PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
YWHAE	0	CEP250	4	affinity chromatography technology	Gloeckner CJ (2007)	1
EED	1	BMI1	0	affinity chromatography technology, imaging technique, pull down, affinity chromatography technology	Cao Q (2014), Cao Q (2014), Cao Q (2014), Cao Q (2014)	4
RNF2	1	G3BP1	4	affinity chromatography technology	Cao Q (2014)	1
G3BP1	4	YWHAQ	0	affinity chromatography technology	Jain S (2016)	1
LPAR6	0	PKP2	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CEP250	4	APC	5	affinity chromatography technology	Fogeron ML (2013)	1
BMI1	0	G3BP1	4	affinity chromatography technology	Cao Q (2014)	1
PKP2	4	JUP	7	affinity chromatography technology, two hybrid	Chen X (2002), Chen X (2002)	2
EED	1	DSG2	8	affinity chromatography technology	Cao Q (2014)	1
YWHAQ	0	PKP2	4	affinity chromatography technology	Mueller J (2003)	1
PKP2	4	DSC2	2	two hybrid	Chen X (2002)	1
CUL3	17	DROSHA	0	affinity chromatography technology	Bennett EJ (2010)	1
KLHL40	4	PKP2	4	affinity chromatography technology	Huttlin EL (2017)	1
CEP250	4	SEC16A	7	affinity chromatography technology	Fogeron ML (2013)	1
TMEM17	0	JUP	7	bioid	Gupta GD (2015)	1
EED	1	RNF2	1	affinity chromatography technology, imaging technique, pull down, affinity chromatography technology	Cao Q (2014), Cao Q (2014), Cao Q (2014), Cao Q (2014)	4
MATR3	2	PKP2	4	affinity chromatography technology	Hein MY (2015)	1
CUL3	17	BMI1	0	affinity chromatography technology	Hernandez-Munoz I (2005)	1
GTF2B	1	PKP2	4	affinity chromatography technology	Mertens C (2001)	1
TMEM52B	0	PKP2	4	affinity chromatography technology	Huttlin EL (2017)	1
ARMC8	1	KRT18	2	affinity chromatography technology	Lampert F (2018)	1
CEP250	4	PKP2	4	affinity chromatography technology	Fogeron ML (2013)	1
TNFRSF19	5	PKP2	4	affinity chromatography technology	Huttlin EL (2017)	1
ARMC8	1	PKP2	4	affinity chromatography technology	Lampert F (2018)	1
EED	1	JUP	7	affinity chromatography technology	Cao Q (2014)	1
PCDHGB1	3	PKP2	4	affinity chromatography technology	Huttlin EL (2017)	1
GRN	2	PKP2	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDH1	4	JUP	7	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Kinch MS (1995), Hazan RB (1998), Shibata T (1994), Hinck L (1994), Knudsen KA (1992), Geng F (2012), Guo Z (2014)	7
CUL3	17	YWHAB	1	affinity chromatography technology	Bennett EJ (2010)	1
TMEM17	0	DSG2	8	bioid	Gupta GD (2015)	1
EGLN3	0	GTSE1	3	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	EYA4	1	affinity chromatography technology	Rodriguez J (2016)	1
DSC1	2	DSP	8	pull down	Smith EA (1998)	1
CUL3	17	PKP2	4	affinity chromatography technology	Bennett EJ (2010)	1
EGLN3	0	YWHAE	0	affinity chromatography technology	Rodriguez J (2016)	1
DSC2	2	DSG2	8	pull down	Syed SE (2002)	1
PKP2	4	DSG1	1	affinity chromatography technology, two hybrid	Chen X (2002), Chen X (2002)	2
APC	5	PKP2	4	affinity chromatography technology	Hein MY (2015)	1
CDH1	4	YWHAB	1	bioid	Guo Z (2014)	1
CEP250	4	MATR3	2	affinity chromatography technology	Fogeron ML (2013)	1
MTUS2	4	NDEL1	2	two hybrid	Rolland T (2014)	1
PKP2	4	KRT18	2	pull down	Hofmann I (2000)	1
