology	Huttlin EL (2017)	1
EIF4E2	2	NECAB2	1	two hybrid	Rolland T (2014)	1
CCDC151	1	KDM1A	2	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
NECAB2	1	LNX1	7	two hybrid, two hybrid, two hybrid	Rual JF (2005), Rolland T (2014), Yu H (2011)	3
CCNK	1	NECAB2	1	two hybrid	Rual JF (2005)	1
NECAB2	1	NOC4L	3	two hybrid	Rual JF (2005)	1
USHBP1	1	KLC4	2	two hybrid	Rolland T (2014)	1
CCDC121	0	USHBP1	1	two hybrid	Rolland T (2014)	1
SH2D4A	0	USHBP1	1	two hybrid	Rolland T (2014)	1
BEX3	0	NECAB2	1	two hybrid	Rolland T (2014)	1
KDM1A	2	RCOR3	0	affinity chromatography technology, two hybrid, biochemical	Bantscheff M (2011), Weimann M (2013), Wan C (2015)	3
BYSL	3	CCDC33	3	two hybrid	Rolland T (2014)	1
CCNK	1	USHBP1	1	two hybrid	Rual JF (2005)	1
NECAB2	1	LENG1	2	two hybrid	Rolland T (2014)	1
GCC1	1	USHBP1	1	two hybrid	Rual JF (2005)	1
NECAB1	2	NECAB3	2	affinity chromatography technology	Huttlin EL (2017)	1
NECAB2	1	CCDC146	3	two hybrid	Rolland T (2014)	1
AIMP2	0	LNX1	7	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
NECAB2	1	GTPBP10	0	two hybrid	Rual JF (2005)	1
LENG1	2	USHBP1	1	two hybrid	Rolland T (2014)	1
NIP7	2	NECAB2	1	two hybrid	Rolland T (2014)	1
NECAB2	1	TTC25	0	two hybrid	Rolland T (2014)	1
NECAB2	1	PCM1	5	affinity chromatography technology	Huttlin EL (2017)	1
KIFC3	3	PRKAA2	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
KDM1A	2	KLC3	3	two hybrid	Rolland T (2014)	1
NECAB2	1	CENPO	2	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
BYSL	3	NOC4L	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
KIFC3	3	LENG1	2	two hybrid	Rolland T (2014)	1
DAXX	5	CARD9	3	two hybrid	Rolland T (2014)	1
KIFC3	3	HAUS1	0	two hybrid	Rolland T (2014)	1
PCM1	5	HAUS1	0	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
NECAB2	1	TEX11	0	two hybrid	Rual JF (2005)	1
NECAB2	1	SH2D4A	0	two hybrid	Rolland T (2014)	1
SDCBP	0	AIMP2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NECAB2	1	KANSL1	11	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
PRKAA2	1	DFFA	0	affinity chromatography technology	Behrends C (2010)	1
NECAB1	2	NECAB2	1	affinity chromatography technology	Huttlin EL (2017)	1
BEX3	0	VTA1	1	two hybrid	Wang J (2011)	1
KIFC3	3	C1orf109	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
USHBP1	1	HAUS1	0	two hybrid	Rolland T (2014)	1
PSMA1	1	NECAB2	1	two hybrid	Rual JF (2005)	1
NECAB2	1	RCOR3	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
NECAB2	1	ZYG11B	0	affinity chromatography technology	Huttlin EL (2017)	1
CCDC121	0	KDM1A	2	two hybrid	Weimann M (2013)	1
NECAB2	1	CCDC153	0	two hybrid	Rolland T (2014)	1
NECAB2	1	KLC3	3	two hybrid	Rolland T (2014)	1
NECAB2	1	CCDC151	1	two hybrid	Rolland T (2014)	1
KIFC3	3	KANSL1	11	two hybrid	Rolland T (2014)	1
NECAB2	1	DGCR6L	0	two hybrid	Rual JF (2005)	1
NECAB2	1	CCDC33	3	two hybrid	Rual JF (2005)	1
KLC3	3	ACBD5	0	affinity chromatography technology	Hein MY (2015)	1
EHHADH	1	NECAB2	1	two hybrid	Rolland T (2014)	1
DFFA	0	NECAB2	1	two hybrid	Rual JF (2005)	1
NECAB2	1	USHBP1	1	two hybrid	Yu H (2011)	1
LNX1	7	PCM1	5	affinity chromatography technology	Lenihan JA (2017)	1
PRKAA2	1	USHBP1	1	two hybrid	Rolland T (2014)	1
NECAB2	1	CCDC121	0	two hybrid	Yu H (2011)	1
KANSL1	11	KDM1A	2	two hybrid	Weimann M (2013)	1
SDCBP	0	C1orf109	1	two hybrid	Rolland T (2014)	1
CARD9	3	FAM161A	2	two hybrid	Rolland T (2014)	1
CCDC33	3	FAM161A	2	two hybrid	Rolland T (2014)	1
USHBP1	1	KLC3	3	two hybrid	Rolland T (2014)	1
NECAB2	1	SSC5D	7	two hybrid	Rolland T (2014)	1
NEK6	2	LNX1	7	two hybrid	Rolland T (2014)	1
DGCR6	0	CCDC33	3	two hybrid	Corominas R (2014)	1
NECAB2	1	WDYHV1	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
NECAB2	1	BEX2	0	two hybrid	Rolland T (2014)	1
VTA1	1	NECAB2	1	two hybrid	Rual JF (2005)	1
BEX3	0	USHBP1	1	two hybrid	Rolland T (2014)	1
DGCR6	0	NECAB2	1	two hybrid	Corominas R (2014)	1
NECAB2	1	GCC1	1	two hybrid	Rolland T (2014)	1
NECAB2	1	FAM161A	2	two hybrid	Rolland T (2014)	1
BYSL	3	NECAB2	1	two hybrid	Rolland T (2014)	1
AIMP2	0	NECAB2	1	two hybrid	Rolland T (2014)	1
C1orf109	1	USHBP1	1	two hybrid	Rolland T (2014)	1
NECAB2	1	ACBD5	0	affinity chromatography technology	Huttlin EL (2017)	1
INPP1	0	NECAB2	1	two hybrid	Corominas R (2014)	1
CPEB2	7	NECAB2	1	two hybrid	Chen PJ (2012)	1
BYSL	3	FXR2	2	two hybrid	Rolland T (2014)	1
KPNA2	0	NECAB2	1	two hybrid	Rolland T (2014)	1
NEK6	2	NECAB2	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
NECAB2	1	C1orf109	1	two hybrid	Rolland T (2014)	1