PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ALDOA	0	GAPDH	0	biochemical	Wan C (2015)	1
XPO1	8	RPTOR	4	affinity chromatography technology	Kirli K (2015)	1
CHRM3	1	PLD2	1	affinity chromatography technology	Huttlin EL (2017)	1
CACNG5	0	PLD2	1	affinity chromatography technology	Huttlin EL (2017)	1
CDH8	2	PLD2	1	affinity chromatography technology	Huttlin EL (2017)	1
PLD2	1	PRKCA	7	affinity chromatography technology	Slaaby R (2000)	1
CDH5	2	PLD2	1	affinity chromatography technology	Huttlin EL (2017)	1
VHL	0	PRKCD	2	fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Iturrioz X (2006), Iturrioz X (2006), Yong HJ (2017), Yong HJ (2017)	4
EGFR	5	CAV2	0	affinity chromatography technology, two hybrid, protein complementation assay, pull down	Wu SL (2006), Kotlyar M (2015), Petschnigg J (2014), Abulrob A (2004)	4
EGFR	5	GAPDH	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay	Foerster S (2013), Wu SL (2006), Wu SL (2006), Kotlyar M (2015), Petschnigg J (2014)	5
EGFR	5	ALDOA	0	protein complementation assay	Deribe YL (2009)	1
CUL3	17	ALDOA	0	affinity chromatography technology	Bennett EJ (2010)	1
TNFRSF19	5	PLD2	1	affinity chromatography technology	Huttlin EL (2017)	1
SPC24	0	PLD2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BRAF	12	EGFR	5	genetic interference	Shen JP (2017)	1
SRC	2	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, two hybrid	Olayioye MA (1999), Keely SJ (2000), Sato K (2000), Lee CW (2007), Jaganathan S (2011), Jaganathan S (2011), Lee IT (2010), Hitosugi T (2007), Chang CC (2012), Chang CC (2012), Tung WH (2011), Kotlyar M (2015), Petschnigg J (2014), Li J (2013), Yao Z (2017)	15
CAV1	0	CUL3	17	affinity chromatography technology, affinity chromatography technology	Dubiel D (2017), Dubiel D (2017)	2
VHL	0	EGLN1	3	affinity chromatography technology, affinity chromatography technology, pull down	Foxler DE (2012), Zhang CS (2015), Zhang CS (2015)	3
TUBB	3	PLD2	1	affinity chromatography technology	Huttlin EL (2017)	1
PLD2	1	PEA15	0	affinity chromatography technology	Zhang Y (2000)	1
CUL3	17	GAPDH	0	affinity chromatography technology	Bennett EJ (2010)	1
MTOR	14	RPTOR	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jacinto E (2004), Jacinto E (2004), Sarbassov DD (2004), Sarbassov DD (2004), Sarbassov DD (2004), Schalm SS (2003), Hara K (2002), Ha SH (2006), Wang L (2006), Frias MA (2006), Frias MA (2006), Buerger C (2006), Jacinto E (2006), McMahon LP (2005), Oshiro N (2004), Kawai S (2003), Choi KM (2003), Hara K (2002), Hara K (2002), Kim DH (2002), Kim DH (2002), Schieke SM (2006), Ha SH (2006), Wang L (2006), Frias MA (2006), Buerger C (2006), Sarbassov DD (2006), Tzatsos A (2006), Sarbassov DD (2005), Yang Q (2006), Kaizuka T (2010), Pearce LR (2007), Oh WJ (2010), Oh WJ (2010), Agrawal P (2012), Kwak D (2012), Wu D (2012), Wu D (2012), Wu D (2012), Wu D (2012), Gwinn DM (2010), Sancak Y (2007), Sancak Y (2007), Yang Q (2006), Carriere A (2011), Jacinto E (2006), Rosner M (2010), Kim DH (2003), Kim DH (2003), Carriere A (2008), Murata H (2011), Koike-Kumagai M (2009), Koike-Kumagai M (2009), Hussain S (2013), Hussain S (2013), Peterson TR (2009), Peterson TR (2009), Su WC (2009), Hernandez-Negrete I (2007), Yan X (2012), Ramirez-Rangel I (2011), Ramirez-Rangel I (2011), Martin J (2008), Martin J (2008), Linares JF (2013), Coffman K (2014), Oshiro N (2014), Thedieck K (2007), Thedieck K (2007), Thedieck K (2007), Dan HC (2008), Dan HC (2008), Dan HC (2008), Hong F (2008), Hong F (2008), Choo AY (2008), Toschi A (2009), Loewith R (2002), Xu Y (2013), Sancak Y (2010), Sancak Y (2010), Vander Haar E (2007), Vander Haar E (2007), Kaadige MR (2015), Misra UK (2014), Misra UK (2014), Thedieck K (2007), Thomas JD (2014), Park D (2014), Alayev A (2016), Alayev A (2016)	91