PKP2	4	POLR3A	4	pull down, affinity chromatography technology	Mertens C (2001), Mertens C (2001)	2
SEC16A	7	DSP	8	affinity chromatography technology	Hein MY (2015)	1
CDH1	4	KRT18	2	affinity chromatography technology, bioid	Catimel B (2005), Guo Z (2014)	2
BMI1	0	RNF2	1	biochemical, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, biochemical, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Cao R (2005), Cao R (2005), Ben-Saadon R (2006), Li Z (2006), Maertens GN (2009), Wei J (2006), Gao Z (2012), Gao Z (2012), Gao Z (2012), Gao Z (2012), Pan MR (2011), Pan MR (2011), Voncken JW (2005), Woodsmith J (2012), Voncken JW (2003), Woodsmith J (2012), Li Z (2006), Li Z (2006), McGinty RK (2014), Cao Q (2014), Cao Q (2014), Hein MY (2015), Balasubramanian S (2015), Taherbhoy AM (2015), Taherbhoy AM (2015), Abdouh M (2016), Sanchez A (2016), Wheaton K (2017), Hauri S (2016), Hauri S (2016)	30
G3BP1	4	DSP	8	affinity chromatography technology	Jain S (2016)	1
DSP	8	JUP	7	affinity chromatography technology, affinity chromatography technology, two hybrid	Kowalczyk AP (1998), Kowalczyk AP (1997), Kowalczyk AP (1997)	3
PKP2	4	MARK3	2	affinity chromatography technology, enzymatic study	Mueller J (2003), Mueller J (2003)	2
CUL3	17	SEC16A	7	affinity chromatography technology	Bennett EJ (2010)	1
HAVCR2	0	PKP2	4	affinity chromatography technology	Huttlin EL (2017)	1
KRT5	1	KRT18	2	biochemical	Hutton E (1998)	1
ILK	0	PKP2	4	affinity chromatography technology	So J (2015)	1
JUP	7	APC	5	pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique	Shibata T (1994), Daniel JM (1995), Bandyopadhyay S (2010), Hein MY (2015), Chen TC (2014)	5
EGLN3	0	ARMC8	1	affinity chromatography technology	Rodriguez J (2016)	1
RPGRIP1L	2	PKP2	4	bioid	Gupta GD (2015)	1
LRRC4C	3	PKP2	4	affinity chromatography technology	Huttlin EL (2017)	1
SMAD9	0	RMND5A	0	two hybrid	Colland F (2004)	1
CUL3	17	G3BP1	4	affinity chromatography technology	Bennett EJ (2010)	1
TMEM17	0	PKP2	4	bioid	Gupta GD (2015)	1
YWHAQ	0	SFN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pozuelo-Rubio M (2010), Huttlin EL (2015), Huttlin EL (2017)	3
HSPB2	1	PKP2	4	two hybrid	Grose JH (2015)	1
BMI1	0	DROSHA	0	affinity chromatography technology	Cao Q (2014)	1
EED	1	GRN	2	affinity chromatography technology	Cao Q (2014)	1
TACR1	2	PKP2	4	affinity chromatography technology	Huttlin EL (2017)	1
YWHAE	0	YWHAQ	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Bandyopadhyay S (2010), Pozuelo-Rubio M (2010), Gloeckner CJ (2007), Wang J (2011)	4
PKP2	4	DSC1	2	two hybrid	Chen X (2002)	1
SFN	1	WDYHV1	0	two hybrid	Rual JF (2005)	1
KRT18	2	SEC16A	7	biochemical, affinity chromatography technology	Kristensen AR (2012), Hein MY (2015)	2
JUP	7	WDYHV1	0	two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009)	2
EGLN3	0	NDEL1	2	affinity chromatography technology	Rodriguez J (2016)	1
YWHAB	1	PKP2	4	affinity chromatography technology	Couzens AL (2013)	1
DSC1	2	DSG2	8	pull down, affinity chromatography technology	Chitaev NA (1997), Chitaev NA (1997)	2
JUP	7	DSC1	2	two hybrid	Cheng X (2004)	1
YWHAQ	0	APC	5	pull down	Meek SE (2004)	1
