PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SIKE1	1	STRN	1	affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), Goudreault M (2009), Couzens AL (2013), Hauri S (2013), Hein MY (2015), Hein MY (2015)	6
PLP1	0	GATD1	1	affinity chromatography technology	Huttlin EL (2017)	1
REEP5	1	FAM241A	0	affinity chromatography technology	Huttlin EL (2017)	1
ITGAV	7	PLP1	0	affinity chromatography technology, affinity chromatography technology	Gudz TI (2002), Gudz TI (2002)	2
LMNA	2	REEP6	0	two hybrid	Dittmer TA (2014)	1
SIKE1	1	FGFR1OP2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), Hein MY (2015), Hein MY (2015)	3
PLP1	0	ITGB5	3	affinity chromatography technology	Gudz TI (2002)	1
PLP1	0	SLMAP	3	affinity chromatography technology	Huttlin EL (2017)	1
STRN	1	STRN4	2	affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), Couzens AL (2013), Hauri S (2013), Hein MY (2015)	4
LMNA	2	PLP1	0	two hybrid	Dittmer TA (2014)	1
PLP1	0	RNF114	0	affinity chromatography technology	Huttlin EL (2017)	1
MBP	0	PLP1	0	biochemical, pull down	Wood DD (1984), Edwards AM (1989)	2
STRIP1	3	STRN4	2	affinity chromatography technology, biochemical	Goudreault M (2009), Havugimana PC (2012)	2
SLMAP	3	FGFR1OP2	0	bioid, affinity chromatography technology, affinity chromatography technology	Couzens AL (2013), Hauri S (2013), Hein MY (2015)	3
CLN8	0	PLP1	0	two hybrid	Passantino R (2013)	1
PLP1	0	PTPRN	3	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
PLP1	0	REEP5	1	affinity chromatography technology	Huttlin EL (2017)	1
STRIP1	3	SLMAP	3	affinity chromatography technology, bioid, affinity chromatography technology, biochemical	Goudreault M (2009), Couzens AL (2013), Hauri S (2013), Wan C (2015)	4
STRN	1	SLMAP	3	affinity chromatography technology, bioid, bioid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Goudreault M (2009), Couzens AL (2013), Couzens AL (2013), Hauri S (2013), Hauri S (2013), Wan C (2015), Hein MY (2015)	7
PLP1	0	STRN	1	affinity chromatography technology	Huttlin EL (2017)	1
CLN8	0	PTPRN	3	two hybrid	Passantino R (2013)	1
PLP1	0	FGFR1OP2	0	affinity chromatography technology	Huttlin EL (2017)	1
PLP1	0	STRN4	2	affinity chromatography technology	Huttlin EL (2017)	1
PLP1	0	CALR	1	affinity chromatography technology	Gudz TI (2002)	1
STRN	1	FGFR1OP2	0	affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), Couzens AL (2013), Hauri S (2013), Hein MY (2015), Hein MY (2015)	5
SLMAP	3	STRN4	2	bioid, affinity chromatography technology, biochemical	Couzens AL (2013), Hauri S (2013), Wan C (2015)	3
STRIP1	3	FGFR1OP2	0	affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), Hein MY (2015)	2
SIKE1	1	STRN4	2	affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), Hein MY (2015)	2
STRIP1	3	STRN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), Goudreault M (2009), Goudreault M (2009), Couzens AL (2013), Hauri S (2013), Hein MY (2015)	6
ITGAV	7	ITGB5	3	affinity chromatography technology	Avraham HK (2003)	1
SIKE1	1	SLMAP	3	affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), Couzens AL (2013), Hauri S (2013), Hein MY (2015)	4
PTPRN	3	CALR	1	bioid	St-Denis N (2016)	1
AKT1	1	PLP1	0	two hybrid	Arroyo R (2015)	1
PLP1	0	FAM241A	0	affinity chromatography technology	Huttlin EL (2017)	1
PLP1	0	NRAS	1	affinity chromatography technology	Huttlin EL (2017)	1
STRIP1	3	SIKE1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), Goudreault M (2009), Hein MY (2015)	3
FGFR1OP2	0	STRN4	2	affinity chromatography technology	Hein MY (2015)	1
PLP1	0	RTN2	3	affinity chromatography technology	Huttlin EL (2017)	1
PLP1	0	SIKE1	1	affinity chromatography technology	Huttlin EL (2017)	1
REEP5	1	REEP6	0	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
PLP1	0	STRIP1	3	affinity chromatography technology	Huttlin EL (2017)	1
PLP1	0	REEP6	0	affinity chromatography technology	Huttlin EL (2017)	1