Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
PGR 5241 DROSPIRENONE CHEMBL1509 agonist TdgClinicalTrial, ChemblInteractions, TEND, DrugBank 8922878, 16291771, 11024226, 17000933, 16157482, 15493951
PGR 5241 DESOGESTREL CHEMBL1533 agonist, modulator TdgClinicalTrial, ChemblInteractions, TEND, DrugBank, TTD 7750284, 11752352, 10601100, 6645495, 11041225, 3139361
PGR 5241 SPIRONOLACTONE CHEMBL1393 agonist DrugBank 20650892
PGR 5241 MEDROXYPROGESTERONE ACETATE CHEMBL717 agonist GuideToPharmacologyInteractions, ChemblInteractions, NCI, DrugBank 17109827, 16985038, 11752352, 17013809, 17015480, 17138644, 12846422
PGR 5241 NORGESTIMATE CHEMBL1200934 agonist TdgClinicalTrial, ChemblInteractions, TEND, DrugBank, TTD 7750291, 11752352, 17107221, 8384965, 1324557
PGR 5241 ALLYLESTRENOL CHEMBL2105618 agonist DrugBank 17109827, 17169175, 17013809, 17015480, 17138644, 3928974
PGR 5241 HYDROXYPROGESTERONE CAPROATE CHEMBL1200848 agonist ChemblInteractions, DrugBank 26558340
PGR 5241 LAPATINIB CHEMBL554 FDA
PGR 5241 PROMEGESTONE CHEMBL196003 agonist GuideToPharmacologyInteractions
PGR 5241 CHEMBL2311103 CHEMBL2311103 agonist GuideToPharmacologyInteractions
PGR 5241 PF-03882845 CHEMBL3545175 antagonist GuideToPharmacologyInteractions
PGR 5241 NORETHYNODREL CHEMBL1387 agonist ChemblInteractions
PGR 5241 MIFEPRISTONE CHEMBL1276308 agonist, antagonist TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, TEND, DrugBank, TTD 10806733, 11752352, 10374120, 11783365, 10699595, 10682471
PGR 5241 METRIBOLONE CHEMBL166444 DrugBank 17139284, 17016423, 10592235
PGR 5241 NORELGESTROMIN CHEMBL1200807 agonist TdgClinicalTrial, ChemblInteractions, DrugBank 17107221, 8384965, 19962254, 7750291, 1324557
PGR 5241 Ribociclib CHEMBL3545110 FDA
PGR 5241 NORETHINDRONE CHEMBL1162 agonist TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, TEND, TTD
PGR 5241 ULIPRISTAL ACETATE CHEMBL260538 agonist, antagonist, modulator GuideToPharmacologyInteractions, ChemblInteractions
PGR 5241 CHEMBL407848 CHEMBL407848 antagonist GuideToPharmacologyInteractions
PGR 5241 GESTODENE CHEMBL1213583 TdgClinicalTrial
PGR 5241 ASOPRISNIL CHEMBL267431 antagonist, modulator GuideToPharmacologyInteractions, ChemblInteractions, TTD
PGR 5241 DANAZOL CHEMBL1479 agonist ChemblInteractions, DrugBank 2404115, 18061638, 17636649, 8000225
PGR 5241 ETONOGESTREL CHEMBL1531 agonist, binder TdgClinicalTrial, ChemblInteractions, TEND, DrugBank, TTD 11752352, 10601100, 15063480, 11041225
PGR 5241 DYDROGESTERONE CHEMBL1200853 agonist TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, TEND, DrugBank, TTD 8486204, 15128769, 11752352, 6827166, 16045524, 436795
PGR 5241 PROGESTERONE CHEMBL103 agonist TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, TEND, DrugBank 17109827, 17169175, 17013809, 17015480, 17138644, 9506743
PGR 5241 TANAPROGET CHEMBL539163 agonist GuideToPharmacologyInteractions, DrugBank 15937332, 10592235
PGR 5241 ULIPRISTAL CHEMBL2103846 modulator TdgClinicalTrial, ChemblInteractions, TEND, DrugBank, TTD 23437846
PGR 5241 LETROZOLE CHEMBL1444 ClearityFoundationBiomarkers, FDA
PGR 5241 TRASTUZUMAB CHEMBL1201585 FDA
PGR 5241 NORETHINDRONE ACETATE CHEMBL1201146 agonist ChemblInteractions
PGR 5241 DIENOGEST CHEMBL1201864 TdgClinicalTrial
PGR 5241 ETHYNODIOL DIACETATE CHEMBL1200624 agonist, binder TdgClinicalTrial, ChemblInteractions, TEND, TTD
PGR 5241 ANASTROZOLE CHEMBL1399 ClearityFoundationBiomarkers
PGR 5241 PF-05019702 CHEMBL3545239 antagonist ChemblInteractions
PGR 5241 TELAPRISTONE ACETATE CHEMBL2105694 modulator ChemblInteractions, DrugBank
PGR 5241 ONAPRISTONE CHEMBL1908373 antagonist GuideToPharmacologyInteractions, ChemblInteractions
PGR 5241 MEGESTROL ACETATE CHEMBL1201139 agonist, binder ClearityFoundationBiomarkers, TdgClinicalTrial, ChemblInteractions, TEND, DrugBank, TTD 14687437, 15086241, 16343217, 9744490, 2982481, 19434889, 11752352, 19731987, 15595341
PGR 5241 LEVONORGESTREL CHEMBL1389 agonist, binder TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, TEND, DrugBank 11752352, 17077229, 17531625, 16084894, 17484506, 16157482
PGR 5241 NORGESTREL CHEMBL2107797 agonist, binder TdgClinicalTrial, ChemblInteractions, TEND, DrugBank 11521119
PGR 5241 LONAPRISAN CHEMBL146032 antagonist ChemblInteractions
PGR 5241 CHEMBL1390 CHEMBL1390 agonist TTD
PGR 5241 TAMOXIFEN CHEMBL83 ClearityFoundationBiomarkers, NCI, FDA 3793272
PGR 5241 TOREMIFENE CHEMBL1655 NCI 2147123
PGR 5241 SIROLIMUS CHEMBL413 NCI 1284044

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
PGR rs537681 CT + TT etonogestrel "efficacy","metabolism/PK" no "11.7% (31/266) of carriers for rs537681 had serum etonogestrel concentrations that fell below 90 pg/mL" (the level for suppression of ovulation) in contraceptive implant users which may theoretically put them at risk for contraceptive failure. Corrected P-value cutoff of 5.0E-4 was not met. Genotypes CT + TT is associated with decreased steady-state concentration of etonogestrel in women as compared to genotype CC. 30870275 1450375846