PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PIAS4	5	SMAD3	1	affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down	Imoto S (2003), Long J (2003), Long J (2003), Long J (2003), Long J (2003), Long J (2003)	6
PIAS2	2	PIAS1	4	imaging technique	Chen TC (2014)	1
PIAS1	4	PLAG1	2	pull down	Van Dyck F (2004)	1
KPNA2	0	PLAG1	2	two hybrid, pull down	Braem CV (2002), Braem CV (2002)	2
PIAS2	2	PIAS4	5	two hybrid	Wang J (2011)	1
PIAS2	2	PLAG1	2	pull down	Van Dyck F (2004)	1
ALB	1	PLAG1	2	affinity chromatography technology	Zhou M (2004)	1
PIAS4	5	PLAG1	2	pull down	Van Dyck F (2004)	1
PIAS2	2	SMAD3	1	pull down	Li X (2006)	1
SMAD3	1	PLAG1	2	two hybrid	Colland F (2004)	1