PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
POLB	0	HIST2H2AB	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
POLB	0	APTX	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EP300	36	BRCA1	7	affinity chromatography technology, pull down, affinity chromatography technology, pull down, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pao GM (2000), Pao GM (2000), Pao GM (2000), Pao GM (2000), Fan S (2002), Fan S (2002), Ma Y (2010), Subbaramaiah K (2011), Subbaramaiah K (2012)	9
POLB	0	KAT7	3	two hybrid	Stelzl U (2005)	1
EP300	36	POLB	0	affinity chromatography technology, pull down, pull down, enzymatic study	Hasan S (2002), Hasan S (2002), Hasan S (2002), Hasan S (2002)	4
8339	0	POLB	0	bioid	Lambert JP (2015)	1
UNG	1	POLB	0	biochemical, biochemical	Mendez F (2000), Mendez F (2000)	2
PARP1	3	APLF	3	pull down, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kanno S (2007), Kanno S (2007), Eustermann S (2010), Ahel I (2008), Huttlin EL (2015), Gibbs-Seymour I (2016), Huttlin EL (2017)	7
EP300	36	PARP1	3	affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Messner S (2009), Hassa PO (2005), Hassa PO (2005), Hassa PO (2005), Hassa PO (2008), Hassa PO (2008), Hassa PO (2003), Hassa PO (2003), Hassa PO (2003), Kim BK (2014), Kim BK (2014)	11
XPC	1	CETN2	0	biochemical, pull down, affinity chromatography technology, biochemical, bioid, affinity chromatography technology, affinity chromatography technology	Araki M (2001), Araki M (2001), Bunick CG (2006), Havugimana PC (2012), Gupta GD (2015), Huttlin EL (2017), Lan X (2016)	7
POLB	0	XPC	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CRBN	2	POLB	0	affinity chromatography technology	Kroenke J (2014)	1
POLB	0	TDP1	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PNKP	3	PARP1	3	affinity chromatography technology	Koch CA (2004)	1
8339	0	KAT7	3	bioid	Lambert JP (2015)	1
NEIL1	2	POLB	0	far western blotting	Wiederhold L (2004)	1
UNG	1	PCNA	0	pull down	Otterlei M (1999)	1
EMC2	3	LIG3	6	affinity chromatography technology	Hein MY (2015)	1
APLF	3	SUPT16H	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
POLB	0	LIG3	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CRBN	2	APTX	3	affinity chromatography technology	Kroenke J (2014)	1
STUB1	4	PARP1	3	affinity chromatography technology, affinity chromatography technology	Choi JR (2016), Choi JR (2016)	2
CRBN	2	7515	0	affinity chromatography technology	Kroenke J (2014)	1
PARP1	3	SUPT16H	4	enzymatic study	Huang JY (2006)	1
PARP1	3	7515	0	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gueven N (2004), Gueven N (2004), Masson M (1998), Masson M (1998), Cazzalini O (2010), Lee CH (2010), Leppard JB (2003)	7
XPC	1	HIST1H2AG	1	affinity chromatography technology	Huttlin EL (2017)	1
APLF	3	PARP2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
POLB	0	CETN2	0	affinity chromatography technology	Huttlin EL (2015)	1
BRCA1	7	PCNA	0	affinity chromatography technology, affinity chromatography technology	Hill SJ (2014), Ertych N (2016)	2
7515	0	NEIL1	2	pull down	Wiederhold L (2004)	1
HUWE1	22	PCNA	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Markkanen E (2011), Thompson JW (2014), Choe KN (2016), Choe KN (2016), Choe KN (2016), Choe KN (2016)	6
XPC	1	PARP1	3	affinity chromatography technology	Huttlin EL (2017)	1
SSRP1	1	SUPT16H	4	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Birch JL (2009), Tan BC (2006), Tan BC (2006), Pavri R (2006), Huang JY (2006), Huang JY (2006), OConnell BC (2010), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	12
XPC	1	HIST2H2AB	1	affinity chromatography technology	Huttlin EL (2017)	1
PCNA	0	APEX1	1	pull down	Dianova II (2001)	1
8339	0	7515	0	bioid	Lambert JP (2015)	1
BRCA1	7	TPP2	2	affinity chromatography technology	Ertych N (2016)	1
EMC2	3	POLB	0	affinity chromatography technology	Hein MY (2015)	1
MMGT1	0	POLB	0	affinity chromatography technology	Hein MY (2015)	1
SRPK2	1	POLB	0	enzymatic study	Varjosalo M (2013)	1
APTX	3	LIG3	6	affinity chromatography technology	Luo H (2004)	1
