PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
UBE2V2	0	UBC	7	x-ray crystallography, pull down, x-ray crystallography, x-ray crystallography, pull down	McKenna S (2003), McKenna S (2003), McKenna S (2003), Lewis MJ (2006), McKenna S (2001)	5
RC3H2	5	TRIM8	6	two hybrid	Woodsmith J (2012)	1
PFDN4	0	RC3H2	5	affinity chromatography technology	Huttlin EL (2017)	1
RC3H1	6	RC3H2	5	affinity chromatography technology	Murakawa Y (2015)	1
UBE2D2	0	UBE2V1	0	biochemical	Havugimana PC (2012)	1
TRIM25	5	OGT	4	affinity chromatography technology	Choudhury NR (2017)	1
ELAVL1	0	MMGT1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
RC3H2	5	UBE2D2	0	pull down	Zhang Q (2015)	1
UBE2V1	0	UBE2V2	0	biochemical	Havugimana PC (2012)	1
RC3H1	6	UBE2V1	0	pull down	Zhang Q (2015)	1
RC3H2	5	UBE2G2	0	pull down	Zhang Q (2015)	1
TRIM25	5	ELAVL1	0	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
UBE2D2	0	TRIM25	5	two hybrid, pull down, pull down, pull down, affinity chromatography technology	Markson G (2009), Nakajima A (2007), Ronchi VP (2012), Sanchez JG (2016), Choudhury NR (2017)	5
UBE2K	0	UBC	7	enzymatic study, x-ray crystallography, x-ray crystallography, pull down, enzymatic study, enzymatic study, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Flierman D (2006), Ko S (2010), Wilson RC (2011), Wilson RC (2011), Wilson RC (2011), Sheng Y (2012), Raasi S (2005), Bishop N (2002), Rajsbaum R (2014), Chong RA (2014), Whitby FG (1998), Singh RK (2012), Cook BW (2015)	13
UBE2E3	0	UBC	7	enzymatic study	Sheng Y (2012)	1
UBE2V2	0	UBE2B	3	biochemical	Havugimana PC (2012)	1
UBE2I	0	RC3H2	5	two hybrid	Markson G (2009)	1
RC3H1	6	OGT	4	affinity chromatography technology	Murakawa Y (2015)	1
UBC	7	OGT	4	pull down	Zhang X (2017)	1
RC3H1	6	UBE2B	3	pull down	Zhang Q (2015)	1
RC3H2	5	UBC	7	enzymatic study	Zhang Q (2015)	1
UBE2V1	0	UBE2B	3	biochemical	Havugimana PC (2012)	1
RC3H1	6	UBE2G2	0	pull down	Zhang Q (2015)	1
UBC	7	UBE2B	3	affinity chromatography technology, affinity chromatography technology	Bish RA (2007), Hong JH (2015)	2
RC3H2	5	UBE2B	3	pull down	Zhang Q (2015)	1
UBE2K	0	UBE2N	1	biochemical	Wan C (2015)	1
RC3H1	6	UBE2D2	0	pull down	Zhang Q (2015)	1
UBE2D2	0	TRIM8	6	two hybrid, pull down	Markson G (2009), Li Q (2011)	2
UBE2N	1	RC3H2	5	two hybrid, pull down	Markson G (2009), Zhang Q (2015)	2
OGT	4	RC3H2	5	affinity chromatography technology	Hauri S (2016)	1
UBE2V1	0	UBC	7	pull down	McKenna S (2003)	1
ELAVL1	0	UBE2N	1	affinity chromatography technology	Abdelmohsen K (2009)	1
RC3H2	5	UBE2V1	0	pull down	Zhang Q (2015)	1
UBC	7	UBE2N	1	affinity chromatography technology, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down	Matsumoto M (2005), Scheper J (2010), Wu PY (2003), McKenna S (2003), Wiener R (2012), Ye Y (2003), Bish RA (2007), Juang YC (2012), Pastushok L (2007), Singh RK (2012), McKenna S (2001), McKenna S (2001)	12
RC3H2	5	UBE2K	0	pull down	Zhang Q (2015)	1
UBE2I	0	UBE2K	0	enzymatic study, enzymatic study, enzymatic study, enzymatic study, biochemical	Knipscheer P (2008), Gruenwald M (2011), Pichler A (2005), Galisson F (2011), Wan C (2015)	5
TRIM25	5	UBE2V1	0	pull down	Sanchez JG (2016)	1
TRIM25	5	UBE2G2	0	affinity chromatography technology	Choudhury NR (2017)	1
RC3H2	5	CYP19A1	1	affinity chromatography technology	Huttlin EL (2017)	1
