PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
KCTD13	1	PCNA	0	pull down, far western blotting	He H (2001), He H (2001)	2
EP300	36	POLD2	2	two hybrid	Wang J (2011)	1
XPO1	8	POLA2	2	affinity chromatography technology	Kirli K (2015)	1
PCNA	0	POLD2	2	pull down, pull down, far western blotting, biochemical, affinity chromatography technology, affinity chromatography technology	Lu X (2002), Lu X (2002), Lu X (2002), Shikata K (2001), Cazzalini O (2014), Hein MY (2015)	6
FOXK1	5	POLD2	2	biochemical	Kristensen AR (2012)	1
SIRT6	2	TRIM25	5	affinity chromatography technology	Simeoni F (2013)	1
PPP5C	2	XPO1	8	biochemical	Kristensen AR (2012)	1
XPO1	8	POLD3	0	affinity chromatography technology	Kirli K (2015)	1
TRIM25	5	EP300	36	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
AMZ1	7	POLD2	2	affinity chromatography technology	Huttlin EL (2017)	1
POLD3	0	POLD2	2	two hybrid, affinity chromatography technology, affinity chromatography technology	Pohler JR (2005), Shikata K (2001), Huttlin EL (2017)	3
MMS19	5	XPO1	8	affinity chromatography technology	Stehling O (2012)	1
POLD4	0	PCNA	0	pull down, far western blotting, pull down	Li H (2006), Li H (2006), Terai K (2013)	3
FAM129A	3	POLD2	2	biochemical	Kristensen AR (2012)	1
ERP44	1	POLD2	2	affinity chromatography technology	Huttlin EL (2017)	1
TRIM25	5	POLD2	2	affinity chromatography technology	Choudhury NR (2017)	1
SPRTN	0	POLD1	5	affinity chromatography technology, affinity chromatography technology	Kim MS (2013), Kim MS (2013)	2
PCNA	0	POLD1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, far western blotting, pull down, affinity chromatography technology, affinity chromatography technology	Ohta S (2002), Naryzhny SN (2005), Naryzhny SN (2004), Ogi T (2010), Shikata K (2001), Shikata K (2001), Xie B (2002), Li H (2006), Park JM (2014), Han J (2014), Hein MY (2015)	11
POLD4	0	POLD1	5	pull down, pull down, affinity chromatography technology	Li H (2006), Li H (2006), Hein MY (2015)	3
CCHCR1	2	POLD2	2	two hybrid	Wang J (2011)	1
POLD3	0	POLD1	5	affinity chromatography technology, affinity chromatography technology	Shikata K (2001), Hein MY (2015)	2
MUS81	1	POLD2	2	genetic interference	Vizeacoumar FJ (2013)	1
SPRTN	0	POLD4	0	affinity chromatography technology	Kim MS (2013)	1
SPRTN	0	POLD3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Ghosal G (2012), Ghosal G (2012), Kim MS (2013), Kim MS (2013), Kim MS (2013)	5
TRIM25	5	PCNA	0	affinity chromatography technology, affinity chromatography technology	Park JM (2014), Park JM (2014)	2
MMS19	5	POLD2	2	affinity chromatography technology, biochemical	Stehling O (2012), Wan C (2015)	2
EP300	36	PCNA	0	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Hasan S (2001), Hasan S (2001), Hasan S (2001), Hong R (2003), Hong R (2003), Cazzalini O (2008), Cazzalini O (2008), Naryzhny SN (2004), Cazzalini O (2014), Cazzalini O (2014)	10
POLD2	2	P4HA2	3	affinity chromatography technology	Huttlin EL (2017)	1
POLD4	0	POLD3	0	pull down	Li H (2006)	1
XPO1	8	POLD1	5	affinity chromatography technology	Kirli K (2015)	1
SIRT6	2	POLD3	0	affinity chromatography technology	Simeoni F (2013)	1
MMS19	5	POLA2	2	affinity chromatography technology	Stehling O (2012)	1
FAM129A	3	FOXK1	5	biochemical	Kristensen AR (2012)	1
SPRTN	0	POLH	1	affinity chromatography technology, affinity chromatography technology	Ghosal G (2012), Ghosal G (2012)	2
