PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RBPMS	0	C1orf94	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
PITX1	2	TRIM23	3	two hybrid	Corominas R (2014)	1
EGLN3	0	ALG13	9	affinity chromatography technology	Rodriguez J (2016)	1
LZTS2	4	RHOXF2	0	two hybrid	Rual JF (2005)	1
DVL3	7	PITX1	2	two hybrid	Rual JF (2005)	1
PITX1	2	PRR20A	0	two hybrid	Corominas R (2014)	1
XPO1	8	FOXO1	2	affinity chromatography technology	Kirli K (2015)	1
TRAPPC2	0	NR5A1	1	affinity chromatography technology, two hybrid	Jeyabalan J (2010), Jeyabalan J (2010)	2
MAGED1	0	RBPMS	0	two hybrid	Rolland T (2014)	1
PITX1	2	ALG13	9	two hybrid	Corominas R (2014)	1
SMAD3	1	HGS	5	affinity chromatography technology	Miura S (2000)	1
UPF2	2	PITX1	2	two hybrid	Lehner B (2004)	1
RNF31	3	SMAD3	1	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
C1orf94	1	PRR20A	0	two hybrid	Rolland T (2014)	1
PLSCR1	0	MGAT5B	5	two hybrid	Rolland T (2014)	1
EGLN3	0	DVL3	7	affinity chromatography technology	Rodriguez J (2016)	1
EWSR1	2	PLSCR1	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
RBPMS	0	RHOXF2	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
TRAPPC2	0	PITX1	2	affinity chromatography technology, two hybrid	Jeyabalan J (2010), Jeyabalan J (2010)	2
EGLN3	0	XPO1	8	affinity chromatography technology	Rodriguez J (2016)	1
MAGED1	0	RHOXF2	0	two hybrid	Rolland T (2014)	1
XPO1	8	DVL3	7	affinity chromatography technology	Kirli K (2015)	1
PITX1	2	SMARCA2	17	pull down	Bilodeau S (2006)	1
PITX1	2	CDX4	0	two hybrid	Corominas R (2014)	1
PITX1	2	LZTS2	4	two hybrid	Corominas R (2014)	1
PITX1	2	PLSCR1	0	two hybrid	Corominas R (2014)	1
SMAD3	1	FOXO1	2	affinity chromatography technology	Seoane J (2004)	1
EGLN3	0	LZTS2	4	affinity chromatography technology	Rodriguez J (2016)	1
PITX1	2	IPO13	6	two hybrid	Corominas R (2014)	1
PITX1	2	RHOXF2	0	two hybrid	Rual JF (2005)	1
PITX1	2	HGS	5	two hybrid	Corominas R (2014)	1
RBPMS	0	MGAT5B	5	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
XPO1	8	PITX1	2	affinity chromatography technology	Kirli K (2015)	1
PITX1	2	RNF31	3	two hybrid	Corominas R (2014)	1
SMAD3	1	PITX1	2	affinity chromatography technology	Lamba P (2008)	1
EWSR1	2	PITX1	2	bioid	Elzi DJ (2014)	1
PITX1	2	FOXO1	2	pull down	Skarra DV (2013)	1
PITX1	2	POU1F1	2	two hybrid, pull down	Szeto DP (1996), Szeto DP (1996)	2
PITX1	2	MAGED1	0	two hybrid	Corominas R (2014)	1
MAGED1	0	C1orf94	1	two hybrid	Rolland T (2014)	1
PITX1	2	MGAT5B	5	two hybrid	Corominas R (2014)	1
ZBTB32	0	RHOXF2	0	two hybrid, two hybrid, two hybrid	Rual JF (2005), Xin X (2009), Rolland T (2014)	3
XPO1	8	LZTS2	4	affinity chromatography technology	Kirli K (2015)	1
EGR1	1	PITX1	2	pull down	Tremblay JJ (1999)	1
RBPMS	0	PRR20A	0	two hybrid	Rolland T (2014)	1
RBPMS	0	ZBTB32	0	two hybrid	Rolland T (2014)	1
PITX1	2	RBPMS	0	two hybrid, two hybrid, two hybrid	Rual JF (2005), Corominas R (2014), Rolland T (2014)	3
PITX1	2	SPAG8	0	two hybrid	Corominas R (2014)	1
NR5A1	1	PITX1	2	pull down	Tremblay JJ (1999)	1
EWSR1	2	RBPMS	0	two hybrid	Rual JF (2005)	1
PITX1	2	RFX6	3	two hybrid	Corominas R (2014)	1
XPO1	8	UPF2	2	affinity chromatography technology	Kirli K (2015)	1
RBPMS	0	LZTS2	4	two hybrid	Rual JF (2005)	1
PITX1	2	ZBTB32	0	two hybrid	Corominas R (2014)	1
EGLN3	0	PITX1	2	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	MAGED1	0	affinity chromatography technology	Rodriguez J (2016)	1
EWSR1	2	RHOXF2	0	two hybrid	Rual JF (2005)	1
PITX1	2	C1orf94	1	two hybrid	Corominas R (2014)	1