7515	0	PNKP	3	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Whitehouse CJ (2001), Ewing RM (2007), Ewing RM (2007), Whitehouse CJ (2001), Whitehouse CJ (2001), Whitehouse CJ (2001), Luo H (2004), Koch CA (2004), Hein MY (2015)	9
APLF	3	CETN2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NCAPG	3	LIG3	6	affinity chromatography technology	Heale JT (2006)	1
8339	0	LIG3	6	bioid	Lambert JP (2015)	1
PARP1	3	PCNA	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Frouin I (2003), Cazzalini O (2010), Cazzalini O (2010), Lee CH (2010), Pozo FM (2011), Sekimoto T (2010)	6
POLB	0	SSRP1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NCAPG	3	POLB	0	affinity chromatography technology	Heale JT (2006)	1
STUB1	4	POLB	0	enzymatic study	Parsons JL (2009)	1
EMC2	3	XPC	1	affinity chromatography technology	Hein MY (2015)	1
POLB	0	SUPT16H	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
APLF	3	HIST1H2AG	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LIG3	6	PARP1	3	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology	Leppard JB (2003), Leppard JB (2003), Leppard JB (2003), Leppard JB (2003)	4
PCNA	0	WRN	6	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, fluorescent resonance energy transfe	Rodriguez-Lopez AM (2003), Rodriguez-Lopez AM (2003), Huang S (2000), Kobayashi J (2010), Baynton K (2003)	5
EP300	36	PCNA	0	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Hasan S (2001), Hasan S (2001), Hasan S (2001), Hong R (2003), Hong R (2003), Cazzalini O (2008), Cazzalini O (2008), Naryzhny SN (2004), Cazzalini O (2014), Cazzalini O (2014)	10
BRCA1	7	SSRP1	1	genetic interference, imaging technique	Hill SJ (2014), Hill SJ (2014)	2
BRCA1	7	APEX1	1	affinity chromatography technology	Ertych N (2016)	1
MMGT1	0	EMC2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Christianson JC (2012), Christianson JC (2012), Huttlin EL (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	6
APTX	3	7515	0	affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Date H (2004), Date H (2004), Date H (2004), Date H (2004), Gueven N (2004), Gueven N (2004), Gueven N (2004), Lim J (2006), Luo H (2004), Luo H (2004), Luo H (2004), Luo H (2004), Hein MY (2015)	13
CRBN	2	LIG3	6	affinity chromatography technology	Kroenke J (2014)	1
NCAPG	3	PARP1	3	affinity chromatography technology	Heale JT (2006)	1
APLF	3	TDP1	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
POLB	0	PARP2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PARP1	3	CETN2	0	affinity chromatography technology	Wu T (2013)	1
APEX1	1	POLB	0	two hybrid, pull down	Bennett RA (1997), Bennett RA (1997)	2
7515	0	LIG3	6	two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Whitehouse CJ (2001), Ewing RM (2007), Caldecott KW (1994), Nash RA (1997), Dulic A (2001), Taylor RM (1998), Ogi T (2010), Hein MY (2015)	8
PARP1	3	BRCA1	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, genetic interference, genetic interference, affinity chromatography technology	Hu Y (2014), Hu Y (2014), Hu Y (2014), Shen JP (2017), Srivas R (2016), Ertych N (2016)	6
XPC	1	PARP2	0	affinity chromatography technology	Huttlin EL (2017)	1
APLF	3	SSRP1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BRCA1	7	CRBN	2	affinity chromatography technology	Ertych N (2016)	1
PARP1	3	POLB	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cazzalini O (2010), Cazzalini O (2010), Lee CH (2010), Huttlin EL (2015), Huttlin EL (2017)	5
POLB	0	BRCA1	7	affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique	Masaoka A (2013), Masaoka A (2013), Masaoka A (2013), Masaoka A (2013), Masaoka A (2013)	5
NCAPG	3	7515	0	affinity chromatography technology	Heale JT (2006)	1
POLB	0	TLE1	6	two hybrid	Stelzl U (2005)	1
XPC	1	SUPT16H	4	affinity chromatography technology	Huttlin EL (2017)	1
PNKP	3	SUPT16H	4	affinity chromatography technology	Koch CA (2004)	1
8339	0	UNG	1	bioid	Lambert JP (2015)	1
APLF	3	LIG3	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
POLB	0	TPP2	2	two hybrid	Rolland T (2014)	1
SSRP1	1	PARP1	3	affinity chromatography technology	Huttlin EL (2017)	1
