PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
DDIT4	0	HUWE1	22	affinity chromatography technology, affinity chromatography technology	Thompson JW (2014), Thompson JW (2014)	2
HUWE1	22	YWHAZ	1	affinity chromatography technology	Thompson JW (2014)	1
DDIT4	0	BTRC	1	affinity chromatography technology	Katiyar S (2009)	1
CUL4A	2	BTRC	1	affinity chromatography technology	He YJ (2006)	1
YWHAB	1	DDIT4	0	affinity chromatography technology	DeYoung MP (2008)	1
DDIT4	0	DDB1	6	affinity chromatography technology	Katiyar S (2009)	1
HSPB2	1	TXNIP	2	two hybrid	Grose JH (2015)	1
PRKN	1	DDIT4	0	enzymatic study, affinity chromatography technology, affinity chromatography technology	Romani-Aumedes J (2014), Romani-Aumedes J (2014), Romani-Aumedes J (2014)	3
YWHAB	1	YWHAZ	1	affinity chromatography technology, biochemical, affinity chromatography technology	Couzens AL (2013), Wan C (2015), Hein MY (2015)	3
TXNIP	2	DDIT4	0	pull down, affinity chromatography technology, imaging technique	Jin HO (2011), Jin HO (2011), Jin HO (2011)	3
HUWE1	22	HSPA4	3	affinity chromatography technology, affinity chromatography technology	Bewley MA (2011), Thompson JW (2014)	2
DDIT4	0	CUL4A	2	affinity chromatography technology	Katiyar S (2009)	1
CUL4A	2	DDB1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Guerrero-Santoro J (2008), Guerrero-Santoro J (2008), Angers S (2006), Angers S (2006), Jin J (2006), Wang H (2006), Kapetanaki MG (2006), Matsuda N (2005), Hu J (2004), Hu J (2004), Hu J (2004), Ahn J (2010), Maddika S (2009), Fischer ES (2011), Tan L (2007), He YJ (2006), He YJ (2006), He YJ (2006), McCall CM (2008), McCall CM (2008), Shiyanov P (1999), Bennett EJ (2010), Gastaldello S (2012), Kanei-Ishii C (2012), Hodgson AJ (2012), Kulaksiz G (2005), Wu Z (2012), Wu Z (2012), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Rao F (2014), Wan C (2015), Liu Y (2015), Zha Z (2015), Mouysset J (2015), Gao J (2015), Yang Y (2016), Yang Y (2016), Scherer PC (2016), Eichner R (2016), Mo Y (2017), Mo Y (2017), Peng Z (2016), Higa LA (2006), Ohtake F (2007)	46
DDIT4	0	LRIF1	3	two hybrid	Stelzl U (2005)	1
YWHAZ	1	DDIT4	0	affinity chromatography technology	Hernandez G (2011)	1
DDIT4	0	NEDD4	2	affinity chromatography technology	Canal M (2016)	1
HSPB2	1	DDIT4	0	two hybrid	Grose JH (2015)	1
BTRC	1	NEDD4	2	affinity chromatography technology, affinity chromatography technology	Liu J (2014), Liu J (2014)	2
PDPK1	0	DDIT4	0	two hybrid	Vinayagam A (2011)	1
GSK3B	1	DDIT4	0	enzymatic study, affinity chromatography technology	Katiyar S (2009), Katiyar S (2009)	2
HSPA4	3	PRKN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Moore DJ (2008), Hampe C (2006), Tsai YC (2003), Morishima Y (2008), Kalia SK (2004), Kalia SK (2004), Imai Y (2003), Imai Y (2003)	8
HSPA4	3	DDIT4	0	two hybrid	Lim J (2006)	1
DDB1	6	BTRC	1	affinity chromatography technology	He YJ (2006)	1
BTRC	1	YWHAZ	1	affinity chromatography technology	Coyaud E (2015)	1
GSK3B	1	HSPA4	3	enzymatic study, pull down	Muller P (2012), Kawakami F (2011)	2
GSK3B	1	BTRC	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Kitagawa M (1999), Gao C (2014), Gao C (2014), Gao C (2014)	4
HUWE1	22	DDB1	6	affinity chromatography technology, affinity chromatography technology	Thompson JW (2014), Yi J (2015)	2
BTRC	1	YWHAB	1	affinity chromatography technology	Coyaud E (2015)	1