PPI network (data source: BioGrid)

Symbol A GeneA coding DNM count Symbol B GeneB coding DNM count Interaction detection method Publication Evidence
TP53 0 TP73 2 affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology Stindt MH (2015), Puca R (2011), De Laurenzi V (1998), Di Como CJ (1999) 4
PML 7 DAXX 5 two hybrid, two hybrid, affinity chromatography technology, imaging technique, two hybrid, affinity chromatography technology, imaging technique, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique Ishov AM (1999), Li H (2000), Li H (2000), Li H (2000), Lehembre F (2001), Zhong S (2000), Cuchet-Lourenco D (2011), Chu Y (2011), Meinecke I (2007), Jang MS (2002), Chang CC (2011), Wethkamp N (2011), Ferguson BJ (2007), Delbarre E (2013), Delbarre E (2013), Sahin U (2014), Lin DY (2006), Lin DY (2006), Lin DY (2006), Lin DY (2006), Torii S (1999) 21
UBE2I 0 EP300 36 enzymatic study, affinity chromatography technology Girdwood D (2003), Bian XL (2017) 2
TP73 2 PLAGL1 0 affinity chromatography technology, pull down, pull down, imaging technique, imaging technique Hoffmann A (2008), Hoffmann A (2008), Hoffmann A (2008), Hoffmann A (2008), Hoffmann A (2008) 5
EP300 36 SMAD3 1 affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Qiu P (2006), Furumatsu T (2005), Itoh S (2000), Akiyoshi S (1999), Abecassis L (2004), Kaimori A (2010), Janknecht R (1998), Janknecht R (1998), Nishihara A (1999), Nishihara A (1999), Furumatsu T (2005), Ghosh AK (2004), Shen X (1998), Shen X (1998), Ghosh AK (2001), Postigo AA (2003), Postigo AA (2003), Yang WS (2005), Lim JY (2012), Lim JY (2012), Jinnin M (2007), Wang G (2005) 22
TRIM25 5 PLAGL1 0 affinity chromatography technology Choudhury NR (2017) 1
SUMO1 0 TP73 2 two hybrid Minty A (2000) 1
CREBBP 29 DAXX 5 two hybrid, affinity chromatography technology Kuo HY (2005), Kuo HY (2005) 2
DAXX 5 SUMO1 0 two hybrid, two hybrid, pull down, affinity chromatography technology, x-ray crystallography, pull down, pull down, x-ray crystallography, pull down, two hybrid, affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, two hybrid, x-ray crystallography, two hybrid Lin DY (2002), Ryu SW (2000), Ryu SW (2000), Ryu SW (2000), Escobar-Cabrera E (2011), Escobar-Cabrera E (2011), Naik MT (2011), Chang CC (2011), Chang CC (2011), Chen A (2006), Chen A (2006), Saul VV (2014), Ullmann R (2012), Lin DY (2006), Lin DY (2006), Ullmann R (2012), Ullmann R (2012), Lin DY (2006), Naik MT (2011), Li C (2017) 20
PML 7 CREBBP 29 pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Matsuzaki K (2003), Matsuzaki K (2003), Matsuzaki K (2003), Doucas V (1999), Doucas V (1999), Zhong S (1999), Chen Y (2015) 7
UBE2I 0 PLAGL1 0 pull down, two hybrid Chang YL (2007), Chang YL (2007) 2
DAXX 5 TP53 0 affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, unspecified method Tang J (2006), Kim EJ (2003), Kim EJ (2003), Kim EJ (2003), Ohiro Y (2003), Ohiro Y (2003), Ohiro Y (2003), Ohiro Y (2003), Wethkamp N (2011), Zhao LY (2004), Zhao LY (2004), Zhao LY (2004), Gostissa M (2004), Gostissa M (2004), Gostissa M (2004), Gostissa M (2004), Gostissa M (2004), Zhao LY (2004), Zhao LY (2004), Zhang H (2013), Zhang H (2013), Chen TC (2014), Li Z (2017) 23
CREBBP 29 TP73 2 pull down, pull down Zeng X (2000), Lemasson I (2001) 2
PLAGL1 0 KAT2B 2 pull down, pull down Hoffmann A (2008), Hoffmann A (2008) 2
TRIM25 5 EP300 36 affinity chromatography technology, affinity chromatography technology Choudhury NR (2017), Choudhury NR (2017) 2
SUMO1 0 PIAS2 2 two hybrid, two hybrid, two hybrid, two hybrid, pull down, two hybrid Lee BH (2003), Stehmeier P (2009), Wang J (2011), Hecker CM (2006), Hecker CM (2006), Rolland T (2014) 6
EP300 36 HDAC1 4 affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology Han Y (2008), Mayanil CS (2006), Simone C (2004), Simone C (2004), Simone C (2004), Liu Y (2012), Mizuguchi Y (2012) 7