XRCC3	1	POLB	0	affinity chromatography technology	Hein MY (2015)	1
POLB	0	7515	0	two hybrid, pull down, pull down, far western blotting, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang L (2004), Fan J (2004), Kubota Y (1996), Kubota Y (1996), Bhattacharyya N (2001), Bhattacharyya N (2001), Luo H (2004), Huttlin EL (2015), Hein MY (2015), Fang Q (2014), Fang Q (2014), Huttlin EL (2017)	12
TDP1	5	LIG3	6	affinity chromatography technology	Fam HK (2018)	1
BRCA1	7	SUPT16H	4	genetic interference, imaging technique, affinity chromatography technology	Hill SJ (2014), Hill SJ (2014), Ertych N (2016)	3
PCNA	0	7515	0	affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, fluorescent resonance energy transfe, affinity chromatography technology	Fan J (2004), Fan J (2004), Fan J (2004), Fan J (2004), Fan J (2004), Ogi T (2010)	6
APTX	3	PARP1	3	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Date H (2004), Date H (2004), Gueven N (2004), Gueven N (2004), Gueven N (2004)	5
APLF	3	7515	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Gibbs-Seymour I (2016), Huttlin EL (2017)	3
POLB	0	APLF	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BRCA1	7	HUWE1	22	affinity chromatography technology, affinity chromatography technology	Wang X (2014), Wang X (2014)	2
7515	0	PARP2	0	affinity chromatography technology, affinity chromatography technology	Schreiber V (2002), Schreiber V (2002)	2
SSRP1	1	XPC	1	affinity chromatography technology	Huttlin EL (2017)	1
POLB	0	PNKP	3	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Whitehouse CJ (2001), Whitehouse CJ (2001), Whitehouse CJ (2001), Huttlin EL (2015), Huttlin EL (2017)	5
POLB	0	BCKDHB	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PARP1	3	PARP2	0	affinity chromatography technology	Schreiber V (2002)	1
EP300	36	HIST2H2AB	1	enzymatic study, enzymatic study	Bordoli L (2001), Kim MY (2001)	2
SSRP1	1	HIST2H2AB	1	affinity chromatography technology	Huttlin EL (2017)	1
PCNA	0	POLB	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Naryzhny SN (2004), Zhang Z (2014), Zhang Z (2014), Zhang Z (2014)	4
HUWE1	22	POLB	0	enzymatic study	Parsons JL (2009)	1
SRPK2	1	SUPT16H	4	enzymatic study	Varjosalo M (2013)	1
BCKDHB	3	BCKDHA	1	affinity chromatography technology	Huttlin EL (2017)	1
8339	0	PARP2	0	bioid	Lambert JP (2015)	1
NEIL1	2	LIG3	6	far western blotting, pull down, two hybrid	Wiederhold L (2004), Wiederhold L (2004), Wiederhold L (2004)	3
PNKP	3	SSRP1	1	affinity chromatography technology	Koch CA (2004)	1
POLB	0	TAF1D	0	two hybrid, affinity chromatography technology	Wang L (2004), Wang L (2004)	2
WRN	6	PARP1	3	affinity chromatography technology, pull down, affinity chromatography technology	Li B (2004), Li B (2004), Li B (2004)	3
MMGT1	0	LIG3	6	affinity chromatography technology	Hein MY (2015)	1
PNKP	3	LIG3	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Ewing RM (2007), Whitehouse CJ (2001), Whitehouse CJ (2001), Whitehouse CJ (2001)	4
POLB	0	HIST1H2AG	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
POLB	0	BCKDHA	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HSD17B7	1	POLB	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SRPK2	1	APEX1	1	enzymatic study	Varjosalo M (2013)	1
HUWE1	22	PARP1	3	affinity chromatography technology	Thompson JW (2014)	1
APLF	3	XPC	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
APEX1	1	7515	0	two hybrid, far western blotting, affinity chromatography technology	Vidal AE (2001), Vidal AE (2001), Yamamori T (2010)	3
APLF	3	HIST2H2AB	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
POLB	0	WRN	6	far western blotting	Jiao R (2007)	1
8339	0	BRCA1	7	bioid	Lambert JP (2015)	1
SUPT16H	4	WRN	6	affinity chromatography technology	Boldt K (2016)	1
8339	0	XPC	1	bioid	Lambert JP (2015)	1
APEX1	1	EP300	36	affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, enzymatic study, pull down	Sengupta S (2011), Sengupta S (2011), Sengupta S (2011), Sengupta S (2011), Bhakat KK (2003), Yamamori T (2010), Karmakar S (2010)	7