PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ADRB2	0	GNB4	2	affinity chromatography technology, affinity chromatography technology	Roy SJ (2013), Roy SJ (2013)	2
GNG2	0	GNB5	2	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Snow BE (1999), Howlett AC (2009), Zhou JY (2003)	3
TBXA2R	1	GNB1	4	fluorescent resonance energy transfe, pull down	Gales C (2005), Manganello JM (2003)	2
ARMC1	2	ATP4A	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GNG2	0	RPTOR	4	affinity chromatography technology	Robles-Molina E (2014)	1
MRGPRX1	1	GNAI2	1	fluorescent resonance energy transfe	Gales C (2005)	1
TBXA2R	1	GNAS	9	fluorescent resonance energy transfe	Gales C (2005)	1
RACK1	2	FYN	1	affinity chromatography technology, pull down, affinity chromatography technology	Yaka R (2003), Yaka R (2002), Yaka R (2002)	3
GNG2	0	GNA13	0	affinity chromatography technology	Manganello JM (2003)	1
ADRB2	0	GNAI2	1	fluorescent resonance energy transfe	Gales C (2005)	1
AVPR2	0	GNB1	4	fluorescent resonance energy transfe	Gales C (2005)	1
GNG2	0	GNAI2	1	affinity chromatography technology	Stallmeyer B (2017)	1
RACK1	2	GNG2	0	affinity chromatography technology, affinity chromatography technology	Sun Z (2011), Knezevic N (2009)	2
MTOR	14	RPTOR	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jacinto E (2004), Jacinto E (2004), Sarbassov DD (2004), Sarbassov DD (2004), Sarbassov DD (2004), Schalm SS (2003), Hara K (2002), Ha SH (2006), Wang L (2006), Frias MA (2006), Frias MA (2006), Buerger C (2006), Jacinto E (2006), McMahon LP (2005), Oshiro N (2004), Kawai S (2003), Choi KM (2003), Hara K (2002), Hara K (2002), Kim DH (2002), Kim DH (2002), Schieke SM (2006), Ha SH (2006), Wang L (2006), Frias MA (2006), Buerger C (2006), Sarbassov DD (2006), Tzatsos A (2006), Sarbassov DD (2005), Yang Q (2006), Kaizuka T (2010), Pearce LR (2007), Oh WJ (2010), Oh WJ (2010), Agrawal P (2012), Kwak D (2012), Wu D (2012), Wu D (2012), Wu D (2012), Wu D (2012), Gwinn DM (2010), Sancak Y (2007), Sancak Y (2007), Yang Q (2006), Carriere A (2011), Jacinto E (2006), Rosner M (2010), Kim DH (2003), Kim DH (2003), Carriere A (2008), Murata H (2011), Koike-Kumagai M (2009), Koike-Kumagai M (2009), Hussain S (2013), Hussain S (2013), Peterson TR (2009), Peterson TR (2009), Su WC (2009), Hernandez-Negrete I (2007), Yan X (2012), Ramirez-Rangel I (2011), Ramirez-Rangel I (2011), Martin J (2008), Martin J (2008), Linares JF (2013), Coffman K (2014), Oshiro N (2014), Thedieck K (2007), Thedieck K (2007), Thedieck K (2007), Dan HC (2008), Dan HC (2008), Dan HC (2008), Hong F (2008), Hong F (2008), Choo AY (2008), Toschi A (2009), Loewith R (2002), Xu Y (2013), Sancak Y (2010), Sancak Y (2010), Vander Haar E (2007), Vander Haar E (2007), Kaadige MR (2015), Misra UK (2014), Misra UK (2014), Thedieck K (2007), Thomas JD (2014), Park D (2014), Alayev A (2016), Alayev A (2016)	91
GNG2	0	GNB4	2	affinity chromatography technology, affinity chromatography technology, pull down	Snow BE (1999), Howlett AC (2009), Rosskopf D (2003)	3
GNB1	4	GNAS	9	fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Gales C (2005), Huttlin EL (2015), Huttlin EL (2017)	3
GNG2	0	FYN	1	affinity chromatography technology	Knezevic N (2009)	1
ADRA2A	0	GNAI2	1	fluorescent resonance energy transfe	Gales C (2005)	1
GNB1	4	WDR26	6	pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sun Z (2011), Sun Z (2011), Sun Z (2011), Sun Z (2011), Sun Z (2013), Ye Y (2016)	6
RRP7A	1	ATP4A	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MTOR	14	GNB2	3	affinity chromatography technology	Robles-Molina E (2014)	1