RPTOR	4	RPS6KB1	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study	Ali SM (2005), Ha SH (2006), Hara K (2002), Nojima H (2003), Kwak D (2012), Carriere A (2011), Ha SH (2006), Li L (2013), Garcia-Martinez JM (2009)	9
CRYL1	0	PLD2	1	affinity chromatography technology	Huttlin EL (2017)	1
VHL	0	PLD2	1	affinity chromatography technology, pull down, pull down	Park MH (2015), Park MH (2015), Park MH (2015)	3
CUL3	17	DNAJC7	2	affinity chromatography technology	Bennett EJ (2010)	1
SKAP1	0	PLD2	1	affinity chromatography technology	Huttlin EL (2015)	1
ARF1	1	CHRM3	1	affinity chromatography technology, pull down	Mitchell R (2003), Mitchell R (2003)	2
BRAF	12	PLD2	1	affinity chromatography technology	Eisenhardt AE (2016)	1
CAV1	0	PLCG1	6	affinity chromatography technology	Boettcher JP (2010)	1
BRAF	12	DNAJA1	2	affinity chromatography technology	Eisenhardt AE (2016)	1
RPS6KB1	1	VHL	0	genetic interference	Shen JP (2017)	1
EGLN1	3	PLD2	1	affinity chromatography technology, affinity chromatography technology	Park MH (2015), Park MH (2015)	2
CUL3	17	PLD2	1	affinity chromatography technology	Bennett EJ (2010)	1
TEX264	0	PLD2	1	affinity chromatography technology	Huttlin EL (2015)	1
CAV1	0	AQP3	1	affinity chromatography technology, affinity chromatography technology	Zheng X (2003), Zheng X (2003)	2
EGFR	5	TUBB	3	affinity chromatography technology	Foerster S (2013)	1
PRKCD	2	MTOR	14	affinity chromatography technology, affinity chromatography technology	Kumar V (2000), Kumar V (2000)	2
CUL3	17	TUBB	3	affinity chromatography technology	Bennett EJ (2010)	1
OPRM1	0	ARF1	1	affinity chromatography technology	Koch T (2003)	1
SRC	2	RPS6KB1	1	enzymatic study	Rebholz H (2006)	1
MTOR	14	PRKCA	7	enzymatic study	Oh WJ (2010)	1
DNAJC7	2	PLD2	1	affinity chromatography technology	Huttlin EL (2017)	1
CCDC107	0	PLD2	1	affinity chromatography technology	Huttlin EL (2017)	1
SDF4	1	PLD2	1	affinity chromatography technology	Huttlin EL (2015)	1
POU5F1	0	GAPDH	0	affinity chromatography technology	Hawkins PG (2010)	1
PLD2	1	BIN1	2	genetic interference, pull down	Lee C (2000), Lee C (2000)	2
HAVCR2	0	PLD2	1	affinity chromatography technology	Huttlin EL (2017)	1
CDK5RAP3	0	PLD2	1	affinity chromatography technology	Huttlin EL (2017)	1
PLD2	1	PRKCD	2	affinity chromatography technology, pull down	Han JM (2002), Han JM (2002)	2
AMPH	4	BIN1	2	affinity chromatography technology, affinity chromatography technology	Wigge P (1997), Huttlin EL (2017)	2
EGFR	5	PLD2	1	affinity chromatography technology	Slaaby R (1998)	1
EGFR	5	PLCG1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tvorogov D (2002), Bedrin MS (1997), Crovello CS (1998), Choi JH (2003), Jones RB (2006), Tong J (2014), Egan JE (2002), Wu D (2009), Wu D (2009)	9
PLD2	1	AMPH	4	genetic interference, pull down, affinity chromatography technology	Lee C (2000), Lee C (2000), Lee C (2000)	3
PLD2	1	HIF1A	1	affinity chromatography technology, affinity chromatography technology, pull down	Park MH (2015), Park MH (2015), Park MH (2015)	3