UBE2I 0 HDAC1 4 enzymatic study Citro S (2013) 1
EP300 36 KAT2B 2 enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Kiernan R (2003), Kim JH (2011), Lee M (2010), Santos-Rosa H (2003), Yang XJ (1996), Yang XJ (1996), Yang XJ (1996), Mizuguchi Y (2012) 8
HDAC1 4 PML 7 pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology Khan MM (2001), Khan MM (2001), Wu WS (2001), Wu WS (2001), Wu WS (2001), Wu WS (2001), Wu WS (2001), Morey L (2008), Kuo HY (2013), Kim YE (2015) 10
UBE2I 0 CREBBP 29 affinity chromatography technology, pull down, enzymatic study, two hybrid Hsieh YL (2013), Hsieh YL (2013), Hsieh YL (2013), Liu ST (2012) 4
UBE2I 0 PML 7 enzymatic study, pull down, enzymatic study, two hybrid, two hybrid, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, pull down Knipscheer P (2008), Kim YE (2005), Satow R (2012), Duprez E (1999), Wang J (2011), Tatham MH (2003), Duprez E (1999), Gocke CB (2005), Lin DY (2006), Jo S (2016), Schilling EM (2017) 11
DAXX 5 PLAGL1 0 two hybrid, pull down Ho CL (2010), Ho CL (2010) 2
TP53 0 PIAS2 2 pull down, pull down, two hybrid, enzymatic study, enzymatic study, imaging technique Schmidt D (2002), Schmidt D (2002), Wang J (2008), Wu SY (2009), Schmidt D (2002), Chen TC (2014) 6
TP53 0 SMAD3 1 affinity chromatography technology, pull down, affinity chromatography technology, imaging technique Cordenonsi M (2003), Cordenonsi M (2003), Lu D (2013), Ali A (2013) 4
SUMO1 0 TP53 0 two hybrid Minty A (2000) 1
SMAD3 1 HDAC1 4 two hybrid, pull down Liberati NT (2001), Akiyoshi S (1999) 2
PML 7 SUMO1 0 two hybrid, imaging technique, fluorescent resonance energy transfe, two hybrid, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down, x-ray crystallography, fluorescent resonance energy transfe, unspecified method, two hybrid, pull down Lin DY (2002), Cuchet-Lourenco D (2011), Percherancier Y (2009), Cuchet-Lourenco D (2012), Stehmeier P (2009), Duprez E (1999), Shen TH (2006), Shen TH (2006), Saether T (2007), Cappadocia L (2015), Cappadocia L (2015), Cappadocia L (2015), Li C (2017), Li C (2017) 14
PML 7 PLAGL1 0 pull down Ho CL (2010) 1
TP53 0 EP300 36 pull down, genetic interference, pull down, enzymatic study, pull down, pull down, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, imaging technique, affinity chromatography technology, enzymatic study, affinity chromatography technology, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, unspecified method, affinity chromatography technology, enzymatic study, unspecified method, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, unspecified method An W (2004), Pastorcic M (2000), Livengood JA (2002), Livengood JA (2002), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Tang Y (2008), Wang H (2008), Valbuena A (2008), Shi D (2009), Vega FM (2004), Finlan L (2004), Groenroos E (2004), Zhao Y (2006), Roe JS (2006), Pedeux R (2005), Sekaric P (2007), Pan X (2009), Tang Y (2006), Sen GS (2011), Li Y (2012), Li Y (2012), Gillotin S (2010), Grossman SR (2003), Issaeva N (2004), Kitagawa M (2008), Sabbatini P (2002), Burge S (2009), Zilfou JT (2001), Issaeva N (2004), Issaeva N (2004), Feng H (2009), Feng H (2009), Lill NL (1997), Dornan D (2004), Dornan D (2004), Di Agostino S (2006), Wells M (2008), Fath DM (2006), Kobet E (2000), Costanzo A (2002), Kumazawa T (2011), Borger DR (2006), Cui D (2013), Borger DR (2006), Lee SJ (2013), Tang HY (2006), Lin C (2011), Choi WI (2014), Ding G (2013), Kim MK (2013), Ali A (2013), Wu G (2014), Mizuguchi Y (2012), Sinha S (2012), Sinha S (2012), Her YR (2013), Her YR (2013), Wu SY (2009), Wu SY (2009), Liu L (1999), Sakaguchi K (1998), Harrod R (2003), Gu W (1997), Teufel DP (2007), Mantovani F (2007), Mantovani F (2007), Dornan D (2003), Dornan D (2003), Dornan D (2003), Dornan D (2003), Dornan D (2003), MacPartlin M (2005), Mujtaba S (2004), Wang YH (2003), Chen H (1999), Tang Z (2013), Graczyk A (2013), Graczyk A (2013), Chan HM (2001), Thomas MC (2005), Miller Jenkins LM (2015), Miller Jenkins LM (2015), Koh DI (2014), Koh DI (2014), Koh DI (2014), Li H (2015), Chen LF (2005), Shi D (2016), Wright DG (2016), Zhang X (2016), Procopio MG (2015), Tong Q (2015) 95
