Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
PI4KA 5297 WORTMANNIN CHEMBL428496 inhibitor GuideToPharmacologyInteractions
PI4KA 5297 PHENYLARSINE OXIDE CHEMBL477683 inhibitor GuideToPharmacologyInteractions

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
PI4KA rs165854 AG + GG antipsychotics efficacy yes When combined with rs1468412 AA and AT genotypes. rs165854 AG+GG/rs1468412 AA+AT was associated with a significantly increased likelihood of patients having an incomplete antipsychotic response within a cohort of 1) all patients, 2) patients receiving atypical monotherapy and 3) patients receiving risperidone. Response assessed using CGI scale, patients were either complete responders (CR) or incomplete responders (IR) based on this scale. Genotypes AG + GG is associated with decreased response to antipsychotics in people with Schizophrenia. 25209194 1446895651