MTOR	14	GNB3	1	affinity chromatography technology	Robles-Molina E (2014)	1
PIK3CG	3	GNG2	0	genetic interference	Brock C (2003)	1
RRP7A	1	GNG2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GNB1	4	ARRB1	2	affinity chromatography technology, pull down	Yang M (2009), Yang M (2009)	2
ADRB2	0	GNAS	9	fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Gales C (2005), Roy SJ (2013), Feldman DS (2002)	3
PTK2	2	FYN	1	affinity chromatography technology, x-ray crystallography	Messina S (2003), Arold ST (2001)	2
GNB1	4	PTK2	2	affinity chromatography technology	Knezevic N (2009)	1
HAX1	1	ATP4A	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TBXA2R	1	GNG2	0	fluorescent resonance energy transfe	Gales C (2005)	1
TBXA2R	1	RACK1	2	two hybrid, pull down, affinity chromatography technology	Parent A (2008), Parent A (2008), Parent A (2008)	3
ARMC1	2	GNG2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PLEKHG2	5	GNG2	0	affinity chromatography technology, pull down	Ueda H (2008), Ueda H (2008)	2
MTOR	14	GNG2	0	affinity chromatography technology, affinity chromatography technology	Robles-Molina E (2014), Robles-Molina E (2014)	2
ADRB2	0	GNB1	4	fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Gales C (2005), Roy SJ (2013), Roy SJ (2013)	3
GNB2	3	GNAI2	1	fluorescent resonance energy transfe	Gibson SK (2006)	1
GNG2	0	GNB1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, fluorescent resonance energy transfe	Snow BE (1999), Poon LS (2009), Snow BE (1998), Howlett AC (2009), Lukov GL (2005), Howlett AC (2009), Gales C (2005), Rosskopf D (2003), Zhou JY (2003)	9
PIK3CG	3	GNB1	4	genetic interference	Brock C (2003)	1
PIK3R5	2	GNB1	4	genetic interference	Brock C (2003)	1
GNG2	0	PTK2	2	affinity chromatography technology	Knezevic N (2009)	1
DGUOK	1	GNG2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GNAI2	1	GNB3	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDCA8	0	GNG2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GNB1	4	GNAI2	1	fluorescent resonance energy transfe, biochemical	Gibson SK (2006), Havugimana PC (2012)	2
HAX1	1	GNG2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AVPR2	0	GNAS	9	fluorescent resonance energy transfe	Gales C (2005)	1
GNG2	0	RICTOR	4	affinity chromatography technology	Robles-Molina E (2014)	1
RACK1	2	GNB1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sun Z (2011), Chen S (2008), Knezevic N (2009)	3
GNA13	0	TBXA2R	1	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, pull down	Offermanns S (1994), Gales C (2005), Manganello JM (1999), Manganello JM (2003)	4
ADRB2	0	RACK1	2	affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology	Roy SJ (2013), Kittanakom S (2014), Kittanakom S (2014), Kittanakom S (2014)	4
MRGPRX1	1	GNG2	0	fluorescent resonance energy transfe	Gales C (2005)	1
PLEKHG2	5	GNB1	4	affinity chromatography technology, pull down	Ueda H (2008), Ueda H (2008)	2
GNG2	0	WDR26	6	pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Sun Z (2011), Sun Z (2011), Sun Z (2011), Sun Z (2011)	4
GNG2	0	GNB2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Snow BE (1999), Poon LS (2009), Snow BE (1998), Howlett AC (2009), Zha Z (2015), Zha Z (2015), Stallmeyer B (2017)	7
