PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
STX1A	2	CCSER2	4	two hybrid	Stelzl U (2005)	1
RPGRIP1L	2	CCSER2	4	bioid	Gupta GD (2015)	1
CRADD	0	CCSER2	4	two hybrid	Stelzl U (2005)	1
TCEA2	1	CCSER2	4	two hybrid	Stelzl U (2005)	1
OFD1	3	CCSER2	4	two hybrid	Stelzl U (2005)	1
CEP128	1	CCSER2	4	bioid	Gupta GD (2015)	1
SLMAP	3	OFD1	3	bioid	Couzens AL (2013)	1
EGLN3	0	CCSER2	4	affinity chromatography technology	Rodriguez J (2016)	1
CEP128	1	RPGRIP1L	2	bioid	Gupta GD (2015)	1
MAP1LC3B	1	CCSER2	4	two hybrid	Vinayagam A (2011)	1
ATRX	7	CCSER2	4	two hybrid	Stelzl U (2005)	1
PSMD11	0	CCSER2	4	two hybrid	Stelzl U (2005)	1
EGLN3	0	NDEL1	2	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	PSMD11	0	affinity chromatography technology	Rodriguez J (2016)	1
CEP128	1	OFD1	3	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
NDEL1	2	OFD1	3	affinity chromatography technology	Huttlin EL (2017)	1
RPGRIP1L	2	OFD1	3	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
PSMD11	0	APP	1	pull down	Olah J (2011)	1
CDH1	4	CCSER2	4	bioid	Guo Z (2014)	1
TCEA2	1	APP	1	pull down	Olah J (2011)	1
SLMAP	3	CCSER2	4	bioid	Couzens AL (2013)	1
CRADD	0	APP	1	pull down	Olah J (2011)	1
EXOC1	3	CCSER2	4	two hybrid	Camargo LM (2007)	1
GTF2H1	0	CCSER2	4	two hybrid	Stelzl U (2005)	1
CCSER2	4	APP	1	pull down	Olah J (2011)	1
NDEL1	2	APP	1	pull down	Olah J (2011)	1
NDEL1	2	CCSER2	4	two hybrid, affinity chromatography technology	Camargo LM (2007), Huttlin EL (2017)	2
CEP128	1	NDEL1	2	bioid	Gupta GD (2015)	1