PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ESR1	0	MNAT1	0	pull down, affinity chromatography technology	Talukder AH (2003), Talukder AH (2003)	2
POU2F2	2	MNAT1	0	pull down	Inamoto S (1997)	1
POU2F2	2	AR	3	pull down	Prefontaine GG (1999)	1
ESR1	0	GAPDH	0	affinity chromatography technology	Tarallo R (2011)	1
GAPDH	0	AR	3	two hybrid, pull down	Koshy B (1996), Koshy B (1996)	2
HMGA1	0	POU2F2	2	pull down, far western blotting	Abdulkadir SA (1998), Abdulkadir SA (1998)	2
FOXJ2	3	POU2F2	2	affinity chromatography technology	Li X (2015)	1
POU2F2	2	TXNRD1	2	pull down	Kakizawa T (1999)	1
TMEM108	1	POU2F2	2	affinity chromatography technology	Huttlin EL (2017)	1
NR3C1	2	HMGB2	2	pull down	Boonyaratanakornkit V (1998)	1
ESR1	0	TXNRD1	2	affinity chromatography technology	Okada M (2015)	1
ESR1	0	XRCC6	3	affinity chromatography technology	Ju BG (2006)	1
AR	3	XRCC6	3	affinity chromatography technology	Mayeur GL (2005)	1
PGR	1	HMGB2	2	pull down	Boonyaratanakornkit V (1998)	1
XRCC6	3	HMGA1	0	far western blotting, pull down, affinity chromatography technology	Sgarra R (2008), Sgarra R (2008), Sgarra R (2008)	3
TBP	0	NR3C1	2	pull down	Almloef T (1998)	1
FOXC2	2	POU2F2	2	affinity chromatography technology	Li X (2015)	1
HMGB2	2	HMGA1	0	far western blotting	Sgarra R (2008)	1
TBP	0	RXRA	1	pull down, two hybrid	Schulman IG (1995), Schulman IG (1995)	2
AR	3	HMGB2	2	pull down	Boonyaratanakornkit V (1998)	1
FOXJ2	3	NR3C1	2	affinity chromatography technology	Li X (2015)	1
TLE4	5	POU2F2	2	pull down, affinity chromatography technology	Malin S (2005), Malin S (2005)	2
POU2F2	2	NR3C1	2	pull down, pull down, pull down	Prefontaine GG (1999), Wang JM (1999), Prefontaine GG (1998)	3
FOXJ2	3	TBP	0	affinity chromatography technology	Li X (2015)	1
POU2F2	2	PGR	1	pull down	Prefontaine GG (1999)	1
POU2F2	2	POU2F2	2	pull down	Kakizawa T (1999)	1
PGR	1	XRCC6	3	pull down, enzymatic study, affinity chromatography technology	Sartorius CA (2000), Sartorius CA (2000), Sartorius CA (2000)	3
POU2F2	2	GAPDH	0	pull down	Zheng L (2003)	1
TBP	0	ESR1	0	pull down, pull down	Waernmark A (2001), Lazennec G (1997)	2
FOXS1	2	POU2F2	2	affinity chromatography technology	Li X (2015)	1
PGR	1	ESR1	0	affinity chromatography technology, affinity chromatography technology, imaging technique	Giulianelli S (2012), Giulianelli S (2012), Giulianelli S (2012)	3
POU2F2	2	HMGB2	2	far western blotting, pull down	Zwilling S (1995), Zwilling S (1995)	2
POU2F2	2	ESR1	0	pull down	Prefontaine GG (1999)	1
TBP	0	POU2F2	2	pull down, affinity chromatography technology	Zwilling S (1994), Zwilling S (1994)	2
TEAD2	2	POU2F2	2	affinity chromatography technology	Li X (2015)	1
AR	3	TBP	0	pull down	McEwan IJ (1997)	1
TEAD2	2	NR3C1	2	affinity chromatography technology	Li X (2015)	1
XRCC6	3	POU2F2	2	pull down, two hybrid	Schild-Poulter C (2001), Schild-Poulter C (2001)	2
POU2F2	2	RXRA	1	pull down	Kakizawa T (1999)	1