RC3H1	6	UBE2V2	0	pull down	Zhang Q (2015)	1
UBE2I	0	UBE2D2	0	biochemical	Wan C (2015)	1
KLHL6	1	RC3H2	5	affinity chromatography technology	Huttlin EL (2017)	1
MMGT1	0	RC3H2	5	affinity chromatography technology	Hein MY (2015)	1
RC3H2	5	UBE2V2	0	pull down	Zhang Q (2015)	1
ELAVL1	0	RC3H2	5	affinity chromatography technology	Abdelmohsen K (2009)	1
UBE2V1	0	UBE2K	0	biochemical	Wan C (2015)	1
UBE2N	1	UBE2V1	0	biochemical, pull down, pull down, pull down, two hybrid, two hybrid, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, two hybrid, biochemical, pull down, pull down, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Deng L (2000), Deng L (2000), Zhang M (2005), Andersen PL (2005), Andersen PL (2005), Scheper J (2010), Scheper J (2010), Scheper J (2010), Wooff J (2004), Plans V (2006), Huen MS (2008), Huen MS (2008), Havugimana PC (2012), Bohgaki M (2008), Petroski MD (2007), Sawasaki T (2008), Wan C (2015), Chen J (2015), Boldt K (2016), Zhang Y (2018)	20
RC3H2	5	ACTBL2	0	affinity chromatography technology	Huttlin EL (2017)	1
ELAVL1	0	TRIM8	6	affinity chromatography technology	Abdelmohsen K (2009)	1
UBE2K	0	UBE2D2	0	biochemical	Wan C (2015)	1
TRIM25	5	RC3H2	5	affinity chromatography technology	Choudhury NR (2017)	1
UBE2V1	0	TRIM8	6	two hybrid	Markson G (2009)	1
ELAVL1	0	UBE2E2	1	affinity chromatography technology	Abdelmohsen K (2009)	1
RC3H2	5	UBE2E2	1	pull down	Zhang Q (2015)	1
TRIM25	5	TRIM8	6	two hybrid	Woodsmith J (2012)	1
UBE2N	1	TRIM25	5	two hybrid, pull down, x-ray crystallography, affinity chromatography technology	Markson G (2009), Sanchez JG (2016), Sanchez JG (2016), Choudhury NR (2017)	4
UBE2D2	0	UBC	7	x-ray crystallography, x-ray crystallography, enzymatic study, pull down, pull down	Juang YC (2012), Dou H (2012), Sheng Y (2012), Buetow L (2015), Zhang X (2017)	5
ELAVL1	0	UBE2Q2	4	affinity chromatography technology	Abdelmohsen K (2009)	1
UBE2G2	0	UBC	7	x-ray crystallography, pull down, pull down	Bocik WE (2011), Bocik WE (2011), Reyes LF (2006)	3
RC3H2	5	RC3H2	5	enzymatic study	Zhang Q (2015)	1
RC3H1	6	UBE2N	1	pull down	Zhang Q (2015)	1
RC3H2	5	UBE2E3	0	pull down	Zhang Q (2015)	1
TRIM25	5	UBC	7	enzymatic study	Sanchez JG (2016)	1
TRIM25	5	RC3H1	6	affinity chromatography technology	Choudhury NR (2017)	1
RC3H2	5	UBE2Q2	4	pull down	Zhang Q (2015)	1
UBE2V2	0	UBE2N	1	pull down, two hybrid, x-ray crystallography, two hybrid, two hybrid, two hybrid, pull down, pull down, x-ray crystallography, affinity chromatography technology, pull down, two hybrid, pull down, pull down, affinity chromatography technology, two hybrid, pull down, biochemical, x-ray crystallography, pull down, affinity chromatography technology, pull down, x-ray crystallography, biochemical, x-ray crystallography, affinity chromatography technology	Andersen PL (2005), Andersen PL (2005), Markin CJ (2010), Wooff J (2004), Wooff J (2004), Plans V (2006), Wu PY (2003), McKenna S (2003), McKenna S (2003), Zou W (2005), Takeuchi T (2005), Pastushok L (2005), Pastushok L (2005), Pastushok L (2005), Huen MS (2008), Huen MS (2008), Ye Y (2003), Havugimana PC (2012), Moraes TF (2001), Pastushok L (2007), Zou W (2005), McKenna S (2001), Hodge CD (2015), Wan C (2015), Branigan E (2015), Boldt K (2016)	26