GTF2IRD1	6	PKP2	4	two hybrid	Carmona-Mora P (2015)	1
BMI1	0	PKP2	4	affinity chromatography technology	Cao Q (2014)	1
YWHAE	0	MAST3	6	affinity chromatography technology	Gloeckner CJ (2007)	1
BMI1	0	NDEL1	2	two hybrid	Rolland T (2014)	1
GTF2B	1	POLR3A	4	affinity chromatography technology	Mertens C (2001)	1
EGLN3	0	DROSHA	0	affinity chromatography technology	Rodriguez J (2016)	1
DSG1	1	DSC1	2	pull down	Smith EA (1998)	1
EGLN3	0	ILK	0	affinity chromatography technology	Rodriguez J (2016)	1
MAST3	6	PKP2	4	affinity chromatography technology	So J (2015)	1
DSG2	8	JUP	7	affinity chromatography technology, affinity chromatography technology, pull down	Bannon LJ (2001), Wahl JK3rd (2000), Ozawa M (1995)	3
RMND5A	0	PKP2	4	affinity chromatography technology	Lampert F (2018)	1
TMEM17	0	MARK3	2	bioid	Gupta GD (2015)	1
YWHAE	0	YWHAB	1	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical	Bandyopadhyay S (2010), Gloeckner CJ (2007), Couzens AL (2013), Wan C (2015)	4
SMAD9	0	YWHAQ	0	two hybrid	Colland F (2004)	1
PKP2	4	NDEL1	2	two hybrid	Rolland T (2014)	1
EGLN3	0	DSG2	8	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	APC	5	affinity chromatography technology	Rodriguez J (2016)	1
DSC2	2	DSG1	1	affinity chromatography technology	Marcozzi C (1998)	1
G3BP1	4	YWHAB	1	affinity chromatography technology	Jain S (2016)	1
RNF2	1	CDH1	4	affinity chromatography technology	Cao Q (2014)	1
PKP2	4	DSG2	8	affinity chromatography technology	Chen X (2002)	1
APC	5	KRT5	1	two hybrid	Bandyopadhyay S (2010)	1
CDH1	4	DSG2	8	bioid	Guo Z (2014)	1
YWHAB	1	MARK3	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Jin J (2004), Couzens AL (2013), Nichols RJ (2010)	4
NDEL1	2	YWHAE	0	two hybrid, pull down, affinity chromatography technology	Toyo-oka K (2003), Toyo-oka K (2003), Toyo-oka K (2003)	3
EGLN3	0	YWHAQ	0	affinity chromatography technology	Rodriguez J (2016)	1
CDH1	4	YWHAE	0	bioid	Guo Z (2014)	1
GRN	2	KRT18	2	two hybrid	Wang J (2011)	1
EYA4	1	PKP2	4	affinity chromatography technology	Li X (2016)	1
WDYHV1	0	PKP2	4	affinity chromatography technology	Huttlin EL (2017)	1
EED	1	MATR3	2	affinity chromatography technology	Cao Q (2014)	1
EFNB2	0	PKP2	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
YWHAQ	0	CEP250	4	affinity chromatography technology	Pozuelo-Rubio M (2010)	1
MINDY3	3	PKP2	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CUL3	17	ILK	0	affinity chromatography technology	Bennett EJ (2010)	1
GTSE1	3	SEC16A	7	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
SFN	1	G3BP1	4	affinity chromatography technology, affinity chromatography technology	Wilker EW (2007), Jain S (2016)	2
EGLN3	0	RMND5A	0	affinity chromatography technology	Rodriguez J (2016)	1
EED	1	PKP2	4	affinity chromatography technology	Cao Q (2014)	1
ESRRB	1	YWHAQ	0	affinity chromatography technology	Li J (2013)	1
SCARNA22	0	PKP2	4	affinity chromatography technology	Chu L (2012)	1
SMAD9	0	GRN	2	two hybrid	Colland F (2004)	1
CUL3	17	YWHAQ	0	affinity chromatography technology	Bennett EJ (2010)	1
EED	1	DSP	8	affinity chromatography technology	Cao Q (2014)	1
CUL3	17	YWHAE	0	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	DSP	8	affinity chromatography technology	Bennett EJ (2010)	1
