Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
PIK3CA 5290 GSK-1059615 CHEMBL3544966 inhibitor CKB, ChemblInteractions
PIK3CA 5290 WX-037 CHEMBL3545385 inhibitor ChemblInteractions
PIK3CA 5290 GEDATOLISIB CHEMBL592445 inhibitor ClearityFoundationBiomarkers, MyCancerGenome, CKB, GuideToPharmacologyInteractions, ChemblInteractions, MyCancerGenomeClinicalTrial 17314276, 21325073, 24042735, 24823695, 25977343, 25688157
PIK3CA 5290 VOXTALISIB CHEMBL3545366 inhibitor ClearityFoundationBiomarkers, MyCancerGenome, TdgClinicalTrial, CKB, ChemblInteractions, DrugBank, CancerCommons 24634413, 24583798
PIK3CA 5290 AZD-6482 CHEMBL2165191 inhibitor CKB, GuideToPharmacologyInteractions, ChemblInteractions
PIK3CA 5290 CUDC-907 CHEMBL3545052 inhibitor CKB, GuideToPharmacologyInteractions, ChemblInteractions 22693356, 20570890
PIK3CA 5290 OXAZEPAM CHEMBL568 inhibitor GuideToPharmacologyInteractions
PIK3CA 5290 CHEMBL1086377 CHEMBL1086377 inhibitor GuideToPharmacologyInteractions
PIK3CA 5290 PI-103 CHEMBL573339 inhibitor MyCancerGenome, CKB, GuideToPharmacologyInteractions 22336586
PIK3CA 5290 CHEMBL568150 CHEMBL568150 inhibitor GuideToPharmacologyInteractions
PIK3CA 5290 TASELISIB CHEMBL2387080 inhibitor MyCancerGenome, OncoKB, CKB, GuideToPharmacologyInteractions, ChemblInteractions 28331003, 26333383, 26589432, 23662903, 25172762, 25877889, 27672108, 21362200, 23903756, 24310736, 24076665, 22049316, 22340590, 24561032, 22355357, 20881279, 21169255, 24244612, 23850807, 24900266, 23136191, 23721513, 23258246, 24608574, 22065080, 22188813, 23726034, 22653967
PIK3CA 5290 VS-5584 CHEMBL1079593 inhibitor CKB, GuideToPharmacologyInteractions, ChemblInteractions 23270925
PIK3CA 5290 CAMPTOTHECIN CHEMBL65 CKB, NCI 12464623, 25688157, 24042735
PIK3CA 5290 ALVOCIDIB CHEMBL428690 NCI 14767524
PIK3CA 5290 PACLITAXEL CHEMBL428647 CKB, NCI 12761490, 26469692, 24170767, 26245675, 21216929
PIK3CA 5290 QUERCETIN CHEMBL50 inhibitor MyCancerGenome, NCI 17045724
PIK3CA 5290 RESVERATROL CHEMBL165 NCI 15925284
PIK3CA 5290 STREPTOZOTOCIN CHEMBL1651906 NCI 16130182
PIK3CA 5290 TRASTUZUMAB CHEMBL1201585 OncoKB, CKB, CGI, CIViC 27402769, 23903756, 23085766, 24900266, 23275335, 27126994, 25877889, 22188813, 22915752, 22915751, 24198241, 25425103, 23726034, 22294718, 20453058, 27687302, 26245675, 26469692, 24470511, 17936563, 21676217, 23940356, 21558396, 28167203
PIK3CA 5290 LETROZOLE CHEMBL1444 OncoKB, CKB 27126994, 27402769, 23903756, 23085766, 24900266, 23275335, 25877889, 22188813, 22915752, 22915751, 24198241, 25425103, 23726034
PIK3CA 5290 DS-7423 CHEMBL3545248 inhibitor ClearityFoundationBiomarkers, CKB, ChemblInteractions 24504419
PIK3CA 5290 Panulisib CHEMBL3545322 inhibitor CKB, ChemblInteractions 25700704
PIK3CA 5290 PKI-179 CHEMBL1258517 inhibitor CKB, ChemblInteractions 20797855
PIK3CA 5290 PWT-33587 CHEMBL3545006 inhibitor ChemblInteractions
PIK3CA 5290 RG-7666 CHEMBL3545324 inhibitor ChemblInteractions
PIK3CA 5290 PWT-33579 CHEMBL3545323 inhibitor ChemblInteractions