VHL	0	HIF1A	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, far western blotting, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, pull down, protein complementation assay, pull down, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Corn PG (2003), Li Z (2003), Mahon PC (2001), Tanimoto K (2000), Min JH (2002), Yu F (2001), Yu F (2001), Jung JE (2008), Jung JE (2008), Andre H (2008), Park YK (2008), Kim BY (2008), Park SS (2008), Baek JH (2007), Baek JH (2007), Baek JH (2007), Kondo S (2006), Ietta F (2006), Kwon SJ (2005), Bae MK (2005), Baek JH (2005), Hon WC (2002), Hon WC (2002), Lewis MD (2004), Kasuno K (2004), Metzen E (2003), Metzen E (2003), Zhou J (2003), Yuan Y (2003), Maynard MA (2003), Jeong JW (2002), Yoo YG (2008), Hansen WJ (2002), Masson N (2001), Masson N (2001), Clifford SC (2001), Jaakkola P (2001), Jaakkola P (2001), Kamura T (2000), Kamura T (2000), Kamura T (2000), Ohh M (2000), Ohh M (2000), Cockman ME (2000), Cockman ME (2000), Sufan RI (2006), Chang CC (2011), Sufan RI (2009), Stickle NH (2004), Luo W (2010), Lee HY (2011), Roe JS (2011), Ivan M (2001), Ivan M (2001), Huang LE (2002), Callapina M (2005), Callapina M (2005), Maranchie JK (2002), DAngelo G (2003), DAngelo G (2003), Miller F (2005), Grosfeld A (2007), Grosfeld A (2007), Rajakumar A (2008), Bonicalzi ME (2001), Bemis L (2004), Berra E (2001), Yu F (2001), Bex C (2007), Zhou J (2012), Wiesener MS (2002), Maxwell PH (1999), Maxwell PH (1999), Lee SH (2012), Lee SH (2012), Ivan M (2002), Aprelikova O (2009), Choi CY (2009), Choi CY (2009), Heir P (2013), Russell RC (2008), Russell RC (2008), Park JH (2011), Park JH (2011), Liu Q (2013), Yeh IJ (2013), Choi YK (2010), Yang F (2014), Yang F (2014), Yang F (2014), Parsanejad M (2014), Yang C (2013), Yang C (2013), Chen K (2013), Park MH (2014), Gerez J (2015), Hein MY (2015), Park MH (2015), Fu R (2016), Alahari S (2015), Zhang CS (2015), Song D (2013), Chen K (2016), Hicks KC (2016), Groulx I (2002), Groulx I (2002), Groulx I (2002), Huttlin EL (2017), Guo J (2016), Sun W (2017), Sun W (2017), Guo J (2016), Li YM (2005), Yoo YG (2004), Kimura M (2008), Ferrer CM (2014)	116
PLD2	1	ARF1	1	pull down, pull down	Lee S (2001), Park JB (2000)	2
DNAJA1	2	PLD2	1	affinity chromatography technology	Huttlin EL (2015)	1
VHL	0	DNAJA1	2	affinity chromatography technology	Lai Y (2011)	1
TUBB	3	XPO1	8	biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012)	2
RPS6KB1	1	MTOR	14	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology	Chiang GG (2005), Holz MK (2005), Holz MK (2005), Hara K (2002), Isotani S (1999), Long X (2005), Toral-Barza L (2005), Ali SM (2005), Saitoh M (2002), Kim DH (2002), Edinger AL (2003), Leone M (2006), Takahashi T (2000), Burnett PE (1998), Sarbassov DD (2005), Agrawal P (2012), Sancak Y (2007), Oshiro N (2004), Sarbassov DD (2005), Kim DH (2003), Kim DH (2003), Nojima H (2003), Martin J (2008), Wing LY (2005), Ren HY (2015)	25
CAV1	0	SRC	2	pull down	Li S (1996)	1
PLD2	1	CAV2	0	biochemical	Czarny M (2000)	1
EGLN1	3	SRC	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study	Lee HY (2011), Lee HY (2011), Lee HY (2011), Lee HY (2011), Lee HY (2011)	5
CAV1	0	PLD2	1	affinity chromatography technology, affinity chromatography technology, biochemical	Zheng X (2003), Zheng X (2003), Czarny M (2000)	3