SLC14A2	1	PKP2	4	affinity chromatography technology	Huttlin EL (2017)	1
PKP2	4	DSP	8	affinity chromatography technology, two hybrid	Chen X (2002), Chen X (2002)	2
SMAD9	0	PKP2	4	two hybrid	Colland F (2004)	1
SFN	1	APC	5	affinity chromatography technology	Benzinger A (2005)	1
YWHAE	0	PKP2	4	affinity chromatography technology	Gloeckner CJ (2007)	1
TMEM17	0	DSC2	2	bioid	Gupta GD (2015)	1
CDH1	4	PKP2	4	bioid	Guo Z (2014)	1
SFN	1	PKP2	4	affinity chromatography technology	Benzinger A (2005)	1
EGLN3	0	YWHAB	1	affinity chromatography technology	Rodriguez J (2016)	1
DSG1	1	JUP	7	pull down	Smith EA (1998)	1
YWHAQ	0	YWHAB	1	affinity chromatography technology, affinity chromatography technology, biochemical	Pozuelo-Rubio M (2010), Couzens AL (2013), Kristensen AR (2012)	3
MARK3	2	YWHAE	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goeransson O (2006), Goeransson O (2006), Gloeckner CJ (2007), Nichols RJ (2010)	4
KRT18	2	YWHAQ	0	affinity chromatography technology, affinity chromatography technology	Ku NO (1998), Pozuelo-Rubio M (2010)	2
CUL3	17	KRT5	1	affinity chromatography technology	Bennett EJ (2010)	1
TMEM17	0	EFNB2	0	bioid	Gupta GD (2015)	1
RPGRIP1L	2	APC	5	bioid	Gupta GD (2015)	1
G3BP1	4	PKP2	4	affinity chromatography technology	Jain S (2016)	1
SFN	1	MARK3	2	two hybrid, affinity chromatography technology	Rual JF (2005), Benzinger A (2005)	2
EED	1	CLK2	2	affinity chromatography technology	Cao Q (2014)	1
RMND5A	0	ARMC8	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017), Boldt K (2016), Lampert F (2018), Lampert F (2018)	5
CLK2	2	PKP2	4	affinity chromatography technology	Varjosalo M (2013)	1
SEC16A	7	PKP2	4	affinity chromatography technology	Hein MY (2015)	1
ILK	0	CDH1	4	affinity chromatography technology	So J (2015)	1
ESRRB	1	PKP2	4	affinity chromatography technology	Li J (2013)	1
MTUS2	4	WDYHV1	0	two hybrid	Rolland T (2014)	1
CDH1	4	SFN	1	bioid	Guo Z (2014)	1
CUL3	17	MATR3	2	affinity chromatography technology	Bennett EJ (2010)	1
RNF2	1	PKP2	4	affinity chromatography technology	Cao Q (2014)	1
EGLN3	0	SEC16A	7	affinity chromatography technology	Rodriguez J (2016)	1
PTGER3	2	PKP2	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CUL3	17	ARMC8	1	affinity chromatography technology	Bennett EJ (2010)	1
RNF2	1	SEC16A	7	affinity chromatography technology	Cao Q (2014)	1
PKP2	4	MTUS2	4	two hybrid	Rolland T (2014)	1
EGLN3	0	PKP2	4	affinity chromatography technology	Rodriguez J (2016)	1
GTSE1	3	PKP2	4	affinity chromatography technology	Hein MY (2015)	1
SFN	1	YWHAB	1	affinity chromatography technology	Huttlin EL (2017)	1
YWHAQ	0	MARK3	2	affinity chromatography technology, affinity chromatography technology, pull down	Ewing RM (2007), Nichols RJ (2010), Meek SE (2004)	3
DROSHA	0	PKP2	4	affinity chromatography technology	Li S (2014)	1
DSC2	2	JUP	7	affinity chromatography technology	Marcozzi C (1998)	1
PKP2	4	KRT5	1	pull down	Hofmann I (2000)	1
EED	1	KRT18	2	affinity chromatography technology	Cao Q (2014)	1
CDH1	4	MARK3	2	bioid	Guo Z (2014)	1
EGLN3	0	POLR3A	4	affinity chromatography technology	Rodriguez J (2016)	1