PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
POU3F2	2	TBP	0	two hybrid, pull down	Smit DJ (2000), Smit DJ (2000)	2
POU3F2	2	POU3F2	2	two hybrid	Smit DJ (2000)	1
POU3F2	2	SOX10	2	two hybrid	Smit DJ (2000)	1
TBP	0	EP300	36	affinity chromatography technology	Dallas PB (1997)	1
POU3F2	2	GTF2B	1	pull down	Smit DJ (2000)	1
PAX3	6	SOX10	2	pull down, pull down, affinity chromatography technology, genetic interference	Lang D (2003), Lang D (2003), Lang D (2003), Bondurand N (2000)	4
GTF2B	1	TBP	0	biochemical, pull down, x-ray crystallography, pull down, x-ray crystallography, x-ray crystallography, pull down	Scully R (1997), Scully R (1997), Bushnell DA (2004), Friedman MJ (2007), Tsai FT (2000), Bagby S (1995), Lin Y (1997)	7
EP300	36	GTF2B	1	pull down	Felzien LK (1999)	1
POU3F2	2	EP300	36	two hybrid, pull down	Smit DJ (2000), Smit DJ (2000)	2
TBP	0	PAX3	6	pull down	Cvekl A (1999)	1
UBXN7	3	POU3F2	2	affinity chromatography technology	Raman M (2015)	1
POU3F2	2	PQBP1	1	two hybrid, affinity chromatography technology	Waragai M (1999), Waragai M (1999)	2
POU3F2	2	PAX3	6	two hybrid	Smit DJ (2000)	1