DNAAF2	2	ATP4A	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MTOR	14	RICTOR	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jacinto E (2004), Jacinto E (2004), Sarbassov DD (2004), Sarbassov DD (2004), Sarbassov DD (2004), Frias MA (2006), Jacinto E (2006), Yang Q (2006), Frias MA (2006), Sarbassov DD (2006), Sarbassov DD (2005), Yang Q (2006), Kaizuka T (2010), Pearce LR (2007), Oh WJ (2010), Oh WJ (2010), Agrawal P (2012), Guo Z (2012), Sarbassov DD (2006), Sancak Y (2007), Yang Q (2006), Jacinto E (2006), Jacinto E (2006), Rosner M (2010), Ikenoue T (2008), Ikenoue T (2008), Murata H (2011), Murata H (2011), Koike-Kumagai M (2009), Koike-Kumagai M (2009), Woods NT (2012), Hussain S (2013), Peterson TR (2009), Peterson TR (2009), Su WC (2009), Hernandez-Negrete I (2007), Ramirez-Rangel I (2011), Martin J (2008), Martin J (2008), Martin J (2008), Thedieck K (2007), Thedieck K (2007), Thedieck K (2007), McDonald PC (2008), McDonald PC (2008), Hong F (2008), Hong F (2008), Facchinetti V (2008), Toschi A (2009), Zhang F (2010), Chen CH (2011), Chen CH (2011), Xu Y (2013), Xu Y (2013), Glidden EJ (2012), Glidden EJ (2012), Vander Haar E (2007), Koo J (2015), Thedieck K (2007)	59
ADRB2	0	GNG2	0	fluorescent resonance energy transfe	Gales C (2005)	1
CDCA8	0	ATP4A	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TBXA2R	1	GNAI2	1	fluorescent resonance energy transfe	Gales C (2005)	1
GNB4	2	GNAI2	1	fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Gibson SK (2006), Huttlin EL (2015), Huttlin EL (2017)	3
MTOR	14	GNB1	4	two hybrid, affinity chromatography technology, affinity chromatography technology	Robles-Molina E (2014), Robles-Molina E (2014), Robles-Molina E (2014)	3
NUFIP1	0	GNG2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MRGPRX1	1	GNB1	4	fluorescent resonance energy transfe	Gales C (2005)	1
GNG2	0	ARRB1	2	affinity chromatography technology	Yang M (2009)	1
DNAAF2	2	GNG2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PIK3R5	2	PIK3CG	3	fluorescent resonance energy transfe, biochemical, imaging technique, genetic interference, imaging technique	Brock C (2003), Brock C (2003), Brock C (2003), Brock C (2003), Chen TC (2014)	5
GNB1	4	RICTOR	4	affinity chromatography technology, affinity chromatography technology	Robles-Molina E (2014), Robles-Molina E (2014)	2
AVPR2	0	GNG2	0	fluorescent resonance energy transfe	Gales C (2005)	1
GNG2	0	GNAS	9	affinity chromatography technology	Nagai Y (2010)	1
ADRA2A	0	GNB1	4	fluorescent resonance energy transfe	Gales C (2005)	1
ATP4A	6	GNG2	0	affinity chromatography technology	Lapierre LA (2007)	1
NUFIP1	0	ATP4A	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GNAS	9	GNB4	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GNB1	4	FYN	1	affinity chromatography technology	Knezevic N (2009)	1
ADRA2A	0	GNG2	0	fluorescent resonance energy transfe	Gales C (2005)	1
RPTOR	4	RICTOR	4	affinity chromatography technology, affinity chromatography technology	Rosner M (2010), Rosner M (2010)	2
ATP4A	6	GNAI2	1	affinity chromatography technology	Lapierre LA (2007)	1
GNB1	4	RPTOR	4	affinity chromatography technology, affinity chromatography technology	Robles-Molina E (2014), Robles-Molina E (2014)	2
PIK3R5	2	GNG2	0	genetic interference	Brock C (2003)	1
MTOR	14	GNB5	2	affinity chromatography technology	Robles-Molina E (2014)	1
GNG2	0	GNB3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, fluorescent resonance energy transfe	Snow BE (1999), Poon LS (2009), Snow BE (1998), Howlett AC (2009), Sun Z (2012), Sun Z (2012), Sun Z (2012)	7
GNAS	9	GNB2	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ADRB2	0	GNB2	3	affinity chromatography technology, affinity chromatography technology	Roy SJ (2013), Roy SJ (2013)	2
DGUOK	1	ATP4A	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2