PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
LYN	2	KIT	4	affinity chromatography technology, affinity chromatography technology, pull down	Liang X (2002), Linnekin D (1997), Linnekin D (1997)	3
PIK3CG	3	ZNF282	1	two hybrid	Vinayagam A (2011)	1
PIK3CD	4	PIK3CG	3	pull down, affinity chromatography technology	Vanhaesebroeck B (1997), Vanhaesebroeck B (1997)	2
ERAS	0	PIK3CG	3	affinity chromatography technology	Takahashi K (2003)	1
EPHA8	4	PIK3CG	3	affinity chromatography technology	Gu C (2001)	1
BCR	3	PIK3CG	3	affinity chromatography technology, imaging technique	Skorski T (1995), Chen TC (2014)	2
PRKAA2	1	PIK3CG	3	affinity chromatography technology	Behrends C (2010)	1
PIK3CG	3	UTRN	6	affinity chromatography technology	Behrends C (2010)	1
PIK3CG	3	SET	8	enzymatic study	Vasudevan NT (2011)	1
PIK3CG	3	GNG2	0	genetic interference	Brock C (2003)	1
LYN	2	PIK3CG	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Pigazzi A (1999), Marcilla A (1995), Marcilla A (1995), Marcilla A (1995)	4
HRAS	2	PIK3CG	3	x-ray crystallography	Pacold ME (2000)	1
PIK3CG	3	PRMT7	0	affinity chromatography technology	Behrends C (2010)	1
BECN1	2	PIK3CG	3	affinity chromatography technology	Sun Q (2008)	1
PIK3CG	3	KRAS	1	pull down, affinity chromatography technology	Rubio I (1999), Rubio I (1999)	2
GNG2	0	GNB1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, fluorescent resonance energy transfe	Snow BE (1999), Poon LS (2009), Snow BE (1998), Howlett AC (2009), Lukov GL (2005), Howlett AC (2009), Gales C (2005), Rosskopf D (2003), Zhou JY (2003)	9
PIK3CG	3	GNB1	4	genetic interference	Brock C (2003)	1
PIK3R5	2	GNB1	4	genetic interference	Brock C (2003)	1
NRAS	1	PIK3CG	3	pull down	Pacold ME (2000)	1
SYK	3	PIK3CG	3	affinity chromatography technology	Marcilla A (1995)	1
HRAS	2	PIK3CD	4	two hybrid	Boettner B (2000)	1
KIT	4	PIK3CG	3	imaging technique	Chen TC (2014)	1
BCR	3	KIT	4	affinity chromatography technology, affinity chromatography technology, imaging technique	Hallek M (1996), Hallek M (1996), Chen TC (2014)	3
FPR1	1	PIK3R5	2	genetic interference	Brock C (2003)	1
GABARAPL1	0	PIK3CG	3	affinity chromatography technology	Behrends C (2010)	1
USP45	3	PIK3CG	3	affinity chromatography technology	Sowa ME (2009)	1
FPR1	1	PIK3CG	3	genetic interference	Brock C (2003)	1
SYK	3	LYN	2	affinity chromatography technology, pull down	Sidorenko SP (1995), Sidorenko SP (1995)	2
PIK3R5	2	PIK3CG	3	fluorescent resonance energy transfe, biochemical, imaging technique, genetic interference, imaging technique	Brock C (2003), Brock C (2003), Brock C (2003), Brock C (2003), Chen TC (2014)	5
PIK3R5	2	GNG2	0	genetic interference	Brock C (2003)	1