PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HDAC1	4	TFDP1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Hauri S (2016)	2
PLK1	0	BRCA2	6	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Lee M (2004), Lin HR (2003), Lin HR (2003), Park I (2017)	4
RNF2	1	WIZ	2	affinity chromatography technology	Cao Q (2014)	1
RNF2	1	HDAC2	1	affinity chromatography technology	Cao Q (2014)	1
EHMT2	4	HDAC2	1	affinity chromatography technology, affinity chromatography technology	Bantscheff M (2011), Bantscheff M (2011)	2
MIER2	0	PCGF6	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PCGF6	0	MGA	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016)	4
RNF2	1	EHMT2	4	affinity chromatography technology	Cao Q (2014)	1
HDAC1	4	C16orf87	0	affinity chromatography technology, affinity chromatography technology	Joshi P (2013), Huttlin EL (2017)	2
ZNF318	6	HDAC2	1	affinity chromatography technology	Tao RH (2006)	1
PCGF6	0	TFDP1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	4
EHMT2	4	EHMT1	18	affinity chromatography technology, affinity chromatography technology	Bantscheff M (2011), Hauri S (2016)	2
L3MBTL2	1	E2F6	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Trojer P (2011), Trojer P (2011), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	6
CYBRD1	0	HDAC2	1	affinity chromatography technology	Huttlin EL (2017)	1
HDAC1	4	SIN3A	13	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang Y (2003), Yao YL (2003), Yao YL (2003), Fleischer TC (2003), Fleischer TC (2003), Yang L (2003), Grozinger CM (1999), Zhang J (2002), Zhang J (2002), You A (2001), Zhang Y (1999), Zhang Y (2002), Tong JK (1998), Hassig CA (1998), Yasui D (2002), Huang EY (2000), Huang EY (2000), Kuzmichev A (2002), Kuzmichev A (2002), Martinowich K (2003), Martinowich K (2003), Suzuki M (2003), Suzuki M (2006), Nakamura T (2002), Wei Q (2005), Pflum MK (2001), Pflum MK (2001), Skowyra D (2001), Skowyra D (2001), Humphrey GW (2001), Sekhavat A (2007), Zhang Y (1998), Zhang Y (1998), Sun JM (2007), Karwowska-Desaulniers P (2007), Terhune SS (2010), Xue Y (1998), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Oh YM (2009), Wan C (2015), Hein MY (2015), Hsu DS (2014), Huttlin EL (2017)	45
MIER2	0	SIN3A	13	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EHMT2	4	WIZ	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ueda J (2006), Ueda J (2006), Bantscheff M (2011), Hein MY (2015), Hauri S (2016)	5
HDAC2	1	EHMT1	18	affinity chromatography technology	Bantscheff M (2011)	1
MIER2	0	ACAD11	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MIER2	0	EHMT2	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HDAC1	4	HDAC2	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique, affinity chromatography technology	Hakimi MA (2002), Yao YL (2003), Yao YL (2003), Hakimi MA (2003), Fischle W (2002), Johnson CA (2002), Fischle W (2001), Fischer DD (2002), Fischer DD (2002), Ashburner BP (2001), Zhang Y (1999), Tong JK (1998), Tong JK (1998), Hassig CA (1998), Hassig CA (1998), Zhang Y (1997), van der Vlag J (1999), van der Vlag J (1999), Noh EJ (2009), Noh EJ (2009), Galasinski SC (2002), Galasinski SC (2002), Galasinski SC (2002), He S (2005), Humphrey GW (2001), Park JH (2004), Park JH (2004), Sekhavat A (2007), Zhang Y (1998), Zhang Y (1998), Adenuga D (2010), Xue Y (1998), Xue Y (1998), Martinez FP (2012), Martinez FP (2012), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Joshi P (2013), Schnur N (2007), Schnur N (2007), Oh YM (2009), Wan C (2015), Hein MY (2015), Chen TC (2014), Huttlin EL (2017)	48
MIER2	0	E2F6	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MIER2	0	WIZ	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
L3MBTL2	1	PCGF6	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Trojer P (2011), Trojer P (2011), Gao Z (2012), Gao Z (2012), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	7
MIER2	0	AGAP1	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PEX14	2	TUBA4A	1	biochemical	Bharti P (2011)	1
MIER2	0	PEX14	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RNF2	1	E2F6	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Huttlin EL (2015), Hauri S (2016), Hauri S (2016)	4
MIER2	0	PHLDB3	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
L3MBTL2	1	TFDP1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	3
HDAC2	1	MIER2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bantscheff M (2011), Huttlin EL (2015), Huttlin EL (2017)	3
E2F6	2	HDAC2	1	affinity chromatography technology	Hauri S (2016)	1
HDAC1	4	MIER2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Joshi P (2013), Huttlin EL (2015), Huttlin EL (2017)	3
HDAC2	1	C16orf87	0	affinity chromatography technology	Joshi P (2013)	1
NDN	0	MIER2	0	two hybrid	Corominas R (2014)	1
MIER2	0	MGA	9	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MIER2	0	AGAP3	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PLK1	0	HDAC2	1	affinity chromatography technology	Boldt K (2016)	1
HDAC1	4	L3MBTL2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Hauri S (2016)	2
HDAC1	4	EHMT1	18	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
ZNF644	6	EHMT2	4	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hauri S (2016)	2
TYK2	1	TUBA4A	1	affinity chromatography technology	So J (2015)	1
