PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PLXNB1	12	PLCG2	11	affinity chromatography technology	Swiercz JM (2009)	1
CENPO	2	CENPU	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Okada M (2006), Foltz DR (2006), Huttlin EL (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	6
CENPU	0	PLXNB1	12	affinity chromatography technology	Hein MY (2015)	1
PLXNB1	12	GRB2	2	affinity chromatography technology	Swiercz JM (2009)	1
PLXNB1	12	PLCG1	6	affinity chromatography technology, affinity chromatography technology	Swiercz JM (2009), Swiercz JM (2009)	2
SGTB	2	PLXNB1	12	affinity chromatography technology	Hein MY (2015)	1
PLXNB1	12	SMPX	0	affinity chromatography technology	Huttlin EL (2017)	1
PLCG2	11	PLCG1	6	imaging technique	Chen TC (2014)	1
C21orf59	0	PLXNB1	12	affinity chromatography technology	Hein MY (2015)	1
DIAPH1	4	PLXNB1	12	affinity chromatography technology	Hein MY (2015)	1
HNRNPD	3	PLXNB1	12	affinity chromatography technology	Hein MY (2015)	1
GRB2	2	DIAPH1	4	affinity chromatography technology	Bisson N (2011)	1
PLXNB1	12	RND3	0	pull down, affinity chromatography technology	Oinuma I (2003), Goh LL (2012)	2
PLXNB1	12	RND1	0	pull down, affinity chromatography technology, affinity chromatography technology	Oinuma I (2003), Oinuma I (2003), Goh LL (2012)	3
PLXNB1	12	RND2	0	pull down, affinity chromatography technology	Oinuma I (2003), Goh LL (2012)	2
PLXNB1	12	RHOA	0	affinity chromatography technology	Swiercz JM (2009)	1
ARHGEF12	2	PLXNB1	12	affinity chromatography technology, two hybrid	Hirotani M (2002), Hirotani M (2002)	2
PLXNB1	12	AKT1	1	affinity chromatography technology	Swiercz JM (2009)	1
SOX4	5	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
RHOA	0	DIAPH1	4	pull down, two hybrid	Riento K (2003), Riento K (2003)	2
AKT1	1	HBB	0	affinity chromatography technology	Klein JB (2005)	1
GRB2	2	HNRNPD	3	affinity chromatography technology	Brehme M (2009)	1
PLXNB1	12	HBA2	0	affinity chromatography technology	Huttlin EL (2017)	1
CENPO	2	PLXNB1	12	affinity chromatography technology	Hein MY (2015)	1
AKT1	1	PLCG1	6	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Wang Y (2006), Wang Y (2006), Wang Y (2006), Wang Y (2006)	4
SOX4	5	PLXNB1	12	two hybrid	Jang SM (2015)	1
ARHGEF11	8	PLXNB1	12	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, two hybrid	Perrot V (2002), Oinuma I (2003), Swiercz JM (2002), Swiercz JM (2002), Swiercz JM (2002), Hirotani M (2002), Hirotani M (2002), Hirotani M (2002)	8
PLCG1	6	RHOA	0	affinity chromatography technology, pull down	Thodeti CK (2002), Thodeti CK (2002)	2
PLCG1	6	GRB2	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Pei Z (1997), Pei Z (1997), Nel AE (1995), Scholler JK (2000), Choi JH (2005), Choi JH (2005)	6
ARHGEF11	8	RHOA	0	enzymatic study, pull down, two hybrid, affinity chromatography technology	Ruemenapp U (1999), Ruemenapp U (1999), Wang J (2011), Huttlin EL (2017)	4
PLXNB1	12	HBB	0	affinity chromatography technology	Huttlin EL (2017)	1
RHOA	0	ARHGEF12	2	pull down, affinity chromatography technology, affinity chromatography technology	Reuther GW (2001), Yang Y (2013), Huttlin EL (2017)	3
SEMA4D	1	PLXNB1	12	affinity chromatography technology	Vikis HG (2002)	1