PLAGL1 0 EP300 36 pull down, affinity chromatography technology, affinity chromatography technology Hoffmann A (2006), Hoffmann A (2006), Wang L (2017) 3
SMAD3 1 KAT2B 2 affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology Prokova V (2005), Itoh S (2000), Itoh S (2000), Kahata K (2004), Dai M (2012) 5
UBE2I 0 TP73 2 two hybrid Minty A (2000) 1
HDAC1 4 DAXX 5 far western blotting, pull down, affinity chromatography technology Li H (2000), Li H (2000), Li H (2000) 3
KAT2B 2 TP53 0 enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, two hybrid, enzymatic study, pull down, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study Jin Y (2002), Wang H (2008), Zhao Y (2006), Roe JS (2006), Perez RE (2010), Tang Y (2006), Zhao LY (2003), Liu L (1999), Liu L (1999), Sakaguchi K (1998), Harrod R (2003), Harrod R (2003), MacPartlin M (2005), Chen H (1999), Kang H (2009) 15
TRIM25 5 SMAD3 1 affinity chromatography technology Choudhury NR (2017) 1
PLAGL1 0 HDAC1 4 affinity chromatography technology, affinity chromatography technology Liu PY (2008), Liu PY (2008) 2
TP53 0 PML 7 affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique Kurki S (2003), Kurki S (2003), Fogal V (2000), Fogal V (2000), Guo A (2000), Guo A (2000), Insinga A (2004), Chu Y (2011), Li Q (2011), Li Q (2011), Bernassola F (2005), Yang Q (2013), Yang Q (2013), Catalano A (2004), Chen TC (2014) 15
CREBBP 29 TP53 0 enzymatic study, pull down, genetic interference, pull down, enzymatic study, fluorescent resonance energy transfe, enzymatic study, affinity chromatography technology, imaging technique, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, affinity chromatography technology, unspecified method, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, enzymatic study, enzymatic study, pull down, x-ray crystallography, x-ray crystallography, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down Ito A (2002), Livengood JA (2002), Livengood JA (2002), Giebler HA (2000), Tang Y (2008), Jenkins LM (2009), Shi D (2009), Zhao Y (2006), Saifudeen Z (2005), Scolnick DM (1997), Scolnick DM (1997), Gu W (1997), Gu W (1997), Matsuda S (2004), Pasqualucci L (2011), Lee SK (1999), Dai C (2011), Lee CW (2010), Ferreon JC (2009), Ruas JL (2010), Ruas JL (2010), Huang WC (2007), Huang WC (2007), Mujtaba S (2004), Mujtaba S (2004), Mujtaba S (2004), Mujtaba S (2004), Col E (2002), Jansma AL (2014), Jansma AL (2014), Krois AS (2016), Hasegawa K (2008), Huang X (2013), Huang X (2013), Piskacek M (2016) 35
PIAS2 2 PLAGL1 0 pull down Van Dyck F (2004) 1
CREBBP 29 SUMO1 0 x-ray crystallography, pull down Diehl C (2016), Diehl C (2016) 2
HDAC1 4 TP73 2 affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology Uramoto H (2004), Uramoto H (2004), Uramoto H (2004), Zhang J (2007) 4
SMAD3 1 PLAGL1 0 two hybrid Colland F (2004) 1
CREBBP 29 SMAD3 1 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Kang JS (2005), Alliston T (2005), Xi Q (2008), Cui Q (2005), Cui Q (2005), Chen W (2007), Nishihara A (1999), Tomita M (2004), Oussaief L (2009), Oussaief L (2009), Cui Q (2005) 11
TP73 2 KAT2B 2 two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Zhao LY (2003), Zhao LY (2003), Zhao LY (2003), Zhao LY (2003), Hoffmann A (2008) 5
CREBBP 29 EP300 36 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Crusselle-Davis VJ (2007), Dohda T (2004), Dohda T (2004) 3