CUL3	17	SDF4	1	affinity chromatography technology	Bennett EJ (2010)	1
EGFR	5	DNAJA1	2	affinity chromatography technology, affinity chromatography technology	Foerster S (2013), Tong J (2014)	2
HIF1A	1	SRC	2	imaging technique, affinity chromatography technology	Gray MJ (2005), Ruas JL (2005)	2
SRC	2	PLD2	1	enzymatic study, affinity chromatography technology, pull down	Ahn BH (2003), Ahn BH (2003), Ahn BH (2003)	3
CHRM3	1	CAV1	0	affinity chromatography technology	Huttlin EL (2017)	1
PLCG1	6	SRC	2	affinity chromatography technology	Dhar A (1994)	1
PLD2	1	ALDOA	0	pull down, affinity chromatography technology	Kim JH (2002), Kim JH (2002)	2
THBS3	3	PLD2	1	affinity chromatography technology	Huttlin EL (2015)	1
PLD2	1	PLCG1	6	affinity chromatography technology, pull down	Jang IH (2003), Jang IH (2003)	2
EGFR	5	XPO1	8	affinity chromatography technology	Foerster S (2013)	1
POU5F1	0	TUBB	3	affinity chromatography technology	Oliviero G (2015)	1
XPO1	8	PLD2	1	affinity chromatography technology	Kirli K (2015)	1
MTOR	14	PLD2	1	affinity chromatography technology	Ha SH (2006)	1
BRAF	12	VHL	0	genetic interference	Shen JP (2017)	1
GPR156	2	PLD2	1	affinity chromatography technology	Huttlin EL (2017)	1
EGFR	5	CDH5	2	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
HIF1A	1	RPTOR	4	affinity chromatography technology	Land SC (2007)	1
RPS6KB1	1	PLD2	1	affinity chromatography technology	Ha SH (2006)	1
POU5F1	0	SDF4	1	affinity chromatography technology	Oliviero G (2015)	1
EGFR	5	CAV1	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, pull down, biochemical	Couet J (1997), Couet J (1997), Khan EM (2006), Feldman R (2009), Hua H (2003), Wu SL (2006), Wu SL (2006), Kotlyar M (2015), Petschnigg J (2014), Park WY (2000), Abulrob A (2004), Abulrob A (2004)	12
SRC	2	SKAP1	0	pull down	Marie-Cardine A (1997)	1
POU5F1	0	PLD2	1	affinity chromatography technology	Oliviero G (2015)	1
PRKCA	7	EGFR	5	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Gauthier ML (2003), Gauthier ML (2003), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	5
PTGER3	2	PLD2	1	affinity chromatography technology	Huttlin EL (2015)	1
PLD2	1	AQP3	1	affinity chromatography technology, affinity chromatography technology	Zheng X (2003), Zheng X (2003)	2
OPRM1	0	PLD2	1	affinity chromatography technology	Koch T (2003)	1
HIF1A	1	EGLN1	3	pull down, pull down, pull down, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Percy MJ (2006), Baek JH (2005), Yoo YG (2008), Chowdhury R (2009), Choi YK (2010), Park MH (2014), Park MH (2015), Park MH (2015), Barth S (2007), Song D (2013), Guo J (2016), Kumar P (2015)	12
CAV2	0	CAV1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Breuza L (2002), Scherer PE (1997), Scherer PE (1997), Sowa G (2008)	4
XPO1	8	MTOR	14	affinity chromatography technology	Kirli K (2015)	1
PLD2	1	GAPDH	0	affinity chromatography technology, pull down	Kim JH (2003), Kim JH (2003)	2
CAV2	0	DNAJA1	2	two hybrid	Vinayagam A (2011)	1
CUL3	17	DNAJA1	2	affinity chromatography technology	Bennett EJ (2010)	1
BRAF	12	RPTOR	4	affinity chromatography technology	Huttlin EL (2017)	1
RPS6KB1	1	XPO1	8	affinity chromatography technology	Panasyuk G (2006)	1
CAV2	0	SRC	2	pull down	Lee H (2002)	1
EGFR	5	MTOR	14	affinity chromatography technology	Foerster S (2013)	1
TUBB	3	GAPDH	0	biochemical	Kristensen AR (2012)	1
RPTOR	4	PLD2	1	affinity chromatography technology	Ha SH (2006)	1