HDAC2	1	WIZ	2	affinity chromatography technology	Bantscheff M (2011)	1
CDYL	1	HDAC1	4	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Caron C (2003), Caron C (2003), Caron C (2003), Mulligan P (2008), Joshi P (2013), Hein MY (2015), Huttlin EL (2017)	7
MIER2	0	RNF2	1	affinity chromatography technology	Huttlin EL (2015)	1
MIER2	0	TYK2	1	affinity chromatography technology	Huttlin EL (2015)	1
MIER2	0	TFDP1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
WIZ	2	EHMT1	18	biochemical, affinity chromatography technology	Wan C (2015), Hein MY (2015)	2
PCGF6	0	E2F6	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Trimarchi JM (2001), Gao Z (2012), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	6
USP11	3	RNF2	1	affinity chromatography technology, pull down	Maertens GN (2010), Maertens GN (2010)	2
RNF2	1	TFDP1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Hauri S (2016), Hauri S (2016)	3
MIER2	0	EHMT1	18	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
L3MBTL2	1	RNF2	1	affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Trojer P (2011), Trojer P (2011), Trojer P (2011), Trojer P (2011), Gao Z (2012), Cao Q (2014), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	9
BRCA2	6	USP11	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Schoenfeld AR (2004), Schoenfeld AR (2004), Schoenfeld AR (2004), Schoenfeld AR (2004)	4
HDAC1	4	EHMT2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Joshi P (2013), Hein MY (2015), Huttlin EL (2017)	3
CDYL	1	WIZ	2	affinity chromatography technology, affinity chromatography technology	Kuppuswamy M (2008), Hein MY (2015)	2
ZNF644	6	EHMT1	18	affinity chromatography technology	Hein MY (2015)	1
L3MBTL2	1	MGA	9	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Hauri S (2016)	2
TFDP1	3	MGA	9	affinity chromatography technology	Hauri S (2016)	1
CYBRD1	0	HDAC1	4	affinity chromatography technology	Huttlin EL (2017)	1
CYBRD1	0	MIER2	0	affinity chromatography technology	Huttlin EL (2017)	1
MIER2	0	ZNF644	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MIER2	0	BRCA2	6	affinity chromatography technology	Huttlin EL (2015)	1
CDYL	1	MIER2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bantscheff M (2011), Huttlin EL (2015), Huttlin EL (2017)	3
CYBRD1	0	CDYL	1	affinity chromatography technology	Huttlin EL (2017)	1
MIER2	0	L3MBTL2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDYL	1	HDAC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Caron C (2003), Caron C (2003), Mulligan P (2008), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013)	6
RNF2	1	MGA	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Cao Q (2014), Hein MY (2015), Hauri S (2016)	4
MIER2	0	PLK1	0	affinity chromatography technology	Huttlin EL (2015)	1
C16orf87	0	MIER2	0	affinity chromatography technology	Huttlin EL (2017)	1
L3MBTL2	1	HDAC2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Hauri S (2016)	2
E2F6	2	TFDP1	3	two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Cartwright P (1998), Rolland T (2014), Huttlin EL (2015), Trimarchi JM (1998), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	8
RNF2	1	PCGF6	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Trojer P (2011), Gao Z (2012), Gao Z (2012), Gao Z (2012), Akasaka T (2002), Akasaka T (2002), Akasaka T (2002), Woodsmith J (2012), Cao Q (2014), Hein MY (2015), Taherbhoy AM (2015), Taherbhoy AM (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	15
HDAC1	4	WIZ	2	affinity chromatography technology	Huttlin EL (2017)	1
ZNF644	6	WIZ	2	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
MIER2	0	USP11	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TFDP1	3	HDAC2	1	affinity chromatography technology	Hauri S (2016)	1
E2F6	2	MGA	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016)	3
HDAC1	4	E2F6	2	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
PCGF6	0	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Huttlin EL (2017), Hauri S (2016)	3
MIER2	0	TUBA4A	1	affinity chromatography technology	Huttlin EL (2017)	1
MIER2	0	ZNF318	6	affinity chromatography technology	Huttlin EL (2015)	1
RNF2	1	HDAC1	4	affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Cao Q (2014)	2
CDYL	1	EHMT2	4	affinity chromatography technology, pull down, affinity chromatography technology	Mulligan P (2008), Mulligan P (2008), Bantscheff M (2011)	3
HDAC1	4	MGA	9	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
MIER2	0	PLD1	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDYL	1	ZNF644	6	affinity chromatography technology, affinity chromatography technology	Mulligan P (2008), Hein MY (2015)	2
PCGF6	0	HDAC2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Hauri S (2016)	2
PCGF6	0	ZNF644	6	affinity chromatography technology	Huttlin EL (2017)	1
HDAC2	1	SIN3A	13	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Zhang Y (2003), Fleischer TC (2003), Fleischer TC (2003), Hakimi MA (2003), Yang L (2003), Laherty CD (1997), Zhang Y (2002), Tong JK (1998), Zhang Y (2005), Nakamura T (2002), Sekhavat A (2007), Zou J (2004), Sun JM (2007), Xue Y (1998), Tsai SC (2002), Brandl A (2012), Bantscheff M (2011), Joshi P (2013), Wan C (2015), Hsu DS (2014)	20
MIER2	0	JPH1	0	affinity chromatography technology	Huttlin EL (2015)	1