TP73 2 EP300 36 affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, x-ray crystallography, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology Strano S (2005), Uramoto H (2004), Zeng X (2000), Zeng X (2000), Zeng X (2000), Zeng X (2000), Zeng X (2000), Mantovani F (2004), Burge S (2009), Burge S (2009), Costanzo A (2002), Hoffmann A (2008), Kramer D (2015) 13
HDAC1 4 CREBBP 29 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Mayanil CS (2006), Chuang HC (2006), Chuang HC (2006) 3
TRIM25 5 CREBBP 29 affinity chromatography technology, affinity chromatography technology Choudhury NR (2017), Choudhury NR (2017) 2
TP73 2 DAXX 5 affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology Kim EJ (2003), Kim EJ (2003), Kim EJ (2003), Gostissa M (2004), Gostissa M (2004), Gostissa M (2004) 6
UBE2I 0 DAXX 5 two hybrid, enzymatic study, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, two hybrid Ryu SW (2000), Knipscheer P (2008), Hsieh YL (2013), Hsieh YL (2013), Hsieh YL (2013), Chang CC (2011), Lin DY (2006), Lin DY (2006) 8
TP53 0 HDAC1 4 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, imaging technique Ito A (2002), Wang C (2005), Dohi Y (2008), Jin W (2008), Lei Q (2006), Wu Y (2001), Wu Y (2001), Luo J (2000), Juan LJ (2000), Juan LJ (2000), Juan LJ (2000), Murphy M (1999), Insinga A (2004), Sun JM (2007), Yu XY (2010), Sinha S (2010), Sinha S (2010), Li Y (2012), Di Agostino S (2006), Pavithra L (2009), Pavithra L (2009), Luo J (2000), Chen TC (2014), Park EK (2015), Park EK (2015), Park EK (2015) 26
SMAD3 1 PML 7 affinity chromatography technology Lin HK (2004) 1
PLAGL1 0 TP53 0 pull down, genetic interference Huang SM (2001), Huang SM (2001) 2
UBE2I 0 PIAS2 2 two hybrid, two hybrid, two hybrid, pull down, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down Rual JF (2005), Lee BH (2003), Bandyopadhyay S (2010), Schmidt D (2002), Wang J (2011), Rolland T (2014), Saul VV (2014), van den Akker E (2005), Schmidt D (2002) 9
CREBBP 29 KAT2B 2 pull down, biochemical, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology Tini M (2002), Cho H (1998), Cho H (1998), Cho H (1998), Korzus E (1998), Korzus E (1998), Korzus E (1998), Yang XJ (1996), Yang XJ (1996), Yang XJ (1996) 10
PLAGL1 0 CREBBP 29 pull down Hoffmann A (2006) 1
PIAS2 2 PML 7 imaging technique, affinity chromatography technology, affinity chromatography technology, enzymatic study Cuchet-Lourenco D (2011), Rabellino A (2012), Rabellino A (2012), Rabellino A (2012) 4
UBE2I 0 TP53 0 two hybrid, two hybrid, two hybrid, enzymatic study, two hybrid, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study Minty A (2000), Gallagher WM (1999), Shen Z (1996), Bernier-Villamor V (2002), Wang J (2008), Spektor TM (2011), Jakobs A (2007), Mohideen F (2009), Lin JY (2004), Bennett RL (2012), Heo KS (2013), Morimoto M (2003), Rodriguez MS (1999), Muller S (2000), Fernandez-Lloris R (2006), Mohan RD (2007), Brandt M (2013), Weger S (2005) 18
PIAS2 2 SMAD3 1 pull down Li X (2006) 1
TRIM25 5 PML 7 affinity chromatography technology Choudhury NR (2017) 1
UBE2I 0 SUMO1 0 affinity chromatography technology, pull down, two hybrid, two hybrid, fluorescent resonance energy transfe, pull down, two hybrid, two hybrid, pull down, pull down, two hybrid, pull down, fluorescent resonance energy transfe, pull down, two hybrid, pull down, pull down, enzymatic study, enzymatic study, biochemical, affinity chromatography technology Ewing RM (2007), Tatham MH (2003), Minty A (2000), Shen Z (1996), Song Y (2011), Knipscheer P (2007), Boutell C (2011), Gong L (1997), Gong L (1997), Hemelaar J (2004), Hecker CM (2006), Hecker CM (2006), Martin SF (2008), Everett RD (2014), Rolland T (2014), Zilio N (2013), Carbia-Nagashima A (2007), Knipscheer P (2007), Matic I (2008), Wan C (2015), Hein MY (2015) 21
PLAGL1 0 SUMO1 0 enzymatic study Liu ST (2012) 1