TRIM25	5	XPO1	8	affinity chromatography technology	Choudhury NR (2017)	1
POLD3	0	PCNA	0	pull down, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, unspecified method, two hybrid, far western blotting, fluorescent resonance energy transfe, affinity chromatography technology	Ducoux M (2001), Ohta S (2002), Pohler JR (2005), Shikata K (2001), Shikata K (2001), Bruning JB (2004), Plosky BS (2006), Li H (2006), Nicolae CM (2014), Hein MY (2015)	10
POLD2	2	OSBPL9	4	biochemical	Wan C (2015)	1
TRIM25	5	PPP5C	2	affinity chromatography technology	Choudhury NR (2017)	1
POLD2	2	POLH	1	two hybrid, pull down	Baldeck N (2015), Baldeck N (2015)	2
LSM6	0	POLD2	2	two hybrid	Lehner B (2004)	1
POLD2	2	POLD1	5	pull down, pull down, biochemical, affinity chromatography technology, affinity chromatography technology	Li H (2006), Li H (2006), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	5
POLD2	2	REV3L	8	affinity chromatography technology	Huttlin EL (2017)	1
SIRT6	2	POLD2	2	affinity chromatography technology	Simeoni F (2013)	1
ERBB2	6	POLD2	2	two hybrid	Arroyo R (2015)	1
MMS19	5	POLD1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Stehling O (2012), Stehling O (2012), Gari K (2012), Gari K (2012)	4
XPO1	8	POLD2	2	affinity chromatography technology	Kirli K (2015)	1
POLH	1	PCNA	0	two hybrid, pull down, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, fluorescent resonance energy transfe, pull down, pull down, affinity chromatography technology	Haracska L (2001), Haracska L (2001), Kannouche PL (2004), Bienko M (2010), Bienko M (2010), Bienko M (2010), Bienko M (2010), Jung YS (2011), Zlatanou A (2011), Plosky BS (2006), Vidal AE (2004), Sekimoto T (2010), Hibbert RG (2012), Mosbech A (2012), Durando M (2013), Qin Z (2013), Fu D (2013), Fu D (2013), Sekimoto T (2010), Sekimoto T (2010), Sekimoto T (2010), Ahmed-Seghir S (2015), Inoue A (2014), Hedglin M (2016), Hedglin M (2016), Dai X (2016), Guan J (2017)	27
XPO1	8	FOXK1	5	affinity chromatography technology	Kirli K (2015)	1
XRN1	4	POLD2	2	two hybrid	Lehner B (2004)	1
NAB2	2	POLD2	2	affinity chromatography technology	Huttlin EL (2017)	1
POLD2	2	PPP5C	2	affinity chromatography technology	Huttlin EL (2017)	1
SPRTN	0	KCTD13	1	affinity chromatography technology, affinity chromatography technology	Ghosal G (2012), Ghosal G (2012)	2
POLD2	2	SOX12	0	two hybrid	Wang J (2011)	1
NAB2	2	CCHCR1	2	two hybrid	Rolland T (2014)	1
DKKL1	1	POLD2	2	affinity chromatography technology	Huttlin EL (2017)	1
ERBB2	6	XPO1	8	affinity chromatography technology, affinity chromatography technology	Giri DK (2005), Giri DK (2005)	2
POLD4	0	POLD2	2	pull down, pull down, affinity chromatography technology	Li H (2006), Li H (2006), Huttlin EL (2017)	3
XPO1	8	XRN1	4	affinity chromatography technology	Kirli K (2015)	1
GPR37	3	POLD2	2	affinity chromatography technology	Huttlin EL (2017)	1
POLD2	2	POLA2	2	biochemical	Wan C (2015)	1
SPRTN	0	POLD2	2	affinity chromatography technology, affinity chromatography technology	Kim MS (2013), Kim MS (2013)	2
SPRTN	0	PCNA	0	imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Centore RC (2012), Centore RC (2012), Ghosal G (2012), Ghosal G (2012), Ghosal G (2012), Ghosal G (2012), Machida Y (2012), Machida Y (2012), Davis EJ (2012), Davis EJ (2012), Juhasz S (2012), Mosbech A (2012), Mosbech A (2012), Mosbech A (2012), Juhasz S (2012), Centore RC (2012)	16
KCTD13	1	POLD2	2	pull down	He H (2001)	1