PIK3CA 5290 RIGOSERTIB CHEMBL1241855 TdgClinicalTrial, CKB 23873848, 27104980
PIK3CA 5290 BGT-226 (CHEMBL3545096) CHEMBL3545096 inhibitor ChemblInteractions
PIK3CA 5290 CABOZANTINIB CHEMBL2105717 CIViC 25242168
PIK3CA 5290 TRAMETINIB CHEMBL2103875 CKB 26369631, 26627007, 27659046, 26469692, 27797976, 26882569
PIK3CA 5290 SORAFENIB CHEMBL1336 CKB 25363205, 23629727
PIK3CA 5290 FLUOROURACIL CHEMBL185 CKB 22336586, 28424201, 25714871
PIK3CA 5290 TRASTUZUMAB EMTANSINE CHEMBL1743082 CKB 26920887
PIK3CA 5290 SELUMETINIB CHEMBL1614701 CKB 22271687, 24939055, 26272063, 21358673, 26137449, 26232337
PIK3CA 5290 DEGUELIN CHEMBL393417 CKB 20811676, 24978597
PIK3CA 5290 CHEMBL263664 CHEMBL263664 CKB 21191045
PIK3CA 5290 UPROSERTIB CHEMBL3137336 CKB
PIK3CA 5290 CC-223 CHEMBL3545151 CKB 26177599, 25855786, 24978597
PIK3CA 5290 OSI-027 CHEMBL3120215 CKB 21673091
PIK3CA 5290 MSC-2363318A CHEMBL3545003 CKB 27186432
PIK3CA 5290 TAK-733 CHEMBL1615025 CKB 26439693
PIK3CA 5290 AEW-541 CHEMBL551064 CKB 27196766
PIK3CA 5290 LINSITINIB CHEMBL1091644 CKB 27196766
PIK3CA 5290 DEMCIZUMAB CHEMBL2109384 CKB 26855149
PIK3CA 5290 PONATINIB CHEMBL1171837 CKB 26270481
PIK3CA 5290 BORTEZOMIB CHEMBL325041 CKB 21216929
PIK3CA 5290 TOPOTECAN CHEMBL84 CKB 21216929
PIK3CA 5290 WORTMANNIN CHEMBL428496 inhibitor GuideToPharmacologyInteractions, DrugBank 10592235
PIK3CA 5290 BUPARLISIB CHEMBL2017974 inhibitor MyCancerGenome, OncoKB, CKB, GuideToPharmacologyInteractions, ChemblInteractions, CancerCommons 25877889, 27672108, 21362200, 23903756, 24310736, 23662903, 25172762, 24076665, 22049316, 22340590, 24561032, 22355357, 20881279, 21169255, 24244612, 23850807, 24900266, 23136191, 23721513, 23258246, 24608574, 22065080, 22188813, 23726034, 22653967, 27402769, 23085766, 23275335, 27126994, 22915752, 22915751, 24198241, 25425103, 26098748, 22159814, 26909613, 26715098, 28539475, 26013318, 27974663, 24470511, 23940356, 28119489
PIK3CA 5290 INK-128 CHEMBL3545056 inhibitor OncoKB, CKB, GuideToPharmacologyInteractions 27402769, 23903756, 23085766, 24900266, 23275335, 27126994, 25877889, 22188813, 22915752, 22915751, 24198241, 25425103, 23726034, 26272063, 27974663, 25261369
PIK3CA 5290 PILARALISIB (CHEMBL3360203) CHEMBL3360203 inhibitor GuideToPharmacologyInteractions, ChemblInteractions
PIK3CA 5290 TG100-115 CHEMBL230011 inhibitor GuideToPharmacologyInteractions
PIK3CA 5290 INDOLE-3-CARBINOL CHEMBL155625 NCI 11948137
PIK3CA 5290 ETRETINATE CHEMBL464 NCI 15020266
PIK3CA 5290 VINCRISTINE CHEMBL90555 NCI 12874004
PIK3CA 5290 SAR-260301 CHEMBL3545008 inhibitor CancerCommons
PIK3CA 5290 GSK-2636771 CHEMBL3188551 inhibitor MyCancerGenome
PIK3CA 5290 Puquitinib CHEMBL3545088 inhibitor ChemblInteractions
PIK3CA 5290 MK-2206 CHEMBL1079175 CKB, CIViC 23888070, 26627007, 21289267, 26187616, 22932669, 26084990
PIK3CA 5290 Acalisib CHEMBL3545397 CKB
PIK3CA 5290 COBIMETINIB CHEMBL2146883 CKB 22084396
PIK3CA 5290 VENETOCLAX CHEMBL3137309 CKB 27974663
PIK3CA 5290 TAMOXIFEN CHEMBL83 CKB 26116361
PIK3CA 5290 DABRAFENIB CHEMBL2028663 CKB 27797976
