PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HERC5	2	PITX2	1	pull down	Takeuchi T (2006)	1
RBPJ	1	PITX2	1	affinity chromatography technology	Li X (2015)	1
LEF1	3	SMAD3	1	pull down, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology	Labbe E (2000), Labbe E (2000), Cui Q (2005), Cui Q (2005), Cui Q (2005)	5
PITX2	1	ZNHIT3	0	two hybrid	Ravasi T (2010)	1
IER2	1	PITX2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRIM25	5	CTNNB1	30	affinity chromatography technology	Choudhury NR (2017)	1
WDR5	2	PITX2	1	affinity chromatography technology, affinity chromatography technology	Gan Q (2011), Gan Q (2011)	2
TRIM25	5	PITX2	1	pull down, two hybrid	Takeuchi T (2006), Ravasi T (2010)	2
FOXC2	2	PITX2	1	affinity chromatography technology	Li X (2015)	1
LEF1	3	HDAC1	4	affinity chromatography technology	Billin AN (2000)	1
CTNNB1	30	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vietor I (2005), Billin AN (2000), Iguchi H (2007), Iioka H (2009)	4
PITX2	1	HDAC1	4	affinity chromatography technology	Kioussi C (2002)	1
TRIM25	5	ZNHIT3	0	affinity chromatography technology	Choudhury NR (2017)	1
CTNNB1	30	LEF1	3	affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Edlund S (2005), Grueneberg DA (2003), Behrens J (1996), Behrens J (1996), Labbe E (2000), Sierra J (2006), Gomes NP (2006), Vietor I (2005), Billin AN (2000), Fischer L (2002), Tutter AV (2001), Sadot E (2002), Feigin ME (2008), Daniels DL (2005), Porfiri E (1997), Porfiri E (1997), Hamada F (2004), Vadlamudi U (2005), Lu D (2012), Lu D (2012)	20
SMAD3	1	HDAC1	4	two hybrid, pull down	Liberati NT (2001), Akiyoshi S (1999)	2
LEF1	3	PITX2	1	pull down, pull down	Vadlamudi U (2005), Vadlamudi U (2005)	2
SMAD3	1	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tian YC (2002), Dahle O (2010), Charbonney E (2011), Zhou B (2012)	4
TRIM25	5	SMAD3	1	affinity chromatography technology	Choudhury NR (2017)	1
SMAD3	1	PITX2	1	affinity chromatography technology	Lamba P (2008)	1
HDAC1	4	WDR5	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Joshi P (2013), Xu Z (2012), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016)	5
PITX2	1	AHCYL1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AHCYL2	4	AHCYL1	2	affinity chromatography technology	Huttlin EL (2017)	1
PITX2	1	MSX2	1	genetic interference	Green PD (2002)	1
CTNNB1	30	HERC5	2	affinity chromatography technology, affinity chromatography technology	Lee JH (2010), Park YS (2017)	2
PITX2	1	LRRC46	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PITX2	1	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, imaging technique	Kioussi C (2002), Kioussi C (2002), Chen TC (2014)	3
PITX2	1	AHCYL2	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PITX2	1	PITX2	1	pull down, affinity chromatography technology, pull down	Green PD (2002), Green PD (2002), Amendt BA (1998)	3