PIK3CA 5290 CHEMBL376408 CHEMBL376408 CKB 27974663
PIK3CA 5290 PILARALISIB (CHEMBL3218575) CHEMBL3218575 inhibitor MyCancerGenome, CKB, DrugBank 24166903, 25637314, 21216929
PIK3CA 5290 APITOLISIB CHEMBL1922094 inhibitor MyCancerGenome, CKB, GuideToPharmacologyInteractions, ChemblInteractions 21998291, 26787751, 26951309
PIK3CA 5290 PA-799 CHEMBL1684984 inhibitor CKB, GuideToPharmacologyInteractions, ChemblInteractions, CIViC 21558396, 25231405
PIK3CA 5290 DACTOLISIB CHEMBL1879463 inhibitor ClearityFoundationBiomarkers, MyCancerGenome, CKB, GuideToPharmacologyInteractions, ChemblInteractions, CIViC, CancerCommons, MyCancerGenomeClinicalTrial 19029981, 23619167, 22662154, 26627007, 23475782, 24939055, 22543857, 27974663, 23629727, 26272063, 26013318, 21966435, 26137449, 24927217, 28446642, 26232337, 26270481
PIK3CA 5290 PHENMETRAZINE CHEMBL1201208 inhibitor OncoKB, CKB, GuideToPharmacologyInteractions 22294718, 23394218, 23258740, 21362200, 23903756, 24310736, 23662903, 25172762, 24076665, 22049316, 22340590, 24561032, 22355357, 20881279, 21169255, 24244612, 23850807, 24900266, 23136191, 23721513, 23258246, 25877889, 24608574, 22065080, 22188813, 27672108, 23726034, 22653967, 21668414, 26137449
PIK3CA 5290 IDELALISIB CHEMBL2216870 inhibitor CKB, GuideToPharmacologyInteractions, CIViC 26466009, 26137449
PIK3CA 5290 CHEMBL1081312 CHEMBL1081312 inhibitor GuideToPharmacologyInteractions
PIK3CA 5290 ZSTK-474 CHEMBL586701 inhibitor ClearityFoundationBiomarkers, CKB, GuideToPharmacologyInteractions, ChemblInteractions 26137449
PIK3CA 5290 MILTEFOSINE CHEMBL125 NCI 16752184
PIK3CA 5290 SURAMIN CHEMBL265502 NCI 15833899
PIK3CA 5290 AZD-5363 CHEMBL2178577 OncoKB, CKB, CIViC 22294718, 23394218, 23258740, 24088382, 19755509, 26116361
PIK3CA 5290 FULVESTRANT CHEMBL1358 OncoKB, CKB 25877889, 27672108, 21362200, 23903756, 24310736, 23662903, 25172762, 24076665, 22049316, 22340590, 24561032, 22355357, 20881279, 21169255, 24244612, 23850807, 24900266, 23136191, 23721513, 23258246, 24608574, 22065080, 22188813, 23726034, 22653967, 27174596
PIK3CA 5290 Ribociclib CHEMBL3545110 OncoKB, CIViC 27402769, 23903756, 23085766, 24900266, 23275335, 27126994, 25877889, 22188813, 22915752, 22915751, 24198241, 25425103, 23726034, 25002028
PIK3CA 5290 MLN-1117 CHEMBL3545379 inhibitor ChemblInteractions
PIK3CA 5290 RECILISIB CHEMBL2219421 inhibitor ChemblInteractions
PIK3CA 5290 DOCETAXEL CHEMBL92 PharmGKB
PIK3CA 5290 BUPARLISIB HYDROCHLORIDE CHEMBL2364604 inhibitor MyCancerGenomeClinicalTrial
PIK3CA 5290 PANITUMUMAB CHEMBL1201827 CIViC 19223544
PIK3CA 5290 PALBOCICLIB CHEMBL189963 CKB, CIViC 25002028, 26369631, 27020857
PIK3CA 5290 BEVACIZUMAB CHEMBL1201583 CKB 25363205, 21216929, 27893038, 23940356
PIK3CA 5290 ARQ-092 CHEMBL3545422 CKB 26469692
PIK3CA 5290 A-443654 CHEMBL379300 CKB 24978597, 24569089, 19208828
PIK3CA 5290 NAVITOCLAX CHEMBL443684 CKB 27659046, 27197306
PIK3CA 5290 CHEMBL1765740 CHEMBL1765740 CKB 27451907
PIK3CA 5290 CAPECITABINE CHEMBL1773 CKB 26920887
PIK3CA 5290 REGORAFENIB CHEMBL1946170 CKB 25838391, 23629727
PIK3CA 5290 PIMASERTIB CHEMBL2107832 CKB 23629727
PIK3CA 5290 FLOXURIDINE CHEMBL917 CKB 25714871
PIK3CA 5290 CHEMBL589258 CHEMBL589258 CKB 20371716
PIK3CA 5290 VEMURAFENIB CHEMBL1229517 CKB 26137449, 24265153
PIK3CA 5290 TORIN1 CHEMBL1256459 CKB 27974663
PIK3CA 5290 RIDAFOROLIMUS CHEMBL2103839 CKB 26187616
PIK3CA 5290 DASATINIB CHEMBL1421 CKB 26855149
PIK3CA 5290 PF-04691502 CHEMBL1234354 inhibitor ClearityFoundationBiomarkers, MyCancerGenome, CKB, GuideToPharmacologyInteractions, ChemblInteractions 21750219
PIK3CA 5290 ALPELISIB CHEMBL2396661 inhibitor ClearityFoundationBiomarkers, MyCancerGenome, OncoKB, CKB, GuideToPharmacologyInteractions, ChemblInteractions, CancerCommons, MyCancerGenomeClinicalTrial 25877889, 27672108, 21362200, 23903756, 24310736, 23662903, 25172762, 24076665, 22049316, 22340590, 24561032, 22355357, 20881279, 21169255, 24244612, 23850807, 24900266, 23136191, 23721513, 23258246, 24608574, 22065080, 22188813, 23726034, 22653967, 27402769, 23085766, 23275335, 27126994, 22915752, 22915751, 24198241, 25425103, 26627007, 26013318, 27602501, 27604488, 28119489, 27451907, 27974663
PIK3CA 5290 AMG-319 CHEMBL3545048 inhibitor GuideToPharmacologyInteractions
PIK3CA 5290 AZD-8186 CHEMBL3545424 inhibitor GuideToPharmacologyInteractions
PIK3CA 5290 DUVELISIB CHEMBL3039502 inhibitor GuideToPharmacologyInteractions
PIK3CA 5290 OMIPALISIB CHEMBL1236962 inhibitor ClearityFoundationBiomarkers, CKB, GuideToPharmacologyInteractions, ChemblInteractions, MyCancerGenomeClinicalTrial 26603258
PIK3CA 5290 CHEMBL1231533 CHEMBL1231533 inhibitor GuideToPharmacologyInteractions
PIK3CA 5290 PICTILISIB CHEMBL521851 inhibitor MyCancerGenome, CKB, GuideToPharmacologyInteractions, ChemblInteractions, CIViC 27174596, 26058079, 23674493, 24601221, 27196766, 27020857, 24339963, 27604488, 22084396, 27197306, 23136191, 28119489, 23888070, 27489350
PIK3CA 5290 YOHIMBINE CHEMBL15245 inhibitor OncoKB, GuideToPharmacologyInteractions 21362200, 23903756, 24310736, 23662903, 25172762, 24076665, 22049316, 22340590, 24561032, 22355357, 20881279, 21169255, 24244612, 23850807, 24900266, 23136191, 23721513, 23258246, 25877889, 24608574, 22065080, 22188813, 27672108, 23726034, 22653967, 27402769, 23085766, 23275335, 27126994, 22915752, 22915751, 24198241, 25425103
PIK3CA 5290 CARBOPLATIN CHEMBL1351 CKB, NCI 21216929, 16275998
PIK3CA 5290 IRINOTECAN CHEMBL481 CKB, NCI 15809721, 25714871, 21325073, 16707468, 24042735
PIK3CA 5290 RALOXIFENE CHEMBL81 NCI 11901050
PIK3CA 5290 SIROLIMUS CHEMBL413 CKB, NCI, CIViC 17376864, 15647370, 19029981, 26882569, 28514312, 15878982
PIK3CA 5290 COPANLISIB CHEMBL3218576 inhibitor ClearityFoundationBiomarkers, MyCancerGenome, OncoKB, CKB, ChemblInteractions, CancerCommons, MyCancerGenomeClinicalTrial 25877889, 27672108, 21362200, 23903756, 24310736, 23662903, 25172762, 24076665, 22049316, 22340590, 24561032, 22355357, 20881279, 21169255, 24244612, 23850807, 24900266, 23136191, 23721513, 23258246, 24608574, 22065080, 22188813, 23726034, 22653967, 24170767
PIK3CA 5290 OLAPARIB CHEMBL521686 OncoKB, CKB 26909613, 27402769, 23903756, 23085766, 24900266, 23275335, 27126994, 25877889, 22188813, 22915752, 22915751, 24198241, 25425103, 23726034
PIK3CA 5290 EVEROLIMUS CHEMBL1908360 ClearityFoundationBiomarkers, OncoKB, CKB, CGI, CIViC 27402769, 23903756, 23085766, 24900266, 23275335, 27126994, 25877889, 22188813, 22915752, 22915751, 24198241, 25425103, 23726034, 27091708, 21358673, 20664174, 20664172, 23629727, 22662154, 27893038, 26951309, 27797976
PIK3CA 5290 SONOLISIB CHEMBL411907 inhibitor MyCancerGenome, CKB, ChemblInteractions, CancerCommons, MyCancerGenomeClinicalTrial 22693357
PIK3CA 5290 SF-1126 CHEMBL2326966 inhibitor MyCancerGenome, TdgClinicalTrial, ChemblInteractions
PIK3CA 5290 BAY-1082439 CHEMBL3545245 inhibitor CKB, ChemblInteractions
PIK3CA 5290 HERBIMYCIN CHEMBL479533 NCI 11139143
PIK3CA 5290 TEMSIROLIMUS CHEMBL1201182 ClearityFoundationBiomarkers, CKB, CIViC 19706758, 21216929, 27016228, 22245973, 22271473, 21289267, 25527417, 27893038
PIK3CA 5290 CETUXIMAB CHEMBL1201577 CKB, CGI, CIViC 19223544, 20619739, 28424201, 25714871, 25724520, 25838391, 26715098, 27002107, 28446642
PIK3CA 5290 LAPATINIB CHEMBL554 CKB, CIViC 22294718, 26627007, 27687302, 26245675, 26920887, 23940356, 26270481
PIK3CA 5290 NERATINIB CHEMBL180022 CKB 26627007, 26333383, 26243863
PIK3CA 5290 BAY-1125976 CHEMBL3545049 CKB 27699769
PIK3CA 5290 PD-0325901 CHEMBL507361 CKB 26272063, 24339963, 21325073
PIK3CA 5290 LY-2780301 CHEMBL3545134 CKB 28750271, 25902900
PIK3CA 5290 METFORMIN CHEMBL1431 CKB 23986086
PIK3CA 5290 BENZONATATE CHEMBL1374379 CKB 27974663
PIK3CA 5290 PERTUZUMAB CHEMBL2007641 CKB 23940356
PIK3CA 5290 INFIGRATINIB CHEMBL1852688 CKB 28119489
PIK3CA 5290 LY-294002 CHEMBL98350 inhibitor CKB, GuideToPharmacologyInteractions 18262558
PIK3CA 5290 LY-3023414 CHEMBL3544999 inhibitor CKB, GuideToPharmacologyInteractions, ChemblInteractions 27439478
PIK3CA 5290 CHEMBL126955 CHEMBL126955 NCI 16267832
PIK3CA 5290 REGRAMOSTIM CHEMBL2107881 NCI 15107457
PIK3CA 5290 SULINDAC CHEMBL15770 NCI 12654560
PIK3CA 5290 INK-1117 CHEMBL3545055 inhibitor MyCancerGenome, CKB, ChemblInteractions 28490463
PIK3CA 5290 AT-13148 CHEMBL3544960 CKB 22781553
PIK3CA 5290 CANDICIDIN CHEMBL1200647 inhibitor CKB, GuideToPharmacologyInteractions 26839307
PIK3CA 5290 ZINC SULFATE CHEMBL1200929 NCI 15715661
PIK3CA 5290 MIDOSTAURIN CHEMBL608533 NCI 11719451
PIK3CA 5290 LUCITANIB CHEMBL2220486 CKB 27126994
PIK3CA 5290 IPATASERTIB CHEMBL2177390 CKB 24141624
PIK3CA 5290 CHEMBL428462 CHEMBL428462 CKB 20423992, 24978597
PIK3CA 5290 AFURESERTIB CHEMBL2219422 CKB 24978597
PIK3CA 5290 PRASTERONE CHEMBL90593 NCI 15501480
PIK3CA 5290 DOXORUBICIN CHEMBL53463 CKB, NCI 12761490, 16905201, 27893038
PIK3CA 5290 PERIFOSINE CHEMBL372764 CIViC 19706758
PIK3CA 5290 AZD-8055 CHEMBL1801204 CKB 22271687, 28446642
PIK3CA 5290 GEMCITABINE CHEMBL888 CKB 28750271
PIK3CA 5290 U-0126 CHEMBL100473 CKB 21358673

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID